Structural basis of RNA polymerase II backtracking, arrest and reactivation

Alan C. M. Cheung and Patrick Cramer ()
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Alan C. M. Cheung: Center for Integrated Protein Science Munich, Ludwig-Maximilians-Universität München, Feodor-Lynen-Str. 25
Patrick Cramer: Center for Integrated Protein Science Munich, Ludwig-Maximilians-Universität München, Feodor-Lynen-Str. 25

Nature, 2011, vol. 471, issue 7337, 249-253

Abstract: The to and fro of RNA polymerase RNA polymerase II (RNA pol II) moves forwards along the DNA strand during gene transcription, synthesizing messenger RNA as it goes. It can also move backwards and stall — a useful property for regulatory purposes or if it hits an obstacle such as a nucleosome. This arrested state is reactivated by transcription factor IIS (TFIIS). Now, the crystal structure of a backtracked yeast RNA pol II complex containing observable backtracked RNA has been determined at 3.3 Å resolution, as well as the structure of a backtracked complex containing TFIIS. The structures reveal possible mechanisms of transcriptional stalling and transcription reactivation.

Date: 2011
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DOI: 10.1038/nature09785

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