X chromosome dosage compensation via enhanced transcriptional elongation in Drosophila

Erica Larschan, Eric P. Bishop, Peter V. Kharchenko, Leighton J. Core, John T. Lis, Peter J. Park () and Mitzi I. Kuroda ()
Additional contact information
Erica Larschan: Brigham and Women’s Hospital
Eric P. Bishop: Center for Biomedical Informatics, Harvard Medical School & Informatics Program, Children’s Hospital
Peter V. Kharchenko: Center for Biomedical Informatics, Harvard Medical School & Informatics Program, Children’s Hospital
Leighton J. Core: Cornell University, Ithaca, New York, 14850, USA.
John T. Lis: Cornell University, Ithaca, New York, 14850, USA.
Peter J. Park: Center for Biomedical Informatics, Harvard Medical School & Informatics Program, Children’s Hospital
Mitzi I. Kuroda: Brigham and Women’s Hospital

Nature, 2011, vol. 471, issue 7336, 115-118

Abstract: X chromosome expression in the balance Different organisms use a variety of mechanisms to compensate for X chromosome dosage imbalance between the sexes. In Drosophila, the MSL (Male-specific lethal) complex increases transcription on the single X chromosome of males and is thought to regulate transcription elongation, although mechanistic details have been unclear. A global run-on sequencing technique has now been used to reveal that the MSL complex seems to enhance transcription by facilitating the progression of RNA polymerase II across the bodies of active X-linked genes. In this way, MSL can impose dosage compensation on diverse genes with a wide range of transcription levels along the X chromosome.

Date: 2011
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/nature09757 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:471:y:2011:i:7336:d:10.1038_nature09757

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature09757

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().