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Two independent transcription initiation codes overlap on vertebrate core promoters

Vanja Haberle, Nan Li, Yavor Hadzhiev, Charles Plessy, Christopher Previti, Chirag Nepal, Jochen Gehrig, Xianjun Dong, Altuna Akalin, Ana Maria Suzuki, Wilfred F. J. van IJcken, Olivier Armant, Marco Ferg, Uwe Strähle, Piero Carninci (), Ferenc Müller () and Boris Lenhard ()
Additional contact information
Vanja Haberle: University of Bergen, Thormøhlensgate 53A, N-5008 Bergen, Norway
Nan Li: School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
Yavor Hadzhiev: School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
Charles Plessy: RIKEN Omics Science Center, Yokohama, Kanagawa 230-0045, Japan
Christopher Previti: Computational Biology Unit, Uni Computing, Uni Research AS, University of Bergen, Thormøhlensgate 55, N-5008 Bergen, Norway
Chirag Nepal: Computational Biology Unit, Uni Computing, Uni Research AS, University of Bergen, Thormøhlensgate 55, N-5008 Bergen, Norway
Jochen Gehrig: School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
Xianjun Dong: Computational Biology Unit, Uni Computing, Uni Research AS, University of Bergen, Thormøhlensgate 55, N-5008 Bergen, Norway
Altuna Akalin: Computational Biology Unit, Uni Computing, Uni Research AS, University of Bergen, Thormøhlensgate 55, N-5008 Bergen, Norway
Ana Maria Suzuki: RIKEN Omics Science Center, Yokohama, Kanagawa 230-0045, Japan
Wilfred F. J. van IJcken: Erasmus Medical Center, Center for Biomics, Room Ee679b, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
Olivier Armant: Institute of Toxicology and Genetics, Karlsruhe Institute of Technology, Postfach 3640, 76021 Karlsruhe, Germany
Marco Ferg: Institute of Toxicology and Genetics, Karlsruhe Institute of Technology, Postfach 3640, 76021 Karlsruhe, Germany
Uwe Strähle: Institute of Toxicology and Genetics, Karlsruhe Institute of Technology, Postfach 3640, 76021 Karlsruhe, Germany
Piero Carninci: RIKEN Omics Science Center, Yokohama, Kanagawa 230-0045, Japan
Ferenc Müller: School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
Boris Lenhard: Institute of Clinical Sciences and MRC Clinical Sciences Center, Faculty of Medicine, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK

Nature, 2014, vol. 507, issue 7492, 381-385

Abstract: The transcription start sites used during the maternal to zygotic transition in zebrafish are mapped, revealing that the transition is characterized by a switch between two different sequence signs to guide transcription initiation, which often co-exist in core promoters.

Date: 2014
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DOI: 10.1038/nature12974

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