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2017, volume 541, articles 7638

PLD3 gene and processing of APP pp. E1-E2

Pietro Fazzari, Katrien Horre, Amaia M. Arranz, Carlo Sala Frigerio, Takashi Saito, Takaomi C. Saido and Bart De Strooper

We must urgently clarify data-sharing rules pp. 437-437

Jan-Eric Litton

Trump’s next move? Scientists struggle with foggy future pp. 443-444

Lauren Morello, Sara Reardon, Jeff Tollefson and Alexandra Witze

Billion-dollar project aims to prep vaccines before epidemics hit pp. 444-445

Declan Butler

Plant biologists welcome their robot overlords pp. 445-446

Heidi Ledford

‘You never said my peer review was confidential’ — scientist challenges publisher pp. 446-446

Quirin Schiermeier

D-Wave upgrade: How scientists are using the world’s most controversial quantum computer pp. 447-448

Elizabeth Gibney

Biotech firm backs controversial CRISPR challenger pp. 447-447

David Cyranoski

Controversial patient-consent proposal left out of research-ethics reforms pp. 449-449

Sara Reardon

Big science has a buzzword problem pp. 450-453

Megan Scudellari

Journals invite too few women to referee pp. 455-457

Jory Lerback and Brooks Hanson

Reform predictive policing pp. 458-460

Aaron Shapiro

Higher education: The making of US academia pp. 461-462

Rogers Hollingsworth

Bioethics: Democracy in vitro pp. 462-463

Insoo Hyun

Books in brief pp. 463-463

Barbara Kiser

Crop-health survey aims to fill data gaps pp. 464-464

Andy Nelson

Anthropocene: be wary of social impact pp. 464-464

George Holmes, Jacob Barber and Johannes Lundershausen

Anthropocene: keep communication clear pp. 464-464

Lucy E. Edwards, David A. T. Harper and Philip L. Gibbard

Detecting particles of dark matter pp. 464-464

Jihn E. Kim, Pierre Sikivie and Steven Weinberg

Progressive taxes for sustainability pp. 464-464

Francesco Orsi

Phages make a group decision pp. 466-467

Alan R. Davidson

Optical transition seen in antihydrogen pp. 467-468

Stefan Ulmer

Earth's building blocks pp. 468-469

Richard W. Carlson

Versatile gel assembly on a chip pp. 470-471

Shoji Takeuchi

Unconventional translation in cancer pp. 471-472

Marianne Terndrup Pedersen and Kim B. Jensen

Chiral quantum optics pp. 473-480

Peter Lodahl, Sahand Mahmoodian, Søren Stobbe, Arno Rauschenbeutel, Philipp Schneeweiss, Jürgen Volz, Hannes Pichler and Peter Zoller

Neurotoxic reactive astrocytes are induced by activated microglia pp. 481-487

Shane A. Liddelow, Kevin A. Guttenplan, Laura E. Clarke, Frederick C. Bennett, Christopher J. Bohlen, Lucas Schirmer, Mariko L. Bennett, Alexandra E. Münch, Won-Suk Chung, Todd C. Peterson, Daniel K. Wilton, Arnaud Frouin, Brooke A. Napier, Nikhil Panicker, Manoj Kumar, Marion S. Buckwalter, David H. Rowitch, Valina L. Dawson, Ted M. Dawson, Beth Stevens and Ben A. Barres

Communication between viruses guides lysis–lysogeny decisions pp. 488-493

Zohar Erez, Ida Steinberger-Levy, Maya Shamir, Shany Doron, Avigail Stokar-Avihail, Yoav Peleg, Sarah Melamed, Azita Leavitt, Alon Savidor, Shira Albeck, Gil Amitai and Rotem Sorek

Translation from unconventional 5′ start sites drives tumour initiation pp. 494-499

Ataman Sendoel, Joshua G. Dunn, Edwin H. Rodriguez, Shruti Naik, Nicholas C. Gomez, Brian Hurwitz, John Levorse, Brian D. Dill, Daniel Schramek, Henrik Molina, Jonathan S. Weissman and Elaine Fuchs

Structure of a CLC chloride ion channel by cryo-electron microscopy pp. 500-505

Eunyong Park, Ernest B. Campbell and Roderick MacKinnon

Observation of the 1S–2S transition in trapped antihydrogen pp. 506-510

M. Ahmadi, B. X. R. Alves, C. J. Baker, W. Bertsche, E. Butler, A. Capra, C. Carruth, C. L. Cesar, M. Charlton, S. Cohen, R. Collister, S. Eriksson, A. Evans, N. Evetts, J. Fajans, T. Friesen, M. C. Fujiwara, D. R. Gill, A. Gutierrez, J. S. Hangst, W. N. Hardy, M. E. Hayden, C. A. Isaac, A. Ishida, M. A. Johnson, S. A. Jones, S. Jonsell, L. Kurchaninov, N. Madsen, M. Mathers, D. Maxwell, J. T. K. McKenna, S. Menary, J. M. Michan, T. Momose, J. J. Munich, P. Nolan, K. Olchanski, A. Olin, P. Pusa, C. Ø. Rasmussen, F. Robicheaux, R. L. Sacramento, M. Sameed, E. Sarid, D. M. Silveira, S. Stracka, G. Stutter, C. So, T. D. Tharp, J. E. Thompson, R. I. Thompson, D. P. van der Werf and J. S. Wurtele

High-spatial-resolution mapping of catalytic reactions on single particles pp. 511-515

Chung-Yeh Wu, William J. Wolf, Yehonatan Levartovsky, Hans A. Bechtel, Michael C. Martin, F. Dean Toste and Elad Gross

Compensatory water effects link yearly global land CO2 sink changes to temperature pp. 516-520

Martin Jung, Markus Reichstein, Christopher R. Schwalm, Chris Huntingford, Stephen Sitch, Anders Ahlström, Almut Arneth, Gustau Camps-Valls, Philippe Ciais, Pierre Friedlingstein, Fabian Gans, Kazuhito Ichii, Atul K. Jain, Etsushi Kato, Dario Papale, Ben Poulter, Botond Raduly, Christian Rödenbeck, Gianluca Tramontana, Nicolas Viovy, Ying-Ping Wang, Ulrich Weber, Sönke Zaehle and Ning Zeng

The isotopic nature of the Earth’s accreting material through time pp. 521-524

Nicolas Dauphas

Ruthenium isotopic evidence for an inner Solar System origin of the late veneer pp. 525-527

Mario Fischer-Gödde and Thorsten Kleine

Breeding site sampling across the Arctic by individual males of a polygynous shorebird pp. 528-531

Bart Kempenaers and Mihai Valcu

A solution to the single-question crowd wisdom problem pp. 532-535

Dražen Prelec, H. Sebastian Seung and John McCoy

Evolutionary genomics of the cold-adapted diatom Fragilariopsis cylindrus pp. 536-540

Thomas Mock, Robert P. Otillar, Jan Strauss, Mark McMullan, Pirita Paajanen, Jeremy Schmutz, Asaf Salamov, Remo Sanges, Andrew Toseland, Ben J. Ward, Andrew E. Allen, Christopher L. Dupont, Stephan Frickenhaus, Florian Maumus, Alaguraj Veluchamy, Taoyang Wu, Kerrie W. Barry, Angela Falciatore, Maria I. Ferrante, Antonio E. Fortunato, Gernot Glöckner, Ansgar Gruber, Rachel Hipkin, Michael G. Janech, Peter G. Kroth, Florian Leese, Erika A. Lindquist, Barbara R. Lyon, Joel Martin, Christoph Mayer, Micaela Parker, Hadi Quesneville, James A. Raymond, Christiane Uhlig, Ruben E. Valas, Klaus U. Valentin, Alexandra Z. Worden, E. Virginia Armbrust, Matthew D. Clark, Chris Bowler, Beverley R. Green, Vincent Moulton, Cock van Oosterhout and Igor V. Grigoriev

The Hippo kinases LATS1 and 2 control human breast cell fate via crosstalk with ERα pp. 541-545

Adrian Britschgi, Stephan Duss, Sungeun Kim, Joana Pinto Couto, Heike Brinkhaus, Shany Koren, Duvini De Silva, Kirsten D. Mertz, Daniela Kaup, Zsuzsanna Varga, Hans Voshol, Alexandra Vissieres, Cedric Leroy, Tim Roloff, Michael B. Stadler, Christina H. Scheel, Loren J. Miraglia, Anthony P. Orth, Ghislain M. C. Bonamy, Venkateshwar A. Reddy and Mohamed Bentires-Alj

Structural basis for ArfA–RF2-mediated translation termination on mRNAs lacking stop codons pp. 546-549

Paul Huter, Claudia Müller, Bertrand Beckert, Stefan Arenz, Otto Berninghausen, Roland Beckmann and Daniel N. Wilson

Mechanistic insights into the alternative translation termination by ArfA and RF2 pp. 550-553

Chengying Ma, Daisuke Kurita, Ningning Li, Yan Chen, Hyouta Himeno and Ning Gao

Structural basis of co-translational quality control by ArfA and RF2 bound to ribosome pp. 554-557

Fuxing Zeng, Yanbo Chen, Jonathan Remis, Mrinal Shekhar, James C. Phillips, Emad Tajkhorshid and Hong Jin

Correction: Corrigendum: Lens regeneration using endogenous stem cells with gain of visual function pp. 558-558

Haotian Lin, Hong Ouyang, Jie Zhu, Shan Huang, Zhenzhen Liu, Shuyi Chen, Guiqun Cao, Gen Li, Robert A. J. Signer, Yanxin Xu, Christopher Chung, Ying Zhang, Danni Lin, Sherrina Patel, Frances Wu, Huimin Cai, Jiayi Hou, Cindy Wen, Maryam Jafari, Xialin Liu, Lixia Luo, Jin Zhu, Austin Qiu, Rui Hou, Baoxin Chen, Jiangna Chen, David Granet, Christopher Heichel, Fu Shang, Xuri Li, Michal Krawczyk, Dorota Skowronska-Krawczyk, Yujuan Wang, William Shi, Daniel Chen, Zheng Zhong, Sheng Zhong, Liangfang Zhang, Shaochen Chen, Sean J. Morrison, Richard L. Maas, Kang Zhang and Yizhi Liu

Neuroscience: Big brain, big data pp. 559-561

Esther Landhuis

Scientific computing: Code alert pp. 563-565

Monya Baker

Trade talk: Research writer pp. 565-565

Jack Leeming

The last robot pp. 568-568

S. L. Huang

2017, volume 541, articles 7637

Give the public the tools to trust scientists pp. 261-261

Anita Makri

India’s first GM food crop held up by lawsuit pp. 267-268

Sanjay Kumar

Cancer reproducibility project releases first results pp. 269-270

Monya Baker and Elie Dolgin

Gates Foundation research can’t be published in top journals pp. 270-270

Richard Van Noorden

Space-weather forecast to improve with European satellite pp. 271-271

Elizabeth Gibney

US energy agency strengthens protections for scientists pp. 272-272

Erin Ross

Croatia’s science minister rejects calls to resign amid plagiarism scandal pp. 272-273

Mićo Tatalović and Nenad Jarić Dauenhauer

The $2.4-billion plan to steal a rock from Mars pp. 274-278

Alexandra Witze

Five big mysteries about CRISPR’s origins pp. 280-282

Heidi Ledford

How to turn competitors into collaborators pp. 283-285

Erica Ollmann Saphire, John M. Dye, Gary P. Kobinger, Larry Zeitlin, Kartik Chandran and Robert F. Garry

Technology: He wrote the future pp. 286-287

Andrew Robinson

Books in brief pp. 287-287

Barbara Kiser

Twenty-point plan for science policy pp. 289-289

Michel Kazatchkine, Julian Kinderlerer and Aidan Gilligan

Anthropocene: its stratigraphic basis pp. 289-289

Jan Zalasiewicz, Colin Waters and Martin J. Head

Anthropocene: social science misconstrued pp. 289-289

Noel Castree

Beware scientists wielding red pens pp. 289-289

Bart Penders

John Glenn (1921–2016) pp. 290-290

William A. 'Bill' Anders

Quiet moments in time pp. 292-293

Marco Bellini

Messenger RNAs marked for longer life pp. 293-294

David E. Weinberg and John D. Gross

Shoppers like what they know pp. 294-295

Peter M. Todd

Algorithm for architectural origami pp. 296-297

Jamie Paik

Mind the gaps in cellular evolution pp. 297-299

James O. McInerney and Mary J. O'Connell

Ins and outs of picornaviruses pp. 299-300

Kevin L. McKnight and Stanley M. Lemon

Frontiers in biology pp. 301-301

Orli Bahcall, Angela K. Eggleston, Nathalie Le Bot and Ursula Weiss

Tracing the peopling of the world through genomics pp. 302-310

Rasmus Nielsen, Joshua M. Akey, Mattias Jakobsson, Jonathan K. Pritchard, Sarah Tishkoff and Eske Willerslev

From morphogen to morphogenesis and back pp. 311-320

Darren Gilmour, Martina Rembold and Maria Leptin

Elements of cancer immunity and the cancer–immune set point pp. 321-330

Daniel S. Chen and Ira Mellman

Scaling single-cell genomics from phenomenology to mechanism pp. 331-338

Amos Tanay and Aviv Regev

Chemical and structural effects of base modifications in messenger RNA pp. 339-346

Emily M. Harcourt, Anna M. Kietrys and Eric T. Kool

Rational design of reconfigurable prismatic architected materials pp. 347-352

Johannes T. B. Overvelde, James C. Weaver, Chuck Hoberman and Katia Bertoldi

Asgard archaea illuminate the origin of eukaryotic cellular complexity pp. 353-358

Katarzyna Zaremba-Niedzwiedzka, Eva F. Caceres, Jimmy H. Saw, Disa Bäckström, Lina Juzokaite, Emmelien Vancaester, Kiley W. Seitz, Karthik Anantharaman, Piotr Starnawski, Kasper U. Kjeldsen, Matthew B. Stott, Takuro Nunoura, Jillian F. Banfield, Andreas Schramm, Brett J. Baker, Anja Spang and Thijs J. G. Ettema

Genomic hallmarks of localized, non-indolent prostate cancer pp. 359-364

Michael Fraser, Veronica Y. Sabelnykova, Takafumi N. Yamaguchi, Lawrence E. Heisler, Julie Livingstone, Vincent Huang, Yu-Jia Shiah, Fouad Yousif, Xihui Lin, Andre P. Masella, Natalie S. Fox, Michael Xie, Stephenie D. Prokopec, Alejandro Berlin, Emilie Lalonde, Musaddeque Ahmed, Dominique Trudel, Xuemei Luo, Timothy A. Beck, Alice Meng, Junyan Zhang, Alister D’Costa, Robert E. Denroche, Haiying Kong, Shadrielle Melijah G. Espiritu, Melvin L. K. Chua, Ada Wong, Taryne Chong, Michelle Sam, Jeremy Johns, Lee Timms, Nicholas B. Buchner, Michèle Orain, Valérie Picard, Helène Hovington, Alexander Murison, Ken Kron, Nicholas J. Harding, Christine P’ng, Kathleen E. Houlahan, Kenneth C. Chu, Bryan Lo, Francis Nguyen, Constance H. Li, Ren X. Sun, Richard de Borja, Christopher I. Cooper, Julia F. Hopkins, Shaylan K. Govind, Clement Fung, Daryl Waggott, Jeffrey Green, Syed Haider, Michelle A. Chan-Seng-Yue, Esther Jung, Zhiyuan Wang, Alain Bergeron, Alan Dal Pra, Louis Lacombe, Colin C. Collins, Cenk Sahinalp, Mathieu Lupien, Neil E. Fleshner, Housheng H. He, Yves Fradet, Bernard Tetu, Theodorus van der Kwast, John D. McPherson, Robert G. Bristow and Paul C. Boutros

Integration of temporal and spatial patterning generates neural diversity pp. 365-370

Ted Erclik, Xin Li, Maximilien Courgeon, Claire Bertet, Zhenqing Chen, Ryan Baumert, June Ng, Clara Koo, Urfa Arain, Rudy Behnia, Alberto Del Valle Rodriguez, Lionel Senderowicz, Nicolas Negre, Kevin P. White and Claude Desplan

Reversible methylation of m6Am in the 5′ cap controls mRNA stability pp. 371-375

Jan Mauer, Xiaobing Luo, Alexandre Blanjoie, Xinfu Jiao, Anya V. Grozhik, Deepak P. Patil, Bastian Linder, Brian F. Pickering, Jean-Jacques Vasseur, Qiuying Chen, Steven S. Gross, Olivier Elemento, Françoise Debart, Megerditch Kiledjian and Samie R. Jaffrey

Subcycle quantum electrodynamics pp. 376-379

C. Riek, P. Sulzer, M. Seeger, A. S. Moskalenko, G. Burkard, D. V. Seletskiy and A. Leitenstorfer

Kinetically E-selective macrocyclic ring-closing metathesis pp. 380-385

Xiao Shen, Thach T. Nguyen, Ming Joo Koh, Dongmin Xu, Alexander W. H. Speed, Richard R. Schrock and Amir H. Hoveyda

Evolution of the global phosphorus cycle pp. 386-389

Christopher T. Reinhard, Noah J. Planavsky, Benjamin C. Gill, Kazumi Ozaki, Leslie J. Robbins, Timothy W. Lyons, Woodward W. Fischer, Chunjiang Wang, Devon B. Cole and Kurt O. Konhauser

Hurricane intensification along United States coast suppressed during active hurricane periods pp. 390-393

James P. Kossin

Hyoliths are Palaeozoic lophophorates pp. 394-397

Joseph Moysiuk, Martin R. Smith and Jean-Bernard Caron

A theoretical foundation for multi-scale regular vegetation patterns pp. 398-401

Corina E. Tarnita, Juan A. Bonachela, Efrat Sheffer, Jennifer A. Guyton, Tyler C. Coverdale, Ryan A. Long and Robert M. Pringle

Genetic variants regulating expression levels and isoform diversity during embryogenesis pp. 402-406

Enrico Cannavò, Nils Koelling, Dermot Harnett, David Garfield, Francesco P. Casale, Lucia Ciglar, Hilary E. Gustafson, Rebecca R. Viales, Raquel Marco-Ferreres, Jacob F. Degner, Bingqing Zhao, Oliver Stegle, Ewan Birney and Eileen E. M. Furlong

Structural basis for nutrient acquisition by dominant members of the human gut microbiota pp. 407-411

Amy J. Glenwright, Karunakar R. Pothula, Satya P. Bhamidimarri, Dror S. Chorev, Arnaud Baslé, Susan J. Firbank, Hongjun Zheng, Carol V. Robinson, Mathias Winterhalter, Ulrich Kleinekathöfer, David N. Bolam and Bert van den Berg

PLA2G16 represents a switch between entry and clearance of Picornaviridae pp. 412-416

Jacqueline Staring, Eleonore von Castelmur, Vincent A. Blomen, Lisa G. van den Hengel, Markus Brockmann, Jim Baggen, Hendrik Jan Thibaut, Joppe Nieuwenhuis, Hans Janssen, Frank J. M. van Kuppeveld, Anastassis Perrakis, Jan E. Carette and Thijn R. Brummelkamp

Microenvironmental autophagy promotes tumour growth pp. 417-420

Nadja S. Katheder, Rojyar Khezri, Fergal O’Farrell, Sebastian W. Schultz, Ashish Jain, Mohammed M. Rahman, Kay O. Schink, Theodossis A. Theodossiou, Terje Johansen, Gábor Juhász, David Bilder, Andreas Brech, Harald Stenmark and Tor Erik Rusten

The role of interfacial lipids in stabilizing membrane protein oligomers pp. 421-424

Kallol Gupta, Joseph A. C. Donlan, Jonathan T. S. Hopper, Povilas Uzdavinys, Michael Landreh, Weston B. Struwe, David Drew, Andrew J. Baldwin, Phillip J. Stansfeld and Carol V. Robinson

Communication: Post-truth predicaments pp. 425-427

Virginia Gewin

Turning point: Advocacy ambassador pp. 427-427

Virginia Gewin

Cease and desist pp. 430-430

Tyler Young

2017, volume 541, articles 7636

Where science and nonsense collide pp. 135-135

Alberto Kornblihtt

Chinese AI company plans to mine health data faster than rivals pp. 141-142

David Cyranoski

Google reveals secret test of AI bot to beat top Go players pp. 142-142

Elizabeth Gibney

Legendary radio telescope hangs in the balance pp. 143-144

Alexandra Witze

Deceptive curcumin offers cautionary tale for chemists pp. 144-145

Monya Baker

Brexit offers rare chance to make Britain greener pp. 145-146

Daniel Cressey

Gene-edited cows, rogue clinics, speedier drug approvals: the challenges facing Trump's FDA chief pp. 146-147

Heidi Ledford

Behind New Zealand’s wild plan to purge all pests pp. 148-150

Brian Owens

Compare voting systems to improve them pp. 151-153

Guruprasad Madhavan, Charles Phelps and Rino Rappuoli

Chemistry: The hidden war pp. 154-155

Paul A. Lombardo

Books in brief pp. 155-155

Barbara Kiser

Neuroscience: The risks of reading the brain pp. 156-156

Russell Poldrack

Scale up elephant anti-poaching funds pp. 157-157

Thomas N. E. Gray and Suwanna Gauntlett

Step on the natural gas for German cars pp. 157-157

Dénes Csala and Harry Hoster

Funds to help Eastern Europe close the gap pp. 157-157

Cristian Berce, Ciprian Tomuleasa and Radu Meza

Illegal lemur trade grows in Madagascar pp. 157-157

Kim E. Reuter, Marni LaFleur and Tara A. Clarke

Save last cloud forests in western Andes pp. 157-157

Jens Mutke, Tim Böhnert and Maximilian Weigend

Stomach growth in a dish pp. 160-161

José B. Sáenz and Jason C. Mills

Water flows out of touch pp. 161-162

Björn Hof

Spot the difference pp. 162-163

Noah D. Peyser and Jennifer R. Grandis

Supercavity lasing pp. 164-165

Mikhail Rybin and Yuri Kivshar

Mechanosensor of lung inflation identified pp. 165-166

Christo Goridis

Valine starvation leads to a hungry niche pp. 166-167

R. Grant Rowe and George Q. Daley

The resilience of Amazonian forests pp. 167-168

Mark B. Bush

Piezo2 senses airway stretch and mediates lung inflation-induced apnoea pp. 176-181

Keiko Nonomura, Seung-Hyun Woo, Rui B. Chang, Astrid Gillich, Zhaozhu Qiu, Allain G. Francisco, Sanjeev S. Ranade, Stephen D. Liberles and Ardem Patapoutian

Wnt/β-catenin promotes gastric fundus specification in mice and humans pp. 182-187

Kyle W. McCracken, Eitaro Aihara, Baptiste Martin, Calyn M. Crawford, Taylor Broda, Julie Treguier, Xinghao Zhang, John M. Shannon, Marshall H. Montrose and James M. Wells

Penitentes as the origin of the bladed terrain of Tartarus Dorsa on Pluto pp. 188-190

John E. Moores, Christina L. Smith, Anthony D. Toigo and Scott D. Guzewich

Sideband cooling beyond the quantum backaction limit with squeezed light pp. 191-195

Jeremy B. Clark, Florent Lecocq, Raymond W. Simmonds, José Aumentado and John D. Teufel

Lasing action from photonic bound states in continuum pp. 196-199

Ashok Kodigala, Thomas Lepetit, Qing Gu, Babak Bahari, Yeshaiahu Fainman and Boubacar Kanté

Aromatic and antiaromatic ring currents in a molecular nanoring pp. 200-203

Martin D. Peeks, Timothy D. W. Claridge and Harry L. Anderson

Hydroclimate changes across the Amazon lowlands over the past 45,000 years pp. 204-207

Xianfeng Wang, R. Lawrence Edwards, Augusto S. Auler, Hai Cheng, Xinggong Kong, Yongjin Wang, Francisco W. Cruz, Jeffrey A. Dorale and Hong-Wei Chiang

A symmoriiform chondrichthyan braincase and the origin of chimaeroid fishes pp. 208-211

Michael I. Coates, Robert W. Gess, John A. Finarelli, Katharine E. Criswell and Kristen Tietjen

Genome sequence and genetic diversity of European ash trees pp. 212-216

Elizabeth S. A. Sollars, Andrea L. Harper, Laura J. Kelly, Christine M. Sambles, Ricardo H. Ramirez-Gonzalez, David Swarbreck, Gemy Kaithakottil, Endymion D. Cooper, Cristobal Uauy, Lenka Havlickova, Gemma Worswick, David J. Studholme, Jasmin Zohren, Deborah L. Salmon, Bernardo J. Clavijo, Yi Li, Zhesi He, Alison Fellgett, Lea Vig McKinney, Lene Rostgaard Nielsen, Gerry C. Douglas, Erik Dahl Kjær, J. Allan Downie, David Boshier, Steve Lee, Jo Clark, Murray Grant, Ian Bancroft, Mario Caccamo and Richard J. A. Buggs

Structural variation in amyloid-β fibrils from Alzheimer's disease clinical subtypes pp. 217-221

Wei Qiang, Wai-Ming Yau, Jun-Xia Lu, John Collinge and Robert Tycko

Hypoxia induces heart regeneration in adult mice pp. 222-227

Yuji Nakada, Diana C. Canseco, SuWannee Thet, Salim Abdisalaam, Aroumougame Asaithamby, Celio X. Santos, Ajay M. Shah, Hua Zhang, James E. Faber, Michael T. Kinter, Luke I. Szweda, Chao Xing, Zeping Hu, Ralph J. Deberardinis, Gabriele Schiattarella, Joseph A. Hill, Orhan Oz, Zhigang Lu, Cheng Cheng Zhang, Wataru Kimura and Hesham A. Sadek

mTORC1 and muscle regeneration are regulated by the LINC00961-encoded SPAR polypeptide pp. 228-232

Akinobu Matsumoto, Alessandra Pasut, Masaki Matsumoto, Riu Yamashita, Jacqueline Fung, Emanuele Monteleone, Alan Saghatelian, Keiichi I. Nakayama, John G. Clohessy and Pier Paolo Pandolfi

Genome-wide in vivo screen identifies novel host regulators of metastatic colonization pp. 233-236

Louise van der Weyden, Mark J. Arends, Andrew D. Campbell, Tobias Bald, Hannah Wardle-Jones, Nicola Griggs, Martin Del Castillo Velasco-Herrera, Thomas Tüting, Owen J. Sansom, Natasha A. Karp, Simon Clare, Diane Gleeson, Edward Ryder, Antonella Galli, Elizabeth Tuck, Emma L. Cambridge, Thierry Voet, Iain C. Macaulay, Kim Wong, Sarah Spiegel, Anneliese O. Speak and David J. Adams

Variable chromatin structure revealed by in situ spatially correlated DNA cleavage mapping pp. 237-241

Viviana I. Risca, Sarah K. Denny, Aaron F. Straight and William J. Greenleaf

Structures of riboswitch RNA reaction states by mix-and-inject XFEL serial crystallography pp. 242-246

J. R. Stagno, Y. Liu, Y. R. Bhandari, C. E. Conrad, S. Panja, Mamata Swain, L. Fan, Gerald Nelson, C. Li, D. R. Wendel, T. A. White, J. D. Coe, M. O. Wiedorn, J. Knoska, D. Oberthuer, R. A. Tuckey, P. Yu, M. Dyba, S. G. Tarasov, U. Weierstall, T. D. Grant, C. D. Schwieters, J. Zhang, A. R. Ferré-D’Amaré, P. Fromme, D. E. Draper, M. Liang, M. S. Hunter, S. Boutet, K. Tan, X. Zuo, X. Ji, A. Barty, N. A. Zatsepin, H. N. Chapman, J. C. H. Spence, S. A. Woodson and Y.-X. Wang

Health and safety: Danger zone pp. 247-249

Emily Sohn

Turning point: Uncertain future pp. 249-249

Virginia Gewin

Playing for keeps pp. 252-252

Judy Helfrich

2017, volume 541, articles 7635

Scientists should not resign themselves to Brexit pp. 6-6

Colin Macilwain

Quantum computers ready to leap out of the lab in 2017 pp. 9-10

Davide Castelvecchi

3D ocean map tracks ecosystems in unprecedented detail pp. 10-11

Alexandra Witze

Wolf transplant could reset iconic island study pp. 12-12

Emma Marris

Scientists in Germany, Peru and Taiwan to lose access to Elsevier journals pp. 13-13

Quirin Schiermeier and Emiliano Rodríguez Mega

2017 sneak peek: What the new year holds for science pp. 14-15

Elizabeth Gibney

What’s killing the world’s shorebirds? pp. 16-20

Margaret Munro

The new face of US science pp. 21-23

Misty Heggeness, Kearney T. W. Gunsalus, José Pacas and Gary McDowell

Arts: Hot tickets 2017 pp. 25-27

Nicola Jones

Publishing: A brief history of Stephen Hawking's blockbuster pp. 28-29

Elizabeth Leane

Cap senior salaries to boost junior posts pp. 30-30

Christopher J. Evans

China's energy rush harming ecosystem pp. 30-30

Jianmin Ma and Jianzhong Xu

A European position on genome editing pp. 30-30

François Hirsch, Yves Lévy and Hervé Chneiweiss

India needs agency for energy data pp. 30-30

Rahul Tongia, Varun Rai and Gireesh Shrimali

A few words can make a big impact pp. 30-30

Dario Del Giudice and Andrew B. Davies

Radio burst caught red-handed pp. 32-33

Heino Falcke

Ion-channel mechanisms revealed pp. 33-34

Karl L. Magleby

A unifying mechanism in neurodegeneration pp. 34-35

Christopher A. Ross and Ray Truant

Crops on the fast track for light pp. 36-37

Alexander V. Ruban

The long and winding road to catalysis pp. 37-38

Francisco Zaera

Molecular memoirs of a cellular family pp. 38-39

Lauren E. Beck and Arjun Raj

Targeting metastasis-initiating cells through the fatty acid receptor CD36 pp. 41-45

Gloria Pascual, Alexandra Avgustinova, Stefania Mejetta, Mercè Martín, Andrés Castellanos, Camille Stephan-Otto Attolini, Antoni Berenguer, Neus Prats, Agustí Toll, Juan Antonio Hueto, Coro Bescós, Luciano Di Croce and Salvador Aznar Benitah

Cryo-EM structure of the open high-conductance Ca2+-activated K+ channel pp. 46-51

Xiao Tao, Richard K. Hite and Roderick MacKinnon

Structural basis for gating the high-conductance Ca2+-activated K+ channel pp. 52-57

Richard K. Hite, Xiao Tao and Roderick MacKinnon

A direct localization of a fast radio burst and its host pp. 58-61

S. Chatterjee, C. J. Law, R. S. Wharton, S. Burke-Spolaor, J. W. T. Hessels, G. C. Bower, J. M. Cordes, S. P. Tendulkar, C. G. Bassa, P. Demorest, B. J. Butler, A. Seymour, P. Scholz, M. W. Abruzzo, S. Bogdanov, V. M. Kaspi, A. Keimpema, T. J. W. Lazio, B. Marcote, M. A. McLaughlin, Z. Paragi, S. M. Ransom, M. Rupen, L. G. Spitler and H. J. van Langevelde

Correlated fluorescence blinking in two-dimensional semiconductor heterostructures pp. 62-67

Weigao Xu, Weiwei Liu, Jan F. Schmidt, Weijie Zhao, Xin Lu, Timo Raab, Carole Diederichs, Weibo Gao, Denis V. Seletskiy and Qihua Xiong

Catalyst support effects on hydrogen spillover pp. 68-71

Waiz Karim, Clelia Spreafico, Armin Kleibert, Jens Gobrecht, Joost VandeVondele, Yasin Ekinci and Jeroen A. van Bokhoven

Centennial-scale Holocene climate variations amplified by Antarctic Ice Sheet discharge pp. 72-76

Pepijn Bakker, Peter U. Clark, Nicholas R. Golledge, Andreas Schmittner and Michael E. Weber

Sub-ice-shelf sediments record history of twentieth-century retreat of Pine Island Glacier pp. 77-80

J. A. Smith, T. J. Andersen, M. Shortt, A. M. Gaffney, M. Truffer, T. P. Stanton, R. Bindschadler, P. Dutrieux, A. Jenkins, C.-D. Hillenbrand, W. Ehrmann, H. F. J. Corr, N. Farley, S. Crowhurst and D. G. Vaughan

Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity pp. 81-86

Simone Wahl, Alexander Drong, Benjamin Lehne, Marie Loh, William R. Scott, Sonja Kunze, Pei-Chien Tsai, Janina S. Ried, Weihua Zhang, Youwen Yang, Sili Tan, Giovanni Fiorito, Lude Franke, Simonetta Guarrera, Silva Kasela, Jennifer Kriebel, Rebecca C. Richmond, Marco Adamo, Uzma Afzal, Mika Ala-Korpela, Benedetta Albetti, Ole Ammerpohl, Jane F. Apperley, Marian Beekman, Pier Alberto Bertazzi, S. Lucas Black, Christine Blancher, Marc-Jan Bonder, Mario Brosch, Maren Carstensen-Kirberg, Anton J. M. de Craen, Simon de Lusignan, Abbas Dehghan, Mohamed Elkalaawy, Krista Fischer, Oscar H. Franco, Tom R. Gaunt, Jochen Hampe, Majid Hashemi, Aaron Isaacs, Andrew Jenkinson, Sujeet Jha, Norihiro Kato, Vittorio Krogh, Michael Laffan, Christa Meisinger, Thomas Meitinger, Zuan Yu Mok, Valeria Motta, Hong Kiat Ng, Zacharoula Nikolakopoulou, Georgios Nteliopoulos, Salvatore Panico, Natalia Pervjakova, Holger Prokisch, Wolfgang Rathmann, Michael Roden, Federica Rota, Michelle Ann Rozario, Johanna K. Sandling, Clemens Schafmayer, Katharina Schramm, Reiner Siebert, P. Eline Slagboom, Pasi Soininen, Lisette Stolk, Konstantin Strauch, E-Shyong Tai, Letizia Tarantini, Barbara Thorand, Ettje F. Tigchelaar, Rosario Tumino, Andre G. Uitterlinden, Cornelia van Duijn, Joyce B. J. van Meurs, Paolo Vineis, Ananda Rajitha Wickremasinghe, Cisca Wijmenga, Tsun-Po Yang, Wei Yuan, Alexandra Zhernakova, Rachel L. Batterham, George Davey Smith, Panos Deloukas, Bastiaan T. Heijmans, Christian Herder, Albert Hofman, Cecilia M. Lindgren, Lili Milani, Pim van der Harst, Annette Peters, Thomas Illig, Caroline L. Relton, Melanie Waldenberger, Marjo-Riitta Järvelin, Valentina Bollati, Richie Soong, Tim D. Spector, James Scott, Mark I. McCarthy, Paul Elliott, Jordana T. Bell, Giuseppe Matullo, Christian Gieger, Jaspal S. Kooner, Harald Grallert and John C. Chambers

XRCC1 mutation is associated with PARP1 hyperactivation and cerebellar ataxia pp. 87-91

Nicolas C. Hoch, Hana Hanzlikova, Stuart L. Rulten, Martine Tétreault, Emilia Komulainen, Limei Ju, Peter Hornyak, Zhihong Zeng, William Gittens, Stephanie A. Rey, Kevin Staras, Grazia M. S. Mancini, Peter J. McKinnon, Zhao-Qi Wang, Justin D. Wagner, Grace Yoon and Keith W. Caldecott

Reducing phosphorus accumulation in rice grains with an impaired transporter in the node pp. 92-95

Naoki Yamaji, Yuma Takemoto, Takaaki Miyaji, Namiki Mitani-Ueno, Kaoru T. Yoshida and Jian Feng Ma

Identification of an atypical monocyte and committed progenitor involved in fibrosis pp. 96-101

Takashi Satoh, Katsuhiro Nakagawa, Fuminori Sugihara, Ryusuke Kuwahara, Motooki Ashihara, Fumihiro Yamane, Yosuke Minowa, Kiyoharu Fukushima, Isao Ebina, Yoshichika Yoshioka, Atsushi Kumanogoh and Shizuo Akira

Splicing factor 1 modulates dietary restriction and TORC1 pathway longevity in C. elegans pp. 102-106

Caroline Heintz, Thomas K. Doktor, Anne Lanjuin, Caroline C. Escoubas, Yue Zhang, Heather J. Weir, Sneha Dutta, Carlos Giovanni Silva-García, Gitte H. Bruun, Ianessa Morantte, Gerta Hoxhaj, Brendan D. Manning, Brage S. Andresen and William B. Mair

Synthetic recording and in situ readout of lineage information in single cells pp. 107-111

Kirsten L. Frieda, James M. Linton, Sahand Hormoz, Joonhyuk Choi, Ke-Huan K. Chow, Zakary S. Singer, Mark W. Budde, Michael B. Elowitz and Long Cai

In situ structures of the genome and genome-delivery apparatus in a single-stranded RNA virus pp. 112-116

Xinghong Dai, Zhihai Li, Mason Lai, Sara Shu, Yushen Du, Z. Hong Zhou and Ren Sun

Structural basis of an essential interaction between influenza polymerase and Pol II CTD pp. 117-121

Maria Lukarska, Guillaume Fournier, Alexander Pflug, Patricia Resa-Infante, Stefan Reich, Nadia Naffakh and Stephen Cusack

Correction: Corrigendum: The Asian monsoon over the past 640,000 years and ice age terminations pp. 122-122

Hai Cheng, R. Lawrence Edwards, Ashish Sinha, Christoph Spötl, Liang Yi, Shitao Chen, Megan Kelly, Gayatri Kathayat, Xianfeng Wang, Xianglei Li, Xinggong Kong, Yongjin Wang, Youfeng Ning and Haiwei Zhang

Erratum: Transplanted embryonic neurons integrate into adult neocortical circuits pp. 122-122

Susanne Falkner, Sofia Grade, Leda Dimou, Karl-Klaus Conzelmann, Tobias Bonhoeffer, Magdalena Götz and Mark Hübener

How scientists use Slack pp. 123-124

Jeffrey M. Perkel

By students, for students pp. 125-126

Theresa Mercer

Chrysalis pp. 128-128

Thomas Broderick