Identification of CMTM6 and CMTM4 as PD-L1 protein regulators

Riccardo Mezzadra, Chong Sun, Lucas T. Jae, Raquel Gomez-Eerland, Evert de Vries, Wei Wu, Meike E. W. Logtenberg, Maarten Slagter, Elisa A. Rozeman, Ingrid Hofland, Annegien Broeks, Hugo M. Horlings, Lodewyk F. A. Wessels, Christian U. Blank, Yanling Xiao, Albert J. R. Heck, Jannie Borst, Thijn R. Brummelkamp () and Ton N. M. Schumacher ()
Additional contact information
Riccardo Mezzadra: The Netherlands Cancer Institute
Chong Sun: The Netherlands Cancer Institute
Lucas T. Jae: The Netherlands Cancer Institute
Raquel Gomez-Eerland: The Netherlands Cancer Institute
Evert de Vries: The Netherlands Cancer Institute
Wei Wu: Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences
Meike E. W. Logtenberg: The Netherlands Cancer Institute
Maarten Slagter: The Netherlands Cancer Institute
Elisa A. Rozeman: The Netherlands Cancer Institute
Ingrid Hofland: Core Facility Molecular Pathology & Biobanking, The Netherlands Cancer Institute
Annegien Broeks: Core Facility Molecular Pathology & Biobanking, The Netherlands Cancer Institute
Hugo M. Horlings: The Netherlands Cancer Institute
Lodewyk F. A. Wessels: The Netherlands Cancer Institute
Christian U. Blank: The Netherlands Cancer Institute
Yanling Xiao: The Netherlands Cancer Institute
Albert J. R. Heck: Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences
Jannie Borst: The Netherlands Cancer Institute
Thijn R. Brummelkamp: The Netherlands Cancer Institute
Ton N. M. Schumacher: The Netherlands Cancer Institute

Nature, 2017, vol. 549, issue 7670, 106-110

Abstract: CMTM6 and CMTM4 bind to and stabilize the inhibitory receptor PD-L1 and regulate PD-L1 levels at the surface of human tumour and immune cells.

Date: 2017
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DOI: 10.1038/nature23669

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