Co-adjuvant effects of retinoic acid and IL-15 induce inflammatory immunity to dietary antigens

R. W. DePaolo, V. Abadie, F. Tang, H. Fehlner-Peach, J. A. Hall, W. Wang, E. V. Marietta, D. D. Kasarda, T. A. Waldmann, J. A. Murray, C. Semrad, S. S. Kupfer, Y. Belkaid, S. Guandalini and B. Jabri ()
Additional contact information
R. W. DePaolo: University of Chicago
V. Abadie: University of Chicago
F. Tang: University of Chicago
H. Fehlner-Peach: University of Chicago
J. A. Hall: Mucosal Immunology Unit, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health
W. Wang: University of Chicago
E. V. Marietta: Mayo Clinic College of Medicine
D. D. Kasarda: Agricultural Research Service, Western Regional Research Center
T. A. Waldmann: Metabolism Branch, National Cancer Institute
J. A. Murray: Mayo Clinic College of Medicine
C. Semrad: University of Chicago
S. S. Kupfer: University of Chicago
Y. Belkaid: Mucosal Immunology Unit, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health
S. Guandalini: University of Chicago
B. Jabri: University of Chicago

Nature, 2011, vol. 471, issue 7337, 220-224

Abstract: Gluten intolerance mechanism The vitamin A metabolite retinoic acid is shown to act synergistically with the cytokine interleukin-15 (IL-15) to induce IL-12p70 production by intestinal dendritic cells, thereby promoting an inflammatory T-cell response to dietary antigens. IL-15 is upregulated in the guts of patients with coeliac disease, and this new work points to a previously unknown involvement of IL-15 and retinoic acid in promoting an inflammatory immune response to gluten.

Date: 2011
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DOI: 10.1038/nature09849

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