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2015, volume 527, articles 7579

Ovarian cancer: beyond resistance pp. S217-S217

David Holmes

The problem with platinum pp. S218-S219

David Holmes

A ‘perfect’ agreement in Paris is not essential pp. 411-411

Johan Rockström

Text-mining block prompts online response pp. 413-413

Mollie Bloudoff-Indelicato

Salmon approval heralds rethink of transgenic animals pp. 417-418

Heidi Ledford

Climate optimism builds ahead of Paris talks pp. 418-419

Jeff Tollefson

Green Climate Fund faces slew of criticism pp. 419-420

Sanjay Kumar

Brazilian courts tussle over unproven cancer treatment pp. 420-421

Heidi Ledford

Leap-second decision delayed by eight years pp. 421-422

Elizabeth Gibney

'Digital chimp' trove preserves brains of retired apes pp. 422-423

Sara Reardon

The fragile framework pp. 427-435

Richard Monastersky and Nick Sousanis

Is the 2 °C world a fantasy? pp. 436-438

Jeff Tollefson

Global climate agreement: After the talks pp. 439-441

David G. Victor and James P. Leape

Materials science: Share corrosion data pp. 441-442

Xiaogang Li, Dawei Zhang, Zhiyong Liu, Zhong Li, Cuiwei Du and Chaofang Dong

Sustainability: The launch of Spaceship Earth pp. 443-445

Adam Rome

Books in brief pp. 445-445

Barbara Kiser

Gene editing: Heed disability views pp. 446-446

Tom Shakespeare

Gene editing: Govern ability expectations pp. 446-446

Gregor Wolbring

Gene editing: Survey invites opinions pp. 446-446

Silvia Camporesi and Lara Marks

Climate change also creates expatriates pp. 446-446

Ralf Buckley

Crowdfunding not fit for clinical trials pp. 446-446

Phaik Yeong Cheah

Lessons from EPA on tracking pollutants pp. 446-446

Bo Zhang and Wayne S. Davis

Acorn worms in a nutshell pp. 448-449

Casey W. Dunn

A receptor for subtle temperature changes pp. 449-451

François Rouyer and Abhishek Chatterjee

Super-resolution ultrasound pp. 451-452

Ben Cox and Paul Beard

Transition loses its invasive edge pp. 452-453

Shyamala Maheswaran and Daniel A. Haber

Hidden reservoirs pp. 453-455

Jonathan L. Heeney

The Moon's tilt for gold pp. 455-456

Robin Canup

Assassins of eyesight pp. 456-457

Andrew D. Huberman and Rana N. El-Danaf

Hemichordate genomes and deuterostome origins pp. 459-465

Oleg Simakov, Takeshi Kawashima, Ferdinand Marlétaz, Jerry Jenkins, Ryo Koyanagi, Therese Mitros, Kanako Hisata, Jessen Bredeson, Eiichi Shoguchi, Fuki Gyoja, Jia-Xing Yue, Yi-Chih Chen, Robert M. Freeman, Akane Sasaki, Tomoe Hikosaka-Katayama, Atsuko Sato, Manabu Fujie, Kenneth W. Baughman, Judith Levine, Paul Gonzalez, Christopher Cameron, Jens H. Fritzenwanker, Ariel M. Pani, Hiroki Goto, Miyuki Kanda, Nana Arakaki, Shinichi Yamasaki, Jiaxin Qu, Andrew Cree, Yan Ding, Huyen H. Dinh, Shannon Dugan, Michael Holder, Shalini N. Jhangiani, Christie L. Kovar, Sandra L. Lee, Lora R. Lewis, Donna Morton, Lynne V. Nazareth, Geoffrey Okwuonu, Jireh Santibanez, Rui Chen, Stephen Richards, Donna M. Muzny, Andrew Gillis, Leonid Peshkin, Michael Wu, Tom Humphreys, Yi-Hsien Su, Nicholas H. Putnam, Jeremy Schmutz, Asao Fujiyama, Jr-Kai Yu, Kunifumi Tagawa, Kim C. Worley, Richard A. Gibbs, Marc W. Kirschner, Christopher J. Lowe, Noriyuki Satoh, Daniel S. Rokhsar and John Gerhart

A perisinusoidal niche for extramedullary haematopoiesis in the spleen pp. 466-471

Christopher N. Inra, Bo O. Zhou, Melih Acar, Malea M. Murphy, James Richardson, Zhiyu Zhao and Sean J. Morrison

Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance pp. 472-476

Kari R. Fischer, Anna Durrans, Sharrell Lee, Jianting Sheng, Fuhai Li, Stephen T. C. Wong, Hyejin Choi, Tina El Rayes, Seongho Ryu, Juliane Troeger, Robert F. Schwabe, Linda T. Vahdat, Nasser K. Altorki, Vivek Mittal and Dingcheng Gao

Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65 pp. 477-483

Xi-Ping Huang, Joel Karpiak, Wesley K. Kroeze, Hu Zhu, Xin Chen, Sheryl S. Moy, Kara A. Saddoris, Viktoriya D. Nikolova, Martilias S. Farrell, Sheng Wang, Thomas J. Mangano, Deepak A. Deshpande, Alice Jiang, Raymond B. Penn, Jian Jin, Beverly H. Koller, Terry Kenakin, Brian K. Shoichet and Bryan L. Roth

Extremely metal-poor stars from the cosmic dawn in the bulge of the Milky Way pp. 484-487

L. M. Howes, A. R. Casey, M. Asplund, S. C. Keller, D. Yong, D. M. Nataf, R. Poleski, K. Lind, C. Kobayashi, C. I. Owen, M. Ness, M. S. Bessell, G. S. Da Costa, B. P. Schmidt, P. Tisserand, A. Udalski, M. K. Szymański, I. Soszyński, G. Pietrzyński, K. Ulaczyk, Ł. Wyrzykowski, P. Pietrukowicz, J. Skowron, S. Kozłowski and P. Mróz

Ubiquitous time variability of integrated stellar populations pp. 488-491

Charlie Conroy, Pieter G. van Dokkum and Jieun Choi

Collisionless encounters and the origin of the lunar inclination pp. 492-494

Kaveh Pahlevan and Alessandro Morbidelli

Type-II Weyl semimetals pp. 495-498

Alexey A. Soluyanov, Dominik Gresch, Zhijun Wang, QuanSheng Wu, Matthias Troyer, Xi Dai and B. Andrei Bernevig

Ultrafast ultrasound localization microscopy for deep super-resolution vascular imaging pp. 499-502

Claudia Errico, Juliette Pierre, Sophie Pezet, Yann Desailly, Zsolt Lenkei, Olivier Couture and Mickael Tanter

Extra adsorption and adsorbate superlattice formation in metal-organic frameworks pp. 503-507

Hae Sung Cho, Hexiang Deng, Keiichi Miyasaka, Zhiyue Dong, Minhyung Cho, Alexander V. Neimark, Jeung Ku Kang, Omar M. Yaghi and Osamu Terasaki

Single-molecule sequencing of the desiccation-tolerant grass Oropetium thomaeum pp. 508-511

Robert VanBuren, Doug Bryant, Patrick P. Edger, Haibao Tang, Diane Burgess, Dinakar Challabathula, Kristi Spittle, Richard Hall, Jenny Gu, Eric Lyons, Michael Freeling, Dorothea Bartels, Boudewijn Ten Hallers, Alex Hastie, Todd P. Michael and Todd C. Mockler

Sweet and bitter taste in the brain of awake behaving animals pp. 512-515

Yueqing Peng, Sarah Gillis-Smith, Hao Jin, Dimitri Tränkner, Nicholas J. P. Ryba and Charles S. Zuker

Drosophila Ionotropic Receptor 25a mediates circadian clock resetting by temperature pp. 516-520

Chenghao Chen, Edgar Buhl, Min Xu, Vincent Croset, Johanna S. Rees, Kathryn S. Lilley, Richard Benton, James J. L. Hodge and Ralf Stanewsky

Fungal pathogen uses sex pheromone receptor for chemotropic sensing of host plant signals pp. 521-524

David Turrà, Mennat El Ghalid, Federico Rossi and Antonio Di Pietro

Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer pp. 525-530

Xiaofeng Zheng, Julienne L. Carstens, Jiha Kim, Matthew Scheible, Judith Kaye, Hikaru Sugimoto, Chia-Chin Wu, Valerie S. LeBleu and Raghu Kalluri

In situ structures of the segmented genome and RNA polymerase complex inside a dsRNA virus pp. 531-534

Xing Zhang, Ke Ding, Xuekui Yu, Winston Chang, Jingchen Sun and Z. Hong Zhou

Foreign DNA capture during CRISPR–Cas adaptive immunity pp. 535-538

James K. Nuñez, Lucas B. Harrington, Philip J. Kranzusch, Alan N. Engelman and Jennifer A. Doudna

RETRACTED ARTICLE: Endoperoxide formation by an α-ketoglutarate-dependent mononuclear non-haem iron enzyme pp. 539-543

Wupeng Yan, Heng Song, Fuhang Song, Yisong Guo, Cheng-Hsuan Wu, Ampon Sae Her, Yi Pu, Shu Wang, Nathchar Naowarojna, Andrew Weitz, Michael P. Hendrich, Catherine E. Costello, Lixin Zhang, Pinghua Liu and Yan Jessie Zhang

Correction: Corrigendum: A basal ichthyosauriform with a short snout from the Lower Triassic of China pp. 544-544

Ryosuke Motani, Da-Yong Jiang, Guan-Bao Chen, Andrea Tintori, Olivier Rieppel, Cheng Ji and Jian-Dong Huang

Correction: Corrigendum: Influence maximization in complex networks through optimal percolation pp. 544-544

Flaviano Morone and Hernán A. Makse

Retraction Note: Non-blinking semiconductor nanocrystals pp. 544-544

Xiaoyong Wang, Xiaofan Ren, Keith Kahen, Megan A. Hahn, Manju Rajeswaran, Sara Maccagnano-Zacher, John Silcox, George E. Cragg, Alexander L. Efros and Todd D. Krauss

Antibody anarchy: A call to order pp. 545-551

Monya Baker

Mental health: The mindful way pp. 553-554

Sabine Louet

Turning point: Jason Lunden pp. 554-554

Virginia Gewin

Claimed pp. 556-556

S. J. Rosenstein

2015, volume 527, articles 7578

Breast cancer pp. S101-S101

Chris Woolston

A tumour through time pp. S102-S103

Will Tauxe

Perspective: The risks of overdiagnosis pp. S104-S104

Alexandra Barratt

Immunology: Another shot at cancer pp. S105-S107

Charles Schmidt

Genetics: Big hopes for big data pp. S108-S109

Jill U. Adams

Medicine: Eyes on the target pp. S110-S112

Michael Eisenstein

Molecular biology: Marked progress pp. S114-S115

Hannah Hoag

Genetics: Relative risk pp. S116-S117

Moises Velasquez-Manoff

Screening: Don't look now pp. S118-S119

Emily Sohn

Breast cancer: 4 big questions pp. S120-S120

Chris Woolston

Brain disorders across the lifespan pp. S150-S150

Roger I. Glass

Brain and other nervous system disorders across the lifespan — global challenges and opportunities pp. S151-S154

Donald Silberberg, Nalini P. Anand, Kathleen Michels and Raj N. Kalaria

Reducing neurodevelopmental disorders and disability through research and interventions pp. S155-S160

Michael J. Boivin, Angelina M. Kakooza, Benjamin C. Warf, Leslie L. Davidson and Elena L. Grigorenko

A focus on adolescence to reduce neurological, mental health and substance-use disability pp. S161-S166

Leslie L. Davidson, Elena L. Grigorenko, Michael J. Boivin, Elizabeth Rapa and Alan Stein

Nervous system disorders across the life course in resource-limited settings pp. S167-S171

Gretchen L. Birbeck, Ana-Claire Meyer and Adesola Ogunniyi

Global research challenges and opportunities for mental health and substance-use disorders pp. S172-S177

Florence Baingana, Mustafa al'Absi, Anne E. Becker and Beverly Pringle

Global research priorities for infections that affect the nervous system pp. S178-S186

Chandy C. John, Hélène Carabin, Silvia M. Montano, Paul Bangirana, Joseph R. Zunt and Phillip K. Peterson

A global perspective on the influence of environmental exposures on the nervous system pp. S187-S192

Desire Tshala-Katumbay, Jean-Claude Mwanza, Diane S. Rohlman, Gladys Maestre and Reinaldo B. Oriá

Global neurotrauma research challenges and opportunities pp. S193-S197

Andrés M. Rubiano, Nancy Carney, Randall Chesnut and Juan Carlos Puyana

Regional research priorities in brain and nervous system disorders pp. S198-S206

Vijayalakshmi Ravindranath, Hoang-Minh Dang, Rodolfo G. Goya, Hader Mansour, Vishwajit L. Nimgaonkar, Vivienne Ann Russell and Yu Xin

Building global capacity for brain and nervous system disorders research pp. S207-S213

Linda B. Cottler, Joseph Zunt, Bahr Weiss, Ayeesha Kamran Kamal and Krishna Vaddiparti

Time to cry out for academic freedom pp. 277-277

Colin Macilwain

How to judge scientists’ strengths pp. 279-279

Dalmeet Singh Chawla

Discovery of long-sought biological compass claimed pp. 283-284

David Cyranoski

Freefall space cubes are test for gravitational wave spotter pp. 284-285

Elizabeth Gibney

Wayward satellites repurposed to test general relativity pp. 286-286

Elizabeth Gibney

Racial bias continues to haunt NIH grants pp. 286-287

Erika Check Hayden

The exoplanet files pp. 288-289

Alexandra Witze

The quantum source of space-time pp. 290-293

Ron Cowen

Sustainability: Transfer project cannot meet China's water needs pp. 295-297

Jon Barnett, Sarah Rogers, Michael Webber, Brian Finlayson and Mark Wang

History: Einstein was no lone genius pp. 298-300

Michel Janssen and Jürgen Renn

Mathematics: Logic and Lewis Carroll pp. 302-303

Francine F. Abeles

Books in brief pp. 303-303

Barbara Kiser

Peat fires: emissions likely to worsen pp. 305-305

Susan G. Laurance and William F. Laurance

Peat fires: consumers to help beat them out pp. 305-305

Lahiru S. Wijedasa, Mary Rose C. Posa and Gopalasamy R. Clements

Time for Russia to tap renewables pp. 305-305

Alexander Gorobets

Cannabis: monitor policy changes pp. 305-305

Lucas Wiessing

Cannabis: debated schizophrenia link pp. 305-305

Matthew Large, Marta Di Forti and Robin Murray

Richard Heck (1931–2015) pp. 306-306

Victor Snieckus

Extra dimension for bone analysis pp. 308-309

Peter Fratzl

Homed to the hideout pp. 309-310

Wolf-Dietrich Hardt

Growing planet brought to light pp. 310-311

Zhaohuan Zhu

On the crest of becoming vertebrate pp. 311-312

Marianne E. Bronner

Organ-seeking vesicles pp. 312-314

Janusz Rak

Boost for movement pp. 314-315

Randolph J. Nudo

Ecosystem responses to climate extremes pp. 315-316

Anja Rammig and Miguel D. Mahecha

Dpp spreading is required for medial but not for lateral wing disc growth pp. 317-322

Stefan Harmansa, Fisun Hamaratoglu, Markus Affolter and Emmanuel Caussinus

Novel antibody–antibiotic conjugate eliminates intracellular S. aureus pp. 323-328

Sophie M. Lehar, Thomas Pillow, Min Xu, Leanna Staben, Kimberly K. Kajihara, Richard Vandlen, Laura DePalatis, Helga Raab, Wouter L. Hazenbos, J. Hiroshi Morisaki, Janice Kim, Summer Park, Martine Darwish, Byoung-Chul Lee, Hilda Hernandez, Kelly M. Loyet, Patrick Lupardus, Rina Fong, Donghong Yan, Cecile Chalouni, Elizabeth Luis, Yana Khalfin, Emile Plise, Jonathan Cheong, Joseph P. Lyssikatos, Magnus Strandh, Klaus Koefoed, Peter S. Andersen, John A. Flygare, Man Wah Tan, Eric J. Brown and Sanjeev Mariathasan

Tumour exosome integrins determine organotropic metastasis pp. 329-335

Ayuko Hoshino, Bruno Costa-Silva, Tang-Long Shen, Goncalo Rodrigues, Ayako Hashimoto, Milica Tesic Mark, Henrik Molina, Shinji Kohsaka, Angela Di Giannatale, Sophia Ceder, Swarnima Singh, Caitlin Williams, Nadine Soplop, Kunihiro Uryu, Lindsay Pharmer, Tari King, Linda Bojmar, Alexander E. Davies, Yonathan Ararso, Tuo Zhang, Haiying Zhang, Jonathan Hernandez, Joshua M. Weiss, Vanessa D. Dumont-Cole, Kimberly Kramer, Leonard H. Wexler, Aru Narendran, Gary K. Schwartz, John H. Healey, Per Sandstrom, Knut Jørgen Labori, Elin H. Kure, Paul M. Grandgenett, Michael A. Hollingsworth, Maria de Sousa, Sukhwinder Kaur, Maneesh Jain, Kavita Mallya, Surinder K. Batra, William R. Jarnagin, Mary S. Brady, Oystein Fodstad, Volkmar Muller, Klaus Pantel, Andy J. Minn, Mina J. Bissell, Benjamin A. Garcia, Yibin Kang, Vinagolu K. Rajasekhar, Cyrus M. Ghajar, Irina Matei, Hector Peinado, Jacqueline Bromberg and David Lyden

Gating machinery of InsP3R channels revealed by electron cryomicroscopy pp. 336-341

Guizhen Fan, Matthew L. Baker, Zhao Wang, Mariah R. Baker, Pavel A. Sinyagovskiy, Wah Chiu, Steven J. Ludtke and Irina I. Serysheva

Accreting protoplanets in the LkCa 15 transition disk pp. 342-344

S. Sallum, K. B. Follette, J. A. Eisner, L. M. Close, P. Hinz, K. Kratter, J. Males, A. Skemer, B. Macintosh, P. Tuthill, V. Bailey, D. Defrère, K. Morzinski, T. Rodigas, E. Spalding, A. Vaz and A. J. Weinberger

Nanostructure surveys of macroscopic specimens by small-angle scattering tensor tomography pp. 349-352

Marianne Liebi, Marios Georgiadis, Andreas Menzel, Philipp Schneider, Joachim Kohlbrecher, Oliver Bunk and Manuel Guizar-Sicairos

Six-dimensional real and reciprocal space small-angle X-ray scattering tomography pp. 353-356

Florian Schaff, Martin Bech, Paul Zaslansky, Christoph Jud, Marianne Liebi, Manuel Guizar-Sicairos and Franz Pfeiffer

Methane storage in flexible metal–organic frameworks with intrinsic thermal management pp. 357-361

Jarad A. Mason, Julia Oktawiec, Mercedes K. Taylor, Matthew R. Hudson, Julien Rodriguez, Jonathan E. Bachman, Miguel I. Gonzalez, Antonio Cervellino, Antonietta Guagliardi, Craig M. Brown, Philip L. Llewellyn, Norberto Masciocchi and Jeffrey R. Long

North Pacific deglacial hypoxic events linked to abrupt ocean warming pp. 362-366

S. K. Praetorius, A. C. Mix, M. H. Walczak, M. D. Wolhowe, J. A. Addison and F. G. Prahl

The effects of life history and sexual selection on male and female plumage colouration pp. 367-370

James Dale, Cody J. Dey, Kaspar Delhey, Bart Kempenaers and Mihai Valcu

Migratory neuronal progenitors arise from the neural plate borders in tunicates pp. 371-374

Alberto Stolfi, Kerrianne Ryan, Ian A. Meinertzhagen and Lionel Christiaen

Decapentaplegic and growth control in the developing Drosophila wing pp. 375-378

Takuya Akiyama and Matthew C. Gibson

Diversion of aspartate in ASS1-deficient tumours fosters de novo pyrimidine synthesis pp. 379-383

Shiran Rabinovich, Lital Adler, Keren Yizhak, Alona Sarver, Alon Silberman, Shani Agron, Noa Stettner, Qin Sun, Alexander Brandis, Daniel Helbling, Stanley Korman, Shalev Itzkovitz, David Dimmock, Igor Ulitsky, Sandesh C. S. Nagamani, Eytan Ruppin and Ayelet Erez

DNA-dependent formation of transcription factor pairs alters their binding specificity pp. 384-388

Arttu Jolma, Yimeng Yin, Kazuhiro R. Nitta, Kashyap Dave, Alexander Popov, Minna Taipale, Martin Enge, Teemu Kivioja, Ekaterina Morgunova and Jussi Taipale

Histone H1 couples initiation and amplification of ubiquitin signalling after DNA damage pp. 389-393

Tina Thorslund, Anita Ripplinger, Saskia Hoffmann, Thomas Wild, Michael Uckelmann, Bine Villumsen, Takeo Narita, Titia K. Sixma, Chunaram Choudhary, Simon Bekker-Jensen and Niels Mailand

The inner workings of the hydrazine synthase multiprotein complex pp. 394-397

Andreas Dietl, Christina Ferousi, Wouter J. Maalcke, Andreas Menzel, Simon de Vries, Jan T. Keltjens, Mike S. M. Jetten, Boran Kartal and Thomas R. M. Barends

Correction: Corrigendum: Whole–genome characterization of chemoresistant ovarian cancer pp. 398-398

Ann-Marie Patch, Elizabeth L. Christie, Dariush Etemadmoghadam, Dale W. Garsed, Joshy George, Sian Fereday, Katia Nones, Prue Cowin, Kathryn Alsop, Peter J. Bailey, Karin S. Kassahn, Felicity Newell, Michael C. J. Quinn, Stephen Kazakoff, Kelly Quek, Charlotte Wilhelm-Benartzi, Ed Curry, Huei San Leong, Anne Hamilton, Linda Mileshkin, George Au-Yeung, Catherine Kennedy, Jillian Hung, Yoke-Eng Chiew, Paul Harnett, Michael Friedlander, Michael Quinn, Jan Pyman, Stephen Cordner, Patricia O’Brien, Jodie Leditschke, Greg Young, Kate Strachan, Paul Waring, Walid Azar, Chris Mitchell, Nadia Traficante, Joy Hendley, Heather Thorne, Mark Shackleton, David K. Miller, Gisela Mir Arnau, Richard W. Tothill, Timothy P. Holloway, Timothy Semple, Ivon Harliwong, Craig Nourse, Ehsan Nourbakhsh, Suzanne Manning, Senel Idrisoglu, Timothy J. C. Bruxner, Angelika N. Christ, Barsha Poudel, Oliver Holmes, Matthew Anderson, Conrad Leonard, Andrew Lonie, Nathan Hall, Scott Wood, Darrin F. Taylor, Qinying Xu, J. Lynn Fink, Nick Waddell, Ronny Drapkin, Euan Stronach, Hani Gabra, Robert Brown, Andrea Jewell, Shivashankar H. Nagaraj, Emma Markham, Peter J. Wilson, Jason Ellul, Orla McNally, Maria A. Doyle, Ravikiran Vedururu, Collin Stewart, Ernst Lengyel, John V. Pearson, Nicola Waddell, Anna deFazio, Sean M. Grimmond and David D. L. Bowtell

Erratum: Arithmetic and local circuitry underlying dopamine prediction errors pp. 398-398

Neir Eshel, Michael Bukwich, Vinod Rao, Vivian Hemmelder, Ju Tian and Naoshige Uchida

Erratum: A positional Toll receptor code directs convergent extension in Drosophila pp. 398-398

Adam C. Paré, Athea Vichas, Christopher T. Fincher, Zachary Mirman, Dene L. Farrell, Avantika Mainieri and Jennifer A. Zallen

Correction: Corrigendum: Improving survival by exploiting tumour dependence on stabilized mutant p53 for treatment pp. 398-398

E. M. Alexandrova, A. R. Yallowitz, D. Li, S. Xu, R. Schulz, D. A. Proia, G. Lozano, M. Dobbelstein and U. M. Moll

Lab transitions: The bumpy road to relocation pp. 399-401

Paul Smaglik

Turning point: Daniel Carder pp. 401-401

Virginia Gewin

Age progression pp. 404-404

Susana Martinez-Conde

2015, volume 527, articles 7577

Nature Index 2015 Collaborations pp. S49-S49

Michelle Grayson and Stephen Pincock

Comment: A well-connected world pp. S58-S59

Jonathan Adams and Tamar Loach

China must act decisively to eradicate the ivory trade pp. 135-135

Li Zhang

Scientists debate mega-microbiome initiatives pp. 137-137

Rachel Becker

Keystone XL decision puts spotlight on US climate politics pp. 141-142

Jeff Tollefson

Arecibo Observatory director quits after funding row pp. 142-143

Traci Watson

Uncertainty for UK science ahead of giant spending review pp. 144-145

Daniel Cressey and Elizabeth Gibney

Mega science prize split between 1,377 physicists pp. 145-145

Zeeya Merali

Leukaemia success heralds wave of gene-editing therapies pp. 146-147

Sara Reardon

Canada creates science-minister post pp. 146-146

Nicola Jones

Science and sexism: In the eye of the Twitterstorm pp. 148-151

Lauren Morello

New life for pig-to-human transplants pp. 152-154

Sara Reardon

Biological research: Rethink biosafety pp. 155-158

Tim Trevan

CRISPR: A path through the thicket pp. 159-161

Debra J. H. Mathews, Sarah Chan, Peter J. Donovan, Thomas Douglas, Christopher Gyngell, John Harris, Alan Regenberg and Robin Lovell-Badge

Cancer therapy: Up close and personalized pp. 162-163

Gerard Evan

Books in brief pp. 163-163

Barbara Kiser

History of science: Trial by gender pp. 164-164

Jennifer Rampling

Lessons from Madrid for next climate talks pp. 165-165

Benjamin D. Santer

Account for soil as natural capital pp. 165-165

Carl Obst

Drug pollution: Europe responds pp. 165-165

Hubertus Cranz, Richard Bergström and Adrian van den Hoven

Drug pollution: industry responds pp. 165-165

Jason Snape and Wesley White

Irked by naivety about policymaking pp. 165-165

Kathryn Oliver, Adam Wellstead and Paul Cairney

DNA repair without flipping out pp. 168-169

David S. Shin and John A. Tainer

A small star with an Earth-like planet pp. 169-170

Drake Deming

The enemy of my enemy is my friend pp. 170-171

Isaac S. Harris and Joan S. Brugge

Deadly combination pp. 172-173

Robert Duncan

A rewired food web pp. 173-174

Julia L. Blanchard

Liquefied molecular holes pp. 174-175

Michael Mastalerz

Human sleep before the industrial era pp. 176-177

Derk-Jan Dijk and Anne C. Skeldon

Higher costs of climate change pp. 177-178

Thomas Sterner

Basomedial amygdala mediates top-down control of anxiety and fear pp. 179-185

Avishek Adhikari, Talia N. Lerner, Joel Finkelstein, Sally Pak, Joshua H. Jennings, Thomas J. Davidson, Emily Ferenczi, Lisa A. Gunaydin, Julie J. Mirzabekov, Li Ye, Sung-Yon Kim, Anna Lei and Karl Deisseroth

Oxidative stress inhibits distant metastasis by human melanoma cells pp. 186-191

Elena Piskounova, Michalis Agathocleous, Malea M. Murphy, Zeping Hu, Sara E. Huddlestun, Zhiyu Zhao, A. Marilyn Leitch, Timothy M. Johnson, Ralph J. DeBerardinis and Sean J. Morrison

BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis pp. 192-197

Matthew C. Canver, Elenoe C. Smith, Falak Sher, Luca Pinello, Neville E. Sanjana, Ophir Shalem, Diane D. Chen, Patrick G. Schupp, Divya S. Vinjamur, Sara P. Garcia, Sidinh Luc, Ryo Kurita, Yukio Nakamura, Yuko Fujiwara, Takahiro Maeda, Guo-Cheng Yuan, Feng Zhang, Stuart H. Orkin and Daniel E. Bauer

Cryo-electron microscopy structure of the Slo2.2 Na+-activated K+ channel pp. 198-203

Richard K. Hite, Peng Yuan, Zongli Li, Yichun Hsuing, Thomas Walz and Roderick MacKinnon

A rocky planet transiting a nearby low-mass star pp. 204-207

Zachory K. Berta-Thompson, Jonathan Irwin, David Charbonneau, Elisabeth R. Newton, Jason A. Dittmann, Nicola Astudillo-Defru, Xavier Bonfils, Michaël Gillon, Emmanuël Jehin, Antony A. Stark, Brian Stalder, Francois Bouchy, Xavier Delfosse, Thierry Forveille, Christophe Lovis, Michel Mayor, Vasco Neves, Francesco Pepe, Nuno C. Santos, Stéphane Udry and Anaël Wünsche

Entangling two transportable neutral atoms via local spin exchange pp. 208-211

A. M. Kaufman, B. J. Lester, M. Foss-Feig, M. L. Wall, A. M. Rey and C. A. Regal

Large anomalous Hall effect in a non-collinear antiferromagnet at room temperature pp. 212-215

Satoru Nakatsuji, Naoki Kiyohara and Tomoya Higo

Liquids with permanent porosity pp. 216-220

Nicola Giri, Mario G. Del Pópolo, Gavin Melaugh, Rebecca L. Greenaway, Klaus Rätzke, Tönjes Koschine, Laure Pison, Margarida F. Costa Gomes, Andrew I. Cooper and Stuart L. James

Plate tectonics on the Earth triggered by plume-induced subduction initiation pp. 221-225

T. V. Gerya, R. J. Stern, M. Baes, S. V. Sobolev and S. A. Whattam

Widespread exploitation of the honeybee by early Neolithic farmers pp. 226-230

Mélanie Roffet-Salque, Martine Regert, Richard P. Evershed, Alan K. Outram, Lucy J. E. Cramp, Orestes Decavallas, Julie Dunne, Pascale Gerbault, Simona Mileto, Sigrid Mirabaud, Mirva Pääkkönen, Jessica Smyth, Lucija Šoberl, Helen L. Whelton, Alfonso Alday-Ruiz, Henrik Asplund, Marta Bartkowiak, Eva Bayer-Niemeier, Lotfi Belhouchet, Federico Bernardini, Mihael Budja, Gabriel Cooney, Miriam Cubas, Ed M. Danaher, Mariana Diniz, László Domboróczki, Cristina Fabbri, Jesus E. González-Urquijo, Jean Guilaine, Slimane Hachi, Barrie N. Hartwell, Daniela Hofmann, Isabel Hohle, Juan J. Ibáñez, Necmi Karul, Farid Kherbouche, Jacinta Kiely, Kostas Kotsakis, Friedrich Lueth, James P. Mallory, Claire Manen, Arkadiusz Marciniak, Brigitte Maurice-Chabard, Martin A. Mc Gonigle, Simone Mulazzani, Mehmet Özdoğan, Olga S. Perić, Slaviša R. Perić, Jörg Petrasch, Anne-Marie Pétrequin, Pierre Pétrequin, Ulrike Poensgen, C. Joshua Pollard, François Poplin, Giovanna Radi, Peter Stadler, Harald Stäuble, Nenad Tasić, Dushka Urem-Kotsou, Jasna B. Vuković, Fintan Walsh, Alasdair Whittle, Sabine Wolfram, Lydia Zapata-Peña and Jamel Zoughlami

Deep-time evolution of regeneration and preaxial polarity in tetrapod limb development pp. 231-234

Nadia B. Fröbisch, Constanze Bickelmann, Jennifer C. Olori and Florian Witzmann

Global non-linear effect of temperature on economic production pp. 235-239

Marshall Burke, Solomon M. Hsiang and Edward Miguel

Oxygen regulation of breathing through an olfactory receptor activated by lactate pp. 240-244

Andy J. Chang, Fabian E. Ortega, Johannes Riegler, Daniel V. Madison and Mark A. Krasnow

Resensitizing daclatasvir-resistant hepatitis C variants by allosteric modulation of NS5A pp. 245-248

Jin-Hua Sun, Donald R. O’Boyle, Robert A. Fridell, David R. Langley, Chunfu Wang, Susan B. Roberts, Peter Nower, Benjamin M. Johnson, Frederic Moulin, Michelle J. Nophsker, Ying-Kai Wang, Mengping Liu, Karen Rigat, Yong Tu, Piyasena Hewawasam, John Kadow, Nicholas A. Meanwell, Mark Cockett, Julie A. Lemm, Melissa Kramer, Makonen Belema and Min Gao

Epigenetic silencing of TH1-type chemokines shapes tumour immunity and immunotherapy pp. 249-253

Dongjun Peng, Ilona Kryczek, Nisha Nagarsheth, Lili Zhao, Shuang Wei, Weimin Wang, Yuqing Sun, Ende Zhao, Linda Vatan, Wojciech Szeliga, Jan Kotarski, Rafał Tarkowski, Yali Dou, Kathleen Cho, Sharon Hensley-Alford, Adnan Munkarah, Rebecca Liu and Weiping Zou

The DNA glycosylase AlkD uses a non-base-flipping mechanism to excise bulky lesions pp. 254-258

Elwood A. Mullins, Rongxin Shi, Zachary D. Parsons, Philip K. Yuen, Sheila S. David, Yasuhiro Igarashi and Brandt F. Eichman

Structure of a eukaryotic SWEET transporter in a homotrimeric complex pp. 259-263

Yuyong Tao, Lily S. Cheung, Shuo Li, Joon-Seob Eom, Li-Qing Chen, Yan Xu, Kay Perry, Wolf B. Frommer and Liang Feng

Correction: Corrigendum: Biocontainment of genetically modified organisms by synthetic protein design pp. 264-264

Daniel J. Mandell, Marc J. Lajoie, Michael T. Mee, Ryo Takeuchi, Gleb Kuznetsov, Julie E. Norville, Christopher J. Gregg, Barry L. Stoddard and George M. Church

Correction: Corrigendum: Recoded organisms engineered to depend on synthetic amino acids pp. 264-264

Alexis J. Rovner, Adrian D. Haimovich, Spencer R. Katz, Zhe Li, Michael W. Grome, Brandon M. Gassaway, Miriam Amiram, Jaymin R. Patel, Ryan R. Gallagher, Jesse Rinehart and Farren J. Isaacs

Erratum: Structural imprints in vivo decode RNA regulatory mechanisms pp. 264-264

Robert C. Spitale, Ryan A. Flynn, Qiangfeng Cliff Zhang, Pete Crisalli, Byron Lee, Jong-Wha Jung, Hannes Y. Kuchelmeister, Pedro J. Batista, Eduardo A. Torre, Eric T. Kool and Howard Y. Chang

Non-profit organizations: Scientists on a mission pp. 265-266

Julie Gould

Trade talk: Policy analyst pp. 266-266

Julie Gould

System reboot pp. 268-268

Jeremy Szal

2015, volume 527, articles 7576

Big data in biomedicine pp. S1-S1

Eric Bender

Big data: The power of petabytes pp. S2-S4

Michael Eisenstein

Q&A: Mark Caulfield pp. S5-S5

Claire Ainsworth

Proteomics: High-protein research pp. S6-S7

Neil Savage

Collaborations: Mining the motherlodes pp. S8-S9

Katherine Bourzac

Avoid major disasters by welcoming minor change pp. 9-9

Len Fisher

Cancer: Reshaping the cancer clinic pp. S10-S11

Charlie Schmidt

Does innovation always come from science? pp. 11-11

Alexandra Witze

Mobile data: Made to measure pp. S12-S13

Neil Savage

Deep phenotyping: The details of disease pp. S14-S15

Cathryn M. Delude

Memory-boosting devices tested in humans pp. 15-16

Sara Reardon

Historic Rosetta mission to end with crash into comet pp. 16-17

Elizabeth Gibney

Perspective: Sustaining the big-data ecosystem pp. S16-S17

Philip E. Bourne, Jon R. Lorsch and Eric D. Green

Indonesia blazes threaten endangered orangutans pp. 18-18

Nadia Drake

Q&A: Perry Nisen pp. S18-S18

Eric Bender

Big data in biomedicine: 4 big questions pp. S19-S19

Eric Bender

Synthetic biology lures Silicon Valley investors pp. 19-19

Erika Check Hayden

Software predicts slew of fiendish crystal structures pp. 20-21

Elizabeth Gibney

Indian scientists join protests over killings of prominent secularists pp. 20-20

T. V. Padma

The big baby experiment pp. 22-25

Linda Geddes

The greatest vanishing act in prehistoric America pp. 26-29

Richard Monastersky

Informatics: Make sense of health data pp. 31-32

Julian H. Elliott, Jeremy Grimshaw, Russ Altman, Lisa Bero, Steven N. Goodman, David Henry, Malcolm Macleod, David Tovey, Peter Tugwell, Howard White and Ida Sim

Society: Build digital democracy pp. 33-34

Dirk Helbing and Evangelos Pournaras

Neuroscience: Tortured reasoning pp. 35-36

Lasana T. Harris

Innovation: A binary life pp. 36-37

Timo Hannay

Books in brief pp. 37-37

Barbara Kiser

Volkswagen and the road to Paris pp. 38-38

Gail Whiteman and Harry Hoster

DEFRA responds to badger-cull critique pp. 38-38

Ian L. Boyd

China emissions: stop subsidizing emitters pp. 38-38

Xin Miao

China emissions: alter energy markets pp. 38-38

Dayuan Li, Shenggang Ren and Xiaohong Chen

Europe's first '3Rs' governmental centre pp. 38-38

Gilbert Schönfelder, Barbara Grune and Andreas Hensel

Australia at the crossroads pp. 40-41

Benjamin L. Bodirsky and Alexander Popp

Droplets leap into action pp. 41-42

Doris Vollmer and Hans-Jürgen Butt

Light on leptin link to lipolysis pp. 43-44

Johan Ruud and Jens C. Brüning

Electrical signalling goes bacterial pp. 44-45

Sarah D. Beagle and Steve W. Lockless

Quantum sound waves stick together pp. 45-46

Dave Kielpinski

Expression feels two pulses pp. 46-47

Antoine Baudrimont and Attila Becskei

Australia is ‘free to choose’ economic growth and falling environmental pressures pp. 49-53

Steve Hatfield-Dodds, Heinz Schandl, Philip Adams, Timothy Baynes, Thomas S. Brinsmead, Brett A. Bryan, Francis H. S. Chiew, Paul W. Graham, Mike Grundy, Tom Harwood, Rebecca McCallum, Rod McCrea, Lisa E. McKellar, David Newth, Martin Nolan, Ian Prosser and Alex Wonhas

Combinatorial gene regulation by modulation of relative pulse timing pp. 54-58

Yihan Lin, Chang Ho Sohn, Chiraj K. Dalal, Long Cai and Michael B. Elowitz

Ion channels enable electrical communication in bacterial communities pp. 59-63

Arthur Prindle, Jintao Liu, Munehiro Asally, San Ly, Jordi Garcia-Ojalvo and Gürol M. Süel

Architecture of the mammalian mechanosensitive Piezo1 channel pp. 64-69

Jingpeng Ge, Wanqiu Li, Qiancheng Zhao, Ningning Li, Maofei Chen, Peng Zhi, Ruochong Li, Ning Gao, Bailong Xiao and Maojun Yang

Episodic molecular outflow in the very young protostellar cluster Serpens South pp. 70-73

Adele L. Plunkett, Héctor G. Arce, Diego Mardones, Pieter van Dokkum, Michael M. Dunham, Manuel Fernández-López, José Gallardo and Stuartt A. Corder

Hong–Ou–Mandel interference of two phonons in trapped ions pp. 74-77

Kenji Toyoda, Ryoto Hiji, Atsushi Noguchi and Shinji Urabe

An aqueous, polymer-based redox-flow battery using non-corrosive, safe, and low-cost materials pp. 78-81

Tobias Janoschka, Norbert Martin, Udo Martin, Christian Friebe, Sabine Morgenstern, Hannes Hiller, Martin D. Hager and Ulrich S. Schubert

Spontaneous droplet trampolining on rigid superhydrophobic surfaces pp. 82-85

Thomas M. Schutzius, Stefan Jung, Tanmoy Maitra, Gustav Graeber, Moritz Köhme and Dimos Poulikakos

Rhodium-catalysed syn-carboamination of alkenes via a transient directing group pp. 86-90

Tiffany Piou and Tomislav Rovis

The genetic sex-determination system predicts adult sex ratios in tetrapods pp. 91-94

Ivett Pipoly, Veronika Bókony, Mark Kirkpatrick, Paul F. Donald, Tamás Székely and András Liker

Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorder pp. 95-99

Jerome Mertens, Qiu-Wen Wang, Yongsung Kim, Diana X. Yu, Son Pham, Bo Yang, Yi Zheng, Kenneth E. Diffenderfer, Jian Zhang, Sheila Soltani, Tameji Eames, Simon T. Schafer, Leah Boyer, Maria C. Marchetto, John I. Nurnberger, Joseph R. Calabrese, Ketil J. Oedegaard, Michael J. McCarthy, Peter P. Zandi, Martin Alda, Caroline M. Nievergelt, Shuangli Mi, Kristen J. Brennand, John R. Kelsoe, Fred H. Gage and Jun Yao

Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth pp. 100-104

Lin Zhang, Siyuan Zhang, Jun Yao, Frank J. Lowery, Qingling Zhang, Wen-Chien Huang, Ping Li, Min Li, Xiao Wang, Chenyu Zhang, Hai Wang, Kenneth Ellis, Mujeeburahiman Cheerathodi, Joseph H. McCarty, Diane Palmieri, Jodi Saunus, Sunil Lakhani, Suyun Huang, Aysegul A. Sahin, Kenneth D. Aldape, Patricia S. Steeg and Dihua Yu

Autophagy mediates degradation of nuclear lamina pp. 105-109

Zhixun Dou, Caiyue Xu, Greg Donahue, Takeshi Shimi, Ji-An Pan, Jiajun Zhu, Andrejs Ivanov, Brian C. Capell, Adam M. Drake, Parisha P. Shah, Joseph M. Catanzaro, M. Daniel Ricketts, Trond Lamark, Stephen A. Adam, Ronen Marmorstein, Wei-Xing Zong, Terje Johansen, Robert D. Goldman, Peter D. Adams and Shelley L. Berger

Conformational control of DNA target cleavage by CRISPR–Cas9 pp. 110-113

Samuel H. Sternberg, Benjamin LaFrance, Matias Kaplan and Jennifer A. Doudna

Crystal structure of the RNA-dependent RNA polymerase from influenza C virus pp. 114-117

Narin Hengrung, Kamel El Omari, Itziar Serna Martin, Frank T. Vreede, Stephen Cusack, Robert P. Rambo, Clemens Vonrhein, Gérard Bricogne, David I. Stuart, Jonathan M. Grimes and Ervin Fodor

Structural insight into substrate preference for TET-mediated oxidation pp. 118-122

Lulu Hu, Junyan Lu, Jingdong Cheng, Qinhui Rao, Ze Li, Haifeng Hou, Zhiyong Lou, Lei Zhang, Wei Li, Wei Gong, Mengjie Liu, Chang Sun, Xiaotong Yin, Jie Li, Xiangshi Tan, Pengcheng Wang, Yinsheng Wang, Dong Fang, Qiang Cui, Pengyuan Yang, Chuan He, Hualiang Jiang, Cheng Luo and Yanhui Xu

Eight ways to clean a digital library pp. 123-124

Jeffrey M. Perkel

Supervision: Clear direction pp. 125-126

Boer Deng

One slow step for man pp. 128-128

S. R. Algernon