A right-handed signalling pathway drives heart looping in vertebrates

Oscar H. Ocaña, Hakan Coskun, Carolina Minguillón, Prayag Murawala, Elly M. Tanaka, Joan Galcerán, Ramón Muñoz-Chápuli and M. Angela Nieto ()
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Oscar H. Ocaña: Instituto de Neurociencias (CSIC-UMH), Avenida Ramón y Cajal, s/n, Sant Joan d’Alacant
Hakan Coskun: Instituto de Neurociencias (CSIC-UMH), Avenida Ramón y Cajal, s/n, Sant Joan d’Alacant
Carolina Minguillón: Institut de Biologia Molecular de Barcelona
Prayag Murawala: DFG Center for Regenerative Therapies Dresden (CRTD), Technische Universität Dresden
Elly M. Tanaka: DFG Center for Regenerative Therapies Dresden (CRTD), Technische Universität Dresden
Joan Galcerán: Instituto de Neurociencias (CSIC-UMH), Avenida Ramón y Cajal, s/n, Sant Joan d’Alacant
Ramón Muñoz-Chápuli: University of Málaga
M. Angela Nieto: Instituto de Neurociencias (CSIC-UMH), Avenida Ramón y Cajal, s/n, Sant Joan d’Alacant

Nature, 2017, vol. 549, issue 7670, 86-90

Abstract: Two parallel signalling pathways, driven by Nodal and BMP, respectively integrate left- and right-handed information that drives heart looping and morphogenesis, and are conserved between zebrafish, chicken and mouse.

Date: 2017
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DOI: 10.1038/nature23454

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