Orthotopic patient-derived xenografts of paediatric solid tumours

Elizabeth Stewart, Sara M. Federico, Xiang Chen, Anang A. Shelat, Cori Bradley, Brittney Gordon, Asa Karlstrom, Nathaniel R. Twarog, Michael R. Clay, Armita Bahrami, Burgess B. Freeman, Beisi Xu, Xin Zhou, Jianrong Wu, Victoria Honnell, Monica Ocarz, Kaley Blankenship, Jason Dapper, Elaine R. Mardis, Richard K. Wilson, James Downing, Jinghui Zhang, John Easton, Alberto Pappo and Michael A. Dyer ()
Additional contact information
Elizabeth Stewart: St. Jude Children’s Research Hospital, Memphis
Sara M. Federico: St. Jude Children’s Research Hospital, Memphis
Xiang Chen: St. Jude Children’s Research Hospital
Anang A. Shelat: St. Jude Children’s Research Hospital
Cori Bradley: St. Jude Children’s Research Hospital
Brittney Gordon: St. Jude Children’s Research Hospital
Asa Karlstrom: St. Jude Children’s Research Hospital
Nathaniel R. Twarog: St. Jude Children’s Research Hospital
Michael R. Clay: St. Jude Children’s Research Hospital
Armita Bahrami: St. Jude Children’s Research Hospital
Burgess B. Freeman: St. Jude Children’s Research Hospital
Beisi Xu: St. Jude Children’s Research Hospital
Xin Zhou: St. Jude Children’s Research Hospital
Jianrong Wu: St. Jude Children’s Research Hospital
Victoria Honnell: St. Jude Children’s Research Hospital
Monica Ocarz: St. Jude Children’s Research Hospital, Memphis
Kaley Blankenship: St. Jude Children’s Research Hospital, Memphis
Jason Dapper: St. Jude Children’s Research Hospital
Elaine R. Mardis: The Genome Institute, Washington University School of Medicine in St. Louis
Richard K. Wilson: The Genome Institute, Washington University School of Medicine in St. Louis
James Downing: St. Jude Children’s Research Hospital
Jinghui Zhang: St. Jude Children’s Research Hospital
John Easton: St. Jude Children’s Research Hospital
Alberto Pappo: St. Jude Children’s Research Hospital, Memphis
Michael A. Dyer: St. Jude Children’s Research Hospital

Nature, 2017, vol. 549, issue 7670, 96-100

Abstract: A protocol producing orthotopic patient-derived xenografts at diagnosis, recurrence, and autopsy demonstrates proof of principle for using these tumours for basic and translational research on paediatric solid tumours.

Date: 2017
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DOI: 10.1038/nature23647

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