Aberrant chromosome morphology in human cells defective for Holliday junction resolution

Thomas Wechsler, Scott Newman and Stephen C. West ()
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Thomas Wechsler: London Research Institute, Cancer Research UK, Clare Hall Laboratories
Scott Newman: University of Cambridge
Stephen C. West: London Research Institute, Cancer Research UK, Clare Hall Laboratories

Nature, 2011, vol. 471, issue 7340, 642-646

Abstract: Disruption at Holliday junction Exchange of sister chromatids to form four-stranded Holliday junctions occurs naturally during meiosis, to hold sister chromatids together, and during various repair events. In eukaryotes, double Holliday junctions that escape dissolution by a helicase–topoisomerase (BTR) complex are instead processed by one of several nucleases, known as resolvases. In this study, Stephen West and colleagues define the activities of the GEN1, MUS81–EME1 and SLX1–SLX4 resolvases in the absence of BLM, the helicase component of BTR that is mutated in Bloom's syndrome. The use of these alternatives may come at a price, however, because Bloom's syndrome cells exhibit genomic instability and patients experience a broad spectrum of early-onset cancers.

Date: 2011
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DOI: 10.1038/nature09790

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