Pairwise and higher-order genetic interactions during the evolution of a tRNA

Júlia Domingo, Guillaume Diss and Ben Lehner ()
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Júlia Domingo: Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology
Guillaume Diss: Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology
Ben Lehner: Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology

Nature, 2018, vol. 558, issue 7708, 117-121

Abstract: Abstract A central question in genetics and evolution is the extent to which the outcomes of mutations change depending on the genetic context in which they occur1–3. Pairwise interactions between mutations have been systematically mapped within4–18 and between 19 genes, and have been shown to contribute substantially to phenotypic variation among individuals 20 . However, the extent to which genetic interactions themselves are stable or dynamic across genotypes is unclear21, 22. Here we quantify more than 45,000 genetic interactions between the same 87 pairs of mutations across more than 500 closely related genotypes of a yeast tRNA. Notably, all pairs of mutations interacted in at least 9% of genetic backgrounds and all pairs switched from interacting positively to interacting negatively in different genotypes (false discovery rate

Date: 2018
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DOI: 10.1038/s41586-018-0170-7

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