Palmitoylation-dependent activation of MC1R prevents melanomagenesis

Shuyang Chen, Bo Zhu, Chengqian Yin, Wei Liu, Changpeng Han, Baoen Chen, Tongzheng Liu, Xin Li, Xiang Chen, Chunying Li, Limin Hu, Jun Zhou, Zhi-Xiang Xu, Xiumei Gao, Xu Wu, Colin R. Goding and Rutao Cui ()
Additional contact information
Shuyang Chen: Boston University School of Medicine
Bo Zhu: Boston University School of Medicine
Chengqian Yin: Boston University School of Medicine
Wei Liu: Boston University School of Medicine
Changpeng Han: Boston University School of Medicine
Baoen Chen: Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School
Tongzheng Liu: Jinan University Institute of Tumor Pharmacology
Xin Li: Boston University School of Medicine
Xiang Chen: Xiangya Hospital, Central South University
Chunying Li: Xijing Hospital, The Fourth Military Medical University
Limin Hu: Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine
Jun Zhou: State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai University
Zhi-Xiang Xu: Comprehensive Cancer Center, University of Alabama at Birmingham
Xiumei Gao: Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine
Xu Wu: Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School
Colin R. Goding: Ludwig Institute for Cancer Research, University of Oxford
Rutao Cui: Boston University School of Medicine

Nature, 2017, vol. 549, issue 7672, 399-403

Abstract: The protein modification palmitoylation increases the ability of variant forms of the melanocortin-1 receptor (MC1R) to induce pigmentation, and this is linked to reduced development of melanomas.

Date: 2017
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DOI: 10.1038/nature23887

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