The neuropeptide neuromedin U stimulates innate lymphoid cells and type 2 inflammation

Christoph S. N. Klose, Tanel Mahlakõiv, Jesper B. Moeller, Lucille C. Rankin, Anne-Laure Flamar, Hiroki Kabata, Laurel A. Monticelli, Saya Moriyama, Gregory Garbès Putzel, Nikolai Rakhilin, Xiling Shen, Evi Kostenis, Gabriele M. König, Takashi Senda, Dustin Carpenter, Donna L. Farber and David Artis ()
Additional contact information
Christoph S. N. Klose: Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University
Tanel Mahlakõiv: Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University
Jesper B. Moeller: Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University
Lucille C. Rankin: Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University
Anne-Laure Flamar: Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University
Hiroki Kabata: Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University
Laurel A. Monticelli: Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University
Saya Moriyama: Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University
Gregory Garbès Putzel: Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University
Nikolai Rakhilin: Duke University
Xiling Shen: Duke University
Evi Kostenis: Institute of Pharmaceutical Biology, University of Bonn
Gabriele M. König: Institute of Pharmaceutical Biology, University of Bonn
Takashi Senda: Columbia University Medical Center
Dustin Carpenter: Columbia University Medical Center
Donna L. Farber: Columbia University Medical Center
David Artis: Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University

Nature, 2017, vol. 549, issue 7671, 282-286

Abstract: Intestinal type 2 innate lymphoid cells express the neuropeptide receptor NMUR1, which makes them responsive to neuronal neuromedin U, thereby promoting a type 2 cytokine response and accelerated expulsion of the gastro-intestinal nematode Nippostrongylus brasiliensis.

Date: 2017
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DOI: 10.1038/nature23676

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