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2008, volume 452, articles 7190

Journal club pp. 917-917

Vijay Kuchroo

Data show extent of sexism in physics pp. 918-918

Geoff Brumfiel

Italian group claims to see dark matter - again pp. 918-918

Geoff Brumfiel

Swiss 'dignity' law is threat to plant biology pp. 919-919

Alison Abbott

Biologists initiate plan to map human proteome pp. 920-921

Helen Pearson

Buckyballs give flash a boost pp. 921-921

Eric Hand

Arsenic heats up iron superconductors pp. 922-922

Eric Hand

Politically correct names given to flu viruses pp. 923-923

Declan Butler

Fake drugs: lessons for the world pp. 924-924

Meredith Wadman

Biomedical science: Betting the bank pp. 926-929

Bijal Trivedi

Atmospheric physics: Heating up the heavens pp. 930-932

Sharon Weinberger

Media right to report small value of antidepressants pp. 934-934

Olavo B. Amaral

Tropical farmers need productive alternatives pp. 934-934

Thomas Knoke, Bernd Stimm and Michael Weber

Truth about a plant with many names pp. 934-934

Marko Kreft and Robert Zorec

Europe's research system must change pp. 935-936

Luke Georghiou

Orange revolution pp. 937-938

Harold Cook

Biased brains, messy memories pp. 938-939

Sandra Aamodt

Technological twist on taxonomy pp. 939-939

Kevin Kelly

Hidden treasures: the Cajal collection in Madrid pp. 940-940

Alison Abbott

Food alert pp. 941-942

Joshua P. Thaler and David E. Cummings

Light reined in pp. 942-943

Diederik Sybolt Wiersma

Current views on odour receptors pp. 944-944

Alexander Chesler and Stuart Firestein

Exhaust inspection pp. 945-946

David L. Meier

Bottom of the top of the world pp. 945-945

Tim Lincoln

Two worlds merged pp. 946-947

David M. Lonard and Bert W. O'Malley

Scent of a rose pp. 947-947

Sadaf Shadan

Lateral presynaptic inhibition mediates gain control in an olfactory circuit pp. 956-960

Shawn R. Olsen and Rachel I. Wilson

Crystal structures of DNA/RNA repair enzymes AlkB and ABH2 bound to dsDNA pp. 961-965

Cai-Guang Yang, Chengqi Yi, Erica M. Duguid, Christopher T. Sullivan, Xing Jian, Phoebe A. Rice and Chuan He

The inner jet of an active galactic nucleus as revealed by a radio-to-γ-ray outburst pp. 966-969

Alan P. Marscher, Svetlana G. Jorstad, Francesca D. D’Arcangelo, Paul S. Smith, G. Grant Williams, Valeri M. Larionov, Haruki Oh, Alice R. Olmstead, Margo F. Aller, Hugh D. Aller, Ian M. McHardy, Anne Lähteenmäki, Merja Tornikoski, Esko Valtaoja, Vladimir A. Hagen-Thorn, Eugenia N. Kopatskaya, Walter K. Gear, Gino Tosti, Omar Kurtanidze, Maria Nikolashvili, Lorand Sigua, H. Richard Miller and Wesley T. Ryle

A topological Dirac insulator in a quantum spin Hall phase pp. 970-974

D. Hsieh, D. Qian, L. Wray, Y. Xia, Y. S. Hor, R. J. Cava and M. Z. Hasan

Small phonon contribution to the photoemission kink in the copper oxide superconductors pp. 975-978

Feliciano Giustino, Marvin L. Cohen and Steven G. Louie

Eocene/Oligocene ocean de-acidification linked to Antarctic glaciation by sea-level fall pp. 979-982

Agostino Merico, Toby Tyrrell and Paul A. Wilson

Hydrous silicate melt at high pressure pp. 983-986

Mainak Mookherjee, Lars Stixrude and Bijaya Karki

Mountain pine beetle and forest carbon feedback to climate change pp. 987-990

W. A. Kurz, C. C. Dymond, G. Stinson, G. J. Rampley, E. T. Neilson, A. L. Carroll, T. Ebata and L. Safranyik

The draft genome of the transgenic tropical fruit tree papaya (Carica papaya Linnaeus) pp. 991-996

Ray Ming, Shaobin Hou, Yun Feng, Qingyi Yu, Alexandre Dionne-Laporte, Jimmy H. Saw, Pavel Senin, Wei Wang, Benjamin V. Ly, Kanako L. T. Lewis, Steven L. Salzberg, Lu Feng, Meghan R. Jones, Rachel L. Skelton, Jan E. Murray, Cuixia Chen, Wubin Qian, Junguo Shen, Peng Du, Moriah Eustice, Eric Tong, Haibao Tang, Eric Lyons, Robert E. Paull, Todd P. Michael, Kerr Wall, Danny W. Rice, Henrik Albert, Ming-Li Wang, Yun J. Zhu, Michael Schatz, Niranjan Nagarajan, Ricelle A. Acob, Peizhu Guan, Andrea Blas, Ching Man Wai, Christine M. Ackerman, Yan Ren, Chao Liu, Jianmei Wang, Jianping Wang, Jong-Kuk Na, Eugene V. Shakirov, Brian Haas, Jyothi Thimmapuram, David Nelson, Xiyin Wang, John E. Bowers, Andrea R. Gschwend, Arthur L. Delcher, Ratnesh Singh, Jon Y. Suzuki, Savarni Tripathi, Kabi Neupane, Hairong Wei, Beth Irikura, Maya Paidi, Ning Jiang, Wenli Zhang, Gernot Presting, Aaron Windsor, Rafael Navajas-Pérez, Manuel J. Torres, F. Alex Feltus, Brad Porter, Yingjun Li, A. Max Burroughs, Ming-Cheng Luo, Lei Liu, David A. Christopher, Stephen M. Mount, Paul H. Moore, Tak Sugimura, Jiming Jiang, Mary A. Schuler, Vikki Friedman, Thomas Mitchell-Olds, Dorothy E. Shippen, Claude W. dePamphilis, Jeffrey D. Palmer, Michael Freeling, Andrew H. Paterson, Dennis Gonsalves, Lei Wang and Maqsudul Alam

Genetic variation in human NPY expression affects stress response and emotion pp. 997-1001

Zhifeng Zhou, Guanshan Zhu, Ahmad R. Hariri, Mary-Anne Enoch, David Scott, Rajita Sinha, Matti Virkkunen, Deborah C. Mash, Robert H. Lipsky, Xian-Zhang Hu, Colin A. Hodgkinson, Ke Xu, Beata Buzas, Qiaoping Yuan, Pei-Hong Shen, Robert E. Ferrell, Stephen B. Manuck, Sarah M. Brown, Richard L. Hauger, Christian S. Stohler, Jon-Kar Zubieta and David Goldman

Insect olfactory receptors are heteromeric ligand-gated ion channels pp. 1002-1006

Koji Sato, Maurizio Pellegrino, Takao Nakagawa, Tatsuro Nakagawa, Leslie B. Vosshall and Kazushige Touhara

Drosophila odorant receptors are both ligand-gated and cyclic-nucleotide-activated cation channels pp. 1007-1011

Dieter Wicher, Ronny Schäfer, René Bauernfeind, Marcus C. Stensmyr, Regine Heller, Stefan H. Heinemann and Bill S. Hansson

Upper intestinal lipids trigger a gut–brain–liver axis to regulate glucose production pp. 1012-1016

Penny Y. T. Wang, Liora Caspi, Carol K. L. Lam, Madhu Chari, Xiaosong Li, Peter E. Light, Roger Gutierrez-Juarez, Michelle Ang, Gary J. Schwartz and Tony K. T. Lam

A deadenylation negative feedback mechanism governs meiotic metaphase arrest pp. 1017-1021

Eulàlia Belloc and Raúl Méndez

Crystal structure of the λ repressor and a model for pairwise cooperative operator binding pp. 1022-1025

Steven Stayrook, Peera Jaru-Ampornpan, Jenny Ni, Ann Hochschild and Mitchell Lewis

Even as science and engineering in China ascends, its graduate students and postdocs often struggle pp. 1027-1027

Gene Russo

China's challenge pp. 1028-1029

Wei Zeng

Marja Makarow, chief executive, European Science Foundation, Strasbourg, France pp. 1030-1030

Jill U. Adams

A guiding COMPASS pp. 1030-1030

Betty Mbom

In the name of science pp. 1030-1030

Aliza le Roux

SETI for profit pp. 1032-1032

Gregory Benford

2008, volume 452, articles 7189

Journal club pp. 785-785

Bob O'Hara

Further delays to full Agent Orange study pp. 786-786

Declan Butler

Deal for Holy Land artefacts pp. 787-787

Haim Watzman

Costa Rican biotech centre in peril pp. 787-787

Geoff Brumfiel

James Watson's genome sequenced at high speed pp. 788-788

Meredith Wadman

Novel analysis identifies highly biodiverse hotspots pp. 789-789

Anna Petherick

Kerry Sieh pp. 791-791

David Cyranoski

Merck accused of disguising its role in research pp. 791-791

Daniel Cressey

Glacial melt thaws South Asian rivalry pp. 793-793

David Cyranoski

$50 million cyberchallenge for plant scientists pp. 793-793

Heidi Ledford

Shuttle at cruise speed pp. 794-794

Quirin Schiermeier

Climate change: Losing Greenland pp. 798-802

Alexandra Witze

Quantum computation: The dreamweaver's abacus pp. 803-805

Liesbeth Venema

Archaeology: Bones, isles and videotape pp. 806-808

Rex Dalton

Malaria programmes need informed advocacy pp. 810-810

Matthew Lynch

Malaria: efforts starting to show widespread results pp. 810-810

Awa Marie Coll-Seck, Tedros Adhanom Ghebreyesus and Alan Court

Tibetan wildlife is getting used to the railway pp. 810-811

Qisen Yang and Lin Xia

Vaccine trial provided valuable information pp. 811-811

David Baltimore

NIH funds support more than a researcher's own lab pp. 811-811

Harold Varmus

NIH: grants revamp needs grounding in evidence pp. 811-811

Yusuf A. Hannun

NIH: researchers lose out to war, not to each other pp. 811-811

Sten H. Vermund

Blazing a new trail for nature pp. 812-813

Jon Christensen

Bedtime reading pp. 813-814

Jim Horne

Reflecting on the mind pp. 814-815

Vilayanur S. Ramachandran

Design crystallized in the 1950s pp. 815-815

Colin Martin

Triumph of the medieval mind pp. 816-818

Philip Ball

Dr Watson's base pairs pp. 819-820

Maynard V. Olson

Message from Mercury pp. 820-821

H. Jay Melosh

The sweetest candy for the virus pp. 822-823

Andreas O. Frank and Horst Kessler

Debut of the quarter electron pp. 823-823

Eduardo Fradkin

Genome rewired pp. 824-825

Matthew R. Bennett and Jeff Hasty

Destabilized fish stocks pp. 825-826

Nils Chr. Stenseth and Tristan Rouyer

Blown away by cosmic rays pp. 826-827

Dieter Breitschwerdt

Observation of a quarter of an electron charge at the ν = 5/2 quantum Hall state pp. 829-834

M. Dolev, M. Heiblum, V. Umansky, Ady Stern and D. Mahalu

Why fishing magnifies fluctuations in fish abundance pp. 835-839

Christian N. K. Anderson, Chih-hao Hsieh, Stuart A. Sandin, Roger Hewitt, Anne Hollowed, John Beddington, Robert M. May and George Sugihara

Evolvability and hierarchy in rewired bacterial gene networks pp. 840-845

Mark Isalan, Caroline Lemerle, Konstantinos Michalodimitrakis, Carsten Horn, Pedro Beltrao, Emanuele Raineri, Mireia Garriga-Canut and Luis Serrano

Isolation of an active step I spliceosome and composition of its RNP core pp. 846-850

Sergey Bessonov, Maria Anokhina, Cindy L. Will, Henning Urlaub and Reinhard Lührmann

A massive binary black-hole system in OJ 287 and a test of general relativity pp. 851-853

M. J. Valtonen, H. J. Lehto, K. Nilsson, J. Heidt, L. O. Takalo, A. Sillanpää, C. Villforth, M. Kidger, G. Poyner, T. Pursimo, S. Zola, J.-H. Wu, X. Zhou, K. Sadakane, M. Drozdz, D. Koziel, D. Marchev, W. Ogloza, C. Porowski, M. Siwak, G. Stachowski, M. Winiarski, V.-P. Hentunen, M. Nissinen, A. Liakos and S. Dogru

Thermalization and its mechanism for generic isolated quantum systems pp. 854-858

Marcos Rigol, Vanja Dunjko and Maxim Olshanii

Electrical effects of spin density wave quantization and magnetic domain walls in chromium pp. 859-863

Ravi K. Kummamuru and Yeong-Ah Soh

Changing boreal methane sources and constant biomass burning during the last termination pp. 864-867

Hubertus Fischer, Melanie Behrens, Michael Bock, Ulrike Richter, Jochen Schmitt, Laetitia Loulergue, Jerome Chappellaz, Renato Spahni, Thomas Blunier, Markus Leuenberger and Thomas F. Stocker

Sophisticated particle-feeding in a large Early Cambrian crustacean pp. 868-871

Thomas H. P. Harvey and Nicholas J. Butterfield

The complete genome of an individual by massively parallel DNA sequencing pp. 872-876

David A. Wheeler, Maithreyan Srinivasan, Michael Egholm, Yufeng Shen, Lei Chen, Amy McGuire, Wen He, Yi-Ju Chen, Vinod Makhijani, G. Thomas Roth, Xavier Gomes, Karrie Tartaro, Faheem Niazi, Cynthia L. Turcotte, Gerard P. Irzyk, James R. Lupski, Craig Chinault, Xing-zhi Song, Yue Liu, Ye Yuan, Lynne Nazareth, Xiang Qin, Donna M. Muzny, Marcel Margulies, George M. Weinstock, Richard A. Gibbs and Jonathan M. Rothberg

Chromatin dynamics during epigenetic reprogramming in the mouse germ line pp. 877-881

Petra Hajkova, Katia Ancelin, Tanja Waldmann, Nicolas Lacoste, Ulrike C. Lange, Francesca Cesari, Caroline Lee, Genevieve Almouzni, Robert Schneider and M. Azim Surani

Integration of growth and specification in chick wing digit-patterning pp. 882-886

Matthew Towers, Ruth Mahood, Yili Yin and Cheryll Tickle

NAD synthase NMNAT acts as a chaperone to protect against neurodegeneration pp. 887-891

R. Grace Zhai, Fan Zhang, P. Robin Hiesinger, Yu Cao, Claire M. Haueter and Hugo J. Bellen

Retinotopic order in the absence of axon competition pp. 892-895

Nathan J. Gosse, Linda M. Nevin and Herwig Baier

LNA-mediated microRNA silencing in non-human primates pp. 896-899

Joacim Elmén, Morten Lindow, Sylvia Schütz, Matthew Lawrence, Andreas Petri, Susanna Obad, Marie Lindholm, Maj Hedtjärn, Henrik Frydenlund Hansen, Urs Berger, Steven Gullans, Phil Kearney, Peter Sarnow, Ellen Marie Straarup and Sakari Kauppinen

Erratum: A photosynthetic alveolate closely related to apicomplexan parasites pp. 900-900

Robert B. Moore, Miroslav Oborník, Jan Janouškovec, Tomáš Chrudimský, Marie Vancová, David H. Green, Simon W. Wright, Noel W. Davies, Christopher J. S. Bolch, Kirsten Heimann, Jan Šlapeta, Ove Hoegh-Guldberg, John M. Logsdon and Dee A. Carter

Erratum: Hax1-mediated processing of HtrA2 by Parl allows survival of lymphocytes and neurons pp. 900-900

Jyh-Rong Chao, Evan Parganas, Kelli Boyd, Cheol Yi Hong, Joseph T. Opferman and James N. Ihle

Erratum: Strong dispersive coupling of a high-finesse cavity to a micromechanical membrane pp. 900-900

J. D. Thompson, B. M. Zwickl, A. M. Jayich, Florian Marquardt, S. M. Girvin and J. G. E. Harris

Could it be a small world after all? pp. 901-903

Nathan Blow

We're trying to improve — so you can rest a bit easier pp. 907-907

Gene Russo

Beyond the triangle pp. 908-909

Heidi Ledford

Gregory Crawford, dean, College of Science, University of Notre Dame, Notre Dame, Indiana pp. 910-910

Virginia Gewin

Nucleus of growth at Louisville pp. 910-910

Paul Smaglik

Passion and obsession pp. 910-910

Zachary Lippman

After the snow pp. 912-912

C. N. Simms

2008, volume 452, articles 7188

Journal club pp. 669-669

Norbert Perrimon

Advanced biofuels face an uncertain future pp. 670-671

Jeff Tollefson

FDA to vet embryonic stem cells' safety pp. 670-670

Monya Baker

Chemical weapons agency shifts focus pp. 671-671

Daniel Cressey

Gertrude versus Goliath pp. 672-672

Geoff Brumfiel

The fraudster returns pp. 672-672

Alison Abbott

Bill Foster pp. 673-673

Eric Hand

Poll results: look who's doping pp. 674-675

Brendan Maher

Radio sweat gland - 90 GHz pp. 676-676

Philip Ball

Evolution: Scandal! Sex-starved and still surviving pp. 678-680

Erika Check Hayden

Collaborations: With all good intentions pp. 682-684

Heidi Ledford

CropLife still committed to assessment's original aims pp. 685-685

Howard Minigh

Italy must invest more in science and technology pp. 685-685

Ivano Bertini, Silvio Garattini and Rino Rappuoli

Cleaning up the final phase of the fossil-fuel industry pp. 685-685

Steve Larter

Investigating international misconduct pp. 686-687

Christine Boesz and Nigel Lloyd

Shaking the foundations of archaeology pp. 689-690

Andrew Robinson

Brave new bioethics pp. 690-691

Eugenie Scott

Engines of life pp. 691-692

Tim Lenton

Biology from the bottom up pp. 692-694

Steven Benner

Bottling the nuclear demon pp. 694-695

Martin van Creveld

How music speaks to us pp. 695-696

David Poeppel and Elika Bergelson

Catching a ride on sunshine pp. 696-697

Stuart Clark

Imaging the unseen pp. 697-698

Felice Frankel

Rise of the digital machine pp. 699-699

Mark Pagel

Are plant emissions green? pp. 701-702

Alex Guenther

Blood lines redrawn pp. 702-703

Thomas Graf

Strong teeth, strong seeds pp. 703-704

Peter Ungar

Observations turn up the heat pp. 705-706

Kimberly R. Chapin and Marlan O. Scully

Porter and sorter pp. 706-707

Michael G. Roth

A question of balance pp. 707-708

Leslie Michels Thompson

SUMO pp. 709-711

Erik Meulmeester and Frauke Melchior

Opposing effects of polyglutamine expansion on native protein complexes contribute to SCA1 pp. 713-718

Janghoo Lim, Juan Crespo-Barreto, Paymaan Jafar-Nejad, Aaron B. Bowman, Ronald Richman, David E. Hill, Harry T. Orr and Huda Y. Zoghbi

Clathrin is a key regulator of basolateral polarity pp. 719-723

Sylvie Deborde, Emilie Perret, Diego Gravotta, Ami Deora, Susana Salvarezza, Ryan Schreiner and Enrique Rodriguez-Boulan

Thermodynamic control by frequent quantum measurements pp. 724-727

Noam Erez, Goren Gordon, Mathias Nest and Gershon Kurizki

Microscopic theory of the extraordinary optical transmission pp. 728-731

Haitao Liu and Philippe Lalanne

Improper ferroelectricity in perovskite oxide artificial superlattices pp. 732-736

Eric Bousquet, Matthew Dawber, Nicolas Stucki, Céline Lichtensteiger, Patrick Hermet, Stefano Gariglio, Jean-Marc Triscone and Philippe Ghosez

Atmospheric oxidation capacity sustained by a tropical forest pp. 737-740

J. Lelieveld, T. M. Butler, J. N. Crowley, T. J. Dillon, H. Fischer, L. Ganzeveld, H. Harder, M. G. Lawrence, M. Martinez, D. Taraborrelli and J. Williams

SAR11 marine bacteria require exogenous reduced sulphur for growth pp. 741-744

H. James Tripp, Joshua B. Kitner, Michael S. Schwalbach, John W. H. Dacey, Larry J. Wilhelm and Stephen J. Giovannoni

Broad phylogenomic sampling improves resolution of the animal tree of life pp. 745-749

Casey W. Dunn, Andreas Hejnol, David Q. Matus, Kevin Pang, William E. Browne, Stephen A. Smith, Elaine Seaver, Greg W. Rouse, Matthias Obst, Gregory D. Edgecombe, Martin V. Sørensen, Steven H. D. Haddock, Andreas Schmidt-Rhaesa, Akiko Okusu, Reinhardt Møbjerg Kristensen, Ward C. Wheeler, Mark Q. Martindale and Gonzalo Giribet

Estimating the impact of school closure on influenza transmission from Sentinel data pp. 750-754

Simon Cauchemez, Alain-Jacques Valleron, Pierre-Yves Boëlle, Antoine Flahault and Neil M. Ferguson

A plant pathogen virulence factor inhibits the eukaryotic proteasome by a novel mechanism pp. 755-758

Michael Groll, Barbara Schellenberg, André S. Bachmann, Crystal R. Archer, Robert Huber, Tracy K. Powell, Steven Lindow, Markus Kaiser and Robert Dudler

Endothelins are vascular-derived axonal guidance cues for developing sympathetic neurons pp. 759-763

Takako Makita, Henry M. Sucov, Cheryl E. Gariepy, Masashi Yanagisawa and David D. Ginty

The earliest thymic progenitors for T cells possess myeloid lineage potential pp. 764-767

J. Jeremiah Bell and Avinash Bhandoola

Adult T-cell progenitors retain myeloid potential pp. 768-772

Haruka Wada, Kyoko Masuda, Rumi Satoh, Kiyokazu Kakugawa, Tomokatsu Ikawa, Yoshimoto Katsura and Hiroshi Kawamoto

Impaired TH17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome pp. 773-776

Joshua D. Milner, Jason M. Brenchley, Arian Laurence, Alexandra F. Freeman, Brenna J. Hill, Kevin M. Elias, Yuka Kanno, Christine Spalding, Houda Z. Elloumi, Michelle L. Paulson, Joie Davis, Amy Hsu, Ava I. Asher, John O’Shea, Steven M. Holland, William E. Paul and Daniel C. Douek

The quality of researcher jobs, and not just the quantity, deserves further scrutiny pp. 777-777

Gene Russo

Billie Turner, Gilbert F. White chair in environment and society, School of Geographical Sciences, Arizona State University, Tempe, Arizona pp. 778-778

Virginia Gewin

Focus on health disparities pp. 778-778

Paul Smaglik

The very hungry postdoc pp. 778-778

Jon Yearsley

All over, Rover pp. 780-780

Neale Morison

2008, volume 452, articles 7187

Journal club pp. 507-507

A. P. de Silva

Are the IPCC scenarios 'unachievable'? pp. 508-508

Quirin Schiermeier

Carbon-trading market has uncertain future pp. 508-509

Jeff Tollefson

EPA feels heat over flame retardant pp. 513-513

Brian Vastag

Easy ways to other Earths pp. 514-515

Eric Hand

Snapshot: Flirty in pink pp. 515-515

Anna Petherick

Hazy reasoning behind clean air pp. 519-519

David Goldston

Architecture: Architects of a low-energy future pp. 520-523

Declan Butler

Anatomy: Truly gross anatomy pp. 525-526

Erik Vance

Portugal: Navigating new waters pp. 528-529

Alison Abbott

Radical rethink is needed on climate-change policy pp. 530-530

Gwyn Prins

Comparing the legacies of Gauss, Pasteur and Darwin pp. 530-530

Jürgen Schmidhuber

Spanish funds will finance Bilbao's spallation bid pp. 530-530

Juan Urrutia

Give south Indian authors their true names pp. 530-530

Nalini Puniamoorthy, Jeevananthinee Jeevanandam and Sujatha Narayanan Kutty

Dangerous assumptions pp. 531-532

Roger Pielke, Tom Wigley and Christopher Green

From spies to servers pp. 533-533

Joel Shurkin

Ten years of science off Broadway pp. 534-534

Alan Packer

An astrolabe for the people pp. 534-534

Philip Ball

Celluloid explores life of graduate student killer pp. 535-535

Emma Marris

When the smoke clears pp. 537-538

Stephen J. Chanock and David J. Hunter

With a coarse-tooth comb pp. 538-539

Gordon Walker

Humming a different tune pp. 539-541

Toshiro Tanimoto

The fight against fungi pp. 541-542

André Goffeau

Opposite of a superconductor pp. 542-543

Rosario Fazio

Generic block on angiogenesis pp. 543-545

Raghu Kalluri and Keizo Kanasaki

Arthur C. Clarke (1917–2008) pp. 546-546

Gregory Benford

Molecular cancer diagnostics pp. 547-547

Barbara Marte, Alex Eccleston and Deepa Nath

The cancer biomarker problem pp. 548-552

Charles L. Sawyers

Translating insights from the cancer genome into clinical practice pp. 553-563

Lynda Chin and Joe W. Gray

Enabling personalized cancer medicine through analysis of gene-expression patterns pp. 564-570

Laura J. van 't Veer and René Bernards

Mining the plasma proteome for cancer biomarkers pp. 571-579

Samir M. Hanash, Sharon J. Pitteri and Vitor M. Faca

Imaging in the era of molecular oncology pp. 580-589

Ralph Weissleder and Mikael J. Pittet

Sequence- and target-independent angiogenesis suppression by siRNA via TLR3 pp. 591-597

Mark E. Kleinman, Kiyoshi Yamada, Atsunobu Takeda, Vasu Chandrasekaran, Miho Nozaki, Judit Z. Baffi, Romulo J. C. Albuquerque, Satoshi Yamasaki, Masahiro Itaya, Yuzhen Pan, Binoy Appukuttan, Daniel Gibbs, Zhenglin Yang, Katalin Karikó, Balamurali K. Ambati, Traci A. Wilgus, Luisa A. DiPietro, Eiji Sakurai, Kang Zhang, Justine R. Smith, Ethan W. Taylor and Jayakrishna Ambati

Following translation by single ribosomes one codon at a time pp. 598-603

Jin- Der Wen, Laura Lancaster, Courtney Hodges, Ana-Carolina Zeri, Shige H. Yoshimura, Harry F. Noller, Carlos Bustamante and Ignacio Tinoco

A nuclear receptor-like pathway regulating multidrug resistance in fungi pp. 604-609

Jitendra K. Thakur, Haribabu Arthanari, Fajun Yang, Shih-Jung Pan, Xiaochun Fan, Julia Breger, Dominique P. Frueh, Kailash Gulshan, Darrick K. Li, Eleftherios Mylonakis, Kevin Struhl, W. Scott Moye-Rowley, Brendan P. Cormack, Gerhard Wagner and Anders M. Näär

A laser frequency comb that enables radial velocity measurements with a precision of 1 cm s-1 pp. 610-612

Chih-Hao Li, Andrew J. Benedick, Peter Fendel, Alexander G. Glenday, Franz X. Kärtner, David F. Phillips, Dimitar Sasselov, Andrew Szentgyorgyi and Ronald L. Walsworth

Superinsulator and quantum synchronization pp. 613-615

Valerii M. Vinokur, Tatyana I. Baturina, Mikhail V. Fistul, Aleksey Yu. Mironov, Mikhail R. Baklanov and Christoph Strunk

Dust-climate couplings over the past 800,000 years from the EPICA Dome C ice core pp. 616-619

F. Lambert, B. Delmonte, J. R. Petit, M. Bigler, P. R. Kaufmann, M. A. Hutterli, T. F. Stocker, U. Ruth, J. P. Steffensen and V. Maggi

Absolute plate motions and true polar wander in the absence of hotspot tracks pp. 620-623

Bernhard Steinberger and Trond H. Torsvik

Localization and functionality of microsporidian iron–sulphur cluster assembly proteins pp. 624-628

Alina V. Goldberg, Sabine Molik, Anastasios D. Tsaousis, Karina Neumann, Grit Kuhnke, Frederic Delbac, Christian P. Vivares, Robert P. Hirt, Roland Lill and T. Martin Embley

Functional metagenomic profiling of nine biomes pp. 629-632

Elizabeth A. Dinsdale, Robert A. Edwards, Dana Hall, Florent Angly, Mya Breitbart, Jennifer M. Brulc, Mike Furlan, Christelle Desnues, Matthew Haynes, Linlin Li, Lauren McDaniel, Mary Ann Moran, Karen E. Nelson, Christina Nilsson, Robert Olson, John Paul, Beltran Rodriguez Brito, Yijun Ruan, Brandon K. Swan, Rick Stevens, David L. Valentine, Rebecca Vega Thurber, Linda Wegley, Bryan A. White and Forest Rohwer

A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25 pp. 633-637

Rayjean J. Hung, James D. McKay, Valerie Gaborieau, Paolo Boffetta, Mia Hashibe, David Zaridze, Anush Mukeria, Neonilia Szeszenia-Dabrowska, Jolanta Lissowska, Peter Rudnai, Eleonora Fabianova, Dana Mates, Vladimir Bencko, Lenka Foretova, Vladimir Janout, Chu Chen, Gary Goodman, John K. Field, Triantafillos Liloglou, George Xinarianos, Adrian Cassidy, John McLaughlin, Geoffrey Liu, Steven Narod, Hans E. Krokan, Frank Skorpen, Maiken Bratt Elvestad, Kristian Hveem, Lars Vatten, Jakob Linseisen, Françoise Clavel-Chapelon, Paolo Vineis, H. Bas Bueno- de-Mesquita, Eiliv Lund, Carmen Martinez, Sheila Bingham, Torgny Rasmuson, Pierre Hainaut, Elio Riboli, Wolfgang Ahrens, Simone Benhamou, Pagona Lagiou, Dimitrios Trichopoulos, Ivana Holcátová, Franco Merletti, Kristina Kjaerheim, Antonio Agudo, Gary Macfarlane, Renato Talamini, Lorenzo Simonato, Ray Lowry, David I. Conway, Ariana Znaor, Claire Healy, Diana Zelenika, Anne Boland, Marc Delepine, Mario Foglio, Doris Lechner, Fumihiko Matsuda, Helene Blanche, Ivo Gut, Simon Heath, Mark Lathrop and Paul Brennan

A variant associated with nicotine dependence, lung cancer and peripheral arterial disease pp. 638-642

Thorgeir E. Thorgeirsson, Frank Geller, Patrick Sulem, Thorunn Rafnar, Anna Wiste, Kristinn P. Magnusson, Andrei Manolescu, Gudmar Thorleifsson, Hreinn Stefansson, Andres Ingason, Simon N. Stacey, Jon T. Bergthorsson, Steinunn Thorlacius, Julius Gudmundsson, Thorlakur Jonsson, Margret Jakobsdottir, Jona Saemundsdottir, Olof Olafsdottir, Larus J. Gudmundsson, Gyda Bjornsdottir, Kristleifur Kristjansson, Halla Skuladottir, Helgi J. Isaksson, Tomas Gudbjartsson, Gregory T. Jones, Thomas Mueller, Anders Gottsäter, Andrea Flex, Katja K. H. Aben, Femmie de Vegt, Peter F. A. Mulders, Dolores Isla, Maria J. Vidal, Laura Asin, Berta Saez, Laura Murillo, Thorsteinn Blondal, Halldor Kolbeinsson, Jon G. Stefansson, Ingunn Hansdottir, Valgerdur Runarsdottir, Roberto Pola, Bengt Lindblad, Andre M. van Rij, Benjamin Dieplinger, Meinhard Haltmayer, Jose I. Mayordomo, Lambertus A. Kiemeney, Stefan E. Matthiasson, Hogni Oskarsson, Thorarinn Tyrfingsson, Daniel F. Gudbjartsson, Jeffrey R. Gulcher, Steinn Jonsson, Unnur Thorsteinsdottir, Augustine Kong and Kari Stefansson

A neural representation of depth from motion parallax in macaque visual cortex pp. 642-645

Jacob W. Nadler, Dora E. Angelaki and Gregory C. DeAngelis

Tumour maintenance is mediated by eNOS pp. 646-649

Kian-Huat Lim, Brooke B. Ancrile, David F. Kashatus and Christopher M. Counter

Cutaneous cancer stem cell maintenance is dependent on β-catenin signalling pp. 650-653

Ilaria Malanchi, Hector Peinado, Deepika Kassen, Thomas Hussenet, Daniel Metzger, Pierre Chambon, Marcel Huber, Daniel Hohl, Amparo Cano, Walter Birchmeier and Joerg Huelsken

Dendritic cell PAR1–S1P3 signalling couples coagulation and inflammation pp. 654-658

Frank Niessen, Florence Schaffner, Christian Furlan-Freguia, Rafal Pawlinski, Gourab Bhattacharjee, Jerold Chun, Claudia K. Derian, Patricia Andrade-Gordon, Hugh Rosen and Wolfram Ruf

The startling contrasts of Bangalore pp. 659-659

Gene Russo

Biotech in Bangalore pp. 660-661

Gene Russo

Dave Tapolczay, chief executive, MRC Technology, London pp. 662-662

Jill U. Adams

Göttingen bridges the gap pp. 662-662

Virginia Gewin

Getting that lucky break pp. 662-662

Amanda Goh

Shoppers pp. 664-664

James Patrick Kelly

2008, volume 452, articles 7186

Journal club pp. 391-391

Moty Heiblum

String theorists hope to classify the cosmos pp. 392-393

Geoff Brumfiel

£130-million cut to grants hits UK physical scientists pp. 392-392

Daniel Cressey

Bagged and boxed: it's a frog's life pp. 394-395

Emma Marris

Laptops track Earth's shakes, rattles and rolls pp. 397-397

Erik Vance

Chemistry: The photon trap pp. 400-402

Katharine Sanderson

Biodiversity: Frozen futures pp. 404-405

Michael Hopkin

Stem cells: 5 things to know before jumping on the iPS bandwagon pp. 406-408

David Cyranoski

Canadian government is committed to science pp. 409-409

Jim Prentice

Call for a centralized grant proposal repository pp. 409-409

Noam Y. Harel

Unfair statistics take the bloom off St Louis pp. 409-409

Scott Jacques

View from the top pp. 411-412

Stefan Klein

Industrial paint's artistic legacy pp. 412-412

Christopher Turner

How faces share feelings pp. 413-413

Jascha Hoffman

An eye for detail pp. 413-413

Jenny Meyer

Hidden treasures: Florence's botanical collection pp. 414-414

Alison Abbott

Triumph of a chemical underdog pp. 415-416

Gorka Peris and Scott J. Miller

Stem cells traffic in time pp. 416-417

David T. Scadden

Starbursts near and far pp. 417-419

Yu Gao

Spin surprise in carbon pp. 419-420

Arne Brataas

Strength in numbers pp. 420-421

Nelson Spruston

Do-it-yourself microfluidics pp. 421-421

Tim Lincoln

Joshua Lederberg (1925–2008) pp. 422-422

Baruch S. Blumberg

Genetics of gene expression and its effect on disease pp. 423-428

Valur Emilsson, Gudmar Thorleifsson, Bin Zhang, Amy S. Leonardson, Florian Zink, Jun Zhu, Sonia Carlson, Agnar Helgason, G. Bragi Walters, Steinunn Gunnarsdottir, Magali Mouy, Valgerdur Steinthorsdottir, Gudrun H. Eiriksdottir, Gyda Bjornsdottir, Inga Reynisdottir, Daniel Gudbjartsson, Anna Helgadottir, Aslaug Jonasdottir, Adalbjorg Jonasdottir, Unnur Styrkarsdottir, Solveig Gretarsdottir, Kristinn P. Magnusson, Hreinn Stefansson, Ragnheidur Fossdal, Kristleifur Kristjansson, Hjortur G. Gislason, Tryggvi Stefansson, Bjorn G. Leifsson, Unnur Thorsteinsdottir, John R. Lamb, Jeffrey R. Gulcher, Marc L. Reitman, Augustine Kong, Eric E. Schadt and Kari Stefansson

Variations in DNA elucidate molecular networks that cause disease pp. 429-435

Yanqing Chen, Jun Zhu, Pek Yee Lum, Xia Yang, Shirly Pinto, Douglas J. MacNeil, Chunsheng Zhang, John Lamb, Stephen Edwards, Solveig K. Sieberts, Amy Leonardson, Lawrence W. Castellini, Susanna Wang, Marie-France Champy, Bin Zhang, Valur Emilsson, Sudheer Doss, Anatole Ghazalpour, Steve Horvath, Thomas A. Drake, Aldons J. Lusis and Eric E. Schadt

Compartmentalized dendritic plasticity and input feature storage in neurons pp. 436-441

Attila Losonczy, Judit K. Makara and Jeffrey C. Magee

Haematopoietic stem cell release is regulated by circadian oscillations pp. 442-447

Simón Méndez-Ferrer, Daniel Lucas, Michela Battista and Paul S. Frenette

Coupling of spin and orbital motion of electrons in carbon nanotubes pp. 448-452

F. Kuemmeth, S. Ilani, D. C. Ralph and P. L. McEuen

Proline-catalysed Mannich reactions of acetaldehyde pp. 453-455

Jung Woon Yang, Carley Chandler, Michael Stadler, Daniela Kampen and Benjamin List

Tracing the stepwise oxygenation of the Proterozoic ocean pp. 456-459

C. Scott, T. W. Lyons, A. Bekker, Y. Shen, S. W. Poulton, X. Chu and A. D. Anbar

Lower-crustal intrusion on the North Atlantic continental margin pp. 460-464

R. S. White, L. K. Smith, A. W. Roberts, P. A. F. Christie and N. J. Kusznir

The first hominin of Europe pp. 465-469

Eudald Carbonell, José M. Bermúdez de Castro, Josep M. Parés, Alfredo Pérez-González, Gloria Cuenca-Bescós, Andreu Ollé, Marina Mosquera, Rosa Huguet, Jan van der Made, Antonio Rosas, Robert Sala, Josep Vallverdú, Nuria García, Darryl E. Granger, María Martinón-Torres, Xosé P. Rodríguez, Greg M. Stock, Josep M. Vergès, Ethel Allué, Francesc Burjachs, Isabel Cáceres, Antoni Canals, Alfonso Benito, Carlos Díez, Marina Lozano, Ana Mateos, Marta Navazo, Jesús Rodríguez, Jordi Rosell and Juan L. Arsuaga

Pleiotropic scaling of gene effects and the ‘cost of complexity’ pp. 470-472

Günter P. Wagner, Jane P. Kenney-Hunt, Mihaela Pavlicev, Joel R. Peck, David Waxman and James M. Cheverud

The Drosophila pheromone cVA activates a sexually dimorphic neural circuit pp. 473-477

Sandeep Robert Datta, Maria Luisa Vasconcelos, Vanessa Ruta, Sean Luo, Allan Wong, Ebru Demir, Jorge Flores, Karen Balonze, Barry J. Dickson and Richard Axel

Molecular identification of a retinal cell type that responds to upward motion pp. 478-482

In-Jung Kim, Yifeng Zhang, Masahito Yamagata, Markus Meister and Joshua R. Sanes

CO2 regulator SLAC1 and its homologues are essential for anion homeostasis in plant cells pp. 483-486

Juntaro Negi, Osamu Matsuda, Takashi Nagasawa, Yasuhiro Oba, Hideyuki Takahashi, Maki Kawai-Yamada, Hirofumi Uchimiya, Mimi Hashimoto and Koh Iba

SLAC1 is required for plant guard cell S-type anion channel function in stomatal signalling pp. 487-491

Triin Vahisalu, Hannes Kollist, Yong-Fei Wang, Noriyuki Nishimura, Wai-Yin Chan, Gabriel Valerio, Airi Lamminmäki, Mikael Brosché, Heino Moldau, Radhika Desikan, Julian I. Schroeder and Jaakko Kangasjärvi

SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin pp. 492-496

Eriko Michishita, Ronald A. McCord, Elisabeth Berber, Mitomu Kioi, Hesed Padilla-Nash, Mara Damian, Peggie Cheung, Rika Kusumoto, Tiara L. A. Kawahara, J. Carl Barrett, Howard Y. Chang, Vilhelm A. Bohr, Thomas Ried, Or Gozani and Katrin F. Chua

Disease prevention should be fertile ground for researchers — if policy–makers catch up with the experts pp. 497-497

Gene Russo

The art of self-defence pp. 498-500

Virginia Gewin

Acting up pp. 502-502

Elizabeth Counihan

2008, volume 452, articles 7185

Koenigs et al. reply pp. E5-E6

M. Koenigs, L. Young, R. Adolphs, D. Tranel, F. Cushman, M. Hauser and A. Damasio

Do abnormal responses show utilitarian bias? pp. E5-E5

Guy Kahane and Nicholas Shackel

Journal club pp. 257-257

Masayuki Inoue

222 NIH grants: 22 researchers pp. 258-259

Eric Hand

The Solar System's first breath pp. 259-259

Eric Hand

Water: Purification with a pinch of salt pp. 260-261

Quirin Schiermeier

Banking on the future of stem cells pp. 263-264

Monya Baker

Fly's eye detector spies cosmic-ray cut-off pp. 264-264

Philip Ball

Zooloddities pp. 265-265

Anna Petherick

Stem-cell patents confirmed pp. 265-265

Erika Check Hayden

Water: A long dry summer pp. 270-273

Quirin Schiermeier

Wildlife disease can put conservation at risk pp. 282-282

Darrick T. Evensen

Hall and Keynes join Arbor in the citation indexes pp. 282-282

Daniel C. Postellon

How genetic censorship would harm everyone pp. 282-282

Marcelino Fuentes

Qualities of a lone author are beneficial to science pp. 282-282

Kevin Hallock

Improving on haves and have-nots pp. 283-284

Jamie Bartram

The energy challenge pp. 285-286

Mike Hightower and Suzanne A. Pierce

Internet as utility? pp. 287-288

John Browning

Water policy in the can pp. 288-288

Emma Marris

Water works pp. 289-289

Nick Thomas

Galileo the artist pp. 289-289

Thomas de Padova

Echoes of time in images of the Antarctic pp. 290-290

Martin Kemp

Water — an enduring mystery pp. 291-292

Philip Ball

Song of the electroweak penguin pp. 293-294

Michael E. Peskin

Brain comes to light pp. 294-295

Hitoshi Okamura

Schistosome treatment pp. 296-296

Sadaf Shadan

A whiff of methane pp. 296-297

Adam P. Showman

Punisher pays pp. 297-298

Manfred Milinski and Bettina Rockenbach

Disturbance without the force pp. 298-299

Akira Tonomura and Franco Nori

Science and technology for water purification in the coming decades pp. 301-310

Mark A. Shannon, Paul W. Bohn, Menachem Elimelech, John G. Georgiadis, Benito J. Mariñas and Anne M. Mayes

Ancient, highly heterogeneous mantle beneath Gakkel ridge, Arctic Ocean pp. 311-316

Chuan-Zhou Liu, Jonathan E. Snow, Eric Hellebrand, Gerhard Brügmann, Anette von der Handt, Anette Büchl and Albrecht W. Hofmann

Thyrotrophin in the pars tuberalis triggers photoperiodic response pp. 317-322

Nobuhiro Nakao, Hiroko Ono, Takashi Yamamura, Tsubasa Anraku, Tsuyoshi Takagi, Kumiko Higashi, Shinobu Yasuo, Yasuhiro Katou, Saburo Kageyama, Yumiko Uno, Takeya Kasukawa, Masayuki Iigo, Peter J. Sharp, Atsushi Iwasawa, Yutaka Suzuki, Sumio Sugano, Teruyuki Niimi, Makoto Mizutani, Takao Namikawa, Shizufumi Ebihara, Hiroki R. Ueda and Takashi Yoshimura

Translational control of the innate immune response through IRF-7 pp. 323-328

Rodney Colina, Mauro Costa-Mattioli, Ryan J. O. Dowling, Maritza Jaramillo, Lee-Hwa Tai, Caroline J. Breitbach, Yvan Martineau, Ola Larsson, Liwei Rong, Yuri V. Svitkin, Andrew P. Makrigiannis, John C. Bell and Nahum Sonenberg

The presence of methane in the atmosphere of an extrasolar planet pp. 329-331

Mark R. Swain, Gautam Vasisht and Giovanna Tinetti

Super-chondritic Sm/Nd ratios in Mars, the Earth and the Moon pp. 336-339

Guillaume Caro, Bernard Bourdon, Alex N. Halliday and Ghylaine Quitté

Biodiversity and biogeography of phages in modern stromatolites and thrombolites pp. 340-343

Christelle Desnues, Beltran Rodriguez-Brito, Steve Rayhawk, Scott Kelley, Tuong Tran, Matthew Haynes, Hong Liu, Mike Furlan, Linda Wegley, Betty Chau, Yijun Ruan, Dana Hall, Florent E. Angly, Robert A. Edwards, Linlin Li, Rebecca Vega Thurber, R. Pamela Reid, Janet Siefert, Valeria Souza, David L. Valentine, Brandon K. Swan, Mya Breitbart and Forest Rohwer

Survival variability and population density in fish populations pp. 344-347

Coilín Minto, Ransom A. Myers and Wade Blanchard

Winners don’t punish pp. 348-351

Anna Dreber, David G. Rand, Drew Fudenberg and Martin A. Nowak

Identifying natural images from human brain activity pp. 352-355

Kendrick N. Kay, Thomas Naselaris, Ryan J. Prenger and Jack L. Gallant

Memory CD4 T cells emerge from effector T-cell progenitors pp. 356-360

Laurie E. Harrington, Karen M. Janowski, James R. Oliver, Allan J. Zajac and Casey T. Weaver

Preserving cell shape under environmental stress pp. 361-364

Boaz Cook, Robert W. Hardy, William B. McConnaughey and Charles S. Zuker

Control of chromosome stability by the β-TrCP–REST–Mad2 axis pp. 365-369

Daniele Guardavaccaro, David Frescas, N. Valerio Dorrello, Angelo Peschiaroli, Asha S. Multani, Timothy Cardozo, Anna Lasorella, Antonio Iavarone, Sandy Chang, Eva Hernando and Michele Pagano

SCFβ-TRCP controls oncogenic transformation and neural differentiation through REST degradation pp. 370-374

Thomas F. Westbrook, Guang Hu, Xiaolu L. Ang, Peter Mulligan, Natalya N. Pavlova, Anthony Liang, Yumei Leng, Rene Maehr, Yang Shi, J. Wade Harper and Stephen J. Elledge

X-ray structure of a prokaryotic pentameric ligand-gated ion channel pp. 375-379

Ricarda J. C. Hilf and Raimund Dutzler

Erratum: Structural basis for the function and inhibition of an influenza virus proton channel pp. 380-380

Amanda L. Stouffer, Rudresh Acharya, David Salom, Anna S. Levine, Luigi Di Costanzo, Cinque S. Soto, Valentina Tereshko, Vikas Nanda, Steven Stayrook and William F. DeGrado

Should the NIH spread its wealth? pp. 381-381

Gene Russo

Closing the gaps pp. 382-383

Paul Smaglik

Mike Tyers, director of the Scottish Universities Life Sciences Alliance, Edinburgh, Scotland pp. 384-384

Jill U. Adams

Sea change in business studies pp. 384-384

Virginia Gewin

Thinner air pp. 384-384

Aliza le Roux

Shambles pp. 386-386

Alexander Hay

2008, volume 452, articles 7184

Complex speciation of humans and chimpanzees pp. E3-E4

John Wakeley

Patterson et al. reply pp. E4-E4

Nick Patterson, Daniel J. Richter, Sante Gnerre, Eric S. Lander and David Reich

Journal club pp. 131-131

John Church

Stem-cell claim gets cold reception pp. 132-133

David Cyranoski and Monya Baker

Pacific "dwarf" bones cause controversy pp. 133-134

Rex Dalton

Brazil goes to war against logging pp. 134-135

Jeff Tollefson

All eyes on the Amazon pp. 137-137

Jeff Tollefson

Snapshot: Flooding the canyon pp. 138-138

Anna Petherick

Libya progresses on HIV pp. 138-138

Declan Butler

Probe readies for dip into geyser on Enceladus pp. 139-140

Eric Hand

Astronomy: Eyes as big as the sky pp. 142-145

Eric Hand

Business: Stepping out pp. 146-146

Rex Dalton

Bioterror: The green menace pp. 148-150

Ewen Callaway

Poor countries left behind in rush to claim sea floor pp. 151-151

Morten Sørensen

Directive will unleash new generation of coal polluters pp. 151-151

Mark Avery, John Sauven, Keith Allot, Benedict Southworth and Andrew Pendleton

How academic corporatism can lead to dictatorship pp. 151-151

G. A. Clark

Results of rush to sequence genomes may be nonsense pp. 151-151

Thomas C. Erren, Paul Cullen and Michael Erren

One long argument pp. 153-153

Armand M. Leroi

Storming the language barrier pp. 154-154

Frans B. M. de Waal

A protein ghost etched in glass pp. 155-155

Marta Paterlini

Census of cyberspace censoring pp. 155-156

Bruce Schneier

Beauty meets utility at MoMA pp. 156-156

Josie Glausiusz

Fresh hope to can the worms pp. 157-158

Roger K. Prichard and Timothy G. Geary

Patchy solutions pp. 159-161

George Ellis

Did life grind to a start? pp. 161-162

J. Michael McBride and John C. Tully

Out of reach pp. 162-163

Sybil Seitzinger

Radicals by reduction pp. 163-164

Joseph T. Jarrett

Geomagnetic reversals pp. 165-167

David Gubbins

Genetic basis of fitness differences in natural populations pp. 169-175

Hans Ellegren and Ben C. Sheldon

A new class of anthelmintics effective against drug-resistant nematodes pp. 176-180

Ronald Kaminsky, Pierre Ducray, Martin Jung, Ralph Clover, Lucien Rufener, Jacques Bouvier, Sandra Schorderet Weber, Andre Wenger, Susanne Wieland-Berghausen, Thomas Goebel, Noelle Gauvry, François Pautrat, Thomas Skripsky, Olivier Froelich, Clarisse Komoin-Oka, Bethany Westlund, Ann Sluder and Pascal Mäser

Pyruvate kinase M2 is a phosphotyrosine-binding protein pp. 181-186

Heather R. Christofk, Matthew G. Vander Heiden, Ning Wu, John M. Asara and Lewis C. Cantley

SATB1 reprogrammes gene expression to promote breast tumour growth and metastasis pp. 187-193

Hye-Jung Han, Jose Russo, Yoshinori Kohwi and Terumi Kohwi-Shigematsu

Reflected light from sand grains in the terrestrial zone of a protoplanetary disk pp. 194-197

William Herbst, Catrina M. Hamilton, Katherine LeDuc, Joshua N. Winn, Christopher M. Johns-Krull, Reinhard Mundt and Mansur Ibrahimov

Hierarchical self-assembly of DNA into symmetric supramolecular polyhedra pp. 198-201

Yu He, Tao Ye, Min Su, Chuan Zhang, Alexander E. Ribbe, Wen Jiang and Chengde Mao

Stream denitrification across biomes and its response to anthropogenic nitrate loading pp. 202-205

Patrick J. Mulholland, Ashley M. Helton, Geoffrey C. Poole, Robert O. Hall, Stephen K. Hamilton, Bruce J. Peterson, Jennifer L. Tank, Linda R. Ashkenas, Lee W. Cooper, Clifford N. Dahm, Walter K. Dodds, Stuart E. G. Findlay, Stanley V. Gregory, Nancy B. Grimm, Sherri L. Johnson, William H. McDowell, Judy L. Meyer, H. Maurice Valett, Jackson R. Webster, Clay P. Arango, Jake J. Beaulieu, Melody J. Bernot, Amy J. Burgin, Chelsea L. Crenshaw, Laura T. Johnson, B. R. Niederlehner, Jonathan M. O’Brien, Jody D. Potter, Richard W. Sheibley, Daniel J. Sobota and Suzanne M. Thomas

Influence of the Gulf Stream on the troposphere pp. 206-209

Shoshiro Minobe, Akira Kuwano-Yoshida, Nobumasa Komori, Shang-Ping Xie and Richard Justin Small

Diversity and productivity peak at intermediate dispersal rate in evolving metacommunities pp. 210-214

P. A. Venail, R. C. MacLean, T. Bouvier, M. A. Brockhurst, M. E. Hochberg and N. Mouquet

Shotgun bisulphite sequencing of the Arabidopsis genome reveals DNA methylation patterning pp. 215-219

Shawn J. Cokus, Suhua Feng, Xiaoyu Zhang, Zugen Chen, Barry Merriman, Christian D. Haudenschild, Sriharsa Pradhan, Stanley F. Nelson, Matteo Pellegrini and Steven E. Jacobsen

Adaptive coding of visual information in neural populations pp. 220-224

Diego A. Gutnisky and Valentin Dragoi

A skin microRNA promotes differentiation by repressing ‘stemness’ pp. 225-229

Rui Yi, Matthew N. Poy, Markus Stoffel and Elaine Fuchs

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth pp. 230-233

Heather R. Christofk, Matthew G. Vander Heiden, Marian H. Harris, Arvind Ramanathan, Robert E. Gerszten, Ru Wei, Mark D. Fleming, Stuart L. Schreiber and Lewis C. Cantley

UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes pp. 234-238

You-Me Kim, Melanie M. Brinkmann, Marie-Eve Paquet and Hidde L. Ploegh

An allylic ketyl radical intermediate in clostridial amino-acid fermentation pp. 239-242

Jihoe Kim, Daniel J. Darley, Wolfgang Buckel and Antonio J. Pierik

Transcriptional repression mediated by repositioning of genes to the nuclear lamina pp. 243-247

K. L. Reddy, J. M. Zullo, E. Bertolino and H. Singh

Erratum: The X-ray crystal structure of RNA polymerase from Archaea pp. 248-248

Akira Hirata, Brianna J. Klein and Katsuhiko S. Murakami

The Howard Hughes Medical Institute has unveiled a programme to offer start-up funds for young biomedical scientists pp. 249-249

Paul Smaglik

Daniel Kelly, scientific director, Burnham Institute for Medical Research, Orlando, Florida pp. 250-250

Virginia Gewin

Sunny view for Florida life sciences pp. 250-250

Virginia Gewin

David versus Goliath pp. 250-250

Zachary Lippman

The protocol pp. 252-252

Ralph Greco

2008, volume 452, articles 7183

Schiff et al. reply pp. E1-E2

N. D. Schiff, J. T. Giacino, K. Kalmar, J. D.Victor, K. Baker, M. Gerber, B. Fritz, B. Eisenberg, T. Biondi, J. O’Connor, E. J. Kobylarz, S. Farris, A. Machado, C. McCagg, F. Plum, J. J. Fins and A. R. Rezai

Arousal by stimulation of deep-brain nuclei pp. E1-E1

Hugh Staunton

Journal club pp. 5-5

Keith Devlin

Crunch time for peer review in lawsuit pp. 6-7

Meredith Wadman

Bright hopes pervade dark matter pp. 7-7

Geoff Brumfiel

Entomologists stifled by Indian bureaucracy pp. 7-7

K. S. Jayaraman

Save the trees pp. 8-9

Jeff Tollefson

Hobbit was 'a cretin' pp. 12-12

Rex Dalton

Nobel prizewinner's paper retracted pp. 13-13

Heidi Ledford

The scientist delusion pp. 17-17

David Goldston

Gravitational astronomy: Hearing the heavens pp. 18-21

Trudy E. Bell

Archaeology: Facing up to the past pp. 22-23

Rex Dalton

Oceanography: Red tide rising pp. 24-26

Mark Schrope

Who stands to lose from double-blind review? pp. 28-28

Boyan K. Garvalov

Double-blind review: the paw print is a giveaway pp. 28-28

K. Razi Naqvi

Double-blind review: easy to guess in specialist fields pp. 28-28

David Lane

Double-blind review: let diversity reign pp. 28-28

Bob O'Hara

Tibet's seeds must be stored as climate changes pp. 28-28

W. John Cram, Yang Zhong, Tashi Tersing and Jie Cai

Duplication: stop favouring applicant with longest list pp. 29-29

Martin Fenner

Duplication spreads the word to a wider audience pp. 29-29

Daniel David

Duplication and plagiarism increasing among students pp. 29-29

Brian Derby

Duplication: most cases on database are innocent pp. 29-29

Paul Brennan

Physics to Bragg about pp. 30-30

Jeff Hughes

Climate change for the masses pp. 31-31

David S. Reay

Crafters tinker with technology pp. 32-32

Krista Zala

Home cooking with a twist pp. 32-33

Jascha Hoffman

Toys, bugs and rock 'n' roll pp. 33-33

Joanne Baker

The book that began invasion ecology pp. 34-34

Anthony Ricciardi and Hugh J. MacIsaac

Keeping it regular with protons pp. 35-36

Laura M. Prolo and Miriam B. Goodman

Tangled memories pp. 37-38

Lene Vestergaard Hau

A complex in psychosis pp. 38-39

Solomon H. Snyder

Rushed decisions pp. 39-39

Sadaf Shadan

Modern life in ancient mats pp. 40-41

Michael M. Tice

Hiss from the chorus pp. 41-42

Craig J. Rodger and Mark A. Clilverd

Fungal symbiosis unearthed pp. 42-43

Dan Cullen

How does your quasicrystal grow? pp. 43-44

Paul J. Steinhardt

Cyclical DNA methylation of a transcriptionally active promoter pp. 45-50

Raphaël Métivier, Rozenn Gallais, Christophe Tiffoche, Christine Le Péron, Renata Z. Jurkowska, Richard P. Carmouche, David Ibberson, Peter Barath, Florence Demay, George Reid, Vladimir Benes, Albert Jeltsch, Frank Gannon and Gilles Salbert

The MC-Fold and MC-Sym pipeline infers RNA structure from sequence data pp. 51-55

Marc Parisien and François Major

Structure and metal exchange in the cadmium carbonic anhydrase of marine diatoms pp. 56-61

Yan Xu, Liang Feng, Philip D. Jeffrey, Yigong Shi and François M. M. Morel

The unexpected origin of plasmaspheric hiss from discrete chorus emissions pp. 62-66

Jacob Bortnik, Richard M. Thorne and Nigel P. Meredith

Mapping photonic entanglement into and out of a quantum memory pp. 67-71

K. S. Choi, H. Deng, J. Laurat and H. J. Kimble

Strong dispersive coupling of a high-finesse cavity to a micromechanical membrane pp. 72-75

J. D. Thompson, B. M. Zwickl, A. M. Jayich, Florian Marquardt, S. M. Girvin and J. G. E. Harris

Multi-membrane hydrogels pp. 76-79

Sébastien Ladet, Laurent David and Alain Domard

Near-isothermal conditions in the middle and lower crust induced by melt migration pp. 80-83

Gabriela V. Depine, Christopher L. Andronicos and Jason Phipps-Morgan

High-amplitude fluctuations and alternative dynamical states of midges in Lake Myvatn pp. 84-87

Anthony R. Ives, Árni Einarsson, Vincent A. A. Jansen and Arnthor Gardarsson

The genome of Laccaria bicolor provides insights into mycorrhizal symbiosis pp. 88-92

F. Martin, A. Aerts, D. Ahrén, A. Brun, E. G. J. Danchin, F. Duchaussoy, J. Gibon, A. Kohler, E. Lindquist, V. Pereda, A. Salamov, H. J. Shapiro, J. Wuyts, D. Blaudez, M. Buée, P. Brokstein, B. Canbäck, D. Cohen, P. E. Courty, P. M. Coutinho, C. Delaruelle, J. C. Detter, A. Deveau, S. DiFazio, S. Duplessis, L. Fraissinet-Tachet, E. Lucic, P. Frey-Klett, C. Fourrey, I. Feussner, G. Gay, J. Grimwood, P. J. Hoegger, P. Jain, S. Kilaru, J. Labbé, Y. C. Lin, V. Legué, F. Le Tacon, R. Marmeisse, D. Melayah, B. Montanini, M. Muratet, U. Nehls, H. Niculita-Hirzel, M. P. Oudot-Le Secq, M. Peter, H. Quesneville, B. Rajashekar, M. Reich, N. Rouhier, J. Schmutz, T. Yin, M. Chalot, B. Henrissat, U. Kües, S. Lucas, Y. Van de Peer, G. K. Podila, A. Polle, P. J. Pukkila, P. M. Richardson, P. Rouzé, I. R. Sanders, J. E. Stajich, A. Tunlid, G. Tuskan and I. V. Grigoriev

Identification of a serotonin/glutamate receptor complex implicated in psychosis pp. 93-97

Javier González-Maeso, Rosalind L. Ang, Tony Yuen, Pokman Chan, Noelia V. Weisstaub, Juan F. López-Giménez, Mingming Zhou, Yuuya Okawa, Luis F. Callado, Graeme Milligan, Jay A. Gingrich, Marta Filizola, J. Javier Meana and Stuart C. Sealfon

Hax1-mediated processing of HtrA2 by Parl allows survival of lymphocytes and neurons pp. 98-102

Jyh-Rong Chao, Evan Parganas, Kelli Boyd, Cheol Yi Hong, Joseph T. Opferman and James N. Ihle

The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response pp. 103-107

Daniel A. Muruve, Virginie Pétrilli, Anne K. Zaiss, Lindsay R. White, Sharon A. Clark, P. Joel Ross, Robin J. Parks and Jurg Tschopp

A peptide deformylase–ribosome complex reveals mechanism of nascent chain processing pp. 108-111

Rouven Bingel-Erlenmeyer, Rebecca Kohler, Günter Kramer, Arzu Sandikci, Snježana Antolić, Timm Maier, Christiane Schaffitzel, Brigitte Wiedmann, Bernd Bukau and Nenad Ban

Transient cyclical methylation of promoter DNA pp. 112-115

Sara Kangaspeska, Brenda Stride, Raphaël Métivier, Maria Polycarpou-Schwarz, David Ibberson, Richard Paul Carmouche, Vladimir Benes, Frank Gannon and George Reid

Structure of the DNA deaminase domain of the HIV-1 restriction factor APOBEC3G pp. 116-119

Kuan-Ming Chen, Elena Harjes, Phillip J. Gross, Amr Fahmy, Yongjian Lu, Keisuke Shindo, Reuben S. Harris and Hiroshi Matsuo

Erratum: Behavioural improvements with thalamic stimulation after severe traumatic brain injury pp. 120-120

N. D. Schiff, J. T. Giacino, K. Kalmar, J. D. Victor, K. Baker, M. Gerber, B. Fritz, B. Eisenberg, T. Biondi, J. O’Connor, E. J. Kobylarz, S. Farris, A. Machado, C. McCagg, F. Plum, J. J. Fins and A. R. Rezai

Retraction Note: Genetic tracing reveals a stereotyped sensory map in the olfactory cortex pp. 120-120

Zhihua Zou, Lisa F. Horowitz, Jean-Pierre Montmayeur, Scott Snapper and Linda B. Buck

Are animal-rights attacks affecting career paths? pp. 121-121

Gene Russo

Almost in bloom pp. 122-124

Emma Marris

From Alice to everywhere, with love pp. 126-126

Chaz Brenchley