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Regulation of DNA repair pathway choice in S and G2 phases by the NHEJ inhibitor CYREN

Nausica Arnoult, Adriana Correia, Jiao Ma, Anna Merlo, Sara Garcia-Gomez, Marija Maric, Marco Tognetti, Christopher W. Benner, Simon J. Boulton, Alan Saghatelian and Jan Karlseder ()
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Nausica Arnoult: The Salk Institute for Biological Studies
Adriana Correia: The Salk Institute for Biological Studies
Jiao Ma: The Salk Institute for Biological Studies
Anna Merlo: The Salk Institute for Biological Studies
Sara Garcia-Gomez: Dsb Repair Metabolism Laboratory, The Francis Crick Institute
Marija Maric: Dsb Repair Metabolism Laboratory, The Francis Crick Institute
Marco Tognetti: The Salk Institute for Biological Studies
Christopher W. Benner: University of California San Diego
Simon J. Boulton: Dsb Repair Metabolism Laboratory, The Francis Crick Institute
Alan Saghatelian: The Salk Institute for Biological Studies
Jan Karlseder: The Salk Institute for Biological Studies

Nature, 2017, vol. 549, issue 7673, 548-552

Abstract: CYREN is a direct inhibitor of classical non-homologous end joining that promotes error-free repair by homologous recombination during the S and G2 phases of the cell cycle.

Date: 2017
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DOI: 10.1038/nature24023

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