An excitatory paraventricular nucleus to AgRP neuron circuit that drives hunger

Michael J. Krashes, Bhavik P. Shah, Joseph C. Madara, David P. Olson, David E. Strochlic, Alastair S. Garfield, Linh Vong, Hongjuan Pei, Mitsuko Watabe-Uchida, Naoshige Uchida, Stephen D. Liberles and Bradford B. Lowell ()
Additional contact information
Michael J. Krashes: Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School
Bhavik P. Shah: Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School
Joseph C. Madara: Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School
David P. Olson: Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School
David E. Strochlic: Harvard Medical School
Alastair S. Garfield: Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School
Linh Vong: Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School
Hongjuan Pei: University of Michigan
Mitsuko Watabe-Uchida: Center for Brain Science, Harvard University, 16 Divinity Avenue, Cambridge, Massachusetts 02138, USA
Naoshige Uchida: Program in Neuroscience, Harvard Medical School
Stephen D. Liberles: Harvard Medical School
Bradford B. Lowell: Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School

Nature, 2014, vol. 507, issue 7491, 238-242

Abstract: The AgRP-expressing neurons in the arcuate nucleus drive food-seeking behaviours during caloric restriction; a mouse study of monosynaptic retrograde rabies spread and optogenetic circuit mapping reveals that these neurons are activated by input from hypothalamic paraventricular nucleus cells and their activation or inhibition can modulate feeding behaviour.

Date: 2014
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DOI: 10.1038/nature12956

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