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1999, volume 402, articles 6764

Dissection banned in Israeli schools pp. 845-845

Haim Watzman

Concern as Germany cuts funds to agricultural research centres pp. 845-846

Quirin Schiermeier, Rex Dalton and Colin Macilwain

NSF under fire in survey of customer satisfaction pp. 846-846

Paul Smaglik

Japan to bring in mandatory tests for GM foods pp. 846-846

Yoriko Uozum

Scientists rally to defend schools against creationists pp. 847-848

Rex Dalton

Geophysics union entices biologists with new section pp. 847-847

Rex Dalton

Green light for neutrino beam to pass below the Alps pp. 847-847

Alison Abbott

Spain's universities split over merits of performance table pp. 848-848

Xavier Bosch

Middle East synchrotron crosses first funding hurdle pp. 849-849

Heather McCabe

Top BSE official forced to step down in UK pp. 849-849

David Dickson

Latecomers welcome? pp. 852-852

David Davies

Threat to research in Spanish universities pp. 852-852

José A. Vázquez-Boland

Patent law changes spell problems and opportunities pp. 852-852

James J. Murphy

Seeing both the woods and the trees pp. 853-854

Stuart L. Pimm

Italian art's bequest to science pp. 854-854

Pietro Corsi

Reflections on colour constancy pp. 855-856

Karl R. Gegenfurtner

Making every photon count pp. 856-857

Richard Hailstone

Evolutionary checkers pp. 857-859

Igor Aleksander

Suffering for one's science pp. 857-857

John Whitfield

Insulin resistance and obesity pp. 860-861

Michael W. Schwartz and Steven E. Kahn

Vast snow dunes frozen in time pp. 860-860

Sarah Tomlin

The art of slow change pp. 861-861

David Jones

A funerary feast fit for King Midas pp. 863-864

Patrick E. McGovern, Donald L. Glusker, Robert A. Moreau, Alberto Nuñez, Curt W. Beck, Elizabeth Simpson, Eric D. Butrym, Lawrence J. Exner and Edith C. Stout

Losing strategies can win by Parrondo's paradox pp. 864-864

Gregory P. Harmer and Derek Abbott

Enhanced yield of photoinduced electrons in doped silver halide crystals pp. 865-867

Jacqueline Belloni, Mona Treguer, Hynd Remita and René De Keyzer

Periodic mesoporous organosilicas with organic groups inside the channel walls pp. 867-871

Tewodros Asefa, Mark J. MacLachlan, Neil Coombs and Geoffrey A. Ozin

Seismic anisotropy of the Earth's inner core resulting from flow induced by Maxwell stresses pp. 871-873

Shun-ichiro Karato

Ultraviolet colour variation influences blue tit sex ratios pp. 874-877

Ben C. Sheldon, Staffan Andersson, Simon C. Griffith, Jonas Örnborg and Joanna Sendecka

Perception of three-dimensional shape influences colour perception through mutual illumination pp. 877-879

M. G. Bloj, D. Kersten and A. C. Hurlbert

Dominant negative mutations in human PPARγ associated with severe insulin resistance, diabetes mellitus and hypertension pp. 880-883

I. Barroso, M. Gurnell, V. E. F. Crowley, M. Agostini, J. W. Schwabe, M. A. Soos, G. Li Maslen, T. D. M. Williams, H. Lewis, A. J. Schafer, V. K. K. Chatterjee and S. O'Rahilly

EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF pp. 884-888

Norbert Prenzel, Esther Zwick, Henrik Daub, Michael Leserer, Reimar Abraham, Christian Wallasch and Axel Ullrich

p53 inhibition by the LANA protein of KSHV protects against cell death pp. 889-894

Jacques Friborg, Wing-pui Kong, Michael O. Hottiger and Gary J. Nabel

Structure of a transiently phosphorylated switch in bacterial signal transduction pp. 894-898

Dorothee Kern, Brian F. Volkman, Peter Luginbühl, Michael J. Nohaile, Sydney Kustu and David E. Wemmer

Erratum: A Chinese triconodont mammal and mosaic evolution of the mammalian skeleton pp. 898-898

Ji Qiang, Luo Zhexi and Ji Shu-an

Erratum: Small-bandgap endohedral metallofullerenes in high yield and purity pp. 898-898

S. Stevenson, G. Rice, T. Glass, K. Harich, F. Cromer, M. R. Jordan, J. Craft, E. Hadju, R. Bible, M. M. Olmstead, K. Maitra, A. J. Fisher, A. L. Balch and H. C. Dorn

erratum: Saccharomyces cerevisiae telomerase is an Sm small nuclear ribonucleoprotein particle pp. 898-898

Anita G. Seto, Arthur J. Zaug, Suzanne G. Sobel, Sandra L. Wolin and Thomas R. Cech

Erratum: Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14 pp. 898-898

Robert S. Ames, Henry M. Sarau, Johathan K. Chambers, Robert N. Willette, Nambi V. Aiyar, Anne M. Romanic, Calvert S. Louden, James J. Foley, Charles F. Sauermelch, Robert W. Coatney, Zhaohui Ao, Jyoti Disa, Stephen D. Holmes, Jeffrey M. Stadel, John D. Martin, Wu-Schyong Liu, George I. Glover, Shelagh Wilson, Dean E. McNulty, Catherine E. Ellis, Nabil A. Elshourbagy, Usman Shabon, John J. Trill, Douglas W. P. Hay, Eliot H. Ohlstein, Derk J. Bergsma and Stephen A. Douglas

1999, volume 402, articles 6763

Dual personality of memory T cells pp. 3-4

Charles R. Mackay

Toll gates for pathogen selection pp. 5-5

Richard J. Ulevitch

Selecting and maintaining a diverse T-cell repertoire pp. 6-13

Ananda W. Goldrath and Michael J. Bevan

Commitment to the B-lymphoid lineage depends on the transcription factor Pax5 pp. 14-20

Stephen L. Nutt, Barry Heavey, Antonius G. Rolink and Meinrad Busslinger

ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28 pp. 21-24

Andreas Hutloff, Anna M. Dittrich, Katja C. Beier, Barbara Eljaschewitsch, Regine Kraft, Ionnis Anagnostopoulos and Richard A. Kroczek

Cytotoxic T-cell immunity to virus-infected non-haematopoietic cells requires presentation of exogenous antigen pp. 25-29

Luis J. Sigal, Shane Crotty, Raul Andino and Kenneth L. Rock

Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinase pp. 29-34

Wuyi Meng, Sansana Sawasdikosol, Steven J. Burakoff and Michael J. Eck

Two subsets of memory T lymphocytes with distinct homing potentials and effector functions pp. 34-38

Federica Sallusto, Danielle Lenig, Reinhold Förster, Martin Lipp and Antonio Lanzavecchia

The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens pp. 39-43

David M. Underhill, Adrian Ozinsky, Adeline M. Hajjar, Anne Stevens, Christopher B. Wilson, Michael Bassetti and Alan Aderem

Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand pp. 43-47

Young-Yun Kong, Ulrich Feige, Iidiko Sarosi, Brad Bolon, Anna Tafuri, Sean Morony, Casey Capparelli, Ji Li, Robin Elliott, Susan McCabe, Thomas Wong, Giuseppe Campagnuolo, Erika Moran, Earl R. Bogoch, Gwyneth Van, Linh T. Nguyen, Pamela S. Ohashi, David L. Lacey, Eleanor Fish, William J. Boyle and Josef M. Penninger

Biogen and immune disease pp. 48-48

Joseph M. Davie

…and a chance to tackle protein structure pp. 705-705

Declan Butler

IBM promises scientists 500-fold leap in supercomputing power… pp. 705-706

Declan Butler

Germany drags its feet over demand for genome funds pp. 706-706

Alison Abbott

Tighter watch urged on adenoviral vectors… pp. 707-707

Paul Smaglik

…with proposal to report all ‘adverse events’ pp. 707-707

Paul Smaglik

French research minister waters down CNRS reform pp. 708-708

Heather McCabe

‘Relevant’ teaching turns UK children back on to physics pp. 708-708

Natasha Loder

Lots more cash for UK universities pp. 708-708

Natasha Loder

US sends Livermore laser target chamber to France on loan pp. 709-710

Colin Macilwain

Roche's Taq patent ‘obtained by deceit’, rules US court pp. 709-709

Rex Dalton

Germany's research agencies open up recruiting practices pp. 710-710

Quirin Schiermeier

China and Hong Kong pool effort in high-tech projects pp. 710-710

Tian Xuewen

Have NASA's scientists been the victims of excessive expectations? pp. 711-711

Tony Reichhardt

A post-genomic challenge: learning to read patterns of protein synthesis pp. 715-716

Alison Abbott

How to spot a protein in a crowd pp. 716-717

Alison Abbott

Can researchers find recipe for proteins and chips? pp. 718-719

Rex Dalton and Alison Abbott

Online research archive will be free to all pp. 721-722

Matthew Cockerill

Learning lessons from NASA's failed science missions pp. 721-721

Dave Hall

How reliable is science information on the web? pp. 722-722

Eva S. Allen, John M. Burke, Mark E. Welch and Loren H. Rieseberg

Where nuclear weapons come before basic needs pp. 722-722

Zia Mian and M. V. Ramana

The whens and wherefores of life pp. 723-724

F. Gonzalez-Crussi

Numerical concoctions pp. 724-725

Jeremy Gray

Light from underground pp. 725-725

Hynek Burda

Moving from simple to complex pp. 726-726

Nicholas Dale

Science in culture pp. 726-726

Marina Vaizey

Slanted evidence pp. 727-727

Martin Kemp

The road to the year 3000 pp. 729-729

Harry Harrison

Today we have naming of parts pp. 731-732

Elliot M. Meyerowitz

Direct detection at last pp. 732-733

Adam Burrows and Roger Angel

The prodigal fish pp. 733-735

Stephen R. Palumbi

Injecting spin into electronics pp. 735-736

Michael Oestreich

The male tail pp. 736-736

Jeff Harvey

Breech-birth prions pp. 737-739

James Hope

The mantle's lava lamp pp. 739-740

Marcia McNutt

Common origins pp. 739-739

Lesley Anson

The effects of sensory deprivation pp. 740-741

James H. Thomas

Publication paradise pp. 741-741

David Jones

Johannes A. van Paradijs (1946–99) pp. 742-742

Edward van den Heuvel

The future of cloning pp. 743-746

J. B. Gurdon and Alan Colman

Large eyeballs in diving ichthyosaurs pp. 747-747

Ryosuke Motani, Bruce M. Rothschild and William Wahl

BMP signalling specifies the pyloric sphincter pp. 748-749

Devyn M. Smith and Clifford J. Tabin

Effect of the 1999 solar eclipse on atomic clocks pp. 749-750

Thomas Udem, Jörg Reichert, Ronald Holzwarth, Theodor Hänsch, Rainer Krämer, Jörg Hahn and Jens Hammesfahr

Origin of anomalous multibody interactions pp. 750-750

Jeffrey J. Gray, Benny Chiang and Roger T. Bonnecaze

Probable detection of starlight reflected from the giant planet orbiting τ Boötis pp. 751-755

Andrew Collier Cameron, Keith Horne, Alan Penny and David James

Simultaneous generation of hotspots and superswells by convection in a heterogeneous planetary mantle pp. 756-760

Anne Davaille

Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana pp. 761-768

Xiaoying Lin, Samir Kaul, Steve Rounsley, Terrance P. Shea, Maria-Ines Benito, Christopher D. Town, Claire Y. Fujii, Tanya Mason, Cheryl L. Bowman, Mary Barnstead, Tamara V. Feldblyum, C. Robin Buell, Karen A. Ketchum, John Lee, Catherine M. Ronning, Hean L. Koo, Kelly S. Moffat, Lisa A. Cronin, Mian Shen, Grace Pai, Susan Van Aken, Lowell Umayam, Luke J. Tallon, John E. Gill, Mark D. Adams, Ana J. Carrera, Todd H. Creasy, Howard M. Goodman, Chris R. Somerville, Greg P. Copenhaver, Daphne Preuss, William C. Nierman, Owen White, Jonathan A. Eisen, Steven L. Salzberg, Claire M. Fraser and J. Craig Venter

Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana pp. 769-777

K. Mayer, C. Schüller, R. Wambutt, G. Murphy, G. Volckaert, T. Pohl, A. Düsterhöft, W. Stiekema, K.-D. Entian, N. Terryn, B. Harris, W. Ansorge, P. Brandt, L. Grivell, M. Rieger, M. Weichselgartner, V. de Simone, B. Obermaier, R. Mache, M. Müller, M. Kreis, M. Delseny, P. Puigdomenech, M. Watson, T. Schmidtheini, B. Reichert, D. Portatelle, M. Perez-Alonso, M. Boutry, I. Bancroft, P. Vos, J. Hoheisel, W. Zimmermann, H. Wedler, P. Ridley, S.-A. Langham, B. McCullagh, L. Bilham, J. Robben, J. Van der Schueren, B. Grymonprez, Y.-J. Chuang, F. Vandenbussche, M. Braeken, I. Weltjens, M. Voet, I. Bastiaens, R. Aert, E. Defoor, T. Weitzenegger, G. Bothe, U. Ramsperger, H. Hilbert, M. Braun, E. Holzer, A. Brandt, S. Peters, M. van Staveren, W. Dirkse, P. Mooijman, R. Klein Lankhorst, M. Rose, J. Hauf, P. Kötter, S. Berneiser, S. Hempel, M. Feldpausch, S. Lamberth, H. Van den Daele, A. De Keyser, C. Buysshaert, J. Gielen, R. Villarroel, R. De Clercq, M. Van Montagu, J. Rogers, A. Cronin, M. Quail, S. Bray-Allen, L. Clark, J. Doggett, S. Hall, M. Kay, N. Lennard, K. McLay, R. Mayes, A. Pettett, M.-A. Rajandream, M. Lyne, V. Benes, S. Rechmann, D. Borkova, H. Blöcker, M. Scharfe, M. Grimm, T.-H. Löhnert, S. Dose, M. de Haan, A. Maarse, M. Schäfer, S. Müller-Auer, C. Gabel, M. Fuchs, B. Fartmann, K. Granderath, D. Dauner, A. Herzl, S. Neumann, A. Argiriou, D. Vitale, R. Liguori, E. Piravandi, O. Massenet, F. Quigley, G. Clabauld, A. Mündlein, R. Felber, S. Schnabl, R. Hiller, W. Schmidt, A. Lecharny, S. Aubourg, F. Chefdor, R. Cooke, C. Berger, A. Montfort, E. Casacuberta, T. Gibbons, N. Weber, M. Vandenbol, M. Bargues, J. Terol, A. Torres, A. Perez-Perez, B. Purnelle, E. Bent, S. Johnson, D. Tacon, T. Jesse, L. Heijnen, S. Schwarz, P. Scholler, S. Heber, P. Francs, C. Bielke, D. Frishman, D. Haase, K. Lemcke, H. W. Mewes, S. Stocker, P. Zaccaria, M. Bevan, R. K. Wilson, M. de la Bastide, K. Habermann, L. Parnell, N. Dedhia, L. Gnoj, K. Schutz, E. Huang, L. Spiegel, M. Sehkon, J. Murray, P. Sheet, M. Cordes, J. Abu-Threideh, T. Stoneking, J. Kalicki, T. Graves, G. Harmon, J. Edwards, P. Latreille, L. Courtney, J. Cloud, A. Abbott, K. Scott, D. Johnson, P. Minx, D. Bentley, B. Fulton, N. Miller, T. Greco, K. Kemp, J. Kramer, L. Fulton, E. Mardis, M. Dante, K. Pepin, L. Hillier, J. Nelson, J. Spieth, E. Ryan, S. Andrews, C. Geisel, D. Layman, H. Du, J. Ali, A. Berghoff, K. Jones, K. Drone, M. Cotton, C. Joshu, B. Antonoiu, M. Zidanic, C. Strong, H. Sun, B. Lamar, C. Yordan, P. Ma, J. Zhong, R. Preston, D. Vil, M. Shekher, A. Matero, R. Shah, I'K. Swaby, A. O'Shaughnessy, M. Rodriguez, J. Hoffman, S. Till, S. Granat, N. Shohdy, A. Hasegawa, A. Hameed, M. Lodhi, A. Johnson, E. Chen, M. Marra, R. Martienssen and W. R. McCombie

A structural change in the kinesin motor protein that drives motility pp. 778-784

Sarah Rice, Abel W. Lin, Daniel Safer, Cynthia L. Hart, Nariman Naber, Bridget O. Carragher, Shane M. Cain, Elena Pechatnikova, Elizabeth M. Wilson-Kubalek, Michael Whittaker, Edward Pate, Roger Cooke, Edwin W. Taylor, Ronald A. Milligan and Ronald D. Vale

Thermally activated transitions in a bistable three-dimensional optical trap pp. 785-787

Lowell I. McCann, Mark Dykman and Brage Golding

Injection and detection of a spin-polarized current in a light-emitting diode pp. 787-790

R. Fiederling, M. Keim, G. Reuscher, W. Ossau, G. Schmidt, A. Waag and L. W. Molenkamp

Electrical spin injection in a ferromagnetic semiconductor heterostructure pp. 790-792

Y. Ohno, D. K. Young, B. Beschoten, F. Matsukura, H. Ohno and D. D. Awschalom

Lithium-doped plastic crystal electrolytes exhibiting fast ion conduction for secondary batteries pp. 792-794

Douglas R. MacFarlane, Junhua Huang and Maria Forsyth

Patterning liquid flow on the microscopic scale pp. 794-797

Dawn E. Kataoka and Sandra M. Troian

Stabilizing a solid–solid interface with a molecular-scale adhesive pp. 797-799

R. J. Davey, L. Williams-Seton, H. F. Lieberman and N. Blagden

Larval retention and recruitment in an island population of a coral-reef fish pp. 799-802

Stephen E. Swearer, Jennifer E. Caselle, David W. Lea and Robert R. Warner

Self-recruitment in a coral reef fish population pp. 802-804

G. P. Jones, M. J. Milicich, M. J. Emslie and C. Lunow

Regulation of lifespan by sensory perception in Caenorhabditis elegans pp. 804-809

Javier Apfeld and Cynthia Kenyon

Atomic scale movement of the voltage-sensing region in a potassium channel measured via spectroscopy pp. 809-813

Albert Cha, Gregory E. Snyder, Paul R. Selvin and Francisco Bezanilla

Spectroscopic mapping of voltage sensor movement in the Shaker potassium channel pp. 813-817

K. S. Glauner, L. M. Mannuzzu, C. S. Gandhi and E. Y. Isacoff

Functional characterization of a potassium-selective prokaryotic glutamate receptor pp. 817-821

Guo-Qiang Chen, Changhai Cui, Mark L. Mayer and Eric Gouaux

Transmissible and genetic prion diseases share a common pathway of neurodegeneration pp. 822-826

Ramanujan S. Hegde, Patrick Tremblay, Darlene Groth, Stephen J. DeArmond, Stanley B. Prusiner and Vishwanath R. Lingappa

T-cell co-stimulation through B7RP-1 and ICOS pp. 827-832

Steven K. Yoshinaga, John S. Whoriskey, Sanjay D. Khare, Ulla Sarmiento, Jane Guo, Tom Horan, Grace Shih, Ming Zhang, Marco A. Coccia, Tadahiko Kohno, Anna Tafuri-Bladt, David Brankow, Pauline Campbell, David Chang, Laura Chiu, Tianang Dai, Gordon Duncan, Gary S. Elliott, Ariela Hui, Susan M. McCabe, Sheila Scully, Arda Shahinian, Christine L. Shaklee, Gwyneth Van, Tak W. Mak and Giorgio Senaldi

Functional recognition of the 3′ splice site AG by the splicing factor U2AF35 pp. 832-835

Shaoping Wu, Charles M. Romfo, Timothy W. Nilsen and Michael R. Green

Both subunits of U2AF recognize the 3′ splice site in Caenorhabditis elegans pp. 835-838

Diego A. R. Zorio and Thomas Blumenthal

Inhibition of msl-2 splicing by Sex-lethal reveals interaction between U2AF35 and the 3′ splice site AG pp. 838-841

Livia Merendino, Sabine Guth, Daniel Bilbao, Concepción Martínez and Juan Valcárcel

Correction Long-range electrostatic attraction between like-charge spheres in a charged pore pp. 841-841

W. Richard Bowen and Adel O. Sharif

1999, volume 402, articles 6762

NASA facing awkward questions as hopes for Mars lander fade pp. 565-565

Tony Reichhardt and Alison Abbott

France to lift embryo research ban? pp. 565-565

Declan Butler

Indian patent law will protect crops ‘unless injurious to health’ pp. 566-566

K. S. Jayaraman

EU candidate states impress with Framework proposals pp. 566-566

Natasha Loder

US close to funding stem-cell work pp. 566-566

Paul Smaglik

Columbia extends support for ‘mainstream’ Biosphere 2 pp. 567-567

Rex Dalton

US trade rules seek to balance health and patent protection pp. 567-568

Meredith Wadman and Michael Cherry

AAAS to honour ‘persecuted’ Ukrainian marine biologist pp. 568-568

Natasha Loder

Berlin places genomics among top funding priorities pp. 568-568

Quirin Schiermeier

French plan to exploit genome sparks row … pp. 569-569

Declan Butler

… while Japanese sequencers feel neglected pp. 569-569

Asako Saegusa

Japan pulls its fusion research together … pp. 570-570

Asako Saegusa

… as Europeans lobby for reactor construction pp. 570-570

Alison Abbott

US food-safety body hears protests over genetically modified food pp. 571-571

Colin Macilwain

Seeking clarity in the debate over the safety of GM foods pp. 575-575

Mark Tester

Seeking clarity in the debate over the safety of GM foods pp. 575-575

Steve L. Taylor and Susan L. Hefle

Seeking clarity in the debate over the safety of GM foods pp. 575-575

Mae-Wan Ho

Seeking clarity in the debate over the safety of GM foods pp. 575-576

Erik Millstone, Eric Brunner and Sue Mayer

Why Diamond should go to Daresbury pp. 576-576

John R. Helliwell

Seeking a guide to the quality of web writing pp. 576-576

Roger Elliott and Mark S. Frankel

How ethical principles can aid research pp. 576-576

Joël Sternheimer

Lobbying groups must be trustworthy pp. 576-576

Ketil Haarstad

Expressing a consensus on candour pp. 577-578

Louis M. Guenin

The Church's route to enlightenment pp. 579-580

George V. Coyne

Opening the lines of communication pp. 580-581

Petra Werner

Hidden wealth of data in the depths pp. 581-581

Franciscus Colijn and Sebastian Lippemeier

Story of an obsession pp. 581-581

Colin L. Masters

Science in culture pp. 582-582

Bonnie Hurren and Robert Meech

The forgotten menace pp. 583-583

Paul Doty

Spawn of Satan? pp. 585-585

Nicola Griffith

Giving a boost to atoms pp. 587-588

Kristian Helmerson

The tangled tale of tau pp. 588-589

E. Mandelkow

Magma fragmentation in eruptions pp. 589-591

Dork Sahagian

Water fleas on cycles pp. 592-593

James P. Grover

Climate and the Gulf Stream pp. 593-595

Jean-Claude Duplessy

Glutamate primes the pump pp. 595-596

Patrik Rorsman and Erik Renström

Taking serious risks seriously pp. 596-597

Sheldon L. Glashow and Richard Wilson

The topography of memory pp. 597-598

Howard Eichenbaum

Spotting the goods trains pp. 598-598

Christopher Surridge

Chaotic planet formation pp. 599-600

Renu Malhotra

Citing to infinity pp. 600-600

David Jones

Coral growing on North Sea oil rigs pp. 601-601

Niall Bell and Jan Smith

Conservation of a sex-determining gene pp. 601-602

Craig A. Smith, Peter J. McClive, Patrick S. Western, Kirsty J. Reed and Andrew H. Sinclair

Proton pumping by cytochrome c oxidase pp. 602-603

Hartmut Michel

Electrochemically grown photonic crystals pp. 603-604

Paul V. Braun and Pierre Wiltzius

reply: Proton pumping by cytochrome c oxidase pp. 603-603

M. I. Verkhovsky, A. Jasaitis, M. L. Verkhovskaya, J. E. Morgan and M. Wikström

The role of stress transfer in earthquake occurrence pp. 605-609

Ross S. Stein

Distribution of spatial and nonspatial information in dorsal hippocampus pp. 610-614

Robert E. Hampson, John D. Simeral and Sam A. Deadwyler

Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration pp. 615-622

Gentry N. Patrick, Lawrence Zukerberg, Margareta Nikolic, Suzanne de la Monte, Pieter Dikkes and Li-Huei Tsai

Crystal structure of a lectin-like natural killer cell receptor bound to its MHC class I ligand pp. 623-631

José Tormo, Kannan Natarajan, David H. Margulies and Roy A. Mariuzza

Early planet formation as a trigger for further planet formation pp. 633-635

Philip J. Armitage and Brad M. S. Hansen

The formation of Uranus and Neptune in the Jupiter–Saturn region of the Solar System pp. 635-638

Edward W. Thommes, Martin J. Duncan and Harold F. Levison

First-order phase transitions in a quantum Hall ferromagnet pp. 638-641

Vincenzo Piazza, Vittorio Pellegrini, Fabio Beltram, Werner Wegscheider, Tomáš Jungwirth and Allan H. MacDonald

Phase-coherent amplification of atomic matter waves pp. 641-644

S. Inouye, T. Pfau, S. Gupta, A. P. Chikkatur, A. Görlitz, D. E. Pritchard and W. Ketterle

Weaker Gulf Stream in the Florida Straits during the Last Glacial Maximum pp. 644-648

Jean Lynch-Stieglitz, William B. Curry and Niall Slowey

A criterion for the fragmentation of bubbly magma based on brittle failure theory pp. 648-650

Youxue Zhang

Tube pumices as strain markers of the ductile–brittle transition during magma fragmentation pp. 650-653

J. Martí, C. Soriano and D. B. Dingwell

Large-amplitude cycles of Daphnia and its algal prey in enriched environments pp. 653-656

Edward McCauley, Roger M. Nisbet, William W. Murdoch, Andre M. de Roos and William S. C. Gurney

Ghrelin is a growth-hormone-releasing acylated peptide from stomach pp. 656-660

Masayasu Kojima, Hiroshi Hosoda, Yukari Date, Masamitsu Nakazato, Hisayuki Matsuo and Kenji Kangawa

Central inputs mask multiple adult neural networks within a single embryonic network pp. 660-664

Yves Le Feuvre, Valérie S. Fénelon and Pierre Meyrand

Short-term memory in olfactory network dynamics pp. 664-668

Mark Stopfer and Gilles Laurent

Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons pp. 669-671

James A. Bibb, Gretchen L. Snyder, Akinori Nishi, Zhen Yan, Laurent Meijer, Allen A. Fienberg, Li-Huei Tsai, Young T. Kwon, Jean-Antoine Girault, Andrew J. Czernik, Richard L. Huganir, Hugh C. Hemmings, Angus C. Nairn and Paul Greengard

Induction of autophagy and inhibition of tumorigenesis by beclin 1 pp. 672-676

Xiao Huan Liang, Saadiya Jackson, Matthew Seaman, Kristy Brown, Bettina Kempkes, Hanina Hibshoosh and Beth Levine

Binding of paxillin to α4 integrins modifies integrin-dependent biological responses pp. 676-681

Shouchun Liu, Sheila M. Thomas, Darren G. Woodside, David M. Rose, William B. Kiosses, Martin Pfaff and Mark H. Ginsberg

A novel nuclear export activity in HIV-1 matrix protein required for viral replication pp. 681-685

Stefan Dupont, Natalia Sharova, Caryn DéHoratius, Ching-Man A. Virbasius, Xiaochun Zhu, Alice G. Bukrinskaya, Mario Stevenson and Michael R. Green

Mitochondrial glutamate acts as a messenger in glucose-induced insulin exocytosis pp. 685-689

Pierre Maechler and Claes B. Wollheim

The TOR signalling pathway controls nuclear localization of nutrient-regulated transcription factors pp. 689-692

Thomas Beck and Michael N. Hall

Eukaryotic type II chaperonin CCT interacts with actin through specific subunits pp. 693-696

Oscar Llorca, Elizabeth A. McCormack, Gillian Hynes, Julie Grantham, Jacqueline Cordell, José L. Carrascosa, Keith R. Willison, José J. Fernandez and José M. Valpuesta

Modified reaction centres oxidize tyrosine in reactions that mirror photosystem II pp. 696-699

L. Kálmán, R. LoBrutto, J. P. Allen and J. C. Williams

1999, volume 402, articles 6761

Tales of the expected pp. C7-C9

Philip Campbell

How common are habitable planets? pp. C11-C14

Jack J. Lissauer

Keeping time pp. C17-C17

Philip Ball

Circadian clocks pp. C17-C17

Sara Abdulla

The challenge of conservation pp. C17-C17

Henry Gee

‘Earth system’ analysis and the second Copernican revolution pp. C19-C23

H. J. Schellnhuber

Genetics and general cognitive ability pp. C25-C29

Robert Plomin

Flashes in femtoseconds pp. C30-C30

Philip Ball

Arrhythmias pp. C30-C30

Sara Abdulla

Does the past have a future? pp. C30-C30

Henry Gee

The neurobiology of cognition pp. C35-C38

M. James Nichols and William T. Newsome

The future of evolutionary developmental biology pp. C41-C44

Peter W. H. Holland

From molecular to modular cell biology pp. C47-C52

Leland H. Hartwell, John J. Hopfield, Stanislas Leibler and Andrew W. Murray

Feeding the world in the twenty-first century pp. C55-C58

Gordon Conway and Gary Toenniessen

Physics at the Planck time pp. C61-C61

Philip Ball

The speed of computers pp. C61-C61

Philip Ball

Lifespan extension pp. C61-C61

Sara Abdulla

The future of public health pp. C63-C64

Barry R. Bloom

Computing 2010: from black holes to biology pp. C67-C70

Declan Butler

Transitions still to be made pp. C73-C76

Philip Ball

Adapting to climate change pp. C79-C79

Philip Ball

The shape of the cosmos pp. C79-C79

Henry Gee

Science's new social contract with society pp. C81-C84

Michael Gibbons

Plus çá change pp. C86-C88

J. L. Heilbron and W. F. Bynum

‘Finishing’ success marks major genome sequencing milestone … pp. 447-448

Declan Butler

… as researchers pounce on glut of data pp. 447-447

Declan Butler

Tiny chromosome is rich in genes and medical promise pp. 448-448

Natasha Loder

Unfinished sequence — the catch on 22 pp. 448-448

Natasha Loder

US defence labs face research cutbacks… pp. 449-449

Rex Dalton

…as Livermore blasted for laser project pp. 449-449

Rex Dalton

EMBL rescue package keeps bioinformatics centre running pp. 450-450

Alison Abbott

Centralized German research centres will compete for funds pp. 450-450

Quirin Schiermeier

Nuclear safety and biotech boosted in Japan's budget pp. 451-451

Asako Saegusa

Wellcome Trust backs Rutherford to host synchrotron pp. 451-451

Natasha Loder

Opinion divided on images of Martian ‘ocean’ pp. 452-452

Tony Reichhardt

South African telescope to go ahead pp. 452-452

Michael Cherry

France cuts its ‘big science’ spend to bolster lab research pp. 453-453

Heather McCabe

Champion of India's bomb rewarded with cabinet position pp. 453-453

K. S. Jayaraman

EMBL pay settlement will cost millions pp. 453-453

Alison Abbott

This should not be the end for terminator technology in GM crops pp. 457-457

Andrew Jackson and Chris Inglehearn

Weighing up the threat to the world's corals pp. 457-457

Thomas J. Goreau

Weighing up the threat to the world's corals pp. 457-457

M. Pecheux

Who's doing what in US protein initiative pp. 457-458

Marvin Cassman and Ari Patrinos

Search is on for better search engines pp. 458-458

Vishwas Chavan

Japan builds bridges to rest of the world pp. 458-458

Philippe Buhlmann

Galileo had accurate vision of the Moon pp. 458-458

M. W. Friedlander

Caught in the act pp. 459-459

S. Blair Hedges

A blooming renaissance pp. 460-461

Peter G. Kevan

Knowledge on knowing pp. 460-460

Manfred Fahle

Research as ‘normal’ pp. 461-461

Marco Finetti

Science in culture pp. 462-462

J. L. Heilbron

Annus physicalis 1932 pp. 463-463

H. B. G. Casimir

COMP.BASILISK FAQ pp. 465-465

David Langford

The book of genes pp. 467-468

Peter Little

One more time, from the top pp. 469-471

Erik Hauri

A firm base for drug development pp. 471-472

Bart De Strooper and Gerhard König

Ultrafast relaxation in water pp. 473-475

Abraham Nitzan

Derailed axons get on track pp. 475-476

Kai Zinn and Aloisia Schmid

Spreading the fluid word pp. 476-477

Jonathan Ashmore and Jessica de Boer

Happy landings pp. 477-477

David Jones

Thomas Hughes Jukes (1906–99) pp. 478-478

John Maddox

Precise dating of the Norfolk timber circle pp. 479-479

Alex Bayliss, Cathy Groves, Gerry McCormac, Mike Baillie, Dave Brown and Mark Brennand

Herbivorous diet in an ornithomimid dinosaur pp. 480-481

Yoshitsugu Kobayashi, Jun-Chang Lu, Zhi-Ming Dong, Rinchen Barsbold, Yoichi Azuma and Yukimitsu Tomida

Insecticidal toxin in root exudates from Bt corn pp. 480-480

Deepak Saxena, Saul Flores and G. Stotzky

Germ cells colonized by endosymbiotic bacteria pp. 482-482

Stephen J. Hadfield and J. Myles Axton

Synexpression groups in eukaryotes pp. 483-487

Christof Niehrs and Nicolas Pollet

The DNA sequence of human chromosome 22 pp. 489-495

I. Dunham, A. R. Hunt, J. E. Collins, R. Bruskiewich, D. M. Beare, M. Clamp, L. J. Smink, R. Ainscough, J. P. Almeida, A. Babbage, C. Bagguley, J. Bailey, K. Barlow, K. N. Bates, O. Beasley, C. P. Bird, S. Blakey, A. M. Bridgeman, D. Buck, J. Burgess, W. D. Burrill, J. Burton, C. Carder, N. P. Carter, Y. Chen, G. Clark, S. M. Clegg, V. Cobley, C. G. Cole, R. E. Collier, R. E. Connor, D. Conroy, N. Corby, G. J. Coville, A. V. Cox, J. Davis, E. Dawson, P. D. Dhami, C. Dockree, S. J. Dodsworth, R. M. Durbin, A. Ellington, K. L. Evans, J. M. Fey, K. Fleming, L. French, A. A. Garner, J. G. R. Gilbert, M. E. Goward, D. Grafham, M. N. Griffiths, C. Hall, R. Hall, G. Hall-Tamlyn, R. W. Heathcott, S. Ho, S. Holmes, S. E. Hunt, M. C. Jones, J. Kershaw, A. Kimberley, A. King, G. K. Laird, C. F. Langford, M. A. Leversha, C. Lloyd, D. M. Lloyd, I. D. Martyn, M. Mashreghi-Mohammadi, L. Matthews, O. T. McCann, J. McClay, S. McLaren, A. A. McMurray, S. A. Milne, B. J. Mortimore, C. N. Odell, R. Pavitt, A. V. Pearce, D. Pearson, B. J. Phillimore, S. H. Phillips, R. W. Plumb, H. Ramsay, Y. Ramsey, L. Rogers, M. T. Ross, C. E. Scott, H. K. Sehra, C. D. Skuce, S. Smalley, M. L. Smith, C. Soderlund, L. Spragon, C. A. Steward, J. E. Sulston, R. M. Swann, M. Vaudin, M. Wall, J. M. Wallis, M. N. Whiteley, D. Willey, L. Williams, S. Williams, H. Williamson, T. E. Wilmer, L. Wilming, C. L. Wright, T. Hubbard, D. R. Bentley, S. Beck, J. Rogers, N. Shimizu, S. Minoshima, K. Kawasaki, T. Sasaki, S. Asakawa, J. Kudoh, A. Shintani, K. Shibuya, Y. Yoshizaki, N. Aoki, S. Mitsuyama, B. A. Roe, F. Chen, L. Chu, J. Crabtree, S. Deschamps, A. Do, T. Do, A. Dorman, F. Fang, Y. Fu, P. Hu, A. Hua, S. Kenton, H. Lai, H. I. Lao, J. Lewis, S. Lewis, S.-P. Lin, P. Loh, E. Malaj, Thanh Nguyen, H. Pan, S. Phan, S. Qi, Y. Qian, L. Ray, Q. Ren, S. Shaull, D. Sloan, L. Song, Q. Wang, Y. Wang, Z. Wang, J. White, D. Willingham, H. Wu, Z. Yao, M. Zhan, G. Zhang, S. Chissoe, J. Murray, N. Miller, P. Minx, R. Fulton, D. Johnson, G. Bemis, D. Bentley, H. Bradshaw, S. Bourne, M. Cordes, Z. Du, L. Fulton, D. Goela, T. Graves, J. Hawkins, K. Hinds, K. Kemp, P. Latreille, D. Layman, P. Ozersky, T. Rohlfing, P. Scheet, C. Walker, A. Wamsley, P. Wohldmann, K. Pepin, J. Nelson, I. Korf, J. A. Bedell, L. Hillier, E. Mardis, R. Waterston, R. Wilson, B. S. Emanuel, T. Shaikh, H. Kurahashi, S. Saitta, M. L. Budarf, H. E. McDermid, A. Johnson, A. C. C. Wong, B. E. Morrow, L. Edelmann, U. J. Kim, H. Shizuya, M. I. Simon, J. P. Dumanski, M. Peyrard, D. Kedra, E. Seroussi, I. Fransson, I. Tapia, C. E. Bruder and K. P. O'Brien

The temporal requirement for endothelin receptor-B signalling during neural crest development pp. 496-501

Myung K. Shin, John M. Levorse, Robert S. Ingram and Shirley M. Tilghman

Discovery of a massive equatorial torus in the η Carinae stellar system pp. 502-504

P. W. Morris, L. B. F. M. Waters, M. J. Barlow, T. Lim, A. de Koter, R. H. M. Voors, P. Cox, Th. de Graauw, Th. Henning, S. Hony, H. J. G. L. M. Lamers, H. Mutschke and N. R. Trams

Observation of spin and charge collective modes in one-dimensional metallic chains pp. 504-507

P. Segovia, D. Purdie, M. Hengsberger and Y. Baer

Resonant intermolecular transfer of vibrational energy in liquid water pp. 507-509

Sander Woutersen and Huib J. Bakker

Cyclic transmembrane charge transport by pyrylium ions in a vesicle-based photocatalytic system pp. 509-511

Rafail F. Khairutdinov and James K. Hurst

Warming of the tropical Atlantic Ocean and slowdown of thermohaline circulation during the last deglaciation pp. 511-514

Carsten Rühlemann, Stefan Mulitza, Peter J. Müller, Gerold Wefer and Rainer Zahn

The remelting of hydrothermally altered peridotite at mid-ocean ridges by intruding mantle diapirs pp. 514-518

Mathieu Benoit, Georges Ceuleneer and Mireille Polvé

An early Cambrian craniate-like chordate pp. 518-522

Jun-Yuan Chen, Di-Ying Huang and Chia-Wei Li

Sympatric speciation by sexual selection pp. 523-526

M. Higashi, G. Takimoto and N. Yamamura

Direct measurement of intra-cochlear pressure waves pp. 526-529

Elizabeth S. Olson

Stable propagation of synchronous spiking in cortical neural networks pp. 529-533

Markus Diesmann, Marc-Oliver Gewaltig and Ad Aertsen

Membrane-anchored aspartyl protease with Alzheimer's disease β-secretase activity pp. 533-537

Riqiang Yan, Michael J. Bienkowski, Mary E. Shuck, Huiyi Miao, Monica C. Tory, Adele M. Pauley, John R. Brashler, Nancy C. Stratman, W. Rodney Mathews, Allen E. Buhl, Donald B. Carter, Alfredo G. Tomasselli, Luis A. Parodi, Robert L. Heinrikson and Mark E. Gurney

Purification and cloning of amyloid precursor protein β-secretase from human brain pp. 537-540

Sukanto Sinha, John P. Anderson, Robin Barbour, Guriqbal S. Basi, Russell Caccavello, David Davis, Minhtam Doan, Harry F. Dovey, Normand Frigon, Jin Hong, Kirsten Jacobson-Croak, Nancy Jewett, Pamela Keim, Jeroen Knops, Ivan Lieberburg, Michael Power, Hua Tan, Gwen Tatsuno, Jay Tung, Dale Schenk, Peter Seubert, Susanna M. Suomensaari, Shuwen Wang, Donald Walker, Jun Zhao, Lisa McConlogue and Varghese John

Axon routing across the midline controlled by the Drosophila Derailed receptor pp. 540-544

Joshua L. Bonkowsky, Shingo Yoshikawa, David D. O'Keefe, Audra L. Scully and John B. Thomas

Bazooka provides an apical cue for Inscuteable localization in Drosophila neuroblasts pp. 544-547

Andreas Wodarz, Andreas Ramrath, Ute Kuchinke and Elisabeth Knust

Bazooka recruits Inscuteable to orient asymmetric cell divisions in Drosophila neuroblasts pp. 548-551

Markus Schober, Matthias Schaefer and Juergen A. Knoblich

A telomerase component is defective in the human disease dyskeratosis congenita pp. 551-555

James R. Mitchell, Emily Wood and Kathleen Collins

The RCAF complex mediates chromatin assembly during DNA replication and repair pp. 555-560

Jessica K. Tyler, Christopher R. Adams, Shaw-Ree Chen, Ryuji Kobayashi, Rohinton T. Kamakaka and James T. Kadonaga

1999, volume 402, articles 6760

The epidemic of allergy and asthma pp. 2-4

Stephen T. Holgate

The alliance of genes and environment in asthma and allergy pp. 5-11

William Cookson

The role of allergy in the development of asthma pp. 12-17

P. G. Holt, C. Macaubas, P. A. Stumbles and P. D. Sly

Induction and regulation of the IgE response pp. 18-23

David B. Corry and Farrah Kheradmand

Signalling through the high-affinity IgE receptor FcεRI pp. 24-30

Helen Turner and Jean-Pierre Kinet

Therapeutic strategies for allergic diseases pp. 31-38

Peter J. Barnes

Schering-Plough and allergic disease pp. 40-40

Francis Cuss

‘It's a G’: the one-billionth nucleotide pp. 331-331

David Dickson and Colin Macilwain

German bioethics inquiry ‘could hold up essential changes’ pp. 331-332

Quirin Schiermeier

Israel urged to set up labs to carry out military research pp. 332-332

Haim Watzman

Concern at cheap AIDS drug fears pp. 332-332

Michael Cherry

Praise greets accuracy of Leonid prediction pp. 333-333

Tony Reichhardt

Brookhaven leak reactor to close pp. 333-334

Colin Macilwain

Hughes institute unveils top team pp. 334-335

Colin Macilwain

Science lobby ‘ecstatic’ after triumph in NIH budget battle pp. 334-334

Meredith Wadman

Busquin plans white paper to integrate European research pp. 335-335

Keith Nuttall

Genentech pays $200m over growth hormone ‘theft’ pp. 335-335

Rex Dalton and Quirin Schiermeier

China on verge of putting man into space… pp. 336-336

Tian Xuewen

…as a new failed satellite launch embarrasses Japan pp. 336-336

Asako Saegusa

Gender discrimination ‘undermines science’ pp. 337-337

Natasha Loder

India intends to reap the full commercial benefits pp. 342-343

K. S. Jayaraman

Access issues may determine whether agri-biotech will help the world's poor pp. 343-344

Colin Macilwain

Smugglers aim to circumvent GM court ban in Brazil pp. 344-345

Ricardo Bonalume Neto

Academies link to map scientific priorities for meeting real needs pp. 345-345

David Dickson

What's in a name? pp. 347-348

Tony Smith

Promoting a standard nomenclature for genes and proteins pp. 347-347

Julia White, Hester Wain, Elspeth Bruford and Sue Povey

Sequencing challenge pp. 347-347

Lois J. Maltais and Ian Jackson

Cooperative efforts around Lake Tahoe pp. 348-348

Stephen G. Wells, James S. Coleman, Joseph N. Crowley and Kenneth W. Hunter

Precautionary approach to risk assessment pp. 348-348

Alister Scott, Andy Stirling, Nick Mabey, Frans Berkhout, Chris Williams, Chris Rose, Michael Jacobs, Robin Grove-White, Ian Scoones and Melissa Leach

Mastering the art of the skies pp. 349-350

Euan Nisbet

Personal views of an impersonal world pp. 350-350

Howard P. Segal

A friend of one's own pp. 351-351

Paul L. Harris

Sniffing the world of olfaction pp. 351-352

Vincent Dusastre

Two millennia of animal spirits pp. 353-353

Ian Glynn

Emortality — at last! pp. 355-355

Brian Stableford

Plug-in quantum software pp. 357-358

John Preskill

The family tree flowers pp. 358-359

Paul Kenrick

Clouds from near and far pp. 359-361

W. Butler Burton and Robert Braun

What do yeast proteins do? pp. 362-363

Philip Hieter

Sulphur in the mix pp. 363-365

Ronald P. Kiene

Ancestral primate viewed pp. 365-366

Stephen J. O'Brien and Roscoe Stanyon

Competition and coexistence pp. 366-367

Ulrich Sommer

Internal ecology pp. 367-367

David Jones

Charles M. Steinberg (1932–99) pp. 368-368

Jack von Borstel and John Cairns

Feeding by mandibular raking in a snake pp. 369-370

N. J. Kley and E. L. Brainerd

A universal marker for transgenic insects pp. 370-371

Andreas J. Berghammer, Martin Klingler and Ernst A. Wimmer

Ubiquitin tag for sperm mitochondria pp. 371-372

Peter Sutovsky, Ricardo D. Moreno, João Ramalho-Santos, Tanja Dominko, Calvin Simerly and Gerald Schatten

Iron, nitrogen and phosphorus in the ocean pp. 372-372

John J. Cullen

reply: Iron, nitrogen and phosphorus in the ocean pp. 372-372

Toby Tyrrell

Active site-directed protein regulation pp. 373-376

Bostjan Kobe and Bruce E. Kemp

Structure of fumarate reductase from Wolinella succinogenes at 2.2 Å resolution pp. 377-385

C. Roy D. Lancaster, Achim Kröger, Manfred Auer and Hartmut Michel

Discovery of molecular hydrogen in a high-velocity cloud of the Galactic halo pp. 386-387

P. Richter, K. S. de Boer, H. Widmann, N. Kappelmann, W. Gringel, M. Grewing and J. Barnstedt

Accretion of low-metallicity gas by the Milky Way pp. 388-390

B. P. Wakker, J. C. Howk, B. D. Savage, H. van Woerden, S. L. Tufte, U. J. Schwarz, R. Benjamin, R. J. Reynolds, R. F. Peletier and P. M. W. Kalberla

Demonstrating the viability of universal quantum computation using teleportation and single-qubit operations pp. 390-393

Daniel Gottesman and Isaac L. Chuang

Coupled synthesis and self-assembly of nanoparticles to give structures with controlled organization pp. 393-395

Mei Li, Heimo Schnablegger and Stephen Mann

Role of vertical mixing in controlling the oceanic production of dimethyl sulphide pp. 396-399

Rafel Simó and Carlos Pedrós-Alió

The effect of climate change on ozone depletion through changes in stratospheric water vapour pp. 399-401

Daniel B. Kirk-Davidoff, Eric J. Hintsa, James G. Anderson and David W. Keith

Angiosperm phylogeny inferred from multiple genes as a tool for comparative biology pp. 402-404

Pamela S. Soltis, Douglas E. Soltis and Mark W. Chase

The earliest angiosperms: evidence from mitochondrial, plastid and nuclear genomes pp. 404-407

Yin-Long Qiu, Jungho Lee, Fabiana Bernasconi-Quadroni, Douglas E. Soltis, Pamela S. Soltis, Michael Zanis, Elizabeth A. Zimmer, Zhiduan Chen, Vincent Savolainen and Mark W. Chase

Biodiversity of plankton by species oscillations and chaos pp. 407-410

Jef Huisman and Franz J. Weissing

The dynamics of chromosome evolution in birds and mammals pp. 411-413

David W. Burt, Charlotte Bruley, Ian C. Dunn, Cheryl T. Jones, Anne Ramage, Andy S. Law, David R. Morrice, Ian R. Paton, Jacqueline Smith, Dawn Windsor, Alexei Sazanov, Ruedi Fries and David Waddington

Large-scale analysis of the yeast genome by transposon tagging and gene disruption pp. 413-418

Petra Ross-Macdonald, Paulo S. R. Coelho, Terry Roemer, Seema Agarwal, Anuj Kumar, Ronald Jansen, Kei-Hoi Cheung, Amy Sheehan, Dawn Symoniatis, Lara Umansky, Matthew Heidtman, F. Kenneth Nelson, Hiroshi Iwasaki, Karl Hager, Mark Gerstein, Perry Miller, G. Shirleen Roeder and Michael Snyder

Chromosomal landscape of nucleosome-dependent gene expression and silencing in yeast pp. 418-421

John J. Wyrick, Frank C. P. Holstege, Ezra G. Jennings, Helen C. Causton, David Shore, Michael Grunstein, Eric S. Lander and Richard A. Young

LTP promotes formation of multiple spine synapses between a single axon terminal and a dendrite pp. 421-425

N. Toni, P.-A. Buchs, I. Nikonenko, C. R. Bron and D. Muller

Conserved regulation of proximodistal limb axis development by Meis1/Hth pp. 425-429

Nadia Mercader, Esther Leonardo, Natalia Azpiazu, Antonio Serrano, Ginés Morata, Carlos Martínez-A and Miguel Torres

CtBP/BARS induces fission of Golgi membranes by acylating lysophosphatidic acid pp. 429-433

Roberto Weigert, Maria Giuseppina Silletta, Stefania Spanò, Gabriele Turacchio, Claudia Cericola, Antonino Colanzi, Silvia Senatore, Raffaella Mancini, Elena V. Polishchuk, Mario Salmona, Francesco Facchiano, Koert N. J. Burger, Alexander Mironov, Alberto Luini and Daniela Corda

Crystal structures of the membrane-binding C2 domain of human coagulation factor V pp. 434-439

Sandra Macedo-Ribeiro, Wolfram Bode, Robert Huber, Mary Ann Quinn-Allen, Suhng Wook Kim, Thomas L. Ortel, Gleb P. Bourenkov, Hans D. Bartunik, Milton T. Stubbs, William H. Kane and Pablo Fuentes-Prior

Structure of the C2 domain of human factor VIII at 1.5 Å resolution pp. 439-442

Kathleen P. Pratt, Betty W. Shen, Kazuya Takeshima, Earl W. Davie, Kazuo Fujikawa and Barry L. Stoddard

addendum: Energetic constraints on the diet of terrestrial carnivores pp. 442-442

Chris Carbone, Georgina M. Mace, S. Craig Roberts and David W. Macdonald

1999, volume 402, articles 6759

Scientists reel after Indian cyclone pp. 219-219

K.S. Jayaraman

Alliance of US labs plans to build map of cell signalling pathways pp. 219-220

Alison Abbott

Japan calls for partnership to develop semiconductors pp. 220-220

Asako Saegusa

France could face ‘scientific recession’, warns council pp. 221-221

Heather McCabe

Concern over Mars Lander as inquiry reports on Orbiter loss pp. 221-222

Tony Reichhardt

Professors use web to catch students who plagiarize… pp. 222-222

Rex Dalton

… and author gets similar paper retracted pp. 222-222

Rex Dalton

Privatization of UK weapons labs under fire pp. 223-223

Natasha Loder

Jobs boost for Spanish science pp. 223-224

Xavier Bosch

Opposition pledges to raise New Zealand science budget pp. 224-224

Peter Pockley

Body takes centre stage in UK's Millennium Dome pp. 224-224

Natasha Loder

AZT critics ‘swayed South African president’ pp. 225-225

Mike Cherry

Russian peace researcher detained pp. 225-225

Carl Levitin

Bureaucracy blights Japan's safety record pp. 229-230

Kazuo Inoue

Genetically modified foods face rigorous safety evaluation pp. 229-229

M. J. Gasson

Challenge for global e-journal project pp. 230-230

Lance Sultzbaugh

How the Church moves with the times pp. 230-230

Guy Consolmagno

Unfair exchange pp. 230-230

David Colquhoun

Much food, many problems pp. 231-232

Anthony Trewavas

Creating a climate for change pp. 233-234

Nancy Kete

Let them think cake pp. 234-235

Marian Stamp Dawkins

Cajal's scientific prescience revisited pp. 235-236

Harvey J. Karten

Science in culture pp. 236-236

Martin Kemp

Achilles and the maggots pp. 237-237

Paolo Mazzarello

When thought-mail fails pp. 239-239

Ian Watson

Fishing for function in noise pp. 241-242

James J. Collins

Open season for solid frameworks pp. 242-243

Michael J. Zaworotko

Mutant mice live longer pp. 243-245

Leonard Guarente

Molten rocks in motion pp. 245-247

Michael R. Perfit

What makes ATP synthase spin? pp. 247-249

Paul D. Boyer

Frankenstein lives! pp. 249-249

David Jones

Guido Pontecorvo (1907–99) pp. 250-250

Obaid Siddiqi

Why ‘false’ colours are seen by butterflies pp. 251-251

Almut Kelber

Ferromagnetism in the hexaborides pp. 251-253

M. E. Zhitomirsky, T. M. Rice and V. I. Anisimov

Variable cell number in nematodes pp. 253-253

Ana Cunha, Ricardo B. R. Azevedo, Scott W. Emmons and Armand M. Leroi

Growing Y-junction carbon nanotubes pp. 253-254

Jing Li, Chris Papadopoulos and Jimmy Xu

Selecting and maintaining a diverse T-cell repertoire pp. 255-262

Ananda W. Goldrath and Michael J. Bevan

Structural changes linked to proton translocation by subunit c of the ATP synthase pp. 263-268

Vinit K. Rastogi and Mark E. Girvin

A low-temperature origin for the planetesimals that formed Jupiter pp. 269-270

Tobias Owen, Paul Mahaffy, H. B. Niemann, Sushil Atreya, Thomas Donahue, Akiva Bar-Nun and Imke de Pater

Lithium nucleosynthesis in the Sun inferred from the solar-wind 7Li/6Li ratio pp. 270-273

Marc Chaussidon and François Robert

Carbon nanotube intramolecular junctions pp. 273-276

Zhen Yao, Henk W. Ch. Postma, Leon Balents and Cees Dekker

Design and synthesis of an exceptionally stable and highly porous metal-organic framework pp. 276-279

Hailian Li, Mohamed Eddaoudi, M. O'Keeffe and O. M. Yaghi

Abrupt termination of the 1997–98 El Niño in response to a Madden–Julian oscillation pp. 279-282

Yukari N. Takayabu, Toshio Iguchi, Misako Kachi, Akira Shibata and Hiroshi Kanzawa

Combined dynamic and geochemical evidence for convergent melt flow beneath the East Pacific Rise pp. 282-285

Marc Spiegelman and Jennifer R. Reynolds

Energetic constraints on the diet of terrestrial carnivores pp. 286-288

Chris Carbone, Georgina M. Mace, S. Craig Roberts and David W. Macdonald

Total lipid energy as a proxy for total egg production by fish stocks pp. 288-290

C. Tara Marshall, Nathalia A. Yaragina, Yvan Lambert and Olav S. Kjesbu

Use of behavioural stochastic resonance by paddle fish for feeding pp. 291-294

David F. Russell, Lon A. Wilkens and Frank Moss

The amygdala modulates prefrontal cortex activity relative to conditioned fear pp. 294-296

René Garcia, Rose-Marie Vouimba, Michel Baudry and Richard F. Thompson

Kainate receptors are involved in synaptic plasticity pp. 297-301

Zuner A. Bortolotto, Vernon R. J. Clarke, Caroline M. Delany, Michael C. Parry, Ilse Smolders, Michel Vignes, Ken H. Ho, Peter Miu, Bradford T. Brinton, Robert Fantaske, Ann Ogden, Mary Gates, Paul L. Ornstein, David Lodge, David Bleakman and Graham L. Collingridge

Activation of the epithelial Na+ channel (ENaC) requires CFTR Cl- channel function pp. 301-304

M. M. Reddy, M. J. Light and P. M. Quinton

Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand pp. 304-309

Young-Yun Kong, Ulrich Feige, Iidiko Sarosi, Brad Bolon, Anna Tafuri, Sean Morony, Casey Capparelli, Ji Li, Robin Elliott, Susan McCabe, Thomas Wong, Giuseppe Campagnuolo, Erika Moran, Earl R. Bogoch, Gwyneth Van, Linh T. Nguyen, Pamela S. Ohashi, David L. Lacey, Eleanor Fish, William J. Boyle and Josef M. Penninger

The p66shc adaptor protein controls oxidative stress response and life span in mammals pp. 309-313

Enrica Migliaccio, Marco Giorgio, Simonetta Mele, Giuliana Pelicci, Paolo Reboldi, Pier Paolo Pandolfi, Luisa Lanfrancone and Pier Giuseppe Pelicci

Structural insights into phosphoinositide 3-kinase catalysis and signalling pp. 313-320

Edward H. Walker, Olga Perisic, Christian Ried, Len Stephens and Roger L. Williams

Sustained oscillations in living cells pp. 320-322

Sune Danø, Preben Graae Sørensen and Finn Hynne

A ribozyme that lacks cytidine pp. 323-325

Jeff Rogers and Gerald F. Joyce

1999, volume 402, articles 6758

Career choices for scientists: an introduction pp. 3-3

Helen Gavaghan

Australia ‘tops per capita emissions’ pp. 109-109

Peter Pockley

US universities find that demand for botanists exceeds supply pp. 109-110

Rex Dalton

Publishing group offers peer review on PubMed Central pp. 110-110

Declan Butler

Ukraine denies arresting biologist pp. 110-110

Natasha Loder

Daresbury senses victory in battle for UK synchrotron pp. 111-111

Natasha Loder and Heather McCabe

Cambridge, UK, hopes MIT magic will work on joint institute pp. 111-111

Colin Macilwain

Race is on to find successor to Varmus at NIH pp. 112-112

Meredith Wadman

Surprise boost for stem-cell work pp. 112-112

Colin Macilwain

German scientists must repay fees pp. 113-114

Quirin Schiermeier

University debate boils over in Australia pp. 113-113

Peter Pockley

Israel shuts four ‘incubators’ for high-tech companies pp. 114-114

Haim Watzman

$2m ransom sought for kidnapped ecologists pp. 114-114

Carl Levitin

Publishers map out a way forward in response to free online archives pp. 115-115

Declan Butler

Survey confirms fears about licensing of genetic tests pp. 118-118

Anna Schissel, Jon F. Merz and Mildred K. Cho

Parents need catch-up courses to boost careers pp. 118-118

Wendy Powell

Lacking cover pp. 118-118

Vani Kalyanaraman

Lessons in molecular gymnastics pp. 119-120

Philip Ball

Evolutionary play on maternal behaviour pp. 120-121

Kristen Hawkes

Rocks of the ages pp. 121-121

Robert W. Buddemeier

Growing old in Germany pp. 122-122

John Grimley Evans

Dark on a light subject pp. 123-123

Brian Pippard

Homo sapiens declared extinct pp. 125-125

Bruce Sterling

Survival of the weakest pp. 127-128

Erik Asphaug

Policing rogue genes pp. 128-129

Rueyling Lin and Leon Avery

Distorting sex ratios pp. 131-132

Keith R. Willison

Through a glass, lightly pp. 132-133

A. Lindsay Greer

Dual control of mitotic exit pp. 133-135

Susanne Prinz and Angelika Amon

Knocking out nodules pp. 135-136

Herman P. Spaink

Asteroidal defence pp. 136-136

David Jones

Motherhood improves learning and memory pp. 137-138

Craig H. Kinsley, Lisa Madonia, Gordon W. Gifford, Kara Tureski, Garrett R. Griffin, Catherine Lowry, Jamison Williams, Jennifer Collins, Heather McLearie and Kelly G. Lambert

Fractal modes in unstable resonators pp. 138-138

G. P. Karman, G. S. McDonald, G. H. C. New and J. P. Woerdman

Dichromatism in macaque monkeys pp. 139-140

Akishi Onishi, Satoshi Koike, Miki Ida, Hiroo Imai, Yoshinori Shichida, Osamu Takenaka, Akitoshi Hanazawa, Hidehiko Konatsu, Akichika Mikami, Shunji Goto, Bambang Suryobrotoq, Kenji Kitahara and Tetsuo Yamamori

Seed germination in rainforest fragments pp. 139-139

Emilio M. Bruna

A protein kinase encoded by the t complex responder gene causes non-mendelian inheritance pp. 141-146

Bernhard G. Herrmann, Birgit Koschorz, Karin Wertz, K. John McLaughlin and Andreas Kispert

Identification of in vivo substrates of the chaperonin GroEL pp. 147-154

Walid A. Houry, Dmitrij Frishman, Christoph Eckerskorn, Friedrich Lottspeich and F. Ulrich Hartl

Compaction as the origin of the unusual craters on the asteroid Mathilde pp. 155-157

Kevin R. Housen, Keith A. Holsapple and Michael E. Voss

Spatial sampling of crystal electrons by in-flight annihilation of fast positrons pp. 157-160

A. W. Hunt, D. B. Cassidy, F. A. Selim, R. Haakenaasen, T. E. Cowan, R. H. Howell, K. G. Lynn and J. A. Golovchenko

Diffusion mechanisms in metallic supercooled liquids and glasses pp. 160-162

X.-P. Tang, Ulrich Geyer, Ralf Busch, William L. Johnson and Yue Wu

Diamond formation by thermal activation of graphite pp. 162-165

A. V. Palnichenko, A. M. Jonas, J.-C. Charlier, A. S. Aronin and J.-P. Issi

Modulation of cadmium uptake in phytoplankton by seawater CO2 concentration pp. 165-167

Jay T. Cullen, Todd W. Lane, François M. M. Morel and Robert M. Sherrell

Influence of NOx emissions from ships on tropospheric photochemistry and climate pp. 167-170

Mark G. Lawrence and Paul J. Crutzen

A polar vortex in the Earth's core pp. 170-173

Peter Olson and Jonathan Aurnou

The insidious effect of diatoms on copepod reproduction pp. 173-176

A. Miralto, G. Barone, G. Romano, S. A. Poulet, A. Ianora, G. L. Russo, I. Buttino, Gianluca Mazzarella, M. Laabir, M. Cabrini and M. G. Giacobbe

Signal but not noise changes with perceptual learning pp. 176-178

J. Gold, P. J. Bennett and A. B. Sekuler

Conflict monitoring versus selection-for-action in anterior cingulate cortex pp. 179-181

Matthew Botvinick, Leigh E. Nystrom, Kate Fissell, Cameron S. Carter and Jonathan D. Cohen

Two functionally distinct α2-adrenergic receptors regulate sympathetic neurotransmission pp. 181-184

Lutz Hein, John D. Altman and Brian K. Kobilka

Rapid gating and anion permeability of an intracellular aquaporin pp. 184-187

Masato Yasui, Akihiro Hazama, Tae-Hwan Kwon, Søren Nielsen, Wm. B. Guggino and Peter Agre

Chromosome instability and immunodeficiency syndrome caused by mutations in a DNA methyltransferase gene pp. 187-191

Guo-Liang Xu, Timothy H. Bestor, Déborah Bourc'his, Chih-Lin Hsieh, Niels Tommerup, Merete Bugge, Maj Hulten, Xiaoyan Qu, James J. Russo and Evani Viegas-Péquignot

A plant regulator controlling development of symbiotic root nodules pp. 191-195

Leif Schauser, Andreas Roussis, Jiri Stiller and Jens Stougaard

CaMKII regulates the density of central glutamatergic synapses in vivo pp. 195-199

Christopher Rongo and Joshua M. Kaplan

Diverse behavioural defects caused by mutations in Caenorhabditis elegans unc-43 CaM Kinase II pp. 199-203

David J. Reiner, Elizabeth M. Newton, Hong Tian and James H. Thomas

APCCdc20 promotes exit from mitosis by destroying the anaphase inhibitor Pds1 and cyclin Clb5 pp. 203-207

Masaki Shirayama, Attila Tóth, Marta Gálová and Kim Nasmyth

The RNA splicing factor hSlu7 is required for correct 3′ splice-site choice pp. 207-210

Katrin Chua and Robin Reed

From bench to bedside… research makes the translational transition pp. 213-215

Brendan Horton

Improving the plight of the physician–scientist in the US pp. 215-216

Diane Gershon

Clinical research in practice pp. 215-215

Diane Gershon

1999, volume 402, articles 6757

South Africa says AIDS drug ‘toxic’ pp. 3-3

Michael Cherry

Life science facilities in crisis as Brussels switches off funding pp. 3-4

Declan Butler

Framework funding ban hits mouse mutant archive pp. 4-4

Alison Abbott

Californian universities scrap hospitals merger pp. 5-5

Rex Dalton

Silicon pioneer funds biomedical engineering centre pp. 5-5

Rex Dalton

NIH panel to limit secrecy on gene therapy pp. 6-6

Meredith Wadman

Protests grow over interrogation of Ukraine scientists pp. 6-6

Natasha Loder

Threats to US primate researchers pp. 7-8

Steve Nadis

NASA relativity probe facing costly delay pp. 7-7

Tony Reichhardt

French scientists resign from Allègre's advisory council pp. 8-8

Heather McCabe

Japan plans ethics guidelines pp. 8-8

Asako Saegusa

Providing support and a voice for Europe's young researchers pp. 9-9

Natasha Loder

Europe must grant crucial funds for biological research pp. 12-12

Michael Ashburner

University becomes political football pp. 12-12

Georges Dreyfus

Making no sense, making money pp. 13-13

Alison Mitchell

Making sense, making money pp. 13-14

Norman Myers

Condensed physics matters pp. 14-15

Philip W. Anderson

Simple twists of fate pp. 15-16

Jonathan Hodgkin

Science in culture pp. 16-16

John Carmody

Are you serious, Dr Mitchell? pp. 17-17

Leslie E. Orgel

Improving the neighbourhood pp. 19-19

Arthur C. Clarke

Catching the first fish pp. 21-22

Philippe Janvier

Maxwell's other demon pp. 22-23

Frank Wilczek

Functional links between proteins pp. 23-26

Andrej Šali

Latest spin on the core pp. 26-27

F. A. Dahlen

Linking catalysts to chemistry pp. 27-29

Robert Freedman

Clumps that survive to tell a tale pp. 29-30

Sidney van den Bergh

Grabbing phosphoproteins pp. 30-31

Michael B. Yaffe and Lewis C. Cantley

Chain in miniature pp. 31-31

David Jones

Trans-gender induction of hair follicles pp. 33-34

Amanda J. Reynolds, Clifford Lawrence, Peter B. Cserhalmi-Friedman, Angela M. Christiano and Colin A. B. Jahoda

Restoration of an inbred adder population pp. 34-35

Thomas Madsen, Richard Shine, Mats Olsson and Håkan Wittzell

The world smells different to each nostril pp. 35-35

Noam Sobel, Rehan M. Khan, Amnon Saltman, Edith V. Sullivan and John D. E. Gabrieli

Trichromatic vision in prosimians pp. 36-36

Ying Tan and Wen-Hsiung Li

Nonlinear dynamics of lava dome extrusion pp. 37-41

O. Melnik and R. S. J. Sparks

Lower Cambrian vertebrates from south China pp. 42-46

D-G. Shu, H-L. Luo, S. Conway Morris, X-L. Zhang, S-X. Hu, L. Chen, J. Han, M. Zhu, Y. Li and L-Z. Chen

Natural engineering principles of electron tunnelling in biological oxidation–reduction pp. 47-52

Christopher C. Page, Christopher C. Moser, Xiaoxi Chen and P. Leslie Dutton

Debris streams in the solar neighbourhood as relicts from the formation of the Milky Way pp. 53-55

Amina Helmi, Simon D. M. White, P. Tim de Zeeuw and HongSheng Zhao

Multiple stellar populations in the globular cluster ω Centauri as tracers of a merger event pp. 55-57

Y.-W. Lee, J.-M. Joo, Y.-J. Sohn, S.-C. Rey, H.-c. Lee and A. R. Walker

Discovery of a planet orbiting a binary star system from gravitational microlensing pp. 57-59

D. P. Bennett, S. H. Rhie, A. C. Becker, N. Butler, J. Dann, S. Kaspi, E. M. Leibowitz, Y. Lipkin, D. Maoz, H. Mendelson, B. A. Peterson, J. Quinn, O. Shemmer, S. Thomson and S. E. Turner

The inverse band-structure problem of finding an atomic configuration with given electronic properties pp. 60-63

Alberto Franceschetti and Alex Zunger

Frozen-bed Fennoscandian and Laurentide ice sheets during the Last Glacial Maximum pp. 63-66

Johan Kleman and Clas Hättestrand

Limits on differential rotation of the inner core from an analysis of the Earth's free oscillations pp. 66-69

Gabi Laske and Guy Masters

Environmental warming alters food-web structure and ecosystem function pp. 69-72

Owen L. Petchey, P. Timon McPhearson, Timothy M. Casey and Peter J. Morin

A network of fast-spiking cells in the neocortex connected by electrical synapses pp. 72-75

Mario Galarreta and Shaul Hestrin

Two networks of electrically coupled inhibitory neurons in neocortex pp. 75-79

Jay R. Gibson, Michael Beierlein and Barry W. Connors

Complex lipid determines tissue-specific replication of Mycobacterium tuberculosis in mice pp. 79-83

Jeffery S. Cox, Bing Chen, Michael McNeil and William R. Jacobs

A combined algorithm for genome-wide prediction of protein function pp. 83-86

Edward M. Marcotte, Matteo Pellegrini, Michael J. Thompson, Todd O. Yeates and David Eisenberg

Protein interaction maps for complete genomes based on gene fusion events pp. 86-90

Anton J. Enright, Ioannis Iliopoulos, Nikos C. Kyrpides and Christos A. Ouzounis

Glycoproteins form mixed disulphides with oxidoreductases during folding in living cells pp. 90-93

Maurizio Molinari and Ari Helenius

The CoRNR motif controls the recruitment of corepressors by nuclear hormone receptors pp. 93-96

Xiao Hu and Mitchell A. Lazar

Mitochondrial DNA repairs double-strand breaks in yeast chromosomes pp. 96-100

Miria Ricchetti, Cécile Fairhead and Bernard Dujon

Mechanical unfolding intermediates in titin modules pp. 100-103

Piotr E. Marszalek, Hui Lu, Hongbin Li, Mariano Carrion-Vazquez, Andres F. Oberhauser, Klaus Schulten and Julio M. Fernandez