Epigenetic restriction of extraembryonic lineages mirrors the somatic transition to cancer

Zachary D. Smith, Jiantao Shi, Hongcang Gu, Julie Donaghey, Kendell Clement, Davide Cacchiarelli, Andreas Gnirke, Franziska Michor () and Alexander Meissner ()
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Zachary D. Smith: Broad Institute of MIT and Harvard
Jiantao Shi: Dana-Farber Cancer Institute
Hongcang Gu: Broad Institute of MIT and Harvard
Julie Donaghey: Broad Institute of MIT and Harvard
Kendell Clement: Broad Institute of MIT and Harvard
Davide Cacchiarelli: Broad Institute of MIT and Harvard
Andreas Gnirke: Broad Institute of MIT and Harvard
Franziska Michor: Broad Institute of MIT and Harvard
Alexander Meissner: Broad Institute of MIT and Harvard

Nature, 2017, vol. 549, issue 7673, 543-547

Abstract: Analysis of global remethylation in mouse embryos at several developmental stages identifies an epigenetic landscape that partitions extraembryonic tissues within the embryo and resembles a frequent, global departure in genome regulation in human cancers.

Date: 2017
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DOI: 10.1038/nature23891

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