A cascade of DNA-binding proteins for sexual commitment and development in Plasmodium

Abhinav Sinha, Katie R. Hughes, Katarzyna K. Modrzynska, Thomas D. Otto, Claudia Pfander, Nicholas J. Dickens, Agnieszka A. Religa, Ellen Bushell, Anne L. Graham, Rachael Cameron, Bjorn F. C. Kafsack, April E. Williams, Manuel Llinás, Matthew Berriman, Oliver Billker () and Andrew P. Waters ()
Additional contact information
Abhinav Sinha: Wellcome Trust Centre for Molecular Parasitology, University of Glasgow, Glasgow G12 8QQ, UK
Katie R. Hughes: Wellcome Trust Centre for Molecular Parasitology, University of Glasgow, Glasgow G12 8QQ, UK
Katarzyna K. Modrzynska: Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK
Thomas D. Otto: Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK
Claudia Pfander: Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK
Nicholas J. Dickens: Wellcome Trust Centre for Molecular Parasitology, University of Glasgow, Glasgow G12 8QQ, UK
Agnieszka A. Religa: Wellcome Trust Centre for Molecular Parasitology, University of Glasgow, Glasgow G12 8QQ, UK
Ellen Bushell: Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK
Anne L. Graham: Wellcome Trust Centre for Molecular Parasitology, University of Glasgow, Glasgow G12 8QQ, UK
Rachael Cameron: Wellcome Trust Centre for Molecular Parasitology, University of Glasgow, Glasgow G12 8QQ, UK
Bjorn F. C. Kafsack: Princeton University
April E. Williams: Princeton University
Manuel Llinás: Princeton University
Matthew Berriman: Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK
Oliver Billker: Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK
Andrew P. Waters: Wellcome Trust Centre for Molecular Parasitology, University of Glasgow, Glasgow G12 8QQ, UK

Nature, 2014, vol. 507, issue 7491, 253-257

Abstract: Malaria parasites must produce gametocytes for transmission to the mosquito vector, although the molecular mechanisms underlying commitment to gametocyte production remain unclear; here this process is found to be controlled by PbAP2-G, a member of the ApiAP2 family of DNA-binding proteins, in the rodent-infecting Plasmodium berghei parasite.

Date: 2014
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DOI: 10.1038/nature12970

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