Hippocampal LTP and contextual learning require surface diffusion of AMPA receptors

A. C. Penn, C. L. Zhang, F. Georges, L. Royer, C. Breillat, E. Hosy, J. D. Petersen, Y. Humeau and D. Choquet ()
Additional contact information
A. C. Penn: University of Bordeaux, Interdisciplinary Institute for Neuroscience
C. L. Zhang: University of Bordeaux, Interdisciplinary Institute for Neuroscience
F. Georges: University of Bordeaux, Interdisciplinary Institute for Neuroscience
L. Royer: University of Bordeaux, Interdisciplinary Institute for Neuroscience
C. Breillat: University of Bordeaux, Interdisciplinary Institute for Neuroscience
E. Hosy: University of Bordeaux, Interdisciplinary Institute for Neuroscience
J. D. Petersen: University of Bordeaux, Interdisciplinary Institute for Neuroscience
Y. Humeau: University of Bordeaux, Interdisciplinary Institute for Neuroscience
D. Choquet: University of Bordeaux, Interdisciplinary Institute for Neuroscience

Nature, 2017, vol. 549, issue 7672, 384-388

Abstract: Surface diffusion of AMPA receptors, from extra-synaptic to synaptic sites at the plasma membrane, is essential for full long-term potentiation in hippocampal neurons and for fear conditioning in living mice.

Date: 2017
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DOI: 10.1038/nature23658

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