Shared and distinct transcriptomic cell types across neocortical areas

Bosiljka Tasic (), Zizhen Yao, Lucas T. Graybuck, Kimberly A. Smith, Thuc Nghi Nguyen, Darren Bertagnolli, Jeff Goldy, Emma Garren, Michael N. Economo, Sarada Viswanathan, Osnat Penn, Trygve Bakken, Vilas Menon, Jeremy Miller, Olivia Fong, Karla E. Hirokawa, Kanan Lathia, Christine Rimorin, Michael Tieu, Rachael Larsen, Tamara Casper, Eliza Barkan, Matthew Kroll, Sheana Parry, Nadiya V. Shapovalova, Daniel Hirschstein, Julie Pendergraft, Heather A. Sullivan, Tae Kyung Kim, Aaron Szafer, Nick Dee, Peter Groblewski, Ian Wickersham, Ali Cetin, Julie A. Harris, Boaz P. Levi, Susan M. Sunkin, Linda Madisen, Tanya L. Daigle, Loren Looger, Amy Bernard, John Phillips, Ed Lein, Michael Hawrylycz, Karel Svoboda, Allan R. Jones, Christof Koch and Hongkui Zeng
Additional contact information
Bosiljka Tasic: Allen Institute for Brain Science
Zizhen Yao: Allen Institute for Brain Science
Lucas T. Graybuck: Allen Institute for Brain Science
Kimberly A. Smith: Allen Institute for Brain Science
Thuc Nghi Nguyen: Allen Institute for Brain Science
Darren Bertagnolli: Allen Institute for Brain Science
Jeff Goldy: Allen Institute for Brain Science
Emma Garren: Allen Institute for Brain Science
Michael N. Economo: Howard Hughes Medical Institute
Sarada Viswanathan: Howard Hughes Medical Institute
Osnat Penn: Allen Institute for Brain Science
Trygve Bakken: Allen Institute for Brain Science
Vilas Menon: Allen Institute for Brain Science
Jeremy Miller: Allen Institute for Brain Science
Olivia Fong: Allen Institute for Brain Science
Karla E. Hirokawa: Allen Institute for Brain Science
Kanan Lathia: Allen Institute for Brain Science
Christine Rimorin: Allen Institute for Brain Science
Michael Tieu: Allen Institute for Brain Science
Rachael Larsen: Allen Institute for Brain Science
Tamara Casper: Allen Institute for Brain Science
Eliza Barkan: Allen Institute for Brain Science
Matthew Kroll: Allen Institute for Brain Science
Sheana Parry: Allen Institute for Brain Science
Nadiya V. Shapovalova: Allen Institute for Brain Science
Daniel Hirschstein: Allen Institute for Brain Science
Julie Pendergraft: Allen Institute for Brain Science
Heather A. Sullivan: Massachusetts Institute of Technology
Tae Kyung Kim: Allen Institute for Brain Science
Aaron Szafer: Allen Institute for Brain Science
Nick Dee: Allen Institute for Brain Science
Peter Groblewski: Allen Institute for Brain Science
Ian Wickersham: Massachusetts Institute of Technology
Ali Cetin: Allen Institute for Brain Science
Julie A. Harris: Allen Institute for Brain Science
Boaz P. Levi: Allen Institute for Brain Science
Susan M. Sunkin: Allen Institute for Brain Science
Linda Madisen: Allen Institute for Brain Science
Tanya L. Daigle: Allen Institute for Brain Science
Loren Looger: Howard Hughes Medical Institute
Amy Bernard: Allen Institute for Brain Science
John Phillips: Allen Institute for Brain Science
Ed Lein: Allen Institute for Brain Science
Michael Hawrylycz: Allen Institute for Brain Science
Karel Svoboda: Howard Hughes Medical Institute
Allan R. Jones: Allen Institute for Brain Science
Christof Koch: Allen Institute for Brain Science
Hongkui Zeng: Allen Institute for Brain Science

Nature, 2018, vol. 563, issue 7729, 72-78

Abstract: Abstract The neocortex contains a multitude of cell types that are segregated into layers and functionally distinct areas. To investigate the diversity of cell types across the mouse neocortex, here we analysed 23,822 cells from two areas at distant poles of the mouse neocortex: the primary visual cortex and the anterior lateral motor cortex. We define 133 transcriptomic cell types by deep, single-cell RNA sequencing. Nearly all types of GABA (γ-aminobutyric acid)-containing neurons are shared across both areas, whereas most types of glutamatergic neurons were found in one of the two areas. By combining single-cell RNA sequencing and retrograde labelling, we match transcriptomic types of glutamatergic neurons to their long-range projection specificity. Our study establishes a combined transcriptomic and projectional taxonomy of cortical cell types from functionally distinct areas of the adult mouse cortex.

Keywords: Typical Transcriptome; Cortical Cell Types; Lateral Motor Cortex; Weighted Gene Co-expression Network Analysis (WGCNA); Medial Ganglionic Eminence (search for similar items in EconPapers)
Date: 2018
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Citations: View citations in EconPapers (50)

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DOI: 10.1038/s41586-018-0654-5

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