Cross-dressed dendritic cells drive memory CD8+ T-cell activation after viral infection

Linda M. Wakim and Michael J. Bevan ()
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Linda M. Wakim: Howard Hughes Medical Institute, University of Washington, Box 357370, Seattle, Washington 98195, USA
Michael J. Bevan: Howard Hughes Medical Institute, University of Washington, Box 357370, Seattle, Washington 98195, USA

Nature, 2011, vol. 471, issue 7340, 629-632

Abstract: A prompt response to viral infection A novel mechanism for the activation of naive CD8+ T cells was identified in 2005. Termed cross-dressing, in recognition of the cross-priming and direct priming mechanisms known previously, it involves the transfer of loaded MHC/peptide molecules from an infected cell to dendritic cells. Linda Wakim and Michael Bevan now show that memory T-cell activation in viral infection occurs in part through cross-dressing. As an alternative mode of antigen presentation to memory T cells during viral infection, cross-dressing avoids the need for antigen processing by the presenting dendritic cell and allows prompt presentation of peptide epitopes that closely reflect those expressed on infected cells.

Date: 2011
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DOI: 10.1038/nature09863

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