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2021, volume 594, articles 7864

Lightning talks: science in 5 minutes or less pp. S49-S51

Chris Woolston

Good presentation skills benefit careers — and science pp. S51-S52

David Rubenson

World Bank grants for global vaccination — why so slow? pp. 475-475

Justin Sandefur

How scientists are embracing NFTs pp. 481-482

Nicola Jones

CureVac COVID vaccine let-down spotlights mRNA design challenges pp. 483-483

Elie Dolgin

Mars helicopter kicks up ‘cool’ dust clouds — and unexpected science pp. 484-484

Alexandra Witze

Massive science-funding bill passes US Senate — but China focus worries researchers pp. 485-485

Ariana Remmel

How three missions to Venus could solve the planet’s biggest mysteries pp. 486-487

Jonathan O'Callaghan

How ancient people fell in love with bread, beer and other carbs pp. 488-491

Andrew Curry

COVID vaccines and breastfeeding: what the data say pp. 492-494

Shannon Hall

ISSCR: grave omission of age limit for embryo research pp. 495-495

Josephine Johnston, Françoise Baylis and Henry T. Greely

Fairer taxation to curb inequality and boost health pp. 495-495

Barry Bogin

Ancient oaks of Europe are archives — protect them pp. 495-495

Christian Sonne, Changlei Xia and Su Shiung Lam

United States: invest infrastructure stimulus in astronomy facilities pp. 496-496

Adam Cohen, Matt Mountain and David Reitze

Europe’s pandemic recovery: embed resilience pp. 496-496

Mariya Gabriel and Sandrine Dixson-Declève

Canada is right to classify single-use plastics as toxic pp. 496-496

Tony R. Walker

A dangerous, wrong or unneeded experiment? Don’t do it pp. 496-496

Matthew Cobb and Robert Pollack

Unravelling the enigma of bird magnetoreception pp. 497-498

Eric J. Warrant

Plasmons dragged by drifting electrons pp. 498-499

Hugen Yan

A 4D road map for the formation of hair follicles pp. 500-501

Nivedita Saxena and Michael Rendl

Natural killer cells lull tumours into dormancy pp. 501-502

Noella Lopes and Eric Vivier

Ion dynamics in battery materials imaged rapidly pp. 503-504

Aashutosh Mistry

Past, present and future stars that can see Earth as a transiting exoplanet pp. 505-507

L. Kaltenegger and J. K. Faherty

Accurately computing the electronic properties of a quantum ring pp. 508-512

C. Neill, T. McCourt, X. Mi, Z. Jiang, M. Y. Niu, W. Mruczkiewicz, I. Aleiner, F. Arute, K. Arya, J. Atalaya, R. Babbush, J. C. Bardin, R. Barends, A. Bengtsson, A. Bourassa, M. Broughton, B. B. Buckley, D. A. Buell, B. Burkett, N. Bushnell, J. Campero, Z. Chen, B. Chiaro, R. Collins, W. Courtney, S. Demura, A. R. Derk, A. Dunsworth, D. Eppens, C. Erickson, E. Farhi, A. G. Fowler, B. Foxen, C. Gidney, M. Giustina, J. A. Gross, M. P. Harrigan, S. D. Harrington, J. Hilton, A. Ho, S. Hong, T. Huang, W. J. Huggins, S. V. Isakov, M. Jacob-Mitos, E. Jeffrey, C. Jones, D. Kafri, K. Kechedzhi, J. Kelly, S. Kim, P. V. Klimov, A. N. Korotkov, F. Kostritsa, D. Landhuis, P. Laptev, E. Lucero, O. Martin, J. R. McClean, M. McEwen, A. Megrant, K. C. Miao, M. Mohseni, J. Mutus, O. Naaman, M. Neeley, M. Newman, T. E. O’Brien, A. Opremcak, E. Ostby, B. Pató, A. Petukhov, C. Quintana, N. Redd, N. C. Rubin, D. Sank, K. J. Satzinger, V. Shvarts, D. Strain, M. Szalay, M. D. Trevithick, B. Villalonga, T. C. White, Z. Yao, P. Yeh, A. Zalcman, H. Neven, S. Boixo, L. B. Ioffe, P. Roushan, Y. Chen and V. Smelyanskiy

Fizeau drag in graphene plasmonics pp. 513-516

Y. Dong, L. Xiong, I. Y. Phinney, Z. Sun, R. Jing, A. S. McLeod, S. Zhang, S. Liu, F. L. Ruta, H. Gao, Z. Dong, R. Pan, J. H. Edgar, P. Jarillo-Herrero, L. S. Levitov, A. J. Millis, M. M. Fogler, D. A. Bandurin and D. N. Basov

Efficient Fizeau drag from Dirac electrons in monolayer graphene pp. 517-521

Wenyu Zhao, Sihan Zhao, Hongyuan Li, Sheng Wang, Shaoxin Wang, M. Iqbal Bakti Utama, Salman Kahn, Yue Jiang, Xiao Xiao, SeokJae Yoo, Kenji Watanabe, Takashi Taniguchi, Alex Zettl and Feng Wang

Operando optical tracking of single-particle ion dynamics in batteries pp. 522-528

Alice J. Merryweather, Christoph Schnedermann, Quentin Jacquet, Clare P. Grey and Akshay Rao

A catalysis-driven artificial molecular pump pp. 529-534

Shuntaro Amano, Stephen D. P. Fielden and David A. Leigh

Magnetic sensitivity of cryptochrome 4 from a migratory songbird pp. 535-540

Jingjing Xu, Lauren E. Jarocha, Tilo Zollitsch, Marcin Konowalczyk, Kevin B. Henbest, Sabine Richert, Matthew J. Golesworthy, Jessica Schmidt, Victoire Déjean, Daniel J. C. Sowood, Marco Bassetto, Jiate Luo, Jessica R. Walton, Jessica Fleming, Yujing Wei, Tommy L. Pitcher, Gabriel Moise, Maike Herrmann, Hang Yin, Haijia Wu, Rabea Bartölke, Stefanie J. Käsehagen, Simon Horst, Glen Dautaj, Patrick D. F. Murton, Angela S. Gehrckens, Yogarany Chelliah, Joseph S. Takahashi, Karl-Wilhelm Koch, Stefan Weber, Ilia A. Solov’yov, Can Xie, Stuart R. Mackenzie, Christiane R. Timmel, Henrik Mouritsen and P. J. Hore

Representational drift in primary olfactory cortex pp. 541-546

Carl E. Schoonover, Sarah N. Ohashi, Richard Axel and Andrew J. P. Fink

Tracing the origin of hair follicle stem cells pp. 547-552

Ritsuko Morita, Noriko Sanzen, Hiroko Sasaki, Tetsutaro Hayashi, Mana Umeda, Mika Yoshimura, Takaki Yamamoto, Tatsuo Shibata, Takaya Abe, Hiroshi Kiyonari, Yasuhide Furuta, Itoshi Nikaido and Hironobu Fujiwara

Neutralizing antibody vaccine for pandemic and pre-emergent coronaviruses pp. 553-559

Kevin O. Saunders, Esther Lee, Robert Parks, David R. Martinez, Dapeng Li, Haiyan Chen, Robert J. Edwards, Sophie Gobeil, Maggie Barr, Katayoun Mansouri, S. Munir Alam, Laura L. Sutherland, Fangping Cai, Aja M. Sanzone, Madison Berry, Kartik Manne, Kevin W. Bock, Mahnaz Minai, Bianca M. Nagata, Anyway B. Kapingidza, Mihai Azoitei, Longping V. Tse, Trevor D. Scobey, Rachel L. Spreng, R. Wes Rountree, C. Todd DeMarco, Thomas N. Denny, Christopher W. Woods, Elizabeth W. Petzold, Juanjie Tang, Thomas H. Oguin, Gregory D. Sempowski, Matthew Gagne, Daniel C. Douek, Mark A. Tomai, Christopher B. Fox, Robert Seder, Kevin Wiehe, Drew Weissman, Norbert Pardi, Hana Golding, Surender Khurana, Priyamvada Acharya, Hanne Andersen, Mark G. Lewis, Ian N. Moore, David C. Montefiori, Ralph S. Baric and Barton F. Haynes

MARK4 controls ischaemic heart failure through microtubule detyrosination pp. 560-565

Xian Yu, Xiao Chen, Mamta Amrute-Nayak, Edward Allgeyer, Aite Zhao, Hannah Chenoweth, Marc Clement, James Harrison, Christian Doreth, George Sirinakis, Thomas Krieg, Huiyu Zhou, Hongda Huang, Kiyotaka Tokuraku, Daniel St Johnston, Ziad Mallat and Xuan Li

Hepatic stellate cells suppress NK cell-sustained breast cancer dormancy pp. 566-571

Ana Luísa Correia, Joao C. Guimaraes, Priska Auf der Maur, Duvini De Silva, Marcel P. Trefny, Ryoko Okamoto, Sandro Bruno, Alexander Schmidt, Kirsten Mertz, Katrin Volkmann, Luigi Terracciano, Alfred Zippelius, Marcus Vetter, Christian Kurzeder, Walter Paul Weber and Mohamed Bentires-Alj

Concerted cutting by Spo11 illuminates meiotic DNA break mechanics pp. 572-576

Dominic Johnson, Margaret Crawford, Tim Cooper, Corentin Claeys Bouuaert, Scott Keeney, Bertrand Llorente, Valerie Garcia and Matthew J. Neale

Spo11 generates gaps through concerted cuts at sites of topological stress pp. 577-582

Silvia Prieler, Doris Chen, Lingzhi Huang, Elisa Mayrhofer, Soma Zsótér, Magdalena Vesely, Jean Mbogning and Franz Klein

Structures of Gi-bound metabotropic glutamate receptors mGlu2 and mGlu4 pp. 583-588

Shuling Lin, Shuo Han, Xiaoqing Cai, Qiuxiang Tan, Kexiu Zhou, Dejian Wang, Xinwei Wang, Juan Du, Cuiying Yi, Xiaojing Chu, Antao Dai, Yan Zhou, Yan Chen, Yu Zhou, Hong Liu, Jianfeng Liu, Dehua Yang, Ming-Wei Wang, Qiang Zhao and Beili Wu

Structures of human mGlu2 and mGlu7 homo- and heterodimers pp. 589-593

Juan Du, Dejian Wang, Hongcheng Fan, Chanjuan Xu, Linhua Tai, Shuling Lin, Shuo Han, Qiuxiang Tan, Xinwei Wang, Tuo Xu, Hui Zhang, Xiaojing Chu, Cuiying Yi, Peng Liu, Xiaomei Wang, Yu Zhou, Jean-Philippe Pin, Philippe Rondard, Hong Liu, Jianfeng Liu, Fei Sun, Beili Wu and Qiang Zhao

Structural basis of GABAB receptor–Gi protein coupling pp. 594-598

Cangsong Shen, Chunyou Mao, Chanjuan Xu, Nan Jin, Huibing Zhang, Dan-Dan Shen, Qingya Shen, Xiaomei Wang, Tingjun Hou, Zhong Chen, Philippe Rondard, Jean-Philippe Pin, Yan Zhang and Jianfeng Liu

Six reasons to launch a Young Academy pp. 599-601

Erika Bálint, Dorottya Csuka, Viktória Venglovecz, Gitta Schlosser, Zsófia Lázár, Eszter Gselmann, Donát Alpár and Katalin Solymosi

Five trendy technologies: where are they now? pp. 602-604

Jyoti Madhusoodanan

Shell shock: a biologist’s quest to save the endangered painted snail pp. 606-606

Kendall Powell

2021, volume 594, articles 7863

Clusters of flowstone ages are not supported by statistical evidence pp. E10-E10

Philip Hopley, Pieter Vermeesch, Randall Parrish and Alfred Latham

Reply to: Clusters of flowstone ages are not supported by statistical evidence pp. E11-E11

Robyn Pickering, Andy I. R. Herries, Jon D. Woodhead, John C. Hellstrom, Helen E. Green, Bence Paul, Terrence Ritzman, David S. Strait, Benjamin J. Schoville and John Hancox

How science-funding giant Wellcome is tackling racism pp. 303-303

Kalaiyashni Puvanendran

Landmark Alzheimer’s drug approval confounds research community pp. 309-310

Asher Mullard

First science adviser in US president’s cabinet talks COVID, spying and more pp. 311-311

Nidhi Subbaraman

Does vaccinating adults stop kids from spreading COVID too? pp. 312-312

Dyani Lewis

The COVID lab-leak hypothesis: what scientists do and don’t know pp. 313-315

Amy Maxmen and Smriti Mallapaty

How the COVID pandemic is changing global science collaborations pp. 316-319

Brendan Maher and Richard Van Noorden

Forensic database challenged over ethics of DNA holdings pp. 320-322

Quirin Schiermeier

Katherine Johnson’s memoir charts her bold trajectory to NASA and beyond pp. 323-324

Ainissa Ramirez

Community–academic partnerships helped Flint through its water crisis pp. 326-329

E. Yvonne Lewis and Richard C. Sadler

A white-knuckle ride of open COVID drug discovery pp. 330-332

Frank von Delft, Mark Calmiano, John Chodera, Ed Griffen, Alpha Lee, Nir London, Tatiana Matviuk, Ben Perry, Matt Robinson and Annette von Delft

Concern over use of the term Z-DNA pp. 333-333

Alan Herbert, Andrew H.-J. Wang, Thomas M. Jovin, Edward S. Mocarski, Manolis Pasparakis and Karen M. Vasquez

ISSCR guidelines fudge heritable human-genome editing pp. 333-333

Françoise Baylis

Don’t abandon 14-day limit on embryo research, it makes sense pp. 333-333

Ronald M. Green, Michael D. West and Leonard Hayflick

Regulate waste recycling internationally pp. 333-333

Zhe Liu

Most rivers and streams run dry every year pp. 335-336

Kristin L. Jaeger

Contact-tracing app curbed the spread of COVID in England and Wales pp. 336-337

C. Jason Wang

Glutamate receptor complexes open up and reveal their molecular dialect pp. 338-339

Andrew J. R. Plested

Cancer stem cells in the gut have a bad influence on neighbouring cells pp. 340-341

Shi Biao Chia and James DeGregori

Attraction and repulsion cooperate during brain-circuit wiring pp. 341-343

Yajun Xie and Corey Harwell

Great Dimming of Betelgeuse explained pp. 343-344

Emily M. Levesque

The rise of intelligent matter pp. 345-355

C. Kaspar, B. J. Ravoo, W. G. Wiel, S. V. Wegner and W. H. P. Pernice

Peopling of the Americas as inferred from ancient genomics pp. 356-364

Eske Willerslev and David J. Meltzer

A dusty veil shading Betelgeuse during its Great Dimming pp. 365-368

M. Montargès, E. Cannon, E. Lagadec, A. de Koter, P. Kervella, J. Sanchez-Bermudez, C. Paladini, F. Cantalloube, L. Decin, P. Scicluna, K. Kravchenko, A. K. Dupree, S. Ridgway, M. Wittkowski, N. Anugu, R. Norris, G. Rau, G. Perrin, A. Chiavassa, S. Kraus, J. D. Monnier, F. Millour, J.-B. Le Bouquin, X. Haubois, B. Lopez, P. Stee and W. Danchi

Correlated charge noise and relaxation errors in superconducting qubits pp. 369-373

C. D. Wilen, S. Abdullah, N. A. Kurinsky, C. Stanford, L. Cardani, G. D’Imperio, C. Tomei, L. Faoro, L. B. Ioffe, C. H. Liu, A. Opremcak, B. G. Christensen, J. L. DuBois and R. McDermott

Symmetry-enforced topological nodal planes at the Fermi surface of a chiral magnet pp. 374-379

Marc A. Wilde, Matthias Dodenhöft, Arthur Niedermayr, Andreas Bauer, Moritz M. Hirschmann, Kirill Alpin, Andreas P. Schnyder and Christian Pfleiderer

Double-helical assembly of heterodimeric nanoclusters into supercrystals pp. 380-384

Yingwei Li, Meng Zhou, Yongbo Song, Tatsuya Higaki, He Wang and Rongchao Jin

Localization atomic force microscopy pp. 385-390

George R. Heath, Ekaterina Kots, Janice L. Robertson, Shifra Lansky, George Khelashvili, Harel Weinstein and Simon Scheuring

Global prevalence of non-perennial rivers and streams pp. 391-397

Mathis Loïc Messager, Bernhard Lehner, Charlotte Cockburn, Nicolas Lamouroux, Hervé Pella, Ton Snelder, Klement Tockner, Tim Trautmann, Caitlin Watt and Thibault Datry

Interpreting type 1 diabetes risk with genetics and single-cell epigenomics pp. 398-402

Joshua Chiou, Ryan J. Geusz, Mei-Lin Okino, Jee Yun Han, Michael Miller, Rebecca Melton, Elisha Beebe, Paola Benaglio, Serina Huang, Katha Korgaonkar, Sandra Heller, Alexander Kleger, Sebastian Preissl, David U. Gorkin, Maike Sander and Kyle J. Gaulton

Intercalated amygdala clusters orchestrate a switch in fear state pp. 403-407

Kenta M. Hagihara, Olena Bukalo, Martin Zeller, Ayla Aksoy-Aksel, Nikolaos Karalis, Aaron Limoges, Tanner Rigg, Tiffany Campbell, Adriana Mendez, Chase Weinholtz, Mathias Mahn, Larry S. Zweifel, Richard D. Palmiter, Ingrid Ehrlich, Andreas Lüthi and Andrew Holmes

The epidemiological impact of the NHS COVID-19 app pp. 408-412

Chris Wymant, Luca Ferretti, Daphne Tsallis, Marcos Charalambides, Lucie Abeler-Dörner, David Bonsall, Robert Hinch, Michelle Kendall, Luke Milsom, Matthew Ayres, Chris Holmes, Mark Briers and Christophe Fraser

Thymic development of gut-microbiota-specific T cells pp. 413-417

Daniel F. Zegarra-Ruiz, Dasom V. Kim, Kendra Norwood, Myunghoo Kim, Wan-Jung H. Wu, Fatima B. Saldana-Morales, Andrea A. Hill, Shubhabrata Majumdar, Stephanie Orozco, Rickesha Bell, June L. Round, Randy S. Longman, Takeshi Egawa, Matthew L. Bettini and Gretchen E. Diehl

ARAF mutations confer resistance to the RAF inhibitor belvarafenib in melanoma pp. 418-423

Ivana Yen, Frances Shanahan, Jeeyun Lee, Yong Sang Hong, Sang Joon Shin, Amanda R. Moore, Jawahar Sudhamsu, Matthew T. Chang, Inhwan Bae, Darlene Cruz, Thomas Hunsaker, Christiaan Klijn, Nicholas P. D. Liau, Eva Lin, Scott E. Martin, Zora Modrusan, Robert Piskol, Ehud Segal, Avinashnarayan Venkatanarayan, Xin Ye, Jianping Yin, Liangxuan Zhang, Jin-Soo Kim, Hyeong-Seok Lim, Kyu-Pyo Kim, Yu Jung Kim, Hye Sook Han, Soo Jung Lee, Seung Tae Kim, Minkyu Jung, Yoon-hee Hong, Young Su Noh, Munjeong Choi, Oakpil Han, Malgorzata Nowicka, Shrividhya Srinivasan, Yibing Yan, Tae Won Kim and Shiva Malek

A phase-separated nuclear GBPL circuit controls immunity in plants pp. 424-429

Shuai Huang, Shiwei Zhu, Pradeep Kumar and John D. MacMicking

NOTUM from Apc-mutant cells biases clonal competition to initiate cancer pp. 430-435

Dustin J. Flanagan, Nalle Pentinmikko, Kalle Luopajärvi, Nicky J. Willis, Kathryn Gilroy, Alexander P. Raven, Lynn Mcgarry, Johanna I. Englund, Anna T. Webb, Sandra Scharaw, Nadia Nasreddin, Michael C. Hodder, Rachel A. Ridgway, Emma Minnee, Nathalie Sphyris, Ella Gilchrist, Arafath K. Najumudeen, Beatrice Romagnolo, Christine Perret, Ann C. Williams, Hans Clevers, Pirjo Nummela, Marianne Lähde, Kari Alitalo, Ville Hietakangas, Ann Hedley, William Clark, Colin Nixon, Kristina Kirschner, E. Yvonne Jones, Ari Ristimäki, Simon J. Leedham, Paul V. Fish, Jean-Paul Vincent, Pekka Katajisto and Owen J. Sansom

Apc-mutant cells act as supercompetitors in intestinal tumour initiation pp. 436-441

Sanne M. van Neerven, Nina E. de Groot, Lisanne E. Nijman, Brendon P. Scicluna, Milou S. van Driel, Maria C. Lecca, Daniël O. Warmerdam, Vaishali Kakkar, Leandro F. Moreno, Felipe A. Vieira Braga, Delano R. Sanches, Prashanthi Ramesh, Sanne ten Hoorn, Arthur S. Aelvoet, Marouska F. van Boxel, Lianne Koens, Przemek M. Krawczyk, Jan Koster, Evelien Dekker, Jan Paul Medema, Douglas J. Winton, Maarten F. Bijlsma, Edward Morrissey, Nicolas Léveillé and Louis Vermeulen

Tracing oncogene-driven remodelling of the intestinal stem cell niche pp. 442-447

Min Kyu Yum, Seungmin Han, Juergen Fink, Szu-Hsien Sam Wu, Catherine Dabrowska, Teodora Trendafilova, Roxana Mustata, Lemonia Chatzeli, Roberta Azzarelli, Irina Pshenichnaya, Eunmin Lee, Frances England, Jong Kyoung Kim, Daniel E. Stange, Anna Philpott, Joo-Hyeon Lee, Bon-Kyoung Koo and Benjamin D. Simons

Hippocampal AMPA receptor assemblies and mechanism of allosteric inhibition pp. 448-453

Jie Yu, Prashant Rao, Sarah Clark, Jaba Mitra, Taekjip Ha and Eric Gouaux

Gating and modulation of a hetero-octameric AMPA glutamate receptor pp. 454-458

Danyang Zhang, Jake F. Watson, Peter M. Matthews, Ondrej Cais and Ingo H. Greger

The authorship rows that sour scientific collaborations pp. 459-462

Nic Fleming

‘We need to talk’: ways to prevent collaborations breaking down pp. 462-463

Virginia Gewin

Tapping local knowledge to save a Papua New Guinea forest pp. 466-466

Chris Woolston

2021, volume 594, articles 7862

Heart health pp. S1-S1

Herb Brody

A graphical guide to ischaemic heart disease pp. S3-S3

Benjamin Plackett

How a child’s heart health could be decided before birth pp. S4-S5

Bianca Nogrady

Ranking the risk of heart disease pp. S6-S7

Michael Eisenstein

Perovskite decomposition and missing crystal planes in HRTEM pp. E6-E7

Yu-Hao Deng

Reply to: Perovskite decomposition and missing crystal planes in HRTEM pp. E8-E9

Zhijun Ning, Xiwen Gong, Riccardo Comin, Grant Walters, Fengjia Fan, Oleksandr Voznyy, Emre Yassitepe, Andrei Buin, Sjoerd Hoogland and Edward H. Sargent

Inflammation in heart disease: do researchers know enough? pp. S8-S9

Sarah DeWeerdt

Immune cells that remember inflammation could offer treatment targets for atherosclerosis pp. S10-S11

Amanda B. Keener

Is there more to a healthy-heart diet than cholesterol? pp. S12-S13

Natalie Healey

COVID’s cardiac connection pp. S14-S15

Elie Dolgin

Cells or drugs? The race to regenerate the heart pp. S16-S17

Benjamin Plackett

Women’s heart health is not just about hormones pp. S18-S18

Jumana Saleh

The replication crisis won’t be solved with broad brushstrokes pp. 151-151

David Peterson

Palaeontologists hope Biden will restore protections on fossil-rich US lands pp. 157-158

Freda Kreier

A complete human genome sequence is close: how scientists filled in the gaps pp. 158-159

Sara Reardon

Elite US science academy expels astronomer Geoff Marcy following harassment complaints pp. 159-160

Nidhi Subbaraman

Hundreds of gibberish papers still lurk in the scientific literature pp. 160-161

Richard Van Noorden

WHO approval of Chinese CoronaVac COVID vaccine will be crucial to curbing pandemic pp. 161-162

Smriti Mallapaty

Coronavirus variants get Greek names — but will scientists use them? pp. 162-162

Ewen Callaway

The COVID vaccine pioneer behind southeast Asia’s first mRNA shot pp. 163-163

Smriti Mallapaty

Six months of COVID vaccines: what 1.7 billion doses have taught scientists pp. 164-167

Heidi Ledford

The four most urgent questions about long COVID pp. 168-170

Michael Marshall

It takes a wood to raise a tree: a memoir pp. 171-172

Emma Marris

Managing the ‘dataome’, medical misogyny, and the problem with palm oil: Books in brief pp. 172-172

Andrew Robinson and Sara Abdulla

Climate policy models need to get real about people — here’s how pp. 174-176

Wei Peng, Gokul Iyer, Valentina Bosetti, Vaibhav Chaturvedi, James Edmonds, Allen A. Fawcett, Stephane Hallegatte, David G. Victor, Detlef van Vuuren and John Weyant

Scientists — be political in the good times, not just the bad pp. 177-177

Jane Gregory

Indigenous lands: make Brazil stop mining to secure US deal pp. 177-177

Glenn H. Shepard

Diagnostic genomic laboratories should share their data pp. 177-177

Kok-Siong Poon and Evelyn Siew-Chuan Koay

Chilean polymath Humberto Maturana remembered pp. 177-177

Francisco J. Parada, Alejandra Rossi and Daniel Rojas-Líbano

Activation of retinal neurons triggers tumour formation in cancer-prone mice pp. 179-180

Varun Venkataramani and Frank Winkler

Squeezed light improves sensitivity of microscopy technique pp. 180-181

Eric O. Potma

Ancient human faeces reveal gut microbes of the past pp. 182-183

Matthew R. Olm and Justin L. Sonnenburg

RETRACTED ARTICLE: AI system outperforms humans in designing floorplans for microchips pp. 183-185

Andrew B. Kahng

Ancient seeds spill secrets about the evolution of flowering plants pp. 185-186

Douglas E. Soltis

Anisotropic satellite galaxy quenching modulated by black hole activity pp. 187-190

Ignacio Martín-Navarro, Annalisa Pillepich, Dylan Nelson, Vicente Rodriguez-Gomez, Martina Donnari, Lars Hernquist and Volker Springel

Observation of first and second sound in a BKT superfluid pp. 191-194

Panagiotis Christodoulou, Maciej Gałka, Nishant Dogra, Raphael Lopes, Julian Schmitt and Zoran Hadzibabic

Experimental observation of non-Abelian topological charges and edge states pp. 195-200

Qinghua Guo, Tianshu Jiang, Ruo-Yang Zhang, Lei Zhang, Zhao-Qing Zhang, Biao Yang, Shuang Zhang and C. T. Chan

Quantum-enhanced nonlinear microscopy pp. 201-206

Catxere A. Casacio, Lars S. Madsen, Alex Terrasson, Muhammad Waleed, Kai Barnscheidt, Boris Hage, Michael A. Taylor and Warwick P. Bowen

A graph placement methodology for fast chip design pp. 207-212

Azalia Mirhoseini, Anna Goldie, Mustafa Yazgan, Joe Wenjie Jiang, Ebrahim Songhori, Shen Wang, Young-Joon Lee, Eric Johnson, Omkar Pathak, Azade Nova, Jiwoo Pak, Andy Tong, Kavya Srinivasa, William Hang, Emre Tuncer, Quoc V. Le, James Laudon, Richard Ho, Roger Carpenter and Jeff Dean

Tomographic reconstruction of oxygen orbitals in lithium-rich battery materials pp. 213-216

Hasnain Hafiz, Kosuke Suzuki, Bernardo Barbiellini, Naruki Tsuji, Naoaki Yabuuchi, Kentaro Yamamoto, Yuki Orikasa, Yoshiharu Uchimoto, Yoshiharu Sakurai, Hiroshi Sakurai, Arun Bansil and Venkatasubramanian Viswanathan

Phosphorus-mediated sp2–sp3 couplings for C–H fluoroalkylation of azines pp. 217-222

Xuan Zhang, Kyle G. Nottingham, Chirag Patel, Juan V. Alegre-Requena, Jeffrey N. Levy, Robert S. Paton and Andrew McNally

Mesozoic cupules and the origin of the angiosperm second integument pp. 223-226

Gongle Shi, Fabiany Herrera, Patrick S. Herendeen, Elizabeth G. Clark and Peter R. Crane

Evolutionary and biomedical insights from a marmoset diploid genome assembly pp. 227-233

Chentao Yang, Yang Zhou, Stephanie Marcus, Giulio Formenti, Lucie A. Bergeron, Zhenzhen Song, Xupeng Bi, Juraj Bergman, Marjolaine Marie C. Rousselle, Chengran Zhou, Long Zhou, Yuan Deng, Miaoquan Fang, Duo Xie, Yuanzhen Zhu, Shangjin Tan, Jacquelyn Mountcastle, Bettina Haase, Jennifer Balacco, Jonathan Wood, William Chow, Arang Rhie, Martin Pippel, Margaret M. Fabiszak, Sergey Koren, Olivier Fedrigo, Winrich A. Freiwald, Kerstin Howe, Huanming Yang, Adam M. Phillippy, Mikkel Heide Schierup, Erich D. Jarvis and Guojie Zhang

Reconstruction of ancient microbial genomes from the human gut pp. 234-239

Marsha C. Wibowo, Zhen Yang, Maxime Borry, Alexander Hübner, Kun D. Huang, Braden T. Tierney, Samuel Zimmerman, Francisco Barajas-Olmos, Cecilia Contreras-Cubas, Humberto García-Ortiz, Angélica Martínez-Hernández, Jacob M. Luber, Philipp Kirstahler, Tre Blohm, Francis E. Smiley, Richard Arnold, Sonia A. Ballal, Sünje Johanna Pamp, Julia Russ, Frank Maixner, Omar Rota-Stabelli, Nicola Segata, Karl Reinhard, Lorena Orozco, Christina Warinner, Meradeth Snow, Steven LeBlanc and Aleksandar D. Kostic

SARS-CoV-2 uses a multipronged strategy to impede host protein synthesis pp. 240-245

Yaara Finkel, Avi Gluck, Aharon Nachshon, Roni Winkler, Tal Fisher, Batsheva Rozman, Orel Mizrahi, Yoav Lubelsky, Binyamin Zuckerman, Boris Slobodin, Yfat Yahalom-Ronen, Hadas Tamir, Igor Ulitsky, Tomer Israely, Nir Paran, Michal Schwartz and Noam Stern-Ginossar

Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV pp. 246-252

Alexey Stukalov, Virginie Girault, Vincent Grass, Ozge Karayel, Valter Bergant, Christian Urban, Darya A. Haas, Yiqi Huang, Lila Oubraham, Anqi Wang, M. Sabri Hamad, Antonio Piras, Fynn M. Hansen, Maria C. Tanzer, Igor Paron, Luca Zinzula, Thomas Engleitner, Maria Reinecke, Teresa M. Lavacca, Rosina Ehmann, Roman Wölfel, Jörg Jores, Bernhard Kuster, Ulrike Protzer, Roland Rad, John Ziebuhr, Volker Thiel, Pietro Scaturro, Matthias Mann and Andreas Pichlmair

Adjuvanting a subunit COVID-19 vaccine to induce protective immunity pp. 253-258

Prabhu S. Arunachalam, Alexandra C. Walls, Nadia Golden, Caroline Atyeo, Stephanie Fischinger, Chunfeng Li, Pyone Aye, Mary Jane Navarro, Lilin Lai, Venkata Viswanadh Edara, Katharina Röltgen, Kenneth Rogers, Lisa Shirreff, Douglas E. Ferrell, Samuel Wrenn, Deleah Pettie, John C. Kraft, Marcos C. Miranda, Elizabeth Kepl, Claire Sydeman, Natalie Brunette, Michael Murphy, Brooke Fiala, Lauren Carter, Alexander G. White, Meera Trisal, Ching-Lin Hsieh, Kasi Russell-Lodrigue, Christopher Monjure, Jason Dufour, Skye Spencer, Lara Doyle-Meyers, Rudolph P. Bohm, Nicholas J. Maness, Chad Roy, Jessica A. Plante, Kenneth S. Plante, Alex Zhu, Matthew J. Gorman, Sally Shin, Xiaoying Shen, Jane Fontenot, Shakti Gupta, Derek T. O’Hagan, Robbert Most, Rino Rappuoli, Robert L. Coffman, David Novack, Jason S. McLellan, Shankar Subramaniam, David Montefiori, Scott D. Boyd, JoAnne L. Flynn, Galit Alter, Francois Villinger, Harry Kleanthous, Jay Rappaport, Mehul S. Suthar, Neil P. King, David Veesler and Bali Pulendran

High-dimensional characterization of post-acute sequelae of COVID-19 pp. 259-264

Ziyad Al-Aly, Yan Xie and Benjamin Bowe

Swarm Learning for decentralized and confidential clinical machine learning pp. 265-270

Stefanie Warnat-Herresthal, Hartmut Schultze, Krishnaprasad Lingadahalli Shastry, Sathyanarayanan Manamohan, Saikat Mukherjee, Vishesh Garg, Ravi Sarveswara, Kristian Händler, Peter Pickkers, N. Ahmad Aziz, Sofia Ktena, Florian Tran, Michael Bitzer, Stephan Ossowski, Nicolas Casadei, Christian Herr, Daniel Petersheim, Uta Behrends, Fabian Kern, Tobias Fehlmann, Philipp Schommers, Clara Lehmann, Max Augustin, Jan Rybniker, Janine Altmüller, Neha Mishra, Joana P. Bernardes, Benjamin Krämer, Lorenzo Bonaguro, Jonas Schulte-Schrepping, Elena Domenico, Christian Siever, Michael Kraut, Milind Desai, Bruno Monnet, Maria Saridaki, Charles Martin Siegel, Anna Drews, Melanie Nuesch-Germano, Heidi Theis, Jan Heyckendorf, Stefan Schreiber, Sarah Kim-Hellmuth, Jacob Nattermann, Dirk Skowasch, Ingo Kurth, Andreas Keller, Robert Bals, Peter Nürnberg, Olaf Rieß, Philip Rosenstiel, Mihai G. Netea, Fabian Theis, Sach Mukherjee, Michael Backes, Anna C. Aschenbrenner, Thomas Ulas, Monique M. B. Breteler, Evangelos J. Giamarellos-Bourboulis, Matthijs Kox, Matthias Becker, Sorin Cheran, Michael S. Woodacre, Eng Lim Goh and Joachim L. Schultze

PIK3CA and CCM mutations fuel cavernomas through a cancer-like mechanism pp. 271-276

Aileen A. Ren, Daniel A. Snellings, Yourong S. Su, Courtney C. Hong, Marco Castro, Alan T. Tang, Matthew R. Detter, Nicholas Hobson, Romuald Girard, Sharbel Romanos, Rhonda Lightle, Thomas Moore, Robert Shenkar, Christian Benavides, M. Makenzie Beaman, Helge Müller-Fielitz, Mei Chen, Patricia Mericko, Jisheng Yang, Derek C. Sung, Michael T. Lawton, J. Michael Ruppert, Markus Schwaninger, Jakob Körbelin, Michael Potente, Issam A. Awad, Douglas A. Marchuk and Mark L. Kahn

NF1 mutation drives neuronal activity-dependent initiation of optic glioma pp. 277-282

Yuan Pan, Jared D. Hysinger, Tara Barron, Nicki F. Schindler, Olivia Cobb, Xiaofan Guo, Belgin Yalçın, Corina Anastasaki, Sara B. Mulinyawe, Anitha Ponnuswami, Suzanne Scheaffer, Yu Ma, Kun-Che Chang, Xin Xia, Joseph A. Toonen, James J. Lennon, Erin M. Gibson, John R. Huguenard, Linda M. Liau, Jeffrey L. Goldberg, Michelle Monje and David H. Gutmann

RNA transcripts stimulate homologous recombination by forming DR-loops pp. 283-288

Jian Ouyang, Tribhuwan Yadav, Jia-Min Zhang, Haibo Yang, Esther Rheinbay, Hongshan Guo, Daniel A. Haber, Li Lan and Lee Zou

How COVID changed schools outreach pp. 289-291

T. V. Padma

Education outreach can inspire the next generation of scientists pp. 291-292

David Hiller

Fly me to the Moon pp. 294-294

Virginia Gewin

2021, volume 594, articles 7861

Possible overestimation of isomer depletion due to contamination pp. E1-E2

Song Guo, Yongde Fang, Xiaohong Zhou and C. M. Petrache

Reply to: Possible overestimation of isomer depletion due to contamination pp. E3-E4

C. J. Chiara, J. J. Carroll, M. P. Carpenter, J. P. Greene, D. J. Hartley, R. V. F. Janssens, G. J. Lane, J. C. Marsh, D. A. Matters, M. Polasik, J. Rzadkiewicz, D. Seweryniak, S. Zhu, S. Bottoni and A. B. Hayes

India’s COVID crisis flags need to forecast variants pp. 9-9

Anurag Agrawal

Divisive COVID ‘lab leak’ debate prompts dire warnings from researchers pp. 15-16

Amy Maxmen

Scientific image sleuth faces legal action for criticizing research papers pp. 17-18

Holly Else

Limit on lab-grown human embryos dropped by stem-cell body pp. 18-19

Nidhi Subbaraman

What scientists know about new, fast-spreading coronavirus variants pp. 19-20

David Adam

Controversial forestry experiment will be largest-ever in United States pp. 20-21

Jeff Tollefson

How did Neanderthals and other ancient humans learn to count? pp. 22-25

Colin Barras

French vote for river barriers defies biodiversity strategy pp. 26-26

Simon Blanchet and Pablo A. Tedesco

Academic bullying: mediatiors hear both sides pp. 26-26

Alastair Hay

Boost US federal funding for international trainees pp. 26-26

Oscar E. Reyes Gaido and Mark E. Anderson

COVID: treatment trials are still urgent pp. 26-26

Steve Rauchman

Charge-carrying films for solar cells made quickly and cleanly pp. 27-28

Jianfeng Lu and Fuzhi Huang

Host ubiquitin protein tags lipid to fight bacteria pp. 28-29

Brenda A. Schulman and J. Wade Harper

Hunting the strongest accelerators in our Galaxy pp. 30-31

Petra Huentemeyer

Mapping micronutrients in grain and soil unearths hidden hunger in Africa pp. 31-32

Ken E. Giller and Shamie Zingore

Ultrahigh-energy photons up to 1.4 petaelectronvolts from 12 γ-ray Galactic sources pp. 33-36

Zhen Cao, F. A. Aharonian, Q. An, Axikegu, L. X. Bai, Y. X. Bai, Y. W. Bao, D. Bastieri, X. J. Bi, Y. J. Bi, H. Cai, J. T. Cai, Zhe Cao, J. Chang, J. F. Chang, X. C. Chang, B. M. Chen, J. Chen, L. Chen, Liang Chen, Long Chen, M. J. Chen, M. L. Chen, Q. H. Chen, S. H. Chen, S. Z. Chen, T. L. Chen, X. L. Chen, Y. Chen, N. Cheng, Y. D. Cheng, S. W. Cui, X. H. Cui, Y. D. Cui, B. Z. Dai, H. L. Dai, Z. G. Dai, Danzengluobu, D. Volpe, B. D′Ettorre Piazzoli, X. J. Dong, J. H. Fan, Y. Z. Fan, Z. X. Fan, J. Fang, K. Fang, C. F. Feng, L. Feng, S. H. Feng, Y. L. Feng, B. Gao, C. D. Gao, Q. Gao, W. Gao, M. M. Ge, L. S. Geng, G. H. Gong, Q. B. Gou, M. H. Gu, J. G. Guo, X. L. Guo, Y. Q. Guo, Y. Y. Guo, Y. A. Han, H. H. He, H. N. He, J. C. He, S. L. He, X. B. He, Y. He, M. Heller, Y. K. Hor, C. Hou, X. Hou, H. B. Hu, S. Hu, S. C. Hu, X. J. Hu, D. H. Huang, Q. L. Huang, W. H. Huang, X. T. Huang, Z. C. Huang, F. Ji, X. L. Ji, H. Y. Jia, K. Jiang, Z. J. Jiang, C. Jin, D. Kuleshov, K. Levochkin, B. B. Li, Cong Li, Cheng Li, F. Li, H. B. Li, H. C. Li, H. Y. Li, J. Li, K. Li, W. L. Li, X. Li, Xin Li, X. R. Li, Y. Li, Y. Z. Li, Zhe Li, Zhuo Li, E. W. Liang, Y. F. Liang, S. J. Lin, B. Liu, C. Liu, D. Liu, H. Liu, H. D. Liu, J. Liu, J. L. Liu, J. S. Liu, J. Y. Liu, M. Y. Liu, R. Y. Liu, S. M. Liu, W. Liu, Y. N. Liu, Z. X. Liu, W. J. Long, R. Lu, H. K. Lv, B. Q. Ma, L. L. Ma, X. H. Ma, J. R. Mao, A. Masood, W. Mitthumsiri, T. Montaruli, Y. C. Nan, B. Y. Pang, P. Pattarakijwanich, Z. Y. Pei, M. Y. Qi, D. Ruffolo, V. Rulev, A. Sáiz, L. Shao, O. Shchegolev, X. D. Sheng, J. R. Shi, H. C. Song, Yu. V. Stenkin, V. Stepanov, Q. N. Sun, X. N. Sun, Z. B. Sun, P. H. T. Tam, Z. B. Tang, W. W. Tian, B. D. Wang, C. Wang, H. Wang, H. G. Wang, J. C. Wang, J. S. Wang, L. P. Wang, L. Y. Wang, R. N. Wang, W. Wang, W. Wang, X. G. Wang, X. J. Wang, X. Y. Wang, Y. D. Wang, Y. J. Wang, Y. P. Wang, Zheng Wang, Zhen Wang, Z. H. Wang, Z. X. Wang, D. M. Wei, J. J. Wei, Y. J. Wei, T. Wen, C. Y. Wu, H. R. Wu, S. Wu, W. X. Wu, X. F. Wu, S. Q. Xi, J. Xia, J. J. Xia, G. M. Xiang, G. Xiao, H. B. Xiao, G. G. Xin, Y. L. Xin, Y. Xing, D. L. Xu, R. X. Xu, L. Xue, D. H. Yan, C. W. Yang, F. F. Yang, J. Y. Yang, L. L. Yang, M. J. Yang, R. Z. Yang, S. B. Yang, Y. H. Yao, Z. G. Yao, Y. M. Ye, L. Q. Yin, N. Yin, X. H. You, Z. Y. You, Y. H. Yu, Q. Yuan, H. D. Zeng, T. X. Zeng, W. Zeng, Z. K. Zeng, M. Zha, X. X. Zhai, B. B. Zhang, H. M. Zhang, H. Y. Zhang, J. L. Zhang, J. W. Zhang, L. Zhang, Li Zhang, L. X. Zhang, P. F. Zhang, P. P. Zhang, R. Zhang, S. R. Zhang, S. S. Zhang, X. Zhang, X. P. Zhang, Yong Zhang, Yi Zhang, Y. F. Zhang, Y. L. Zhang, B. Zhao, J. Zhao, L. Zhao, L. Z. Zhao, S. P. Zhao, F. Zheng, Y. Zheng, B. Zhou, H. Zhou, J. N. Zhou, P. Zhou, R. Zhou, X. X. Zhou, C. G. Zhu, F. R. Zhu, H. Zhu, K. J. Zhu and X. Zuo

Telecom-heralded entanglement between multimode solid-state quantum memories pp. 37-40

Dario Lago-Rivera, Samuele Grandi, Jelena V. Rakonjac, Alessandro Seri and Hugues de Riedmatten

Heralded entanglement distribution between two absorptive quantum memories pp. 41-45

Xiao Liu, Jun Hu, Zong-Feng Li, Xue Li, Pei-Yun Li, Peng-Jun Liang, Zong-Quan Zhou, Chuan-Feng Li and Guang-Can Guo

Signatures of moiré trions in WSe2/MoSe2 heterobilayers pp. 46-50

Erfu Liu, Elyse Barré, Jeremiah van Baren, Matthew Wilson, Takashi Taniguchi, Kenji Watanabe, Yong-Tao Cui, Nathaniel M. Gabor, Tony F. Heinz, Yia-Chung Chang and Chun Hung Lui

CO2 doping of organic interlayers for perovskite solar cells pp. 51-56

Jaemin Kong, Yongwoo Shin, Jason A. Röhr, Hang Wang, Juan Meng, Yueshen Wu, Adlai Katzenberg, Geunjin Kim, Dong Young Kim, Tai- De Li, Edward Chau, Francisco Antonio, Tana Siboonruang, Sooncheol Kwon, Kwanghee Lee, Jin Ryoun Kim, Miguel A. Modestino, Hailiang Wang and André D. Taylor

Intrinsic toughening and stable crack propagation in hexagonal boron nitride pp. 57-61

Yingchao Yang, Zhigong Song, Guangyuan Lu, Qinghua Zhang, Boyu Zhang, Bo Ni, Chao Wang, Xiaoyan Li, Lin Gu, Xiaoming Xie, Huajian Gao and Jun Lou

Asymmetric response of interfacial water to applied electric fields pp. 62-65

Angelo Montenegro, Chayan Dutta, Muhammet Mammetkuliev, Haotian Shi, Bingya Hou, Dhritiman Bhattacharyya, Bofan Zhao, Stephen B. Cronin and Alexander V. Benderskii

Widespread deoxygenation of temperate lakes pp. 66-70

Stephen F. Jane, Gretchen J. A. Hansen, Benjamin M. Kraemer, Peter R. Leavitt, Joshua L. Mincer, Rebecca L. North, Rachel M. Pilla, Jonathan T. Stetler, Craig E. Williamson, R. Iestyn Woolway, Lauri Arvola, Sudeep Chandra, Curtis L. DeGasperi, Laura Diemer, Julita Dunalska, Oxana Erina, Giovanna Flaim, Hans-Peter Grossart, K. David Hambright, Catherine Hein, Josef Hejzlar, Lorraine L. Janus, Jean-Philippe Jenny, John R. Jones, Lesley B. Knoll, Barbara Leoni, Eleanor Mackay, Shin-Ichiro S. Matsuzaki, Chris McBride, Dörthe C. Müller-Navarra, Andrew M. Paterson, Don Pierson, Michela Rogora, James A. Rusak, Steven Sadro, Emilie Saulnier-Talbot, Martin Schmid, Ruben Sommaruga, Wim Thiery, Piet Verburg, Kathleen C. Weathers, Gesa A. Weyhenmeyer, Kiyoko Yokota and Kevin C. Rose

The nutritional quality of cereals varies geospatially in Ethiopia and Malawi pp. 71-76

D. Gashu, P. C. Nalivata, T. Amede, E. L. Ander, E. H. Bailey, L. Botoman, C. Chagumaira, S. Gameda, S. M. Haefele, K. Hailu, E. J. M. Joy, A. A. Kalimbira, D. B. Kumssa, R. M. Lark, I. S. Ligowe, S. P. McGrath, A. E. Milne, A. W. Mossa, M. Munthali, E. K. Towett, M. G. Walsh, L. Wilson, S. D. Young and M. R. Broadley

A high-quality bonobo genome refines the analysis of hominid evolution pp. 77-81

Yafei Mao, Claudia R. Catacchio, LaDeana W. Hillier, David Porubsky, Ruiyang Li, Arvis Sulovari, Jason D. Fernandes, Francesco Montinaro, David S. Gordon, Jessica M. Storer, Marina Haukness, Ian T. Fiddes, Shwetha Canchi Murali, Philip C. Dishuck, PingHsun Hsieh, William T. Harvey, Peter A. Audano, Ludovica Mercuri, Ilaria Piccolo, Francesca Antonacci, Katherine M. Munson, Alexandra P. Lewis, Carl Baker, Jason G. Underwood, Kendra Hoekzema, Tzu-Hsueh Huang, Melanie Sorensen, Jerilyn A. Walker, Jinna Hoffman, Françoise Thibaud-Nissen, Sofie R. Salama, Andy W. C. Pang, Joyce Lee, Alex R. Hastie, Benedict Paten, Mark A. Batzer, Mark Diekhans, Mario Ventura and Evan E. Eichler

Cortex-dependent corrections as the tongue reaches for and misses targets pp. 82-87

Tejapratap Bollu, Brendan S. Ito, Samuel C. Whitehead, Brian Kardon, James Redd, Mei Hong Liu and Jesse H. Goldberg

Drugs that inhibit TMEM16 proteins block SARS-CoV-2 spike-induced syncytia pp. 88-93

Luca Braga, Hashim Ali, Ilaria Secco, Elena Chiavacci, Guilherme Neves, Daniel Goldhill, Rebecca Penn, Jose M. Jimenez-Guardeño, Ana M. Ortega-Prieto, Rossana Bussani, Antonio Cannatà, Giorgia Rizzari, Chiara Collesi, Edoardo Schneider, Daniele Arosio, Ajay M. Shah, Wendy S. Barclay, Michael H. Malim, Juan Burrone and Mauro Giacca

Sensory neuron-derived TAFA4 promotes macrophage tissue repair functions pp. 94-99

Guillaume Hoeffel, Guilhaume Debroas, Anais Roger, Rafaelle Rossignol, Jordi Gouilly, Caroline Laprie, Lionel Chasson, Pierre-Vincent Barbon, Anaïs Balsamo, Ana Reynders, Aziz Moqrich and Sophie Ugolini

An aged immune system drives senescence and ageing of solid organs pp. 100-105

Matthew J. Yousefzadeh, Rafael R. Flores, Yi Zhu, Zoe C. Schmiechen, Robert W. Brooks, Christy E. Trussoni, Yuxiang Cui, Luise Angelini, Kyoo-A Lee, Sara J. McGowan, Adam L. Burrack, Dong Wang, Qing Dong, Aiping Lu, Tokio Sano, Ryan D. O’Kelly, Collin A. McGuckian, Jonathan I. Kato, Michael P. Bank, Erin A. Wade, Smitha P. S. Pillai, Jenna Klug, Warren C. Ladiges, Christin E. Burd, Sara E. Lewis, Nicholas F. LaRusso, Nam V. Vo, Yinsheng Wang, Eric E. Kelley, Johnny Huard, Ingunn M. Stromnes, Paul D. Robbins and Laura J. Niedernhofer

AI-based pathology predicts origins for cancers of unknown primary pp. 106-110

Ming Y. Lu, Tiffany Y. Chen, Drew F. K. Williamson, Melissa Zhao, Maha Shady, Jana Lipkova and Faisal Mahmood

Ubiquitylation of lipopolysaccharide by RNF213 during bacterial infection pp. 111-116

Elsje G. Otten, Emma Werner, Ana Crespillo-Casado, Keith B. Boyle, Vimisha Dharamdasani, Claudio Pathe, Balaji Santhanam and Felix Randow

MIR-NATs repress MAPT translation and aid proteostasis in neurodegeneration pp. 117-123

Roberto Simone, Faiza Javad, Warren Emmett, Oscar G. Wilkins, Filipa Lourenço Almeida, Natalia Barahona-Torres, Justyna Zareba-Paslawska, Mazdak Ehteramyan, Paola Zuccotti, Angelika Modelska, Kavitha Siva, Gurvir S. Virdi, Jamie S. Mitchell, Jasmine Harley, Victoria A. Kay, Geshanthi Hondhamuni, Daniah Trabzuni, Mina Ryten, Selina Wray, Elisavet Preza, Demis A. Kia, Alan Pittman, Raffaele Ferrari, Claudia Manzoni, Andrew Lees, John A. Hardy, Michela A. Denti, Alessandro Quattrone, Rickie Patani, Per Svenningsson, Thomas T. Warner, Vincent Plagnol, Jernej Ule and Rohan Silva

Structures of mammalian RNA polymerase II pre-initiation complexes pp. 124-128

Shintaro Aibara, Sandra Schilbach and Patrick Cramer

Structure of the human Mediator–RNA polymerase II pre-initiation complex pp. 129-133

Srinivasan Rengachari, Sandra Schilbach, Shintaro Aibara, Christian Dienemann and Patrick Cramer

How new principal investigators tackled a tumultuous year pp. 135-137

Nikki Forrester

Old-school computing: when your lab PC is ancient pp. 138-139

Julian Nowogrodzki

Fighting food insecurity with CRISPR at Zimbabwe’s first private research institute pp. 142-142

Abdullahi Tsanni