The genomic landscape of Neanderthal ancestry in present-day humans

Sriram Sankararaman (), Swapan Mallick, Michael Dannemann, Kay Prüfer, Janet Kelso, Svante Pääbo, Nick Patterson and David Reich ()
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Sriram Sankararaman: Harvard Medical School
Swapan Mallick: Harvard Medical School
Michael Dannemann: Max Planck Institute for Evolutionary Anthropology, Leipzig 04103, Germany
Kay Prüfer: Max Planck Institute for Evolutionary Anthropology, Leipzig 04103, Germany
Janet Kelso: Max Planck Institute for Evolutionary Anthropology, Leipzig 04103, Germany
Svante Pääbo: Max Planck Institute for Evolutionary Anthropology, Leipzig 04103, Germany
Nick Patterson: Harvard Medical School
David Reich: Harvard Medical School

Nature, 2014, vol. 507, issue 7492, 354-357

Abstract: In the modern human genome, elevated Neanderthal ancestry is found at genes affecting keratin filaments, suggesting that gene flow with Neanderthals helped modern humans to adapt to non-African environments; deficiencies of Neanderthal ancestry are also found, particularly on the X chromosome and in genes expressed highly in testes, suggesting that some Neanderthal mutations were not tolerated on a modern human genetic background as they reduced male fertility.

Date: 2014
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DOI: 10.1038/nature12961

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