Cholangiocytes act as facultative liver stem cells during impaired hepatocyte regeneration

Alexander Raven, Wei-Yu Lu, Tak Yung Man, Sofia Ferreira-Gonzalez, Eoghan O’Duibhir, Benjamin J. Dwyer, John P. Thomson, Richard R. Meehan, Roman Bogorad, Victor Koteliansky, Yuri Kotelevtsev, Charles ffrench-Constant, Luke Boulter and Stuart J. Forbes ()
Additional contact information
Alexander Raven: MRC Centre for Regenerative Medicine, University of Edinburgh
Wei-Yu Lu: MRC Centre for Regenerative Medicine, University of Edinburgh
Tak Yung Man: MRC Centre for Regenerative Medicine, University of Edinburgh
Sofia Ferreira-Gonzalez: MRC Centre for Regenerative Medicine, University of Edinburgh
Eoghan O’Duibhir: MRC Centre for Regenerative Medicine, University of Edinburgh
Benjamin J. Dwyer: MRC Centre for Regenerative Medicine, University of Edinburgh
John P. Thomson: MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh
Richard R. Meehan: MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh
Roman Bogorad: David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
Victor Koteliansky: Functional Genomics and RNAi Therapy CREI, Skolkovo Institute for Science and Technology
Yuri Kotelevtsev: Functional Genomics and RNAi Therapy CREI, Skolkovo Institute for Science and Technology
Charles ffrench-Constant: MRC Centre for Regenerative Medicine, University of Edinburgh
Luke Boulter: MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh
Stuart J. Forbes: MRC Centre for Regenerative Medicine, University of Edinburgh

Nature, 2017, vol. 547, issue 7663, 350-354

Abstract: Two independent systems impairing hepatocyte proliferation during liver injury cause physiologically significant levels of functional hepatocyte regeneration from biliary cells.

Date: 2017
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DOI: 10.1038/nature23015

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