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2012, volume 485, articles 7400

Breast cancer pp. S49-S49

Michelle Grayson

The hard facts pp. S50-S51

Amy Maxmen

Molecular oncology: The positive in the negative pp. S52-S53

Kendall Powell

Pregnancy: Delivery from breast cancer pp. S54-S54

Michael Eisenstein

Metastasis: The rude awakening pp. S55-S57

Jocelyn Rice

Perspective: The right trials pp. S58-S59

Patricia S. Steeg

Risk analysis: A dense issue pp. S60-S61

Duncan Graham-Rowe

Exercise: Powering up pp. S62-S63

Julie Corliss

Environment and genetics: Making sense of the noise pp. S64-S65

Anna Petherick

Perspective: Not just for women pp. S66-S66

Valerie Speirs

Let's mine asteroids — for science and profit pp. 549-549

Martin Elvis

Winners all round in telescope bid pp. 555-556

Geoff Brumfiel

Fracking boom spurs environmental audit pp. 556-557

Helen Thompson

US beef tests cook up a storm pp. 558-559

Helen Shen

Reform falters after Europe’s E. coli scare pp. 559-559

Marian Turner

Anarchists attack science pp. 561-561

Leigh Phillips

Polio’s last stand pp. 563-563

Ewen Callaway

Scientists: your number is up pp. 564-564

Declan Butler

Endangered species: Sex and the single rhinoceros pp. 566-569

Henry Nicholls

Microglia: The constant gardeners pp. 570-572

Virginia Hughes

Stop squandering helium pp. 573-575

William Nuttall, Richard H. Clarke and Bartek A. Glowacki

Bring safe sex to China pp. 576-577

Hong Shang, Junjie Xu, Xiaoxu Han, Jessica Spero Li, Kelly C. Arledge and Linqi Zhang

In retrospect: Silent Spring pp. 578-579

Rob Dunn

Computer science: The great between pp. 580-580

Nigel Shadbolt

Military science: Empires of reason pp. 581-581

Alison Abbott

Reduce uncertainty in UK badger culling pp. 582-582

Christl A. Donnelly and Rosie Woodroffe

Personalized drugs should cut care costs pp. 582-582

Nafees N. Malik

Include all institutes in publishing index pp. 582-582

Stephen Levinson

Food safety body is bound to draw fire pp. 582-582

Kim Hendrickx and Bart Penders

The importance of being modular pp. 584-585

Paul W. K. Rothemund and Ebbe Sloth Andersen

Reprogramming the injured heart pp. 585-586

Nathan J. Palpant and Charles E. Murry

Homo 'incendius' pp. 586-587

Richard G. Roberts and Michael I. Bird

Repulsive polarons found pp. 588-589

Peter Hannaford

Actin' dangerously pp. 589-590

Gordon D. Brown

Tumour friend or foe pp. 590-591

Robert U. Svensson and Reuben J. Shaw

In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes pp. 593-598

Li Qian, Yu Huang, C. Ian Spencer, Amy Foley, Vasanth Vedantham, Lei Liu, Simon J. Conway, Ji-dong Fu and Deepak Srivastava

Heart repair by reprogramming non-myocytes with cardiac transcription factors pp. 599-604

Kunhua Song, Young-Jae Nam, Xiang Luo, Xiaoxia Qi, Wei Tan, Guo N. Huang, Asha Acharya, Christopher L. Smith, Michelle D. Tallquist, Eric G. Neilson, Joseph A. Hill, Rhonda Bassel-Duby and Eric N. Olson

The let-7–Imp axis regulates ageing of the Drosophila testis stem-cell niche pp. 605-610

Hila Toledano, Cecilia D’Alterio, Benjamin Czech, Erel Levine and D. Leanne Jones

A spectrograph for exoplanet observations calibrated at the centimetre-per-second level pp. 611-614

Tobias Wilken, Gaspare Lo Curto, Rafael A. Probst, Tilo Steinmetz, Antonio Manescau, Luca Pasquini, Jonay I. González Hernández, Rafael Rebolo, Theodor W. Hänsch, Thomas Udem and Ronald Holzwarth

Metastability and coherence of repulsive polarons in a strongly interacting Fermi mixture pp. 615-618

C. Kohstall, M. Zaccanti, M. Jag, A. Trenkwalder, P. Massignan, G. M. Bruun, F. Schreck and R. Grimm

Attractive and repulsive Fermi polarons in two dimensions pp. 619-622

Marco Koschorreck, Daniel Pertot, Enrico Vogt, Bernd Fröhlich, Michael Feld and Michael Köhl

Complex shapes self-assembled from single-stranded DNA tiles pp. 623-626

Bryan Wei, Mingjie Dai and Peng Yin

Hafnium isotope evidence for a transition in the dynamics of continental growth 3.2 Gyr ago pp. 627-630

T. Næraa, A. Scherstén, M. T. Rosing, A. I. S. Kemp, J. E. Hoffmann, T. F. Kokfelt and M. J. Whitehouse

Accelerated speciation in colour-polymorphic birds pp. 631-634

Andrew F. Hugall and Devi Stuart-Fox

Genetic recombination is directed away from functional genomic elements in mice pp. 642-645

Kevin Brick, Fatima Smagulova, Pavel Khil, R. Daniel Camerini-Otero and Galina V. Petukhova

Recurrent network activity drives striatal synaptogenesis pp. 646-650

Yevgenia Kozorovitskiy, Arpiar Saunders, Caroline A. Johnson, Bradford B. Lowell and Bernardo L. Sabatini

Prion-like behaviour and tau-dependent cytotoxicity of pyroglutamylated amyloid-β pp. 651-655

Justin M. Nussbaum, Stephan Schilling, Holger Cynis, Antonia Silva, Eric Swanson, Tanaporn Wangsanut, Kaycie Tayler, Brian Wiltgen, Asa Hatami, Raik Rönicke, Klaus Reymann, Birgit Hutter-Paier, Anca Alexandru, Wolfgang Jagla, Sigrid Graubner, Charles G. Glabe, Hans-Ulrich Demuth and George S. Bloom

Inhibitory receptors bind ANGPTLs and support blood stem cells and leukaemia development pp. 656-660

Junke Zheng, Masato Umikawa, Changhao Cui, Jiyuan Li, Xiaoli Chen, Chaozheng Zhang, HoangDinh Huynh, Xunlei Kang, Robert Silvany, Xuan Wan, Jingxiao Ye, Alberto Puig Cantó, Shu-Hsia Chen, Huan-You Wang, E. Sally Ward and Cheng Cheng Zhang

AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress pp. 661-665

Sang-Min Jeon, Navdeep S. Chandel and Nissim Hay

Addendum: Verbal and non-verbal intelligence changes in the teenage brain pp. 666-666

Sue Ramsden, Fiona M. Richardson, Goulven Josse, Michael S. C. Thomas, Caroline Ellis, Clare Shakeshaft, Mohamed L. Seghier and Cathy J. Price

Biotechnology investment: Gains and losses pp. 667-668

Karen Kaplan

Turning point: Mayim Bialik pp. 669-669

Gene Russo

On the edge pp. 672-672

Monya Baker

2012, volume 485, articles 7399

New evidence on testosterone and cooperation pp. E4-E5

Jack van Honk, Estrella R. Montoya, Peter A. Bos, Mark van Vugt and David Terburg

Eisenegger et al. reply pp. E5-E6

C. Eisenegger, M. Naef, R. Snozzi, M. Heinrichs and Ernst Fehr

We must set planetary boundaries wisely pp. 417-417

Simon L. Lewis

Fukushima’s doses tallied pp. 423-424

Geoff Brumfiel

Biosafety concerns for labs in the developing world pp. 425-425

Ewen Callaway

US government sets out Alzheimer’s plan pp. 426-427

Meredith Wadman

Global council aims to coordinate science pp. 427-427

Richard Van Noorden

Hubble to revisit exoplanet puzzle pp. 428-428

Ron Cowen

Cancelled project spurs debate over geoengineering patents pp. 429-429

Daniel Cressey

War on weeds loses ground pp. 430-430

Helen Thompson

Bird-flu research: The biosecurity oversight pp. 431-434

Brendan Maher

Gran Sasso: Chamber of physics pp. 435-438

Nicola Nosengo

Recover the lost art of drug discovery pp. 439-440

Kim Lewis

The hidden costs of flexible fertility pp. 441-441

Richard Owen and Susan Jobling

Development: Striking out for new territory pp. 442-443

Wendy Wolford

Behavioural ecology: Design for living pp. 444-444

Manfred Milinski

Q&A: The graphic historian pp. 445-445

Jascha Hoffman

Categorize probiotics to speed research pp. 446-446

Gregor Reid

Support home-grown plant collectors pp. 446-446

Philip E. Hulme

Careless linking of Wallace and Darwin pp. 446-446

K. Razi Naqvi

Monitoring fungal infections in fish pp. 446-446

Rodolphe Gozlan

Flowering in the greenhouse pp. 448-449

This Rutishauser, Reto Stöckli, John Harte and Lara Kueppers

Molecules meet materials pp. 450-451

Thomas E. Mallouk

A breach in the blood–brain barrier pp. 451-452

Peter Carmeliet and Bart De Strooper

Portrait of Earth's coming of age pp. 452-453

William M. White

Crystal–clear brains pp. 453-455

Joseph R. Fetcho

A reminder of the beauty we know pp. 455-456

Jonathan Butterworth

Startling superflares pp. 456-457

Bradley E. Schaefer

Peroxiredoxins are conserved markers of circadian rhythms pp. 459-464

Rachel S. Edgar, Edward W. Green, Yuwei Zhao, Gerben van Ooijen, Maria Olmedo, Ximing Qin, Yao Xu, Min Pan, Utham K. Valekunja, Kevin A. Feeney, Elizabeth S. Maywood, Michael H. Hastings, Nitin S. Baliga, Martha Merrow, Andrew J. Millar, Carl H. Johnson, Charalambos P. Kyriacou, John S. O’Neill and Akhilesh B. Reddy

Rab5 is necessary for the biogenesis of the endolysosomal system in vivo pp. 465-470

Anja Zeigerer, Jerome Gilleron, Roman L. Bogorad, Giovanni Marsico, Hidenori Nonaka, Sarah Seifert, Hila Epstein-Barash, Satya Kuchimanchi, Chang Geng Peng, Vera M. Ruda, Perla Del Conte-Zerial, Jan G. Hengstler, Yannis Kalaidzidis, Victor Koteliansky and Marino Zerial

Brain-wide neuronal dynamics during motor adaptation in zebrafish pp. 471-477

Misha B. Ahrens, Jennifer M. Li, Michael B. Orger, Drew N. Robson, Alexander F. Schier, Florian Engert and Ruben Portugues

Superflares on solar-type stars pp. 478-481

Hiroyuki Maehara, Takuya Shibayama, Shota Notsu, Yuta Notsu, Takashi Nagao, Satoshi Kusaba, Satoshi Honda, Daisaku Nogami and Kazunari Shibata

Tunable ion–photon entanglement in an optical cavity pp. 482-485

A. Stute, B. Casabone, P. Schindler, T. Monz, P. O. Schmidt, B. Brandstätter, T. E. Northup and R. Blatt

All-solid-state dye-sensitized solar cells with high efficiency pp. 486-489

In Chung, Byunghong Lee, Jiaqing He, Robert P. H. Chang and Mercouri G. Kanatzidis

Statistical geochemistry reveals disruption in secular lithospheric evolution about 2.5 Gyr ago pp. 490-493

C. Brenhin Keller and Blair Schoene

Warming experiments underpredict plant phenological responses to climate change pp. 494-497

E. M. Wolkovich, B. I. Cook, J. M. Allen, T. M. Crimmins, J. L. Betancourt, S. E. Travers, S. Pau, J. Regetz, T. J. Davies, N. J. B. Kraft, T. R. Ault, K. Bolmgren, S. J. Mazer, G. J. McCabe, B. J. McGill, C. Parmesan, N. Salamin, M. D. Schwartz and E. E. Cleland

Discovery of a sensory organ that coordinates lunge feeding in rorqual whales pp. 498-501

Nicholas D. Pyenson, Jeremy A. Goldbogen, A. Wayne Vogl, Gabor Szathmary, Richard L. Drake and Robert E. Shadwick

Melanoma genome sequencing reveals frequent PREX2 mutations pp. 502-506

Michael F. Berger, Eran Hodis, Timothy P. Heffernan, Yonathan Lissanu Deribe, Michael S. Lawrence, Alexei Protopopov, Elena Ivanova, Ian R. Watson, Elizabeth Nickerson, Papia Ghosh, Hailei Zhang, Rhamy Zeid, Xiaojia Ren, Kristian Cibulskis, Andrey Y. Sivachenko, Nikhil Wagle, Antje Sucker, Carrie Sougnez, Robert Onofrio, Lauren Ambrogio, Daniel Auclair, Timothy Fennell, Scott L. Carter, Yotam Drier, Petar Stojanov, Meredith A. Singer, Douglas Voet, Rui Jing, Gordon Saksena, Jordi Barretina, Alex H. Ramos, Trevor J. Pugh, Nicolas Stransky, Melissa Parkin, Wendy Winckler, Scott Mahan, Kristin Ardlie, Jennifer Baldwin, Jennifer Wargo, Dirk Schadendorf, Matthew Meyerson, Stacey B. Gabriel, Todd R. Golub, Stephan N. Wagner, Eric S. Lander, Gad Getz, Lynda Chin and Levi A. Garraway

Sustained translational repression by eIF2α-P mediates prion neurodegeneration pp. 507-511

Julie A. Moreno, Helois Radford, Diego Peretti, Joern R. Steinert, Nicholas Verity, Maria Guerra Martin, Mark Halliday, Jason Morgan, David Dinsdale, Catherine A. Ortori, David A. Barrett, Pavel Tsaytler, Anne Bertolotti, Anne E. Willis, Martin Bushell and Giovanna R. Mallucci

Apolipoprotein E controls cerebrovascular integrity via cyclophilin A pp. 512-516

Robert D. Bell, Ethan A. Winkler, Itender Singh, Abhay P. Sagare, Rashid Deane, Zhenhua Wu, David M. Holtzman, Christer Betsholtz, Annika Armulik, Jan Sallstrom, Bradford C. Berk and Berislav V. Zlokovic

Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity pp. 517-521

Ursula Fünfschilling, Lotti M. Supplie, Don Mahad, Susann Boretius, Aiman S. Saab, Julia Edgar, Bastian G. Brinkmann, Celia M. Kassmann, Iva D. Tzvetanova, Wiebke Möbius, Francisca Diaz, Dies Meijer, Ueli Suter, Bernd Hamprecht, Michael W. Sereda, Carlos T. Moraes, Jens Frahm, Sandra Goebbels and Klaus-Armin Nave

Cryptic peroxisomal targeting via alternative splicing and stop codon read-through in fungi pp. 522-525

Johannes Freitag, Julia Ast and Michael Bölker

The complex of tmRNA–SmpB and EF-G on translocating ribosomes pp. 526-529

David J. F. Ramrath, Hiroshi Yamamoto, Kristian Rother, Daniela Wittek, Markus Pech, Thorsten Mielke, Justus Loerke, Patrick Scheerer, Pavel Ivanov, Yoshika Teraoka, Olga Shpanchenko, Knud H. Nierhaus and Christian M. T. Spahn

Evolution of the chalcone-isomerase fold from fatty-acid binding to stereospecific catalysis pp. 530-533

Micheline N. Ngaki, Gordon V. Louie, Ryan N. Philippe, Gerard Manning, Florence Pojer, Marianne E. Bowman, Ling Li, Elise Larsen, Eve Syrkin Wurtele and Joseph P. Noel

Erratum: Aerosols implicated as a prime driver of twentieth-century North Atlantic climate variability pp. 534-534

Ben B. B. Booth, Nick J. Dunstone, Paul R. Halloran, Timothy Andrews and Nicolas Bellouin

Postgraduate options: Academia misses the mark pp. 535-536

Karen Kaplan

Turning point: Ricardo Dolmetsch pp. 537-537

Virginia Gewin

The common app pp. 540-540

Robert Scherrer

2012, volume 485, articles 7398

Diabetes pp. S1-S1

Herb Brody

Diabetes in numbers pp. S2-S3

Tony Scully

Immunomodulators: Cell savers pp. S4-S5

Sarah DeWeerdt

Medical devices: Managed by machine pp. S6-S8

Elie Dolgin

Perspective: Rethink the immune connection pp. S9-S9

Carla Greenbaum

Pathology: Cause and effect pp. S10-S11

Erika Jonietz

Microbiome: The critters within pp. S12-S13

Lauren Gravitz

Public health: India's diabetes time bomb pp. S14-S16

Priya Shetty

Perspective: Testing failures pp. S17-S17

Thomas Mandrup-Poulsen

Prevention: Nipped in the bud pp. S18-S19

Scott P. Edwards

Reach out to defend evolution pp. 281-281

Russell Garwood

Child-study turmoil leaves bitter taste pp. 287-288

Meredith Wadman

Plagiarism charge for Romanian minister pp. 289-289

Alison Abbott

Messages from the early Universe pp. 290-291

Eric Hand

Malaria surge feared pp. 293-293

Amy Maxmen

EU agencies accused of conflicts of interest pp. 294-295

Declan Butler

Go West, young Russian pp. 295-295

Quirin Schiermeier

Rise of the coyote: The new top dog pp. 296-297

Sharon Levy

Replication studies: Bad copy pp. 298-300

Ed Yong

Beyond the great and good pp. 301-302

Robert Doubleday and James Wilsdon

Last chance to see pp. 303-304

Jay M. Pasachoff

Astronomy: On the track of the transit pp. 305-306

Owen Gingerich

Biology: Mammary chronicles pp. 306-307

Josie Glausiusz

Q&A: Soundscape explorer pp. 308-308

Jascha Hoffman

Don't let furore over neutrinos blur results pp. 309-309

Tommy Ohlsson

Control electronic waste in India pp. 309-309

Govindasamy Agoramoorthy and Chiranjib Chakraborty

Preserve Brazil's aquatic biodiversity pp. 309-309

Jean R. S. Vitule

In defence of the animal model pp. 309-309

Richard M. Baldarelli

The social sciences are already relevant pp. 309-309

Frank J. van Rijnsoever

Martian sand blowing in the wind pp. 312-313

Jasper Kok

Electrons get real pp. 313-314

Manfred Lein

How opioid drugs bind to receptors pp. 314-317

Marta Filizola and Lakshmi A. Devi

Brain-controlled robot grabs attention pp. 317-318

Andrew Jackson

Fish heads and human disease pp. 318-319

Dheeraj Malhotra and Jonathan Sebat

Geomagnetism under scrutiny pp. 319-320

Bruce Buffett

Crystal structure of the µ-opioid receptor bound to a morphinan antagonist pp. 321-326

Aashish Manglik, Andrew C. Kruse, Tong Sun Kobilka, Foon Sun Thian, Jesper M. Mathiesen, Roger K. Sunahara, Leonardo Pardo, William I. Weis, Brian K. Kobilka and Sébastien Granier

Structure of the human κ-opioid receptor in complex with JDTic pp. 327-332

Huixian Wu, Daniel Wacker, Mauro Mileni, Vsevolod Katritch, Gye Won Han, Eyal Vardy, Wei Liu, Aaron A. Thompson, Xi-Ping Huang, F. Ivy Carroll, S. Wayne Mascarella, Richard B. Westkaemper, Philip D. Mosier, Bryan L. Roth, Vadim Cherezov and Raymond C. Stevens

Cardiac angiogenic imbalance leads to peripartum cardiomyopathy pp. 333-338

Ian S. Patten, Sarosh Rana, Sajid Shahul, Glenn C. Rowe, Cholsoon Jang, Laura Liu, Michele R. Hacker, Julie S. Rhee, John Mitchell, Feroze Mahmood, Philip Hess, Caitlin Farrell, Nicole Koulisis, Eliyahu V. Khankin, Suzanne D. Burke, Igor Tudorache, Johann Bauersachs, Federica del Monte, Denise Hilfiker-Kleiner, S. Ananth Karumanchi and Zoltan Arany

Earth-like sand fluxes on Mars pp. 339-342

N. T. Bridges, F. Ayoub, J-P. Avouac, S. Leprince, A. Lucas and S. Mattson

Resolving the time when an electron exits a tunnelling barrier pp. 343-346

Dror Shafir, Hadas Soifer, Barry D. Bruner, Michal Dagan, Yann Mairesse, Serguei Patchkovskii, Misha Yu. Ivanov, Olga Smirnova and Nirit Dudovich

Light-induced liquid crystallinity pp. 347-349

Tamas Kosa, Ludmila Sukhomlinova, Linli Su, Bahman Taheri, Timothy J. White and Timothy J. Bunning

Recent Northern Hemisphere tropical expansion primarily driven by black carbon and tropospheric ozone pp. 350-354

Robert J. Allen, Steven C. Sherwood, Joel R. Norris and Charles S. Zender

Thermal and electrical conductivity of iron at Earth’s core conditions pp. 355-358

Monica Pozzo, Chris Davies, David Gubbins and Dario Alfè

Extended leaf phenology and the autumn niche in deciduous forest invasions pp. 359-362

Jason D. Fridley

KCTD13 is a major driver of mirrored neuroanatomical phenotypes of the 16p11.2 copy number variant pp. 363-367

Christelle Golzio, Jason Willer, Michael E. Talkowski, Edwin C. Oh, Yu Taniguchi, Sébastien Jacquemont, Alexandre Reymond, Mei Sun, Akira Sawa, James F. Gusella, Atsushi Kamiya, Jacques S. Beckmann and Nicholas Katsanis

Restoration of grasp following paralysis through brain-controlled stimulation of muscles pp. 368-371

C. Ethier, E. R. Oby, M. J. Bauman and L. E. Miller

Reach and grasp by people with tetraplegia using a neurally controlled robotic arm pp. 372-375

Leigh R. Hochberg, Daniel Bacher, Beata Jarosiewicz, Nicolas Y. Masse, John D. Simeral, Joern Vogel, Sami Haddadin, Jie Liu, Sydney S. Cash, Patrick van der Smagt and John P. Donoghue

Topological domains in mammalian genomes identified by analysis of chromatin interactions pp. 376-380

Jesse R. Dixon, Siddarth Selvaraj, Feng Yue, Audrey Kim, Yan Li, Yin Shen, Ming Hu, Jun S. Liu and Bing Ren

Spatial partitioning of the regulatory landscape of the X-inactivation centre pp. 381-385

Elphège P. Nora, Bryan R. Lajoie, Edda G. Schulz, Luca Giorgetti, Ikuhiro Okamoto, Nicolas Servant, Tristan Piolot, Nynke L. van Berkum, Johannes Meisig, John Sedat, Joost Gribnau, Emmanuel Barillot, Nils Blüthgen, Job Dekker and Edith Heard

RNF12 initiates X-chromosome inactivation by targeting REX1 for degradation pp. 386-390

Cristina Gontan, Eskeatnaf Mulugeta Achame, Jeroen Demmers, Tahsin Stefan Barakat, Eveline Rentmeester, Wilfred van IJcken, J. Anton Grootegoed and Joost Gribnau

A PPARγ–FGF1 axis is required for adaptive adipose remodelling and metabolic homeostasis pp. 391-394

Johan W. Jonker, Jae Myoung Suh, Annette R. Atkins, Maryam Ahmadian, Pingping Li, Jamie Whyte, Mingxiao He, Henry Juguilon, Yun-Qiang Yin, Colin T. Phillips, Ruth T. Yu, Jerrold M. Olefsky, Robert R. Henry, Michael Downes and Ronald M. Evans

Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic pp. 395-399

Aaron A. Thompson, Wei Liu, Eugene Chun, Vsevolod Katritch, Huixian Wu, Eyal Vardy, Xi-Ping Huang, Claudio Trapella, Remo Guerrini, Girolamo Calo, Bryan L. Roth, Vadim Cherezov and Raymond C. Stevens

Structure of the δ-opioid receptor bound to naltrindole pp. 400-404

Sébastien Granier, Aashish Manglik, Andrew C. Kruse, Tong Sun Kobilka, Foon Sun Thian, William I. Weis and Brian K. Kobilka

Going digital pp. 405-407

Roberta Kwok

Turning point: Mark Lawrence pp. 407-407

Alexandra Bell

Ravages of time pp. 410-410

Alex Shvartsman

2012, volume 485, articles 7397

Nanostructure-enhanced atomic line emission pp. E1-E2

M. Sivis, M. Duwe, B. Abel and C. Ropers

Kim et al. reply pp. E2-E3

Seungchul Kim, Jonghan Jin, Young-Jin Kim, In-Yong Park, Yunseok Kim and Seung-Woo Kim

Beware the creeping cracks of bias pp. 149-149

Daniel Sarewitz

War of words over tribal tongue pp. 155-156

Eugenie Samuel Reich

LHC prepares for data pile-up pp. 156-157

Geoff Brumfiel

A boost for quantum reality pp. 157-158

Eugenie Samuel Reich

Development project touts health victory pp. 158-159

Natasha Gilbert

Drug-making plant blooms pp. 160-160

Amy Maxmen

Radiation risks: Raiders of the lost archive pp. 162-163

Alison Abbott

Climate forecasting: A break in the clouds pp. 164-166

Jeff Tollefson

Time to bury plutonium pp. 167-168

Frank von Hippel, Rodney Ewing, Richard Garwin and Allison Macfarlane

Strengthen and stabilize the FDA pp. 169-170

Daniel Carpenter

Natural selection: The evolutionary struggle pp. 171-172

Andrew Berry

Q&A: Nature's digitizer pp. 172-173

Jascha Hoffman

Indian science needs alternative investors pp. 174-174

Siddhartha P. Kar

Cyprus Institute: It deserves more credit pp. 174-174

Edouard Brézin

Cyprus Institute: Improve oversight pp. 174-174

Emmanouil Lioudakis

A UK tissue bank for breast tumours pp. 174-174

Alastair M. Thompson

Science sociology began before Kuhn pp. 174-174

Ulrich Lehmann

Comparing apples with oranges pp. 176-177

John P. Reganold and Achim Dobermann

Cracks tamed pp. 177-178

Antonio J. Pons

Escaped DNA inflames the heart pp. 179-180

Klitos Konstantinidis and Richard N. Kitsis

A grip on ice-age ocean circulation pp. 180-181

Jochem Marotzke

One step closer to gut repair pp. 181-182

Anisa Shaker and Deborah C. Rubin

Star ripped to shreds pp. 183-183

Giuseppe Lodato

Engineering the third wave of biocatalysis pp. 185-194

U. T. Bornscheuer, G. W. Huisman, R. J. Kazlauskas, S. Lutz, J. C. Moore and K. Robins

ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner pp. 195-200

Huai-Xiang Hao, Yang Xie, Yue Zhang, Olga Charlat, Emma Oster, Monika Avello, Hong Lei, Craig Mickanin, Dong Liu, Heinz Ruffner, Xiaohong Mao, Qicheng Ma, Raffaella Zamponi, Tewis Bouwmeester, Peter M. Finan, Marc W. Kirschner, Jeffery A. Porter, Fabrizio C. Serluca and Feng Cong

Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq pp. 201-206

Dan Dominissini, Sharon Moshitch-Moshkovitz, Schraga Schwartz, Mali Salmon-Divon, Lior Ungar, Sivan Osenberg, Karen Cesarkas, Jasmine Jacob-Hirsch, Ninette Amariglio, Martin Kupiec, Rotem Sorek and Gideon Rechavi

Molecular mechanism of ATP binding and ion channel activation in P2X receptors pp. 207-212

Motoyuki Hattori and Eric Gouaux

The suppression of star formation by powerful active galactic nuclei pp. 213-216

M. J. Page, M. Symeonidis, J. D. Vieira, B. Altieri, A. Amblard, V. Arumugam, H. Aussel, T. Babbedge, A. Blain, J. Bock, A. Boselli, V. Buat, N. Castro-Rodríguez, A. Cava, P. Chanial, D. L. Clements, A. Conley, L. Conversi, A. Cooray, C. D. Dowell, E. N. Dubois, J. S. Dunlop, E. Dwek, S. Dye, S. Eales, D. Elbaz, D. Farrah, M. Fox, A. Franceschini, W. Gear, J. Glenn, M. Griffin, M. Halpern, E. Hatziminaoglou, E. Ibar, K. Isaak, R. J. Ivison, G. Lagache, L. Levenson, N. Lu, S. Madden, B. Maffei, G. Mainetti, L. Marchetti, H. T. Nguyen, B. O’Halloran, S. J. Oliver, A. Omont, P. Panuzzo, A. Papageorgiou, C. P. Pearson, I. Pérez-Fournon, M. Pohlen, J. I. Rawlings, D. Rigopoulou, L. Riguccini, D. Rizzo, G. Rodighiero, I. G. Roseboom, M. Rowan-Robinson, M. Sánchez Portal, B. Schulz, D. Scott, N. Seymour, D. L. Shupe, A. J. Smith, J. A. Stevens, M. Trichas, K. E. Tugwell, M. Vaccari, I. Valtchanov, M. Viero, L. Vigroux, L. Wang, R. Ward, G. Wright, C. K. Xu and M. Zemcov

An ultraviolet–optical flare from the tidal disruption of a helium-rich stellar core pp. 217-220

S. Gezari, R. Chornock, A. Rest, M. E. Huber, K. Forster, E. Berger, P. J. Challis, J. D. Neill, D. C. Martin, T. Heckman, A. Lawrence, C. Norman, G. Narayan, R. J. Foley, G. H. Marion, D. Scolnic, L. Chomiuk, A. Soderberg, K. Smith, R. P. Kirshner, A. G. Riess, S. J. Smartt, C. W. Stubbs, J. L. Tonry, W. M. Wood-Vasey, W. S. Burgett, K. C. Chambers, T. Grav, J. N. Heasley, N. Kaiser, R.-P. Kudritzki, E. A. Magnier, J. S. Morgan and P. A. Price

Patterning by controlled cracking pp. 221-224

Koo Hyun Nam, Il H. Park and Seung Hwan Ko

Twenty-first-century warming of a large Antarctic ice-shelf cavity by a redirected coastal current pp. 225-228

Hartmut H. Hellmer, Frank Kauker, Ralph Timmermann, Jürgen Determann and Jamie Rae

Comparing the yields of organic and conventional agriculture pp. 229-232

Verena Seufert, Navin Ramankutty and Jonathan A. Foley

Selective cortical representation of attended speaker in multi-talker speech perception pp. 233-236

Nima Mesgarani and Edward F. Chang

De novo mutations revealed by whole-exome sequencing are strongly associated with autism pp. 237-241

Stephan J. Sanders, Michael T. Murtha, Abha R. Gupta, John D. Murdoch, Melanie J. Raubeson, A. Jeremy Willsey, A. Gulhan Ercan-Sencicek, Nicholas M. DiLullo, Neelroop N. Parikshak, Jason L. Stein, Michael F. Walker, Gordon T. Ober, Nicole A. Teran, Youeun Song, Paul El-Fishawy, Ryan C. Murtha, Murim Choi, John D. Overton, Robert D. Bjornson, Nicholas J. Carriero, Kyle A. Meyer, Kaya Bilguvar, Shrikant M. Mane, Nenad Šestan, Richard P. Lifton, Murat Günel, Kathryn Roeder, Daniel H. Geschwind, Bernie Devlin and Matthew W. State

Patterns and rates of exonic de novo mutations in autism spectrum disorders pp. 242-245

Benjamin M. Neale, Yan Kou, Li Liu, Avi Ma’ayan, Kaitlin E. Samocha, Aniko Sabo, Chiao-Feng Lin, Christine Stevens, Li-San Wang, Vladimir Makarov, Paz Polak, Seungtai Yoon, Jared Maguire, Emily L. Crawford, Nicholas G. Campbell, Evan T. Geller, Otto Valladares, Chad Schafer, Han Liu, Tuo Zhao, Guiqing Cai, Jayon Lihm, Ruth Dannenfelser, Omar Jabado, Zuleyma Peralta, Uma Nagaswamy, Donna Muzny, Jeffrey G. Reid, Irene Newsham, Yuanqing Wu, Lora Lewis, Yi Han, Benjamin F. Voight, Elaine Lim, Elizabeth Rossin, Andrew Kirby, Jason Flannick, Menachem Fromer, Khalid Shakir, Tim Fennell, Kiran Garimella, Eric Banks, Ryan Poplin, Stacey Gabriel, Mark DePristo, Jack R. Wimbish, Braden E. Boone, Shawn E. Levy, Catalina Betancur, Shamil Sunyaev, Eric Boerwinkle, Joseph D. Buxbaum, Edwin H. Cook, Bernie Devlin, Richard A. Gibbs, Kathryn Roeder, Gerard D. Schellenberg, James S. Sutcliffe and Mark J. Daly

Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations pp. 246-250

Brian J. O’Roak, Laura Vives, Santhosh Girirajan, Emre Karakoc, Niklas Krumm, Bradley P. Coe, Roie Levy, Arthur Ko, Choli Lee, Joshua D. Smith, Emily H. Turner, Ian B. Stanaway, Benjamin Vernot, Maika Malig, Carl Baker, Beau Reilly, Joshua M. Akey, Elhanan Borenstein, Mark J. Rieder, Deborah A. Nickerson, Raphael Bernier, Jay Shendure and Evan E. Eichler

Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure pp. 251-255

Takafumi Oka, Shungo Hikoso, Osamu Yamaguchi, Manabu Taneike, Toshihiro Takeda, Takahito Tamai, Jota Oyabu, Tomokazu Murakawa, Hiroyuki Nakayama, Kazuhiko Nishida, Shizuo Akira, Akitsugu Yamamoto, Issei Komuro and Kinya Otsu

Cell attachment protein VP8* of a human rotavirus specifically interacts with A-type histo-blood group antigen pp. 256-259

Liya Hu, Sue E. Crawford, Rita Czako, Nicolas W. Cortes-Penfield, David F. Smith, Jacques Le Pendu, Mary K. Estes and B. V. Venkataram Prasad

Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia pp. 260-263

Catherine C. Smith, Qi Wang, Chen-Shan Chin, Sara Salerno, Lauren E. Damon, Mark J. Levis, Alexander E. Perl, Kevin J. Travers, Susana Wang, Jeremy P. Hunt, Patrick P. Zarrinkar, Eric E. Schadt, Andrew Kasarskis, John Kuriyan and Neil P. Shah

Systematic discovery of structural elements governing stability of mammalian messenger RNAs pp. 264-268

Hani Goodarzi, Hamed S. Najafabadi, Panos Oikonomou, Todd M. Greco, Lisa Fish, Reza Salavati, Ileana M. Cristea and Saeed Tavazoie

Enterprising science pp. 269-270

Peter Fiske

The appropriate response pp. 272-272

Jeff Samson

2012, volume 485, articles 7396

Mutant flu — the view from the newsroom pp. 7-7

David Brown

Mutant-flu paper published pp. 13-14

Ed Yong

Trial tests Austrian integrity body pp. 15-15

Alison Abbott

Neutrino project changes focus pp. 16-16

Nicola Jones

US satellite laws under scrutiny pp. 17-17

Sharon Weinberger

Brazil set to cut forest protection pp. 19-19

Jeff Tollefson

Pre-term births on the rise pp. 20-20

Eugenie Samuel Reich

Universities clash by the Nile pp. 21-21

Katharine Sanderson

Human migrations: Eastern odyssey pp. 24-26

Tim Appenzeller

Archaeology: Date with history pp. 27-29

Ewen Callaway

Ancient migration: Coming to America pp. 30-32

Andrew Curry

What makes a modern human pp. 33-35

Chris Stringer

Natural history: The wilder side of Edward Lear pp. 36-37

Robert McCracken Peck

Earth science: How a world came to be pp. 39-39

Birger Schmitz

Q&A: Relativistic composer pp. 40-40

Philip Ball

PhDs: Adapt training for developing world pp. 41-41

Robert Colebunders

PhDs: Acquired skills good for marketplace pp. 41-41

Henrik G. Dohlman

No silver bullets for African soil problems pp. 41-41

Ken E. Giller

Keep 'reproducibility' in context pp. 41-41

Brad Picha, Matthew Thompson and Thomas M. Vondriska

Focus on ancient bombardment pp. 44-45

Frank T. Kyte

Time in a bottle pp. 45-46

Joseph Bass

Electrons do the split pp. 46-47

Ralph Claessen

Double protection for weakened bones pp. 47-48

Mone Zaidi and Jameel Iqbal

Two-armed silicon pp. 49-50

Robert West

The director's cut pp. 50-51

Antonio Gentilella and George Thomas

Lower mantle may be rich in silica pp. 51-52

Ian Jackson

Mercury's mysteries start to unfold pp. 52-53

David J. Stevenson

The translational landscape of mTOR signalling steers cancer initiation and metastasis pp. 55-61

Andrew C. Hsieh, Yi Liu, Merritt P. Edlind, Nicholas T. Ingolia, Matthew R. Janes, Annie Sher, Evan Y. Shi, Craig R. Stumpf, Carly Christensen, Michael J. Bonham, Shunyou Wang, Pingda Ren, Michael Martin, Katti Jessen, Morris E. Feldman, Jonathan S. Weissman, Kevan M. Shokat, Christian Rommel and Davide Ruggero

Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists pp. 62-68

Laura A. Solt, Yongjun Wang, Subhashis Banerjee, Travis Hughes, Douglas J. Kojetin, Thomas Lundasen, Youseung Shin, Jin Liu, Michael D. Cameron, Romain Noel, Seung-Hee Yoo, Joseph S. Takahashi, Andrew A. Butler, Theodore M. Kamenecka and Thomas P. Burris

Osteoprotection by semaphorin 3A pp. 69-74

Mikihito Hayashi, Tomoki Nakashima, Masahiko Taniguchi, Tatsuhiko Kodama, Atsushi Kumanogoh and Hiroshi Takayanagi

Impact spherules as a record of an ancient heavy bombardment of Earth pp. 75-77

B. C. Johnson and H. J. Melosh

An Archaean heavy bombardment from a destabilized extension of the asteroid belt pp. 78-81

William F. Bottke, David Vokrouhlický, David Minton, David Nesvorný, Alessandro Morbidelli, Ramon Brasser, Bruce Simonson and Harold F. Levison

Spin–orbital separation in the quasi-one-dimensional Mott insulator Sr2CuO3 pp. 82-85

J. Schlappa, K. Wohlfeld, K. J. Zhou, M. Mourigal, M. W. Haverkort, V. N. Strocov, L. Hozoi, C. Monney, S. Nishimoto, S. Singh, A. Revcolevschi, J.-S. Caux, L. Patthey, H. M. Rønnow, J. van den Brink and T. Schmitt

Liquid-crystal-mediated self-assembly at nanodroplet interfaces pp. 86-89

J. A. Moreno-Razo, E. J. Sambriski, N. L. Abbott, J. P. Hernández-Ortiz and J. J. de Pablo

A perovskitic lower mantle inferred from high-pressure, high-temperature sound velocity data pp. 90-94

Motohiko Murakami, Yasuo Ohishi, Naohisa Hirao and Kei Hirose

Evidence of non-random mutation rates suggests an evolutionary risk management strategy pp. 95-98

Iñigo Martincorena, Aswin S. N. Seshasayee and Nicholas M. Luscombe

Restoration of vision after transplantation of photoreceptors pp. 99-103

R. A. Pearson, A. C. Barber, M. Rizzi, C. Hippert, T. Xue, E. L. West, Y. Duran, A. J. Smith, J. Z. Chuang, S. A. Azam, U. F. O. Luhmann, A. Benucci, C. H. Sung, J. W. Bainbridge, M. Carandini, K.-W. Yau, J. C. Sowden and R. R. Ali

An RNA interference screen uncovers a new molecule in stem cell self-renewal and long-term regeneration pp. 104-108

Ting Chen, Evan Heller, Slobodan Beronja, Naoki Oshimori, Nicole Stokes and Elaine Fuchs

A unifying model for mTORC1-mediated regulation of mRNA translation pp. 109-113

Carson C. Thoreen, Lynne Chantranupong, Heather R. Keys, Tim Wang, Nathanael S. Gray and David M. Sabatini

A Xanthomonas uridine 5′-monophosphate transferase inhibits plant immune kinases pp. 114-118

Feng Feng, Fan Yang, Wei Rong, Xiaogang Wu, Jie Zhang, She Chen, Chaozu He and Jian-Min Zhou

A novel putative auxin carrier family regulates intracellular auxin homeostasis in plants pp. 119-122

Elke Barbez, Martin Kubeš, Jakub Rolčík, Chloé Béziat, Aleš Pěnčík, Bangjun Wang, Michel Ruiz Rosquete, Jinsheng Zhu, Petre I. Dobrev, Yuree Lee, Eva Zažímalovà, Jan Petrášek, Markus Geisler, Jiří Friml and Jürgen Kleine-Vehn

Regulation of circadian behaviour and metabolism by REV-ERB-α and REV-ERB-β pp. 123-127

Han Cho, Xuan Zhao, Megumi Hatori, Ruth T. Yu, Grant D. Barish, Michael T. Lam, Ling-Wa Chong, Luciano DiTacchio, Annette R. Atkins, Christopher K. Glass, Christopher Liddle, Johan Auwerx, Michael Downes, Satchidananda Panda and Ronald M. Evans

Inositol-1,4,5-trisphosphate receptor regulates hepatic gluconeogenesis in fasting and diabetes pp. 128-132

Yiguo Wang, Gang Li, Jason Goode, Jose C. Paz, Kunfu Ouyang, Robert Screaton, Wolfgang H. Fischer, Ju Chen, Ira Tabas and Marc Montminy

Stereospecific binding of a disordered peptide segment mediates BK channel inactivation pp. 133-136

Vivian Gonzalez-Perez, Xu-Hui Zeng, Katie Henzler-Wildman and Christopher J. Lingle

Research: Uncovering misconduct pp. 137-139

Virginia Gewin

Loyalty beyond seasons pp. 142-142

Mohsen H. Darabi