Duplications of the neuropeptide receptor gene VIPR2 confer significant risk for schizophrenia

Vladimir Vacic, Shane McCarthy, Dheeraj Malhotra, Fiona Murray, Hsun-Hua Chou, Aine Peoples, Vladimir Makarov, Seungtai Yoon, Abhishek Bhandari, Roser Corominas, Lilia M. Iakoucheva, Olga Krastoshevsky, Verena Krause, Verónica Larach-Walters, David K. Welsh, David Craig, John R. Kelsoe, Elliot S. Gershon, Suzanne M. Leal, Marie Dell Aquila, Derek W. Morris, Michael Gill, Aiden Corvin, Paul A. Insel, Jon McClellan, Mary-Claire King, Maria Karayiorgou, Deborah L. Levy, Lynn E. DeLisi and Jonathan Sebat ()
Additional contact information
Vladimir Vacic: Stanley Institute for Cognitive Genomics, Cold Spring Harbor Laboratory
Shane McCarthy: Stanley Institute for Cognitive Genomics, Cold Spring Harbor Laboratory
Dheeraj Malhotra: Stanley Institute for Cognitive Genomics, Cold Spring Harbor Laboratory
Fiona Murray: University of California
Hsun-Hua Chou: Beyster Center for Genomics of Psychiatric Diseases, University of California
Aine Peoples: Neuropsychiatric Genetics Research Group, Trinity College Dublin
Vladimir Makarov: Seaver Autism Center, Mount Sinai School of Medicine
Seungtai Yoon: Seaver Autism Center, Mount Sinai School of Medicine
Abhishek Bhandari: Stanley Institute for Cognitive Genomics, Cold Spring Harbor Laboratory
Roser Corominas: University of California
Lilia M. Iakoucheva: University of California
Olga Krastoshevsky: McLean Hospital
Verena Krause: McLean Hospital
Verónica Larach-Walters: Faculty of Medicine, Universidad Andrés Bello
David K. Welsh: University of California
David Craig: Translational Genomics Research Institute
John R. Kelsoe: University of California
Elliot S. Gershon: The University of Chicago
Suzanne M. Leal: Baylor College of Medicine
Marie Dell Aquila: University of California
Derek W. Morris: Neuropsychiatric Genetics Research Group, Trinity College Dublin
Michael Gill: Neuropsychiatric Genetics Research Group, Trinity College Dublin
Aiden Corvin: Neuropsychiatric Genetics Research Group, Trinity College Dublin
Paul A. Insel: University of California
Jon McClellan: University of Washington
Mary-Claire King: University of Washington
Maria Karayiorgou: Columbia University
Deborah L. Levy: McLean Hospital
Lynn E. DeLisi: Boston VA Healthcare System and Harvard Medical School
Jonathan Sebat: Stanley Institute for Cognitive Genomics, Cold Spring Harbor Laboratory

Nature, 2011, vol. 471, issue 7339, 499-503

Abstract: VIP2 receptor link to schizophrenia Based on genome-wide analysis of copy number variants in two large schizophrenia cohorts, Vacic et al. report a significant association between duplications within a region of chromosome 7 and schizophrenia. Using microduplication analysis, the region affected was narrowed down to 7q36.3, just upstream of a gene encoding vasoactive intestinal peptide receptor (VIPR2). Increased expression of VIPR2 in patients with schizophrenia implicates VIP signalling as a molecular mechanism underlying schizophrenia. This work points to the VIPR2 receptor as a potential target for antipsychotic drugs.

Date: 2011
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DOI: 10.1038/nature09884

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