DNA-guided DNA interference by a prokaryotic Argonaute

Daan C. Swarts, Matthijs M. Jore, Edze R. Westra, Yifan Zhu, Jorijn H. Janssen, Ambrosius P. Snijders, Yanli Wang, Dinshaw J. Patel, José Berenguer, Stan J. J. Brouns and John van der Oost ()
Additional contact information
Daan C. Swarts: Laboratory of Microbiology, Wageningen University, Dreijenplein 10, 6703 HB Wageningen, the Netherlands
Matthijs M. Jore: Laboratory of Microbiology, Wageningen University, Dreijenplein 10, 6703 HB Wageningen, the Netherlands
Edze R. Westra: Laboratory of Microbiology, Wageningen University, Dreijenplein 10, 6703 HB Wageningen, the Netherlands
Yifan Zhu: Laboratory of Microbiology, Wageningen University, Dreijenplein 10, 6703 HB Wageningen, the Netherlands
Jorijn H. Janssen: Laboratory of Microbiology, Wageningen University, Dreijenplein 10, 6703 HB Wageningen, the Netherlands
Ambrosius P. Snijders: Clare Hall Laboratories, Cancer Research UK, London Research Institute, South Mimms EN6 3LD, UK
Yanli Wang: Institute of Biophysics, Chinese Academy of Sciences
Dinshaw J. Patel: Structural Biology Program, Memorial Sloan-Kettering Cancer Center
José Berenguer: Centro de Biología Molecular Severo Ochoa, UAM-CSIC, Campus de Cantoblanco, 28049 Madrid, Spain
Stan J. J. Brouns: Laboratory of Microbiology, Wageningen University, Dreijenplein 10, 6703 HB Wageningen, the Netherlands
John van der Oost: Laboratory of Microbiology, Wageningen University, Dreijenplein 10, 6703 HB Wageningen, the Netherlands

Nature, 2014, vol. 507, issue 7491, 258-261

Abstract: Here, Argonaute from the prokaryote Thermus thermophilus is shown to use small DNA guides to interfere directly with invading foreign DNA, rather than being involved in RNA-guided RNA interference, as observed in eukaryotes.

Date: 2014
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DOI: 10.1038/nature12971

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