cGAS senses long and HMGB/TFAM-bound U-turn DNA by forming protein–DNA ladders

Liudmila Andreeva, Björn Hiller, Dirk Kostrewa, Charlotte Lässig, Carina C. de Oliveira Mann, David Jan Drexler, Andreas Maiser, Moritz Gaidt, Heinrich Leonhardt, Veit Hornung and Karl-Peter Hopfner ()
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Liudmila Andreeva: Ludwig-Maximilians-Universität München
Björn Hiller: Ludwig-Maximilians-Universität München
Dirk Kostrewa: Ludwig-Maximilians-Universität München
Charlotte Lässig: Ludwig-Maximilians-Universität München
Carina C. de Oliveira Mann: Ludwig-Maximilians-Universität München
David Jan Drexler: Ludwig-Maximilians-Universität München
Andreas Maiser: Ludwig-Maximilians-Universität München
Moritz Gaidt: Ludwig-Maximilians-Universität München
Heinrich Leonhardt: Ludwig-Maximilians-Universität München
Veit Hornung: Ludwig-Maximilians-Universität München
Karl-Peter Hopfner: Ludwig-Maximilians-Universität München

Nature, 2017, vol. 549, issue 7672, 394-398

Abstract: A molecular mechanism for the sensitive detection of long and U-turn DNA by cyclic GMP–AMP synthase (cGAS) both in vitro and in human cells.

Date: 2017
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DOI: 10.1038/nature23890

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