Derived immune and ancestral pigmentation alleles in a 7,000-year-old Mesolithic European

Iñigo Olalde, Morten E. Allentoft, Federico Sánchez-Quinto, Gabriel Santpere, Charleston W. K. Chiang, Michael DeGiorgio, Javier Prado-Martinez, Juan Antonio Rodríguez, Simon Rasmussen, Javier Quilez, Oscar Ramírez, Urko M. Marigorta, Marcos Fernández-Callejo, María Encina Prada, Julio Manuel Vidal Encinas, Rasmus Nielsen, Mihai G. Netea, John Novembre, Richard A. Sturm, Pardis Sabeti, Tomàs Marquès-Bonet, Arcadi Navarro, Eske Willerslev () and Carles Lalueza-Fox ()
Additional contact information
Iñigo Olalde: Institut de Biologia Evolutiva, CSIC-UPF, Barcelona 08003, Spain
Morten E. Allentoft: Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, DK-1350 Copenhagen K, Denmark
Federico Sánchez-Quinto: Institut de Biologia Evolutiva, CSIC-UPF, Barcelona 08003, Spain
Gabriel Santpere: Institut de Biologia Evolutiva, CSIC-UPF, Barcelona 08003, Spain
Charleston W. K. Chiang: University of California
Michael DeGiorgio: University of California
Javier Prado-Martinez: Institut de Biologia Evolutiva, CSIC-UPF, Barcelona 08003, Spain
Juan Antonio Rodríguez: Institut de Biologia Evolutiva, CSIC-UPF, Barcelona 08003, Spain
Simon Rasmussen: Center for Biological Sequence Analysis, Technical University of Denmark, DK-2800 Kongens Lyngby, Denmark
Javier Quilez: Institut de Biologia Evolutiva, CSIC-UPF, Barcelona 08003, Spain
Oscar Ramírez: Institut de Biologia Evolutiva, CSIC-UPF, Barcelona 08003, Spain
Urko M. Marigorta: Institut de Biologia Evolutiva, CSIC-UPF, Barcelona 08003, Spain
Marcos Fernández-Callejo: Institut de Biologia Evolutiva, CSIC-UPF, Barcelona 08003, Spain
María Encina Prada: I.E.S.O. 'Los Salados', Junta de Castilla y León, E-49600 Benavente, Spain
Julio Manuel Vidal Encinas: Junta de Castilla y León, Servicio de Cultura de León, E-24071 León, Spain
Rasmus Nielsen: Center for Theoretical Evolutionary Genomics, University of California
Mihai G. Netea: Inflammation and Immunity, Radboud University Nijmegen Medical Centre, 6500 Nijmegen, The Netherlands
John Novembre: University of Chicago
Richard A. Sturm: Institute for Molecular Bioscience, Melanogenix Group, The University of Queensland
Pardis Sabeti: Center for Systems Biology, Harvard University
Tomàs Marquès-Bonet: Institut de Biologia Evolutiva, CSIC-UPF, Barcelona 08003, Spain
Arcadi Navarro: Institut de Biologia Evolutiva, CSIC-UPF, Barcelona 08003, Spain
Eske Willerslev: Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, DK-1350 Copenhagen K, Denmark
Carles Lalueza-Fox: Institut de Biologia Evolutiva, CSIC-UPF, Barcelona 08003, Spain

Nature, 2014, vol. 507, issue 7491, 225-228

Abstract: A complete pre-agricultural European human genome from a ∼7,000-year-old Mesolithic skeleton suggests the existence of a common genomic signature across western and central Eurasia from the Upper Paleolithic to the Mesolithic, and ancestral alleles in several skin pigmentation genes suggest that the light skin of modern Europeans was not yet ubiquitous in Mesolithic times.

Date: 2014
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DOI: 10.1038/nature12960

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