A transcriptional switch underlies commitment to sexual development in malaria parasites

Björn F. C. Kafsack, Núria Rovira-Graells, Taane G. Clark, Cristina Bancells, Valerie M. Crowley, Susana G. Campino, April E. Williams, Laura G. Drought, Dominic P. Kwiatkowski, David A. Baker, Alfred Cortés and Manuel Llinás ()
Additional contact information
Björn F. C. Kafsack: Lewis-Sigler Institute for Integrative Genomics, Princeton University
Núria Rovira-Graells: Barcelona Centre for International Health Research (CRESIB, Hospital Clínic-Universitat de Barcelona), Barcelona, 08036 Catalonia, Spain
Taane G. Clark: Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London WC1E 7HT, UK
Cristina Bancells: Barcelona Centre for International Health Research (CRESIB, Hospital Clínic-Universitat de Barcelona), Barcelona, 08036 Catalonia, Spain
Valerie M. Crowley: Lewis-Sigler Institute for Integrative Genomics, Princeton University
Susana G. Campino: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK
April E. Williams: Princeton University
Laura G. Drought: Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London WC1E 7HT, UK
Dominic P. Kwiatkowski: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK
David A. Baker: Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London WC1E 7HT, UK
Alfred Cortés: Barcelona Centre for International Health Research (CRESIB, Hospital Clínic-Universitat de Barcelona), Barcelona, 08036 Catalonia, Spain
Manuel Llinás: Lewis-Sigler Institute for Integrative Genomics, Princeton University

Nature, 2014, vol. 507, issue 7491, 248-252

Abstract: The DNA-binding protein PfAP2-G is found to be a master regulator of sexual development in the malaria parasite; this protein appears to regulate early gametocytogenesis and is epigenetically silenced in the majority of blood-stage parasites.

Date: 2014
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DOI: 10.1038/nature12920

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