Transcription factor achaete-scute homologue 2 initiates follicular T-helper-cell development

Xindong Liu (), Xin Chen, Bo Zhong, Aibo Wang, Xiaohu Wang, Fuliang Chu, Roza I. Nurieva, Xiaowei Yan, Ping Chen, Laurens G. van der Flier, Hiroko Nakatsukasa, Sattva S. Neelapu, Wanjun Chen, Hans Clevers, Qiang Tian, Hai Qi, Lai Wei and Chen Dong ()
Additional contact information
Xindong Liu: Tsinghua University School of Medicine
Xin Chen: Tsinghua University School of Medicine
Bo Zhong: MD Anderson Cancer Center
Aibo Wang: Tsinghua University School of Medicine
Xiaohu Wang: Tsinghua University School of Medicine
Fuliang Chu: MD Anderson Cancer Center
Roza I. Nurieva: MD Anderson Cancer Center
Xiaowei Yan: Institute for Systems Biology
Ping Chen: Laboratory of Immunology, National Eye Institute, NIH, Bethesda, Maryland 20892-1858, USA
Laurens G. van der Flier: Hubrecht Institute-KNAW and University Medical Center Utrecht, Uppsalalaan 8, 3584 CT Utrecht, the Netherlands
Hiroko Nakatsukasa: National Institute of Dental and Craniofacial Research, NIH
Sattva S. Neelapu: MD Anderson Cancer Center
Wanjun Chen: National Institute of Dental and Craniofacial Research, NIH
Hans Clevers: Hubrecht Institute-KNAW and University Medical Center Utrecht, Uppsalalaan 8, 3584 CT Utrecht, the Netherlands
Qiang Tian: Institute for Systems Biology
Hai Qi: Tsinghua University School of Medicine
Lai Wei: State Key Laboratory of Ophthalmology, Sun Yat-sen University
Chen Dong: Tsinghua University School of Medicine

Nature, 2014, vol. 507, issue 7493, 513-518

Abstract: Here, the helix–loop–helix transcription factor Ascl2 is shown to be critically important for the initiation of follicular T-helper-cell development and the germinal centre response.

Date: 2014
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DOI: 10.1038/nature12910

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