Liquid droplet formation by HP1α suggests a role for phase separation in heterochromatin

Adam G. Larson, Daniel Elnatan, Madeline M. Keenen, Michael J. Trnka, Jonathan B. Johnston, Alma L. Burlingame, David A. Agard, Sy Redding and Geeta J. Narlikar ()
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Adam G. Larson: University of California, San Francisco
Daniel Elnatan: University of California, San Francisco
Madeline M. Keenen: University of California, San Francisco
Michael J. Trnka: University of California, San Francisco
Jonathan B. Johnston: University of California, San Francisco
Alma L. Burlingame: University of California, San Francisco
David A. Agard: University of California, San Francisco
Sy Redding: University of California, San Francisco
Geeta J. Narlikar: University of California, San Francisco

Nature, 2017, vol. 547, issue 7662, 236-240

Abstract: Phosphorylation or DNA binding promotes the physical partitioning of HP1α out of a soluble aqueous phase into droplets, suggesting that the repressive action of heterochromatin may in part be mediated by the phase separation of HP1.

Date: 2017
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DOI: 10.1038/nature22822

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