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2016, volume 536, articles 7617

Career guide: Asia-Pacific pp. S1-S1

Nic Fleming

Isotopic composition of plant water sources pp. E1-E3

Mathieu Javaux, Youri Rothfuss, Jan Vanderborght, Harry Vereecken and Nicolas Brüggemann

Evaristo et al. reply pp. E3-E3

J. Evaristo, S. Jasechko and J. J. McDonnell

China pp. S6-S8

Rebecca Kanthor

Japan pp. S14-S16

Smriti Mallapaty

Australia pp. S18-S20

Karen McGhee

South Korea pp. S22-S23

Mark Zastrow

India pp. S26-S27

T.V. Padma

Singapore pp. S28-S29

Tom Benner

New Zealand pp. S30-S31

Annabel McGilvray

China's soil plan needs strong support pp. 375-375

Hong Yang

Earth-sized planet around nearby star is astronomy dream come true pp. 381-382

Alexandra Witze

US personalized-medicine industry takes hit from Supreme Court pp. 382-382

Heidi Ledford

China, Japan, CERN: Who will host the next LHC? pp. 383-384

Elizabeth Gibney

Obama’s science legacy: betting big on biomedical science pp. 385-386

Heidi Ledford

Obama’s science legacy: uneven progress on scientific integrity pp. 386-387

Richard Monastersky

Obama’s science legacy: a space race stalls pp. 386-386

Alexandra Witze

Obama’s science legacy: climate (policy) hots up pp. 387-387

Jeff Tollefson

Busting the billion-dollar myth: how to slash the cost of drug development pp. 388-390

Amy Maxmen

Expand the frontiers of urban sustainability pp. 391-393

David Wachsmuth, Daniel Aldana Cohen and Hillary Angelo

In retrospect: Flowers for Algernon pp. 394-395

Ananyo Bhattacharya

Books in brief pp. 395-395

Barbara Kiser

Don't let climate crush coral efforts pp. 396-396

Jennifer McGowan, Hugh P. Possingham and Ken Anthony

Social changes affect water quality too pp. 396-396

Alec Rolston

Stop marginalizing rare syndromes pp. 396-396

Svein Olav Kolset

Venezuela's brain drain is accelerating pp. 396-396

Jaime Requena

Strengthen China's flood control pp. 396-396

Yang Zhou, Yansui Liu and Wenxiang Wu

Alfred G. Knudson (1922–2016) pp. 397-397

Carlo M. Croce

Generation soft pp. 400-401

Barbara Mazzolai and Virgilio Mattoli

Friendly neighbours feed tumour cells pp. 401-402

Jurre J. Kamphorst and Eyal Gottlieb

Signal locked in pp. 402-404

Kimberley C. Snowden and Bart J. Janssen

Fleeting glimpse of an elusive element pp. 404-405

Thomas E. Albrecht-Schmitt

Memories linked within a window of time pp. 405-406

Howard Eichenbaum

Mitotic regulation comes into focus pp. 407-408

David O. Morgan

Earth-like planet around Sun's neighbour pp. 408-409

Artie P. Hatzes

Early onset of industrial-era warming across the oceans and continents pp. 411-418

Nerilie J. Abram, Helen V. McGregor, Jessica E. Tierney, Michael N. Evans, Nicholas P. McKay and Darrell S. Kaufman

Genomic insights into the origin of farming in the ancient Near East pp. 419-424

Iosif Lazaridis, Dani Nadel, Gary Rollefson, Deborah C. Merrett, Nadin Rohland, Swapan Mallick, Daniel Fernandes, Mario Novak, Beatriz Gamarra, Kendra Sirak, Sarah Connell, Kristin Stewardson, Eadaoin Harney, Qiaomei Fu, Gloria Gonzalez-Fortes, Eppie R. Jones, Songül Alpaslan Roodenberg, György Lengyel, Fanny Bocquentin, Boris Gasparian, Janet M. Monge, Michael Gregg, Vered Eshed, Ahuva-Sivan Mizrahi, Christopher Meiklejohn, Fokke Gerritsen, Luminita Bejenaru, Matthias Blüher, Archie Campbell, Gianpiero Cavalleri, David Comas, Philippe Froguel, Edmund Gilbert, Shona M. Kerr, Peter Kovacs, Johannes Krause, Darren McGettigan, Michael Merrigan, D. Andrew Merriwether, Seamus O'Reilly, Martin B. Richards, Ornella Semino, Michel Shamoon-Pour, Gheorghe Stefanescu, Michael Stumvoll, Anke Tönjes, Antonio Torroni, James F. Wilson, Loic Yengo, Nelli A. Hovhannisyan, Nick Patterson, Ron Pinhasi and David Reich

Uncovering Earth’s virome pp. 425-430

David Paez-Espino, Emiley A. Eloe-Fadrosh, Georgios A. Pavlopoulos, Alex D. Thomas, Marcel Huntemann, Natalia Mikhailova, Edward Rubin, Natalia N. Ivanova and Nikos C. Kyrpides

Molecular basis of APC/C regulation by the spindle assembly checkpoint pp. 431-436

Claudio Alfieri, Leifu Chang, Ziguo Zhang, Jing Yang, Sarah Maslen, Mark Skehel and David Barford

A terrestrial planet candidate in a temperate orbit around Proxima Centauri pp. 437-440

Guillem Anglada-Escudé, Pedro J. Amado, John Barnes, Zaira M. Berdiñas, R. Paul Butler, Gavin A. L. Coleman, Ignacio de la Cueva, Stefan Dreizler, Michael Endl, Benjamin Giesers, Sandra V. Jeffers, James S. Jenkins, Hugh R. A. Jones, Marcin Kiraga, Martin Kürster, Marίa J. López-González, Christopher J. Marvin, Nicolás Morales, Julien Morin, Richard P. Nelson, José L. Ortiz, Aviv Ofir, Sijme-Jan Paardekooper, Ansgar Reiners, Eloy Rodríguez, Cristina Rodrίguez-López, Luis F. Sarmiento, John P. Strachan, Yiannis Tsapras, Mikko Tuomi and Mathias Zechmeister

Extending the lifetime of a quantum bit with error correction in superconducting circuits pp. 441-445

Nissim Ofek, Andrei Petrenko, Reinier Heeres, Philip Reinhold, Zaki Leghtas, Brian Vlastakis, Yehan Liu, Luigi Frunzio, S. M. Girvin, L. Jiang, Mazyar Mirrahimi, M. H. Devoret and R. J. Schoelkopf

Molecular modifiers reveal a mechanism of pathological crystal growth inhibition pp. 446-450

Jihae Chung, Ignacio Granja, Michael G. Taylor, Giannis Mpourmpakis, John R. Asplin and Jeffrey D. Rimer

An integrated design and fabrication strategy for entirely soft, autonomous robots pp. 451-455

Michael Wehner, Ryan L. Truby, Daniel J. Fitzgerald, Bobak Mosadegh, George M. Whitesides, Jennifer A. Lewis and Robert J. Wood

Biodiversity at multiple trophic levels is needed for ecosystem multifunctionality pp. 456-459

Santiago Soliveres, Fons van der Plas, Peter Manning, Daniel Prati, Martin M. Gossner, Swen C. Renner, Fabian Alt, Hartmut Arndt, Vanessa Baumgartner, Julia Binkenstein, Klaus Birkhofer, Stefan Blaser, Nico Blüthgen, Steffen Boch, Stefan Böhm, Carmen Börschig, Francois Buscot, Tim Diekötter, Johannes Heinze, Norbert Hölzel, Kirsten Jung, Valentin H. Klaus, Till Kleinebecker, Sandra Klemmer, Jochen Krauss, Markus Lange, E. Kathryn Morris, Jörg Müller, Yvonne Oelmann, Jörg Overmann, Esther Pašalić, Matthias C. Rillig, H. Martin Schaefer, Michael Schloter, Barbara Schmitt, Ingo Schöning, Marion Schrumpf, Johannes Sikorski, Stephanie A. Socher, Emily F. Solly, Ilja Sonnemann, Elisabeth Sorkau, Juliane Steckel, Ingolf Steffan-Dewenter, Barbara Stempfhuber, Marco Tschapka, Manfred Türke, Paul C. Venter, Christiane N. Weiner, Wolfgang W. Weisser, Michael Werner, Catrin Westphal, Wolfgang Wilcke, Volkmar Wolters, Tesfaye Wubet, Susanne Wurst, Markus Fischer and Eric Allan

The TRPM2 ion channel is required for sensitivity to warmth pp. 460-463

Chun-Hsiang Tan and Peter A. McNaughton

The prion protein is an agonistic ligand of the G protein-coupled receptor Adgrg6 pp. 464-468

Alexander Küffer, Asvin K. K. Lakkaraju, Amit Mogha, Sarah C. Petersen, Kristina Airich, Cédric Doucerain, Rajlakshmi Marpakwar, Pamela Bakirci, Assunta Senatore, Arnaud Monnard, Carmen Schiavi, Mario Nuvolone, Bianka Grosshans, Simone Hornemann, Frederic Bassilana, Kelly R. Monk and Adriano Aguzzi

DWARF14 is a non-canonical hormone receptor for strigolactone pp. 469-473

Ruifeng Yao, Zhenhua Ming, Liming Yan, Suhua Li, Fei Wang, Sui Ma, Caiting Yu, Mai Yang, Li Chen, Linhai Chen, Yuwen Li, Chun Yan, Di Miao, Zhongyuan Sun, Jianbin Yan, Yuna Sun, Lei Wang, Jinfang Chu, Shilong Fan, Wei He, Haiteng Deng, Fajun Nan, Jiayang Li, Zihe Rao, Zhiyong Lou and Daoxin Xie

Vaccine protection against Zika virus from Brazil pp. 474-478

Rafael A. Larocca, Peter Abbink, Jean Pierre S. Peron, Paolo M. de A. Zanotto, M. Justin Iampietro, Alexander Badamchi-Zadeh, Michael Boyd, David Ng’ang’a, Marinela Kirilova, Ramya Nityanandam, Noe B. Mercado, Zhenfeng Li, Edward T. Moseley, Christine A. Bricault, Erica N. Borducchi, Patricia B. Giglio, David Jetton, George Neubauer, Joseph P. Nkolola, Lori F. Maxfield, Rafael A. De La Barrera, Richard G. Jarman, Kenneth H. Eckels, Nelson L. Michael, Stephen J. Thomas and Dan H. Barouch

Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion pp. 479-483

Cristovão M. Sousa, Douglas E. Biancur, Xiaoxu Wang, Christopher J. Halbrook, Mara H. Sherman, Li Zhang, Daniel Kremer, Rosa F. Hwang, Agnes K. Witkiewicz, Haoqiang Ying, John M. Asara, Ronald M. Evans, Lewis C. Cantley, Costas A. Lyssiotis and Alec C. Kimmelman

Diverse activation pathways in class A GPCRs converge near the G-protein-coupling region pp. 484-487

A. J. Venkatakrishnan, Xavier Deupi, Guillaume Lebon, Franziska M. Heydenreich, Tilman Flock, Tamara Miljus, Santhanam Balaji, Michel Bouvier, Dmitry B. Veprintsev, Christopher G. Tate, Gebhard F. X. Schertler and M. Madan Babu

Correction: Corrigendum: Cerebral cavernous malformations arise from endothelial gain of MEKK3–KLF2/4 signalling pp. 488-488

Zinan Zhou, Alan T. Tang, Weng-Yew Wong, Sharika Bamezai, Lauren M. Goddard, Robert Shenkar, Su Zhou, Jisheng Yang, Alexander C. Wright, Matthew Foley, J. Simon C. Arthur, Kevin J. Whitehead, Issam A. Awad, Dean Y. Li, Xiangjian Zheng and Mark L. Kahn

Retraction Note: Odour receptors and neurons for DEET and new insect repellents pp. 488-488

Pinky Kain, Sean Michael Boyle, Sana Khalid Tharadra, Tom Guda, Christine Pham, Anupama Dahanukar and Anandasankar Ray

Erratum: The bacterial DnaA-trio replication origin element specifies single-stranded DNA initiator binding pp. 488-488

Tomas T. Richardson, Omar Harran and Heath Murray

Moonlighting: Dip your toes pp. 489-491

Amy Maxmen

Trade talk: Binational liaison pp. 491-491

Monya Baker

Interdimensional trade benefits pp. 494-494

Brian Trent

2016, volume 536, articles 7616

Define the Anthropocene in terms of the whole Earth pp. 251-251

Clive Hamilton

Mosquito guns and heavy fines: how Cuba kept Zika at bay for so long pp. 257-258

Sara Reardon

Artificial black hole creates its own version of Hawking radiation pp. 258-259

Davide Castelvecchi

Trump’s border-wall pledge threatens delicate desert ecosystems pp. 260-261

Brian Owens

Nobel laureate’s death highlights struggles at Egyptian science hub pp. 260-260

Pakinam Amer and Mohammed Yahia

Morphing neutrinos provide clue to antimatter mystery pp. 261-262

Elizabeth Gibney

Bottles, bags, ropes and toothbrushes: the struggle to track ocean plastics pp. 263-265

Daniel Cressey

The plastics revolution: how chemists are pushing polymers to new limits pp. 266-268

Mark Peplow

Rethink how chemical hazards are tested pp. 269-270

John C. Warner and Jennifer K. Ludwig

Ethics: Taming our technologies pp. 271-272

Steven Aftergood

Q&A: Brenda Keneghan: The polymer conservator pp. 272-273

Elizabeth Gibney

Books in brief pp. 273-273

Barbara Kiser

Royal Society helps guide Brexit science pp. 274-274

Julie Maxton

Being more open about PhD papers pp. 274-274

Joy Burrough-Boenisch

World's last in vitro fertilization ban falls pp. 274-274

Felipe Mora-Bermúdez

Stop vultures from striking aircraft pp. 274-274

Antoni Margalida

Music calculations out of tune pp. 274-274

Adrian Goldman

Sixty years of living polymers pp. 276-277

Gary Patterson

A deep dive into genetic variation pp. 277-278

Jay Shendure

Flipping the sleep switch pp. 278-280

Stephane Dissel and Paul J. Shaw

Elusive active site in focus pp. 280-281

Jay A. Labinger

Mechanics drives cell differentiation pp. 281-282

Berenika Plusa and Anna-Katerina Hadjantonakis

Superconducting electrons go missing pp. 282-283

Jan Zaanen

Analysis of protein-coding genetic variation in 60,706 humans pp. 285-291

Monkol Lek, Konrad J. Karczewski, Eric V. Minikel, Kaitlin E. Samocha, Eric Banks, Timothy Fennell, Anne H. O’Donnell-Luria, James S. Ware, Andrew J. Hill, Beryl B. Cummings, Taru Tukiainen, Daniel P. Birnbaum, Jack A. Kosmicki, Laramie E. Duncan, Karol Estrada, Fengmei Zhao, James Zou, Emma Pierce-Hoffman, Joanne Berghout, David N. Cooper, Nicole Deflaux, Mark DePristo, Ron Do, Jason Flannick, Menachem Fromer, Laura Gauthier, Jackie Goldstein, Namrata Gupta, Daniel Howrigan, Adam Kiezun, Mitja I. Kurki, Ami Levy Moonshine, Pradeep Natarajan, Lorena Orozco, Gina M. Peloso, Ryan Poplin, Manuel A. Rivas, Valentin Ruano-Rubio, Samuel A. Rose, Douglas M. Ruderfer, Khalid Shakir, Peter D. Stenson, Christine Stevens, Brett P. Thomas, Grace Tiao, Maria T. Tusie-Luna, Ben Weisburd, Hong-Hee Won, Dongmei Yu, David M. Altshuler, Diego Ardissino, Michael Boehnke, John Danesh, Stacey Donnelly, Roberto Elosua, Jose C. Florez, Stacey B. Gabriel, Gad Getz, Stephen J. Glatt, Christina M. Hultman, Sekar Kathiresan, Markku Laakso, Steven McCarroll, Mark I. McCarthy, Dermot McGovern, Ruth McPherson, Benjamin M. Neale, Aarno Palotie, Shaun M. Purcell, Danish Saleheen, Jeremiah M. Scharf, Pamela Sklar, Patrick F. Sullivan, Jaakko Tuomilehto, Ming T. Tsuang, Hugh C. Watkins, James G. Wilson, Mark J. Daly and Daniel G. MacArthur

Circadian neuron feedback controls the Drosophila sleep–activity profile pp. 292-297

Fang Guo, Junwei Yu, Hyung Jae Jung, Katharine C. Abruzzi, Weifei Luo, Leslie C. Griffith and Michael Rosbash

Defining the clonal dynamics leading to mouse skin tumour initiation pp. 298-303

Adriana Sánchez-Danés, Edouard Hannezo, Jean-Christophe Larsimont, Mélanie Liagre, Khalil Kass Youssef, Benjamin D. Simons and Cédric Blanpain

Capturing a substrate in an activated RING E3/E2–SUMO complex pp. 304-308

Frederick C. Streich and Christopher D. Lima

Dependence of the critical temperature in overdoped copper oxides on superfluid density pp. 309-311

I. Božović, X. He, J. Wu and A. T. Bollinger

High-efficiency two-dimensional Ruddlesden–Popper perovskite solar cells pp. 312-316

Hsinhan Tsai, Wanyi Nie, Jean-Christophe Blancon, Constantinos C. Stoumpos, Reza Asadpour, Boris Harutyunyan, Amanda J. Neukirch, Rafael Verduzco, Jared J. Crochet, Sergei Tretiak, Laurent Pedesseau, Jacky Even, Muhammad A. Alam, Gautam Gupta, Jun Lou, Pulickel M. Ajayan, Michael J. Bedzyk, Mercouri G. Kanatzidis and Aditya D. Mohite

The active site of low-temperature methane hydroxylation in iron-containing zeolites pp. 317-321

Benjamin E. R. Snyder, Pieter Vanelderen, Max L. Bols, Simon D. Hallaert, Lars H. Böttger, Liviu Ungur, Kristine Pierloot, Robert A. Schoonheydt, Bert F. Sels and Edward I. Solomon

Metallaphotoredox-catalysed sp3–sp3 cross-coupling of carboxylic acids with alkyl halides pp. 322-325

Craig P. Johnston, Russell T. Smith, Simon Allmendinger and David W. C. MacMillan

An early geodynamo driven by exsolution of mantle components from Earth’s core pp. 326-328

James Badro, Julien Siebert and Francis Nimmo

Natural courtship song variation caused by an intronic retroelement in an ion channel gene pp. 329-332

Yun Ding, Augusto Berrocal, Tomoko Morita, Kit D. Longden and David L. Stern

Operation of a homeostatic sleep switch pp. 333-337

Diogo Pimentel, Jeffrey M. Donlea, Clifford B. Talbot, Seoho M. Song, Alexander J. F. Thurston and Gero Miesenböck

A human neurodevelopmental model for Williams syndrome pp. 338-343

Thanathom Chailangkarn, Cleber A. Trujillo, Beatriz C. Freitas, Branka Hrvoj-Mihic, Roberto H. Herai, Diana X. Yu, Timothy T. Brown, Maria C. Marchetto, Cedric Bardy, Lauren McHenry, Lisa Stefanacci, Anna Järvinen, Yvonne M. Searcy, Michelle DeWitt, Wenny Wong, Philip Lai, M. Colin Ard, Kari L. Hanson, Sarah Romero, Bob Jacobs, Anders M. Dale, Li Dai, Julie R. Korenberg, Fred H. Gage, Ursula Bellugi, Eric Halgren, Katerina Semendeferi and Alysson R. Muotri

Asymmetric division of contractile domains couples cell positioning and fate specification pp. 344-348

Jean-Léon Maître, Hervé Turlier, Rukshala Illukkumbura, Björn Eismann, Ritsuya Niwayama, François Nédélec and Takashi Hiiragi

HIV-1 uses dynamic capsid pores to import nucleotides and fuel encapsidated DNA synthesis pp. 349-353

David A. Jacques, William A. McEwan, Laura Hilditch, Amanda J. Price, Greg J. Towers and Leo C. James

Structure of mammalian respiratory complex I pp. 354-358

Jiapeng Zhu, Kutti R. Vinothkumar and Judy Hirst

Correction: Corrigendum: CEACAM1 regulates TIM-3-mediated tolerance and exhaustion pp. 359-359

Yu-Hwa Huang, Chen Zhu, Yasuyuki Kondo, Ana C. Anderson, Amit Gandhi, Andrew Russell, Stephanie K. Dougan, Britt-Sabina Petersen, Espen Melum, Thomas Pertel, Kiera L. Clayton, Monika Raab, Qiang Chen, Nicole Beauchemin, Paul J. Yazaki, Michal Pyzik, Mario A. Ostrowski, Jonathan N. Glickman, Christopher E. Rudd, Hidde L. Ploegh, Andre Franke, Gregory A. Petsko, Vijay K. Kuchroo and Richard S. Blumberg

Correction: Corrigendum: A receptor heteromer mediates the male perception of female attractants in plants pp. 360-360

Tong Wang, Liang Liang, Yong Xue, Peng-Fei Jia, Wei Chen, Meng-Xia Zhang, Ying-Chun Wang, Hong-Ju Li and Wei-Cai Yang

Correction: Corrigendum: Mitochondrial ROS regulate thermogenic energy expenditure and sulfenylation of UCP1 pp. 360-360

Edward T. Chouchani, Lawrence Kazak, Mark P. Jedrychowski, Gina Z. Lu, Brian K. Erickson, John Szpyt, Kerry A. Pierce, Dina Laznik-Bogoslavski, Ramalingam Vetrivelan, Clary B. Clish, Alan J. Robinson, Steve P. Gygi and Bruce M. Spiegelman

Correction: Corrigendum: Mycocerosic acid synthase exemplifies the architecture of reducing polyketide synthases pp. 360-360

Dominik A. Herbst, Roman P. Jakob, Franziska Zähringer and Timm Maier

Let the structural symphony begin pp. 361-363

Stephen Ornes

Work abroad: Visa to visit pp. 365-366

Barbra Rodriguez

Legacy admissions pp. 368-368

S. R. Algernon

2016, volume 536, articles 7615

Steer driverless cars towards full automation pp. 127-127

John Baruch

Hopes for revolutionary new LHC particle dashed pp. 133-134

Elizabeth Gibney

Glider aims to break world record — and boost climate science pp. 134-135

Declan Butler

US agency to lift ban on funding human–animal hybrids pp. 135-135

Sara Reardon

Replications, ridicule and a recluse: the controversy over NgAgo gene-editing intensifies pp. 136-137

David Cyranoski

Beyond CRISPR: A guide to the many other ways to edit a genome pp. 137-137

Heidi Ledford

Plant and animal DNA suggests first Americans took the coastal route pp. 138-138

Ewen Callaway

The bandwidth bottleneck that is throttling the Internet pp. 139-142

Jeff Hecht

Biodiversity: The ravages of guns, nets and bulldozers pp. 143-145

Sean L. Maxwell, Richard A. Fuller, Thomas M. Brooks and James E. M. Watson

Microbiology: Mob rule pp. 146-147

Adrian Woolfson

Books in brief pp. 147-147

Barbara Kiser

Reforms set to seep into India's schools pp. 148-148

Sanchit Misra

Kudos for female Antarctic researchers pp. 148-148

Jan Strugnell

Would Mendel have won it? pp. 148-148

Daniel Hebenstreit

Spot value in grant proposals pp. 148-148

Gabriele Bammer

Satellite company clarifies proposal pp. 148-148

Doug Smith

Fast track for silver pp. 150-151

Tom Nilges

Nanocolumns at the heart of the synapse pp. 151-152

Stephan J. Sigrist and Astrid G. Petzoldt

A modern map of the human cerebral cortex pp. 152-154

B. T. Thomas Yeo and Simon B. Eickhoff

Endothelial-cell killing promotes metastasis pp. 154-155

Claudio R. Alarcón and Sohail F. Tavazoie

The TORC1 pathway to protein destruction pp. 155-156

Lynne Chantranupong and David M. Sabatini

Fat and the fate of pancreatic tumours pp. 157-157

Melek Canan Arkan

Synergistic, ultrafast mass storage and removal in artificial mixed conductors pp. 159-164

Chia-Chin Chen, Lijun Fu and Joachim Maier

Tempo and mode of genome evolution in a 50,000-generation experiment pp. 165-170

Olivier Tenaillon, Jeffrey E. Barrick, Noah Ribeck, Daniel E. Deatherage, Jeffrey L. Blanchard, Aurko Dasgupta, Gabriel C. Wu, Sébastien Wielgoss, Stéphane Cruveiller, Claudine Médigue, Dominique Schneider and Richard E. Lenski

A multi-modal parcellation of human cerebral cortex pp. 171-178

Matthew F. Glasser, Timothy S. Coalson, Emma C. Robinson, Carl D. Hacker, John Harwell, Essa Yacoub, Kamil Ugurbil, Jesper Andersson, Christian F. Beckmann, Mark Jenkinson, Stephen M. Smith and David C. Van Essen

SAR11 bacteria linked to ocean anoxia and nitrogen loss pp. 179-183

Despina Tsementzi, Jieying Wu, Samuel Deutsch, Sangeeta Nath, Luis M. Rodriguez-R, Andrew S. Burns, Piyush Ranjan, Neha Sarode, Rex R. Malmstrom, Cory C. Padilla, Benjamin K. Stone, Laura A. Bristow, Morten Larsen, Jennifer B. Glass, Bo Thamdrup, Tanja Woyke, Konstantinos T. Konstantinidis and Frank J. Stewart

An evolutionarily conserved pathway controls proteasome homeostasis pp. 184-189

Adrien Rousseau and Anne Bertolotti

Heating of Jupiter’s upper atmosphere above the Great Red Spot pp. 190-192

J. O’Donoghue, L. Moore, T. S. Stallard and H. Melin

A photon–photon quantum gate based on a single atom in an optical resonator pp. 193-196

Bastian Hacker, Stephan Welte, Gerhard Rempe and Stephan Ritter

Single-layer MoS2 nanopores as nanopower generators pp. 197-200

Jiandong Feng, Michael Graf, Ke Liu, Dmitry Ovchinnikov, Dumitru Dumcenco, Mohammad Heiranian, Vishal Nandigana, Narayana R. Aluru, Andras Kis and Aleksandra Radenovic

Abrupt plate accelerations shape rifted continental margins pp. 201-204

Sascha Brune, Simon E. Williams, Nathaniel P. Butterworth and R. Dietmar Müller

Emergence of a Homo sapiens-specific gene family and chromosome 16p11.2 CNV susceptibility pp. 205-209

Xander Nuttle, Giuliana Giannuzzi, Michael H. Duyzend, Joshua G. Schraiber, Iñigo Narvaiza, Peter H. Sudmant, Osnat Penn, Giorgia Chiatante, Maika Malig, John Huddleston, Chris Benner, Francesca Camponeschi, Simone Ciofi-Baffoni, Holly A. F. Stessman, Maria C. N. Marchetto, Laura Denman, Lana Harshman, Carl Baker, Archana Raja, Kelsi Penewit, Nicolette Janke, W. Joyce Tang, Mario Ventura, Lucia Banci, Francesca Antonacci, Joshua M. Akey, Chris T. Amemiya, Fred H. Gage, Alexandre Reymond and Evan E. Eichler

A trans-synaptic nanocolumn aligns neurotransmitter release to receptors pp. 210-214

Ai-Hui Tang, Haiwen Chen, Tuo P. Li, Sarah R. Metzbower, Harold D. MacGillavry and Thomas A. Blanpied

Tumour-cell-induced endothelial cell necroptosis via death receptor 6 promotes metastasis pp. 215-218

Boris Strilic, Lida Yang, Julián Albarrán-Juárez, Laurens Wachsmuth, Kang Han, Ulrike C. Müller, Manolis Pasparakis and Stefan Offermanns

Global profiling of SRP interaction with nascent polypeptides pp. 219-223

Daniela Schibich, Felix Gloge, Ina Pöhner, Patrik Björkholm, Rebecca C. Wade, Gunnar von Heijne, Bernd Bukau and Günter Kramer

Cotranslational signal-independent SRP preloading during membrane targeting pp. 224-228

Justin W. Chartron, Katherine C. L. Hunt and Judith Frydman

Mechanism of arginine sensing by CASTOR1 upstream of mTORC1 pp. 229-233

Robert A. Saxton, Lynne Chantranupong, Kevin E. Knockenhauer, Thomas U. Schwartz and David M. Sabatini

Reconstruction of bacterial transcription-coupled repair at single-molecule resolution pp. 234-237

Jun Fan, Mathieu Leroux-Coyau, Nigel J. Savery and Terence R. Strick

Erratum: Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis pp. 238-238

Minoru Takasato, Pei X. Er, Han S. Chiu, Barbara Maier, Gregory J. Baillie, Charles Ferguson, Robert G. Parton, Ernst J. Wolvetang, Matthias S. Roost, Susana M. Chuva de Sousa Lopes and Melissa H. Little

Correction: Corrigendum: Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome pp. 238-238

Benoit Chassaing, Omry Koren, Julia K. Goodrich, Angela C. Poole, Shanthi Srinivasan, Ruth E. Ley and Andrew T. Gewirtz

Erratum: Universal resilience patterns in complex networks pp. 238-238

Jianxi Gao, Baruch Barzel and Albert-László Barabási

Research protocols: A forest of hypotheses pp. 239-241

Julia Rosen

Turning point: Planet navigator pp. 241-241

Smriti Mallapaty

Walls of Nigeria pp. 244-244

Jeremy Szal

2016, volume 536, articles 7614

Donald Trump’s appeal should be a call to arms pp. 7-7

Daniel Sarewitz

Troubled Japanese space agency seeks fresh start pp. 13-14

Alexandra Witze

Monumental proof to torment mathematicians for years to come pp. 14-15

Davide Castelvecchi

Scientists seek influence on ‘Brexit ministry’ pp. 15-16

Elizabeth Gibney

Legal confusion threatens to slow data science pp. 16-17

Simon Oxenham

Scholarly Olympics: How the games have shaped research pp. 18-19

Daniel Cressey, Ramin Skibba and Richard Van Noorden

Welcome to the Cyborg Olympics pp. 20-22

Sara Reardon

Take responsibility for electronic-waste disposal pp. 23-25

Zhaohua Wang, Bin Zhang and Dabo Guan

Economics: Singular currency pp. 26-27

Jonathan Portes

Child development: A cognitive case for un‑parenting pp. 27-28

Josie Glausiusz

China: A hydrological history pp. 28-29

Andrea Janku

China: Change tack to boost basic research pp. 30-30

Raphael K. Didham and Chao-Dong Zhu

China: Standardize R&D costing pp. 30-30

Yutao Sun and Cong Cao

Mentoring female scientists in Africa pp. 30-30

Rose G. F. Leke and S. Kwedi Nolna

Refereed science to guide action on EDCs pp. 30-30

Leonardo Trasande

Death-defying plaque cells pp. 32-33

Ira Tabas

Bacteria synchronized for drug delivery pp. 33-34

Shibin Zhou

A milestone in quantum computing pp. 35-36

Stephen D. Bartlett

Protection for anaesthetized mice pp. 36-37

Laura Cornelissen and Charles Berde

Still a geneticist's nightmare pp. 37-38

Stephen S. Rich

Destruction of discrete charge pp. 38-39

Yuli V. Nazarov

The genetic architecture of type 2 diabetes pp. 41-47

Christian Fuchsberger, Jason Flannick, Tanya M. Teslovich, Anubha Mahajan, Vineeta Agarwala, Kyle J. Gaulton, Clement Ma, Pierre Fontanillas, Loukas Moutsianas, Davis J. McCarthy, Manuel A. Rivas, John R. B. Perry, Xueling Sim, Thomas W. Blackwell, Neil R. Robertson, N. William Rayner, Pablo Cingolani, Adam E. Locke, Juan Fernandez Tajes, Heather M. Highland, Josee Dupuis, Peter S. Chines, Cecilia M. Lindgren, Christopher Hartl, Anne U. Jackson, Han Chen, Jeroen R. Huyghe, Martijn van de Bunt, Richard D. Pearson, Ashish Kumar, Martina Müller-Nurasyid, Niels Grarup, Heather M. Stringham, Eric R. Gamazon, Jaehoon Lee, Yuhui Chen, Robert A. Scott, Jennifer E. Below, Peng Chen, Jinyan Huang, Min Jin Go, Michael L. Stitzel, Dorota Pasko, Stephen C. J. Parker, Tibor V. Varga, Todd Green, Nicola L. Beer, Aaron G. Day-Williams, Teresa Ferreira, Tasha Fingerlin, Momoko Horikoshi, Cheng Hu, Iksoo Huh, Mohammad Kamran Ikram, Bong-Jo Kim, Yongkang Kim, Young Jin Kim, Min-Seok Kwon, Juyoung Lee, Selyeong Lee, Keng-Han Lin, Taylor J. Maxwell, Yoshihiko Nagai, Xu Wang, Ryan P. Welch, Joon Yoon, Weihua Zhang, Nir Barzilai, Benjamin F. Voight, Bok-Ghee Han, Christopher P. Jenkinson, Teemu Kuulasmaa, Johanna Kuusisto, Alisa Manning, Maggie C. Y. Ng, Nicholette D. Palmer, Beverley Balkau, Alena Stančáková, Hanna E. Abboud, Heiner Boeing, Vilmantas Giedraitis, Dorairaj Prabhakaran, Omri Gottesman, James Scott, Jason Carey, Phoenix Kwan, George Grant, Joshua D. Smith, Benjamin M. Neale, Shaun Purcell, Adam S. Butterworth, Joanna M. M. Howson, Heung Man Lee, Yingchang Lu, Soo-Heon Kwak, Wei Zhao, John Danesh, Vincent K. L. Lam, Kyong Soo Park, Danish Saleheen, Wing Yee So, Claudia H. T. Tam, Uzma Afzal, David Aguilar, Rector Arya, Tin Aung, Edmund Chan, Carmen Navarro, Ching-Yu Cheng, Domenico Palli, Adolfo Correa, Joanne E. Curran, Denis Rybin, Vidya S. Farook, Sharon P. Fowler, Barry I. Freedman, Michael Griswold, Daniel Esten Hale, Pamela J. Hicks, Chiea-Chuen Khor, Satish Kumar, Benjamin Lehne, Dorothée Thuillier, Wei Yen Lim, Jianjun Liu, Yvonne T. van der Schouw, Marie Loh, Solomon K. Musani, Sobha Puppala, William R. Scott, Loïc Yengo, Sian-Tsung Tan, Herman A. Taylor, Farook Thameem, Gregory Wilson, Tien Yin Wong, Pål Rasmus Njølstad, Jonathan C. Levy, Massimo Mangino, Lori L. Bonnycastle, Thomas Schwarzmayr, João Fadista, Gabriela L. Surdulescu, Christian Herder, Christopher J. Groves, Thomas Wieland, Jette Bork-Jensen, Ivan Brandslund, Cramer Christensen, Heikki A. Koistinen, Alex S. F. Doney, Leena Kinnunen, Tõnu Esko, Andrew J. Farmer, Liisa Hakaste, Dylan Hodgkiss, Jasmina Kravic, Valeriya Lyssenko, Mette Hollensted, Marit E. Jørgensen, Torben Jørgensen, Claes Ladenvall, Johanne Marie Justesen, Annemari Käräjämäki, Jennifer Kriebel, Wolfgang Rathmann, Lars Lannfelt, Torsten Lauritzen, Narisu Narisu, Allan Linneberg, Olle Melander, Lili Milani, Matt Neville, Marju Orho-Melander, Lu Qi, Qibin Qi, Michael Roden, Olov Rolandsson, Amy Swift, Anders H. Rosengren, Kathleen Stirrups, Andrew R. Wood, Evelin Mihailov, Christine Blancher, Mauricio O. Carneiro, Jared Maguire, Ryan Poplin, Khalid Shakir, Timothy Fennell, Mark DePristo, Martin Hrabé de Angelis, Panos Deloukas, Anette P. Gjesing, Goo Jun, Peter Nilsson, Jacquelyn Murphy, Robert Onofrio, Barbara Thorand, Torben Hansen, Christa Meisinger, Frank B. Hu, Bo Isomaa, Fredrik Karpe, Liming Liang, Annette Peters, Cornelia Huth, Stephen P. O’Rahilly, Colin N. A. Palmer, Oluf Pedersen, Rainer Rauramaa, Jaakko Tuomilehto, Veikko Salomaa, Richard M. Watanabe, Ann-Christine Syvänen, Richard N. Bergman, Dwaipayan Bharadwaj, Erwin P. Bottinger, Yoon Shin Cho, Giriraj R. Chandak, Juliana C. N. Chan, Kee Seng Chia, Mark J. Daly, Shah B. Ebrahim, Claudia Langenberg, Paul Elliott, Kathleen A. Jablonski, Donna M. Lehman, Weiping Jia, Ronald C. W. Ma, Toni I. Pollin, Manjinder Sandhu, Nikhil Tandon, Philippe Froguel, Inês Barroso, Yik Ying Teo, Eleftheria Zeggini, Ruth J. F. Loos, Kerrin S. Small, Janina S. Ried, Ralph A. DeFronzo, Harald Grallert, Benjamin Glaser, Andres Metspalu, Nicholas J. Wareham, Mark Walker, Eric Banks, Christian Gieger, Erik Ingelsson, Hae Kyung Im, Thomas Illig, Paul W. Franks, Gemma Buck, Joseph Trakalo, David Buck, Inga Prokopenko, Reedik Mägi, Lars Lind, Yossi Farjoun, Katharine R. Owen, Anna L. Gloyn, Konstantin Strauch, Tiinamaija Tuomi, Jaspal Singh Kooner, Jong-Young Lee, Taesung Park, Peter Donnelly, Andrew D. Morris, Andrew T. Hattersley, Donald W. Bowden, Francis S. Collins, Gil Atzmon, John C. Chambers, Timothy D. Spector, Markku Laakso, Tim M. Strom, Graeme I. Bell, John Blangero, Ravindranath Duggirala, E. Shyong Tai, Gilean McVean, Craig L. Hanis, James G. Wilson, Mark Seielstad, Timothy M. Frayling, James B. Meigs, Nancy J. Cox, Rob Sladek, Eric S. Lander, Stacey Gabriel, Noël P. Burtt, Karen L. Mohlke, Thomas Meitinger, Leif Groop, Goncalo Abecasis, Jose C. Florez, Laura J. Scott, Andrew P. Morris, Hyun Min Kang, Michael Boehnke, David Altshuler and Mark I. McCarthy

Structural basis of potent Zika–dengue virus antibody cross-neutralization pp. 48-53

Giovanna Barba-Spaeth, Wanwisa Dejnirattisai, Alexander Rouvinski, Marie-Christine Vaney, Iris Medits, Arvind Sharma, Etienne Simon-Lorière, Anavaj Sakuntabhai, Cao-Lormeau Van-Mai, Ahmed Haouz, Patrick England, Karin Stiasny, Juthathip Mongkolsapaya, Franz X. Heinz, Gavin R. Screaton and Félix A. Rey

Bright carbonate deposits as evidence of aqueous alteration on (1) Ceres pp. 54-57

M. C. De Sanctis, A. Raponi, E. Ammannito, M. Ciarniello, M. J. Toplis, H. Y. McSween, J. C. Castillo-Rogez, B. L. Ehlmann, F. G. Carrozzo, S. Marchi, F. Tosi, F. Zambon, F. Capaccioni, M. T. Capria, S. Fonte, M. Formisano, A. Frigeri, M. Giardino, A. Longobardo, G. Magni, E. Palomba, L. A. McFadden, C. M. Pieters, R. Jaumann, P. Schenk, R. Mugnuolo, C. A. Raymond and C. T. Russell

Controlling charge quantization with quantum fluctuations pp. 58-62

S. Jezouin, Z. Iftikhar, A. Anthore, F. D. Parmentier, U. Gennser, A. Cavanna, A. Ouerghi, I. P. Levkivskyi, E. Idrisov, E. V. Sukhorukov, L. I. Glazman and F. Pierre

Demonstration of a small programmable quantum computer with atomic qubits pp. 63-66

S. Debnath, N. M. Linke, C. Figgatt, K. A. Landsman, K. Wright and C. Monroe

Carbon-based tribofilms from lubricating oils pp. 67-71

Ali Erdemir, Giovanni Ramirez, Osman L. Eryilmaz, Badri Narayanan, Yifeng Liao, Ganesh Kamath and Subramanian K. R. S. Sankaranarayanan

Evidence for climate change in the satellite cloud record pp. 72-75

Joel R. Norris, Robert J. Allen, Amato T. Evan, Mark D. Zelinka, Christopher W. O’Dell and Stephen A. Klein

A novel excitatory network for the control of breathing pp. 76-80

Tatiana M. Anderson, Alfredo J. Garcia, Nathan A. Baertsch, Julia Pollak, Jacob C. Bloom, Aguan D. Wei, Karan G. Rai and Jan-Marino Ramirez

Synchronized cycles of bacterial lysis for in vivo delivery pp. 81-85

M. Omar Din, Tal Danino, Arthur Prindle, Matt Skalak, Jangir Selimkhanov, Kaitlin Allen, Ellixis Julio, Eta Atolia, Lev S. Tsimring, Sangeeta N. Bhatia and Jeff Hasty

CD47-blocking antibodies restore phagocytosis and prevent atherosclerosis pp. 86-90

Yoko Kojima, Jens-Peter Volkmer, Kelly McKenna, Mete Civelek, Aldons Jake Lusis, Clint L. Miller, Daniel Direnzo, Vivek Nanda, Jianqin Ye, Andrew J. Connolly, Eric E. Schadt, Thomas Quertermous, Paola Betancur, Lars Maegdefessel, Ljubica Perisic Matic, Ulf Hedin, Irving L. Weissman and Nicholas J. Leeper

Neoantigen landscape dynamics during human melanoma–T cell interactions pp. 91-95

Els M. E. Verdegaal, Noel F. C. C. de Miranda, Marten Visser, Tom Harryvan, Marit M. van Buuren, Rikke S. Andersen, Sine R. Hadrup, Caroline E. van der Minne, Remko Schotte, Hergen Spits, John B. A. G. Haanen, Ellen H. W. Kapiteijn, Ton N. Schumacher and Sjoerd H. van der Burg

eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation pp. 96-99

Amy S. Y. Lee, Philip J. Kranzusch, Jennifer A. Doudna and Jamie H. D. Cate

The structural basis of modified nucleosome recognition by 53BP1 pp. 100-103

Marcus D. Wilson, Samir Benlekbir, Amélie Fradet-Turcotte, Alana Sherker, Jean-Philippe Julien, Andrea McEwan, Sylvie M. Noordermeer, Frank Sicheri, John L. Rubinstein and Daniel Durocher

Structure of the adenosine A2A receptor bound to an engineered G protein pp. 104-107

Byron Carpenter, Rony Nehmé, Tony Warne, Andrew G. W. Leslie and Christopher G. Tate

Architecture of fully occupied GluA2 AMPA receptor–TARP complex elucidated by cryo-EM pp. 108-111

Yan Zhao, Shanshuang Chen, Craig Yoshioka, Isabelle Baconguis and Eric Gouaux

Retraction Note: Effects of electron correlations on transport properties of iron at Earth’s core conditions pp. 112-112

Peng Zhang, R. E. Cohen and K. Haule

Correction: Corrigendum: Flexible high-temperature dielectric materials from polymer nanocomposites pp. 112-112

Qi Li, Lei Chen, Matthew R. Gadinski, Shihai Zhang, Guangzu Zhang, Haoyu U. Li, Elissei Iagodkine, Aman Haque, Long-Qing Chen, Thomas N. Jackson and Qing Wang

Correction: Corrigendum: Structure of promoter-bound TFIID and model of human pre-initiation complex assembly pp. 112-112

Robert K. Louder, Yuan He, José Ramón López-Blanco, Jie Fang, Pablo Chacón and Eva Nogales

‘Kudos’ promises to help scientists promote their papers to new audiences pp. 113-114

Jeffrey Perkel

Conference presentations: Lead the poster parade pp. 115-117

Chris Woolston

Turning point: Kevin Esvelt pp. 117-117

Vijee Venkatraman

Floating in my tin can pp. 120-120

Gerri Leen