IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice

Martin Holzenberger (), Joëlle Dupont, Bertrand Ducos, Patricia Leneuve, Alain Géloën, Patrick C. Even, Pascale Cervera and Yves Le Bouc
Additional contact information
Martin Holzenberger: Hôpital Saint-Antoine
Joëlle Dupont: Institut National de la Recherche Agronomique
Bertrand Ducos: Hôpital Saint-Antoine
Patricia Leneuve: Hôpital Saint-Antoine
Alain Géloën: Institut National de la Santé et de la Recherche Médicale U352, INSA
Patrick C. Even: Institut National de la Recherche Agronomique, INA P-G
Pascale Cervera: Hôpital Saint-Antoine
Yves Le Bouc: Hôpital Saint-Antoine

Nature, 2003, vol. 421, issue 6919, 182-187

Abstract: Abstract Studies in invertebrates have led to the identification of a number of genes that regulate lifespan, some of which encode components of the insulin or insulin-like signalling pathways1,2,3. Examples include the related tyrosine kinase receptors InR (Drosophila melanogaster) and DAF-2 (Caenorhabditis elegans) that are homologues of the mammalian insulin-like growth factor type 1 receptor (IGF-1R). To investigate whether IGF-1R also controls longevity in mammals, we inactivated the IGF-1R gene in mice (Igf1r). Here, using heterozygous knockout mice because null mutants are not viable, we report that Igf1r+/- mice live on average 26% longer than their wild-type littermates (P

Date: 2003
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DOI: 10.1038/nature01298

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