Unique roles for histone H3K9me states in RNAi and heritable silencing of transcription

Gloria Jih, Nahid Iglesias, Mark A. Currie, Natarajan V. Bhanu, Joao A. Paulo, Steven P. Gygi, Benjamin A. Garcia and Danesh Moazed ()
Additional contact information
Gloria Jih: Harvard Medical School
Nahid Iglesias: Harvard Medical School
Mark A. Currie: Harvard Medical School
Natarajan V. Bhanu: Epigenetics Program, Perelman School of Medicine, University of Pennsylvania
Joao A. Paulo: Harvard Medical School
Steven P. Gygi: Harvard Medical School
Benjamin A. Garcia: Epigenetics Program, Perelman School of Medicine, University of Pennsylvania
Danesh Moazed: Harvard Medical School

Nature, 2017, vol. 547, issue 7664, 463-467

Abstract: Heterochromatin formation involves histone H3 methylation, with H3K9me2 defining a distinct heterochromatin state that is transcriptionally permissive and can couple with RNAi, and the transition to non-permissive H3K9me3 required for the epigenetic heritability of heterochromatin.

Date: 2017
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DOI: 10.1038/nature23267

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