MHC class II transactivator CIITA is a recurrent gene fusion partner in lymphoid cancers

Christian Steidl, Sohrab P. Shah, Bruce W. Woolcock, Lixin Rui, Masahiro Kawahara, Pedro Farinha, Nathalie A. Johnson, Yongjun Zhao, Adele Telenius, Susana Ben Neriah, Andrew McPherson, Barbara Meissner, Ujunwa C. Okoye, Arjan Diepstra, Anke van den Berg, Mark Sun, Gillian Leung, Steven J. Jones, Joseph M. Connors, David G. Huntsman, Kerry J. Savage, Lisa M. Rimsza, Douglas E. Horsman, Louis M. Staudt, Ulrich Steidl, Marco A. Marra and Randy D. Gascoyne ()
Additional contact information
Christian Steidl: Centre for Lymphoid Cancers and the Centre for Translational and Applied Genomics (CTAG)
Sohrab P. Shah: Centre for Lymphoid Cancers and the Centre for Translational and Applied Genomics (CTAG)
Bruce W. Woolcock: Centre for Lymphoid Cancers and the Centre for Translational and Applied Genomics (CTAG)
Lixin Rui: Metabolism Branch, Center for Cancer Research, National Cancer Institute
Masahiro Kawahara: Albert Einstein College of Medicine
Pedro Farinha: Centre for Lymphoid Cancers and the Centre for Translational and Applied Genomics (CTAG)
Nathalie A. Johnson: Centre for Lymphoid Cancers and the Centre for Translational and Applied Genomics (CTAG)
Yongjun Zhao: Genome Sciences Centre, BC Cancer Agency
Adele Telenius: Centre for Lymphoid Cancers and the Centre for Translational and Applied Genomics (CTAG)
Susana Ben Neriah: Centre for Lymphoid Cancers and the Centre for Translational and Applied Genomics (CTAG)
Andrew McPherson: Centre for Lymphoid Cancers and the Centre for Translational and Applied Genomics (CTAG)
Barbara Meissner: Centre for Lymphoid Cancers and the Centre for Translational and Applied Genomics (CTAG)
Ujunwa C. Okoye: Albert Einstein College of Medicine
Arjan Diepstra: University Medical Center Groningen, University of Groningen
Anke van den Berg: University Medical Center Groningen, University of Groningen
Mark Sun: Centre for Lymphoid Cancers and the Centre for Translational and Applied Genomics (CTAG)
Gillian Leung: Centre for Lymphoid Cancers and the Centre for Translational and Applied Genomics (CTAG)
Steven J. Jones: Genome Sciences Centre, BC Cancer Agency
Joseph M. Connors: BC Cancer Agency Centre for Lymphoid Cancer
David G. Huntsman: Centre for Lymphoid Cancers and the Centre for Translational and Applied Genomics (CTAG)
Kerry J. Savage: BC Cancer Agency Centre for Lymphoid Cancer
Lisa M. Rimsza: University of Arizona
Douglas E. Horsman: Centre for Lymphoid Cancers and the Centre for Translational and Applied Genomics (CTAG)
Louis M. Staudt: Metabolism Branch, Center for Cancer Research, National Cancer Institute
Ulrich Steidl: Albert Einstein College of Medicine
Marco A. Marra: Genome Sciences Centre, BC Cancer Agency
Randy D. Gascoyne: Centre for Lymphoid Cancers and the Centre for Translational and Applied Genomics (CTAG)

Nature, 2011, vol. 471, issue 7338, 377-381

Abstract: MHC regulator in cancers Using whole transcriptome sequencing, Steidl et al. identify recurrent gene translocations in B-cell lymphomas that involve the class II transactivator CIITA, the 'master regulator' of the major histocompatibility complex. These translocations downregulate cell surface HLA class II and, with some fusion partners, lead to overexpression of CD274/CD273 ligands, potentially reducing the anti-tumour immune response against these lymphomas. Recurrent rearrangements of CIITA may represent a genetic mechanism that is involved more widely in interactions between tumours and their microenvironment in lymphoid cancers.

Date: 2011
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DOI: 10.1038/nature09754

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