Intestinal crypt homeostasis revealed at single-stem-cell level by in vivo live imaging

Laila Ritsma, Saskia I. J. Ellenbroek, Anoek Zomer, Hugo J. Snippert, Frederic J. de Sauvage, Benjamin D. Simons, Hans Clevers () and Jacco van Rheenen ()
Additional contact information
Laila Ritsma: Cancer Genomics Netherlands, Hubrecht Institute-KNAW and University Medical Centre Utrecht, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands
Saskia I. J. Ellenbroek: Cancer Genomics Netherlands, Hubrecht Institute-KNAW and University Medical Centre Utrecht, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands
Anoek Zomer: Cancer Genomics Netherlands, Hubrecht Institute-KNAW and University Medical Centre Utrecht, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands
Hugo J. Snippert: University Medical Centre Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
Frederic J. de Sauvage: Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA
Benjamin D. Simons: Cavendish Laboratory, J. J. Thomson Avenue, University of Cambridge, Cambridge CB3 0HE, UK
Hans Clevers: Cancer Genomics Netherlands, Hubrecht Institute-KNAW and University Medical Centre Utrecht, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands
Jacco van Rheenen: Cancer Genomics Netherlands, Hubrecht Institute-KNAW and University Medical Centre Utrecht, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands

Nature, 2014, vol. 507, issue 7492, 362-365

Abstract: Long-term in vivo imaging of Confetti-labelled Lgr5-expressing intestinal stem cells shows that a dynamically heterogeneous cell population is able to function long-term as an equipotent stem-cell pool.

Date: 2014
References: Add references at CitEc
Citations: View citations in EconPapers (6)

Downloads: (external link)
https://www.nature.com/articles/nature12972 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:507:y:2014:i:7492:d:10.1038_nature12972

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature12972

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().