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2016, volume 537, articles 7622

The dark universe pp. S193-S193

Richard Hodson

Dark matter: What's the matter? pp. S194-S197

Jeff Hecht

Revealing the unseen Universe pp. S198-S199

Mark Zastrow

Q&A: George Smoot pp. S200-S200

Richard Hodson

Dark energy: Staring into darkness pp. S201-S204

Stephen Battersby

Q&A: Brian Schmidt pp. S205-S205

Richard Hodson

The dark universe: 4 big questions pp. S206-S206

Neil Savage

Encourage governments to heed scientific advice pp. 587-587

Bill Colglazier

Daring Chinese telescope is poised to transform astronomy pp. 593-594

David Cyranoski

Facebook couple commits $3 billion to cure disease pp. 595-595

Erika Check Hayden

Cuban crocodiles pose conservation conundrum pp. 596-597

Sara Reardon

Worldwide brain-mapping project sparks excitement — and concern pp. 597-597

Sara Reardon

Solar on the steppe: Ukraine embraces renewables revolution pp. 598-598

Quirin Schiermeier

Zimbabwean scientists fight to preserve national academy pp. 599-599

Sarah Wild

Can Cuban science go global? pp. 600-603

Sara Reardon

Boost resilience of small and mid-sized cities pp. 605-608

Joern Birkmann, Torsten Welle, William Solecki, Shuaib Lwasa and Matthias Garschagen

Where to put the next billion people pp. 608-611

Richard T. T. Forman and Jianguo Wu

Give cities a seat at the top table pp. 611-613

Michele Acuto

Cities: Humanizing the urban fabric pp. 614-615

Austin Williams

Books in brief pp. 615-615

Barbara Kiser

Physics: Finding the time pp. 616-616

Andrew Jaffe

Nourish as well as feed the world pp. 617-617

Sandy Thomas

Species loss: diverse takes on biodiversity pp. 617-617

Andrew Beattie

Species loss: a crude view of climate pp. 617-617

Nikhil Advani, Susan Evans and Arjette Stevens

Species loss: climate plan saves only trees pp. 617-617

Tim Caro and Monique Borgerhoff Mulder

Mobile networks aid weather monitoring pp. 617-617

Pinhas Alpert, Hagit Messer and Noam David

Hybrid vigour characterized pp. 620-621

James A. Birchler

MRI illuminated by γ-rays pp. 621-622

Richard Bowtell

The bacterial cell wall takes centre stage pp. 622-624

Kevin D. Young

A collaboration worth its weight in grain pp. 624-625

Leah H. Samberg

Long-term effects of permafrost thaw pp. 625-626

Donatella Zona

Forecast for water balance pp. 626-627

Michael J. Krashes

Small molecular replicators go organic pp. 627-628

Annette F. Taylor

Genomic architecture of heterosis for yield traits in rice pp. 629-633

Xuehui Huang, Shihua Yang, Junyi Gong, Qiang Zhao, Qi Feng, Qilin Zhan, Yan Zhao, Wenjun Li, Benyi Cheng, Junhui Xia, Neng Chen, Tao Huang, Lei Zhang, Danlin Fan, Jiaying Chen, Congcong Zhou, Yiqi Lu, Qijun Weng and Bin Han

SEDS proteins are a widespread family of bacterial cell wall polymerases pp. 634-638

Alexander J. Meeske, Eammon P. Riley, William P. Robins, Tsuyoshi Uehara, John J. Mekalanos, Daniel Kahne, Suzanne Walker, Andrew C. Kruse, Thomas G. Bernhardt and David Z. Rudner

The architecture of the mammalian respirasome pp. 639-643

Jinke Gu, Meng Wu, Runyu Guo, Kaige Yan, Jianlin Lei, Ning Gao and Maojun Yang

The architecture of respiratory supercomplexes pp. 644-648

James A. Letts, Karol Fiedorczuk and Leonid A. Sazanov

The awakening of a classical nova from hibernation pp. 649-651

Przemek Mróz, Andrzej Udalski, Paweł Pietrukowicz, Michał K. Szymański, Igor Soszyński, Łukasz Wyrzykowski, Radosław Poleski, Szymon Kozłowski, Jan Skowron, Krzysztof Ulaczyk, Dorota Skowron and Michał Pawlak

A method for imaging and spectroscopy using γ-rays and magnetic resonance pp. 652-655

Yuan Zheng, G. Wilson Miller, William A. Tobias and Gordon D. Cates

Autocatalytic, bistable, oscillatory networks of biologically relevant organic reactions pp. 656-660

Sergey N. Semenov, Lewis J. Kraft, Alar Ainla, Mengxia Zhao, Mostafa Baghbanzadeh, Victoria E. Campbell, Kyungtae Kang, Jerome M. Fox and George M. Whitesides

Directed evolution of artificial metalloenzymes for in vivo metathesis pp. 661-665

Markus Jeschek, Raphael Reuter, Tillmann Heinisch, Christian Trindler, Juliane Klehr, Sven Panke and Thomas R. Ward

Key new pieces of the HIMU puzzle from olivines and diamond inclusions pp. 666-670

Yaakov Weiss, Cornelia Class, Steven L. Goldstein and Takeshi Hanyu

Closing yield gaps in China by empowering smallholder farmers pp. 671-674

Weifeng Zhang, Guoxin Cao, Xiaolin Li, Hongyan Zhang, Chong Wang, Quanqing Liu, Xinping Chen, Zhenling Cui, Jianbo Shen, Rongfeng Jiang, Guohua Mi, Yuxin Miao, Fusuo Zhang and Zhengxia Dou

CHD8 haploinsufficiency results in autistic-like phenotypes in mice pp. 675-679

Yuta Katayama, Masaaki Nishiyama, Hirotaka Shoji, Yasuyuki Ohkawa, Atsuki Kawamura, Tetsuya Sato, Mikita Suyama, Toru Takumi, Tsuyoshi Miyakawa and Keiichi I. Nakayama

Thirst neurons anticipate the homeostatic consequences of eating and drinking pp. 680-684

Christopher A. Zimmerman, Yen-Chu Lin, David E. Leib, Ling Guo, Erica L. Huey, Gwendolyn E. Daly, Yiming Chen and Zachary A. Knight

Clock-driven vasopressin neurotransmission mediates anticipatory thirst prior to sleep pp. 685-688

C. Gizowski, C. Zaelzer and C. W. Bourque

Ecogenomics and potential biogeochemical impacts of globally abundant ocean viruses pp. 689-693

Simon Roux, Jennifer R. Brum, Bas E. Dutilh, Shinichi Sunagawa, Melissa B. Duhaime, Alexander Loy, Bonnie T. Poulos, Natalie Solonenko, Elena Lara, Julie Poulain, Stéphane Pesant, Stefanie Kandels-Lewis, Céline Dimier, Marc Picheral, Sarah Searson, Corinne Cruaud, Adriana Alberti, Carlos M. Duarte, Josep M. Gasol, Dolors Vaqué, Peer Bork, Silvia G. Acinas, Patrick Wincker and Matthew B. Sullivan

Rewriting yeast central carbon metabolism for industrial isoprenoid production pp. 694-697

Adam L. Meadows, Kristy M. Hawkins, Yoseph Tsegaye, Eugene Antipov, Youngnyun Kim, Lauren Raetz, Robert H. Dahl, Anna Tai, Tina Mahatdejkul-Meadows, Lan Xu, Lishan Zhao, Madhukar S. Dasika, Abhishek Murarka, Jacob Lenihan, Diana Eng, Joshua S. Leng, Chi-Li Liu, Jared W. Wenger, Hanxiao Jiang, Lily Chao, Patrick Westfall, Jefferson Lai, Savita Ganesan, Peter Jackson, Robert Mans, Darren Platt, Christopher D. Reeves, Poonam R. Saija, Gale Wichmann, Victor F. Holmes, Kirsten Benjamin, Paul W. Hill, Timothy S. Gardner and Annie E. Tsong

Single-cell analysis of mixed-lineage states leading to a binary cell fate choice pp. 698-702

Andre Olsson, Meenakshi Venkatasubramanian, Viren K. Chaudhri, Bruce J. Aronow, Nathan Salomonis, Harinder Singh and H. Leighton Grimes

Reproducibility: Seek out stronger science pp. 703-704

Monya Baker

The sixth circle pp. 706-706

J. W. Armstrong

2016, volume 537, articles 7621

Royalactin is not a royal making of a queen pp. E10-E12

Anja Buttstedt, Christian H. Ihling, Markus Pietzsch and Robin F. A. Moritz

Kamakura replies pp. E13-E13

M. Kamakura

Lysosomal storage disorders pp. S145-S145

Michelle Grayson

Myriad maladies pp. S146-S147

Michael Eisenstein

Biomedicine: A rare opportunity pp. S148-S150

Kelly Rae Chi

Perspective: The rare must become common pp. S151-S151

Marc C. Patterson

Advocacy: Strong foundations pp. S152-S154

James Mitchell Crow

Drug development: Through the barrier pp. S154-S157

Sarah DeWeerdt

Gene therapy: A new chapter pp. S158-S159

Anthony King

Perspective: Finding common ground pp. S160-S161

Anthony H. Futerman and John Hardy

Screening: Baby's first test pp. S162-S164

Sujata Gupta

Lysosomal storage disorders: 4 big questions pp. S165-S165

Michael Eisenstein

Religion and science can have a true dialogue pp. 451-451

Kathryn Pritchard

Geneticists attempt to heal rifts with Aboriginal communities pp. 457-458

Ewen Callaway

US sharpens surveillance of crippling solar storms pp. 458-459

Alexandra Witze

Detailed map shows Milky Way is bigger than we thought pp. 459-459

Davide Castelvecchi

Titanic clash over CRISPR patents turns ugly pp. 460-461

Heidi Ledford

Human skeleton found on famed Antikythera shipwreck pp. 462-463

Jo Marchant

Science’s 1%: How income inequality is getting worse in research pp. 471-473

Corie Lok

End class wars pp. 475-479

Mike Savage

Income inequality is cyclical pp. 479-482

Branko Milanovic

Public health: Beating Ebola pp. 484-485

Peter Piot

Books in brief pp. 485-485

Barbara Kiser

Geoengineering: Code of conduct for geoengineering pp. 488-488

Anna-Maria Hubert, Tim Kruger and Steve Rayner

Pollution: Do microplastics spill on to farm soils? pp. 488-488

Luca Nizzetto, Sindre Langaas and Martyn Futter

Species loss: lack of data leaves a gap pp. 488-488

Lucie Bland and Ben Collen

Health research: Africa–India health-science partnerships pp. 488-488

Shahid Jameel, Thomas Kariuki and Simon Kay

Wildlife monitoring: Lure gamers into citizen science pp. 488-488

Rassim Khelifa

James Cronin (1931–2016) pp. 489-489

Alan Watson

Structure of aggregates revealed pp. 492-493

Robert Tycko

Motion controlled by sound pp. 493-494

Adrian Neild

Panoramic views of the early epigenome pp. 494-496

Juan M. Vaquerizas and Maria-Elena Torres-Padilla

Migration of giants pp. 496-497

Amaury Triaud

Channelling potassium to fight cancer pp. 497-499

K. George Chandy and Raymond S. Norton

Multitasking materials from atomic templates pp. 499-500

Manfred Fiebig

Evidence of life in Earth's oldest rocks pp. 500-501

Abigail C. Allwood

Perimortem fractures in Lucy suggest mortality from fall out of tall tree pp. 503-507

John Kappelman, Richard A. Ketcham, Stephen Pearce, Lawrence Todd, Wiley Akins, Matthew W. Colbert, Mulugeta Feseha, Jessica A. Maisano and Adrienne Witzel

High-throughput discovery of novel developmental phenotypes pp. 508-514

Mary E. Dickinson, Ann M. Flenniken, Xiao Ji, Lydia Teboul, Michael D. Wong, Jacqueline K. White, Terrence F. Meehan, Wolfgang J. Weninger, Henrik Westerberg, Hibret Adissu, Candice N. Baker, Lynette Bower, James M. Brown, L. Brianna Caddle, Francesco Chiani, Dave Clary, James Cleak, Mark J. Daly, James M. Denegre, Brendan Doe, Mary E. Dolan, Sarah M. Edie, Helmut Fuchs, Valerie Gailus-Durner, Antonella Galli, Alessia Gambadoro, Juan Gallegos, Shiying Guo, Neil R. Horner, Chih-Wei Hsu, Sara J. Johnson, Sowmya Kalaga, Lance C. Keith, Louise Lanoue, Thomas N. Lawson, Monkol Lek, Manuel Mark, Susan Marschall, Jeremy Mason, Melissa L. McElwee, Susan Newbigging, Lauryl M. J. Nutter, Kevin A. Peterson, Ramiro Ramirez-Solis, Douglas J. Rowland, Edward Ryder, Kaitlin E. Samocha, John R. Seavitt, Mohammed Selloum, Zsombor Szoke-Kovacs, Masaru Tamura, Amanda G. Trainor, Ilinca Tudose, Shigeharu Wakana, Jonathan Warren, Olivia Wendling, David B. West, Leeyean Wong, Atsushi Yoshiki, Wolfgang Wurst, Daniel G. MacArthur, Glauco P. Tocchini-Valentini, Xiang Gao, Paul Flicek, Allan Bradley, William C. Skarnes, Monica J. Justice, Helen E. Parkinson, Mark Moore, Sara Wells, Robert E. Braun, Karen L. Svenson, Martin Hrabe de Angelis, Yann Herault, Tim Mohun, Ann-Marie Mallon, R. Mark Henkelman, Steve D. M. Brown, David J. Adams, K. C. Kent Lloyd, Colin McKerlie, Arthur L. Beaudet, Maja Bućan and Stephen A. Murray

A partially differentiated interior for (1) Ceres deduced from its gravity field and shape pp. 515-517

R. S. Park, A. S. Konopliv, B. G. Bills, N. Rambaux, J. C. Castillo-Rogez, C. A. Raymond, A. T. Vaughan, A. I. Ermakov, M. T. Zuber, R. R. Fu, M. J. Toplis, C. T. Russell, A. Nathues and F. Preusker

Holograms for acoustics pp. 518-522

Kai Melde, Andrew G. Mark, Tian Qiu and Peer Fischer

Atomically engineered ferroic layers yield a room-temperature magnetoelectric multiferroic pp. 523-527

Julia A. Mundy, Charles M. Brooks, Megan E. Holtz, Jarrett A. Moyer, Hena Das, Alejandro F. Rébola, John T. Heron, James D. Clarkson, Steven M. Disseler, Zhiqi Liu, Alan Farhan, Rainer Held, Robert Hovden, Elliot Padgett, Qingyun Mao, Hanjong Paik, Rajiv Misra, Lena F. Kourkoutis, Elke Arenholz, Andreas Scholl, Julie A. Borchers, William D. Ratcliff, Ramamoorthy Ramesh, Craig J. Fennie, Peter Schiffer, David A. Muller and Darrell G. Schlom

Switching on electrocatalytic activity in solid oxide cells pp. 528-531

Jae-ha Myung, Dragos Neagu, David N. Miller and John T. S. Irvine

Molecular-scale evidence of aerosol particle formation via sequential addition of HIO3 pp. 532-534

Mikko Sipilä, Nina Sarnela, Tuija Jokinen, Henning Henschel, Heikki Junninen, Jenni Kontkanen, Stefanie Richters, Juha Kangasluoma, Alessandro Franchin, Otso Peräkylä, Matti P. Rissanen, Mikael Ehn, Hanna Vehkamäki, Theo Kurten, Torsten Berndt, Tuukka Petäjä, Douglas Worsnop, Darius Ceburnis, Veli-Matti Kerminen, Markku Kulmala and Colin O’Dowd

Rapid emergence of life shown by discovery of 3,700-million-year-old microbial structures pp. 535-538

Allen P. Nutman, Vickie C. Bennett, Clark R. L. Friend, Martin J. Van Kranendonk and Allan R. Chivas

Ionic immune suppression within the tumour microenvironment limits T cell effector function pp. 539-543

Robert Eil, Suman K. Vodnala, David Clever, Christopher A. Klebanoff, Madhusudhanan Sukumar, Jenny H. Pan, Douglas C. Palmer, Alena Gros, Tori N. Yamamoto, Shashank J. Patel, Geoffrey C. Guittard, Zhiya Yu, Valentina Carbonaro, Klaus Okkenhaug, David S. Schrump, W. Marston Linehan, Rahul Roychoudhuri and Nicholas P. Restifo

Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition pp. 544-547

Marco Sciacovelli, Emanuel Gonçalves, Timothy Isaac Johnson, Vincent Roberto Zecchini, Ana Sofia Henriques da Costa, Edoardo Gaude, Alizee Vercauteren Drubbel, Sebastian Julian Theobald, Sandra Riekje Abbo, Maxine Gia Binh Tran, Vinothini Rajeeve, Simone Cardaci, Sarah Foster, Haiyang Yun, Pedro Cutillas, Anne Warren, Vincent Gnanapragasam, Eyal Gottlieb, Kristian Franze, Brian Huntly, Eamonn Richard Maher, Patrick Henry Maxwell, Julio Saez-Rodriguez and Christian Frezza

Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition pp. 548-552

John Arne Dahl, Inkyung Jung, Håvard Aanes, Gareth D. Greggains, Adeel Manaf, Mads Lerdrup, Guoqiang Li, Samantha Kuan, Bin Li, Ah Young Lee, Sebastian Preissl, Ingunn Jermstad, Mads Haugland Haugen, Rajikala Suganthan, Magnar Bjørås, Klaus Hansen, Knut Tomas Dalen, Peter Fedorcsak, Bing Ren and Arne Klungland

Allelic reprogramming of the histone modification H3K4me3 in early mammalian development pp. 553-557

Bingjie Zhang, Hui Zheng, Bo Huang, Wenzhi Li, Yunlong Xiang, Xu Peng, Jia Ming, Xiaotong Wu, Yu Zhang, Qianhua Xu, Wenqiang Liu, Xiaochen Kou, Yanhong Zhao, Wenteng He, Chong Li, Bo Chen, Yuanyuan Li, Qiujun Wang, Jing Ma, Qiangzong Yin, Kehkooi Kee, Anming Meng, Shaorong Gao, Feng Xu, Jie Na and Wei Xie

Distinct features of H3K4me3 and H3K27me3 chromatin domains in pre-implantation embryos pp. 558-562

Xiaoyu Liu, Chenfei Wang, Wenqiang Liu, Jingyi Li, Chong Li, Xiaochen Kou, Jiayu Chen, Yanhong Zhao, Haibo Gao, Hong Wang, Yong Zhang, Yawei Gao and Shaorong Gao

A blue-light photoreceptor mediates the feedback regulation of photosynthesis pp. 563-566

Dimitris Petroutsos, Ryutaro Tokutsu, Shinichiro Maruyama, Serena Flori, Andre Greiner, Leonardo Magneschi, Loic Cusant, Tilman Kottke, Maria Mittag, Peter Hegemann, Giovanni Finazzi and Jun Minagawa

Structural basis of kainate subtype glutamate receptor desensitization pp. 567-571

Joel R. Meyerson, Sagar Chittori, Alan Merk, Prashant Rao, Tae Hee Han, Mihaela Serpe, Mark L. Mayer and Sriram Subramaniam

Correction: Corrigendum: A large light-mass component of cosmic rays at 1017–1017.5 electronvolts from radio observations pp. 572-572

S. Buitink, A. Corstanje, H. Falcke, J. R. Hörandel, T. Huege, A. Nelles, J. P. Rachen, L. Rossetto, P. Schellart, O. Scholten, S. ter Veen, S. Thoudam, T. N. G. Trinh, J. Anderson, A. Asgekar, I. M. Avruch, M. E. Bell, M. J. Bentum, G. Bernardi, P. Best, A. Bonafede, F. Breitling, J. W. Broderick, W. N. Brouw, M. Brüggen, H. R. Butcher, D. Carbone, B. Ciardi, J. E. Conway, F. de Gasperin, E. de Geus, A. Deller, R.-J. Dettmar, G. van Diepen, S. Duscha, J. Eislöffel, D. Engels, J. E. Enriquez, R. A. Fallows, R. Fender, C. Ferrari, W. Frieswijk, M. A. Garrett, J. M. Grießmeier, A. W. Gunst, M. P. van Haarlem, T. E. Hassall, G. Heald, J. W. T. Hessels, M. Hoeft, A. Horneffer, M. Iacobelli, H. Intema, E. Juette, A. Karastergiou, V. I. Kondratiev, M. Kramer, M. Kuniyoshi, G. Kuper, J. van Leeuwen, G. M. Loose, P. Maat, G. Mann, S. Markoff, R. McFadden, D. McKay-Bukowski, J. P. McKean, M. Mevius, D. D. Mulcahy, H. Munk, M. J. Norden, E. Orru, H. Paas, M. Pandey-Pommier, V. N. Pandey, M. Pietka, R. Pizzo, A. G. Polatidis, W. Reich, H. J. A. Röttgering, A. M. M. Scaife, D. J. Schwarz, M. Serylak, J. Sluman, O. Smirnov, B. W. Stappers, M. Steinmetz, A. Stewart, J. Swinbank, M. Tagger, Y. Tang, C. Tasse, M. C. Toribio, R. Vermeulen, C. Vocks, C. Vogt, R. J. van Weeren, R. A. M. J. Wijers, S. J. Wijnholds, M. W. Wise, O. Wucknitz, S. Yatawatta, P. Zarka and J. A. Zensus

Salaries: Reality check pp. 573-576

Chris Woolston

Houston, Houston, Do You Read James Tiptree? pp. 578-578

Rachael K. Jones

2016, volume 537, articles 7620

Amyloid-β transmission or unexamined bias? pp. E7-E9

Hieab H. H. Adams, Sonja A. Swanson, Albert Hofman and M. Arfan Ikram

Collinge et al. reply pp. E9-E9

John Collinge, Zane Jaunmuktane, Simon Mead, Peter Rudge and Sebastian Brandner

Kidney cancer pp. S97-S97

Brian Owens

The silent disease pp. S98-S99

Graham Shaw

Obesity: The fat advantage pp. S100-S102

Sujata Gupta

Alcohol: Fortifying spirits pp. S103-S104

Jesse Emspak

Perspective: Beyond the genome pp. S105-S105

John Leppert and Chirag Patel

Targeted therapy: An elusive cancer target pp. S106-S108

Carolyn Brown

Immunotherapy: Controlled attack pp. S109-S110

Charles Schmidt

Perspective: What next for treatment? pp. S111-S111

Robert J. Motzer

Illusory fears must not stifle chimaera research pp. 281-281

Insoo Hyun

Mystery deportation of particle physicist leads to swell of protest pp. 287-288

Declan Butler

Cancer experts unveil wishlist for US government ‘moonshot’ pp. 288-289

Heidi Ledford

Medical Nobel prize committee deals with surgical scandal pp. 289-290

Alison Abbott

DNA reveals that giraffes are four species — not one pp. 290-291

Chris Woolston

Ebola virus lingers longer than scientists thought pp. 291-292

Erika Check Hayden

Milky Way mapper: 6 ways the Gaia spacecraft will change astronomy pp. 292-293

Davide Castelvecchi

The office experiment: Can science build the perfect workspace? pp. 294-296

Emily Anthes

Secrets of life in the soil pp. 298-300

Rachel Cernansky

Agricultural R&D is on the move pp. 301-303

Philip Pardey, Connie Chan-Kang, Steven P. Dehmer and Jason Beddow

Technology: Selfies in space pp. 304-305

Alexandra Witze

Books in brief pp. 305-305

Barbara Kiser

Dendrology: The community of trees pp. 306-306

Richard Fortey

Harness passion of private fossil owners pp. 307-307

Robert R. Reisz and Michael W. Caldwell

Species can be named from photos pp. 307-307

Thomas Pape

China's sponge cities to soak up rainwater pp. 307-307

Dasheng Liu

Clearing the way for reef destruction pp. 307-307

April E. Reside, Tom C. L. Bridge and Jodie L. Rummer

Avoid bias against junior researchers pp. 307-307

Andrew K. Skidmore

Seymour Papert (1928–2016) pp. 308-308

Gary S. Stager

Extraordinary world pp. 310-311

James M. D. Day

Teenage tetrapods pp. 311-312

Nadia B. Fröbisch

Cytotoxic T cells that escape exhaustion pp. 312-314

Cindy S. Ma and Stuart G. Tangye

Geography matters for Arabidopsis pp. 314-315

Outi Savolainen and Martin Lascoux

Not so creepy under stress pp. 315-316

Jonathan Cormier

Dietary protection for genes pp. 316-317

Junko Oshima and George M. Martin

The protein world pp. 319-319

Joshua Finkelstein, Alex Eccleston and Sadaf Shadan

The coming of age of de novo protein design pp. 320-327

Po-Ssu Huang, Scott E. Boyken and David Baker

Proteome complexity and the forces that drive proteome imbalance pp. 328-338

J. Wade Harper and Eric J. Bennett

Unravelling biological macromolecules with cryo-electron microscopy pp. 339-346

Rafael Fernandez-Leiro and Sjors H. W. Scheres

Mass-spectrometric exploration of proteome structure and function pp. 347-355

Ruedi Aebersold and Matthias Mann

Locus coeruleus and dopaminergic consolidation of everyday memory pp. 357-362

Tomonori Takeuchi, Adrian J. Duszkiewicz, Alex Sonneborn, Patrick A. Spooner, Miwako Yamasaki, Masahiko Watanabe, Caroline C. Smith, Guillén Fernández, Karl Deisseroth, Robert W. Greene and Richard G. M. Morris

Activation mechanism of endothelin ETB receptor by endothelin-1 pp. 363-368

Wataru Shihoya, Tomohiro Nishizawa, Akiko Okuta, Kazutoshi Tani, Naoshi Dohmae, Yoshinori Fujiyoshi, Osamu Nureki and Tomoko Doi

m6A RNA methylation promotes XIST-mediated transcriptional repression pp. 369-373

Deepak P. Patil, Chun-Kan Chen, Brian F. Pickering, Amy Chow, Constanza Jackson, Mitchell Guttman and Samie R. Jaffrey

A radio-pulsing white dwarf binary star pp. 374-377

T. R. Marsh, B. T. Gänsicke, S. Hümmerich, F.-J. Hambsch, K. Bernhard, C. Lloyd, E. Breedt, E. R. Stanway, D. T. Steeghs, S. G. Parsons, O. Toloza, M. R. Schreiber, P. G. Jonker, J. van Roestel, T. Kupfer, A. F. Pala, V. S. Dhillon, L. K. Hardy, S. P. Littlefair, A. Aungwerojwit, S. Arjyotha, D. Koester, J. J. Bochinski, C. A. Haswell, P. Frank and P. J. Wheatley

Extreme creep resistance in a microstructurally stable nanocrystalline alloy pp. 378-381

K. A. Darling, M. Rajagopalan, M. Komarasamy, M. A. Bhatia, B. C. Hornbuckle, R. S. Mishra and K. N. Solanki

Enhanced electrocatalytic CO2 reduction via field-induced reagent concentration pp. 382-386

Min Liu, Yuanjie Pang, Bo Zhang, Phil De Luna, Oleksandr Voznyy, Jixian Xu, Xueli Zheng, Cao Thang Dinh, Fengjia Fan, Changhong Cao, F. Pelayo García de Arquer, Tina Saberi Safaei, Adam Mepham, Anna Klinkova, Eugenia Kumacheva, Tobin Filleter, David Sinton, Shana O. Kelley and Edward H. Sargent

Catalytic enantioselective 1,6-conjugate additions of propargyl and allyl groups pp. 387-393

Fanke Meng, Xiben Li, Sebastian Torker, Ying Shi, Xiao Shen and Amir H. Hoveyda

A nucleosynthetic origin for the Earth’s anomalous 142Nd composition pp. 394-398

C. Burkhardt, L. E. Borg, G. A. Brennecka, Q. R. Shollenberger, N. Dauphas and T. Kleine

Primitive Solar System materials and Earth share a common initial 142Nd abundance pp. 399-402

A. Bouvier and M. Boyet

Discovery of species-wide tool use in the Hawaiian crow pp. 403-407

Christian Rutz, Barbara C. Klump, Lisa Komarczyk, Rosanna Leighton, Joshua Kramer, Saskia Wischnewski, Shoko Sugasawa, Michael B. Morrissey, Richard James, James J. H. St Clair, Richard A. Switzer and Bryce M. Masuda

Life history of the stem tetrapod Acanthostega revealed by synchrotron microtomography pp. 408-411

Sophie Sanchez, Paul Tafforeau, Jennifer A. Clack and Per E. Ahlberg

Follicular CXCR5-expressing CD8+ T cells curtail chronic viral infection pp. 412-416

Ran He, Shiyue Hou, Cheng Liu, Anli Zhang, Qiang Bai, Miao Han, Yu Yang, Gang Wei, Ting Shen, Xinxin Yang, Lifan Xu, Xiangyu Chen, Yaxing Hao, Pengcheng Wang, Chuhong Zhu, Juanjuan Ou, Houjie Liang, Ting Ni, Xiaoyan Zhang, Xinyuan Zhou, Kai Deng, Yaokai Chen, Yadong Luo, Jianqing Xu, Hai Qi, Yuzhang Wu and Lilin Ye

Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy pp. 417-421

Se Jin Im, Masao Hashimoto, Michael Y. Gerner, Junghwa Lee, Haydn T. Kissick, Matheus C. Burger, Qiang Shan, J. Scott Hale, Judong Lee, Tahseen H. Nasti, Arlene H. Sharpe, Gordon J. Freeman, Ronald N. Germain, Helder I. Nakaya, Hai-Hui Xue and Rafi Ahmed

A PGC1α-mediated transcriptional axis suppresses melanoma metastasis pp. 422-426

Chi Luo, Ji-Hong Lim, Yoonjin Lee, Scott R. Granter, Ajith Thomas, Francisca Vazquez, Hans R. Widlund and Pere Puigserver

Restricted diet delays accelerated ageing and genomic stress in DNA-repair-deficient mice pp. 427-431

W. P. Vermeij, M. E. T. Dollé, E. Reiling, D. Jaarsma, C. Payan-Gomez, C. R. Bombardieri, H. Wu, A. J. M. Roks, S. M. Botter, B. C. van der Eerden, S. A. Youssef, R. V. Kuiper, B. Nagarajah, C. T. van Oostrom, R. M. C. Brandt, S. Barnhoorn, S. Imholz, J. L. A. Pennings, A. de Bruin, Á. Gyenis, J. Pothof, J. Vijg, H. van Steeg and J. H. J. Hoeijmakers

Correction: Corrigendum: Convergence of terrestrial plant production across global climate gradients pp. 432-432

Sean T. Michaletz, Dongliang Cheng, Andrew J. Kerkhoff and Brian J. Enquist

Reproducibility: Respect your cells! pp. 433-435

Monya Baker

Industry: Open for business pp. 437-439

Chris Woolston

Turning point: Activist engineer pp. 439-439

Virginia Gewin

A perfect medium for unrequited love pp. 442-442

Alex Shvartsman

2016, volume 537, articles 7619

Precision medicine pp. S49-S49

Richard Hodson

Medical histories pp. S52-S53

Amber Dance

Technology: Read the instructions pp. S54-S56

Andrew R. Scott

Gene therapy: Industrial strength pp. S57-S59

Eric Bender

Pharmacogenetics: The right drug for you pp. S60-S62

Liam Drew

Perspective: The precision-oncology illusion pp. S63-S63

Vinay Prasad

Diagnosis: A clear answer pp. S64-S65

Emily Sohn

Participation: Power to the patients pp. S66-S68

Katherine Bourzac

Q&A: Kathy Hudson pp. S69-S69

Eric Bender

Privacy: The myth of anonymity pp. S70-S72

Neil Savage

The debate over GM crops is making history pp. 139-139

Vivian Moses

Mars contamination fear could divert Curiosity rover pp. 145-146

Alexandra Witze

London super-lab opens under cloud of Brexit pp. 147-147

Ewen Callaway

Boom in unproven cell therapies intensifies regulatory debate pp. 148-148

Heidi Ledford

Venerable brain-cancer cell line faces identity crisis pp. 149-150

Elie Dolgin

US science agencies face budget limbo pp. 149-149

Sara Reardon

How to raise a genius: lessons from a 45-year study of super-smart children pp. 152-155

Tom Clynes

The new breed of cutting-edge catalysts pp. 156-158

XiaoZhi Lim

Use antimicrobials wisely pp. 159-161

Peter S. Jørgensen, Didier Wernli, Scott P. Carroll, Robert R. Dunn, Stephan Harbarth, Simon A. Levin, Anthony D. So, Maja Schlüter and Ramanan Laxminarayan

Science journals: The worlds of H. G. Wells pp. 162-164

Simon J. James

Science fiction: Boldly going for 50 years pp. 165-166

Sidney Perkowitz

Report released on antibiotic resistance pp. 167-167

Jeremy Farrar and Sally Davies

Antibiotic partners promote discovery pp. 167-167

Johan S. Bakken

Brexit threatens China collaboration pp. 167-167

Hong Yang, Roger J. Flower and Xianjin Huang

Gap widens for honorary PhDs pp. 167-167

Steven Watterson

Bite like a spider, sting like a scorpion pp. 167-167

Reza Afshari

Ahmed Hassan Zewail (1946–2016) pp. 168-168

Warren S. Warren

Designing the ideal opioid pp. 170-171

Brigitte L. Kieffer

Slippery when narrow pp. 171-172

Angelos Michaelides

Mapping the terrestrial human footprint pp. 172-173

Philip J. K. McGowan

Violent emissions of newborn stars pp. 174-175

Markus Röllig

Catalytic spliceosome captured pp. 175-176

Brian Kosmyna and Charles C. Query

Fin to limb within our grasp pp. 176-177

Aditya Saxena and Kimberly L. Cooper

Photocontrol of fluid slugs in liquid crystal polymer microactuators pp. 179-184

Jiu-an Lv, Yuyun Liu, Jia Wei, Erqiang Chen, Lang Qin and Yanlei Yu

Structure-based discovery of opioid analgesics with reduced side effects pp. 185-190

Aashish Manglik, Henry Lin, Dipendra K. Aryal, John D. McCorvy, Daniela Dengler, Gregory Corder, Anat Levit, Ralf C. Kling, Viachaslau Bernat, Harald Hübner, Xi-Ping Huang, Maria F. Sassano, Patrick M. Giguère, Stefan Löber, Da Duan, Grégory Scherrer, Brian K. Kobilka, Peter Gmeiner, Bryan L. Roth and Brian K. Shoichet

Structure of the voltage-gated calcium channel Cav1.1 at 3.6 Å resolution pp. 191-196

Jianping Wu, Zhen Yan, Zhangqiang Li, Xingyang Qian, Shan Lu, Mengqiu Dong, Qiang Zhou and Nieng Yan

Cryo-EM structure of the spliceosome immediately after branching pp. 197-201

Wojciech P. Galej, Max E. Wilkinson, Sebastian M. Fica, Chris Oubridge, Andrew J. Newman and Kiyoshi Nagai

Structural basis for the antifolding activity of a molecular chaperone pp. 202-206

Chengdong Huang, Paolo Rossi, Tomohide Saio and Charalampos G. Kalodimos

Compression and ablation of the photo-irradiated molecular cloud the Orion Bar pp. 207-209

Javier R. Goicoechea, Jérôme Pety, Sara Cuadrado, José Cernicharo, Edwige Chapillon, Asunción Fuente, Maryvonne Gerin, Christine Joblin, Nuria Marcelino and Paolo Pilleri

Massive radius-dependent flow slippage in carbon nanotubes pp. 210-213

Eleonora Secchi, Sophie Marbach, Antoine Niguès, Derek Stein, Alessandro Siria and Lydéric Bocquet

Oxidative diversification of amino acids and peptides by small-molecule iron catalysis pp. 214-219

Thomas J. Osberger, Donald C. Rogness, Jeffrey T. Kohrt, Antonia F. Stepan and M. Christina White

A progressively wetter climate in southern East Africa over the past 1.3 million years pp. 220-224

T. C. Johnson, J. P. Werne, E. T. Brown, A. Abbott, M. Berke, B. A. Steinman, J. Halbur, S. Contreras, S. Grosshuesch, A. Deino, C. A. Scholz, R. P. Lyons, S. Schouten and J. S. Sinninghe Damsté

Digits and fin rays share common developmental histories pp. 225-228

Tetsuya Nakamura, Andrew R. Gehrke, Justin Lemberg, Julie Szymaszek and Neil H. Shubin

Proteasome inhibition for treatment of leishmaniasis, Chagas disease and sleeping sickness pp. 229-233

Shilpi Khare, Advait S. Nagle, Agnes Biggart, Yin H. Lai, Fang Liang, Lauren C. Davis, S. Whitney Barnes, Casey J. N. Mathison, Elmarie Myburgh, Mu-Yun Gao, J. Robert Gillespie, Xianzhong Liu, Jocelyn L. Tan, Monique Stinson, Ianne C. Rivera, Jaime Ballard, Vince Yeh, Todd Groessl, Glenn Federe, Hazel X. Y. Koh, John D. Venable, Badry Bursulaya, Michael Shapiro, Pranab K. Mishra, Glen Spraggon, Ansgar Brock, Jeremy C. Mottram, Frederick S. Buckner, Srinivasa P. S. Rao, Ben G. Wen, John R. Walker, Tove Tuntland, Valentina Molteni, Richard J. Glynne and Frantisek Supek

Germinal centre hypoxia and regulation of antibody qualities by a hypoxia response system pp. 234-238

Sung Hoon Cho, Ariel L. Raybuck, Kristy Stengel, Mei Wei, Thomas C. Beck, Emmanuel Volanakis, James W. Thomas, Scott Hiebert, Volker H. Haase and Mark R. Boothby

The long non-coding RNA Morrbid regulates Bim and short-lived myeloid cell lifespan pp. 239-243

Jonathan J. Kotzin, Sean P. Spencer, Sam J. McCright, Dinesh B. Uthaya Kumar, Magalie A. Collet, Walter K. Mowel, Ellen N. Elliott, Asli Uyar, Michelle A. Makiya, Margaret C. Dunagin, Christian C. D. Harman, Anthony T. Virtue, Stella Zhu, Will Bailis, Judith Stein, Cynthia Hughes, Arjun Raj, E. John Wherry, Loyal A. Goff, Amy D. Klion, John L. Rinn, Adam Williams, Richard A. Flavell and Jorge Henao-Mejia

PionX sites mark the X chromosome for dosage compensation pp. 244-248

Raffaella Villa, Tamas Schauer, Pawel Smialowski, Tobias Straub and Peter B. Becker

Insights from biochemical reconstitution into the architecture of human kinetochores pp. 249-253

John R. Weir, Alex C. Faesen, Kerstin Klare, Arsen Petrovic, Federica Basilico, Josef Fischböck, Satyakrishna Pentakota, Jenny Keller, Marion E. Pesenti, Dongqing Pan, Doro Vogt, Sabine Wohlgemuth, Franz Herzog and Andrea Musacchio

Correction: Corrigendum: Malaria: Thermoregulation in a parasite’s life cycle pp. 254-254

Jun Fang and Thomas F. McCutchan

Correction: Corrigendum: sFRP2 in the aged microenvironment drives melanoma metastasis and therapy resistance pp. 254-254

Amanpreet Kaur, Marie R. Webster, Katie Marchbank, Reeti Behera, Abibatou Ndoye, Curtis H. Kugel, Vanessa M. Dang, Jessica Appleton, Michael P. O’Connell, Phil Cheng, Alexander A. Valiga, Rachel Morissette, Nazli B. McDonnell, Luigi Ferrucci, Andrew V. Kossenkov, Katrina Meeth, Hsin-Yao Tang, Xiangfan Yin, William H. Wood, Elin Lehrmann, Kevin G. Becker, Keith T. Flaherty, Dennie T. Frederick, Jennifer A. Wargo, Zachary A. Cooper, Michael T. Tetzlaff, Courtney Hudgens, Katherine M. Aird, Rugang Zhang, Xiaowei Xu, Qin Liu, Edmund Bartlett, Giorgos Karakousis, Zeynep Eroglu, Roger S. Lo, Matthew Chan, Alexander M. Menzies, Georgina V. Long, Douglas B. Johnson, Jeffrey Sosman, Bastian Schilling, Dirk Schadendorf, David W. Speicher, Marcus Bosenberg, Antoni Ribas and Ashani T. Weeraratna

Correction: Corrigendum: Enhancer loops appear stable during development and are associated with paused polymerase pp. 254-254

Yad Ghavi-Helm, Felix A. Klein, Tibor Pakozdi, Lucia Ciglar, Daan Noordermeer, Wolfgang Huber and Eileen E. M. Furlong

Lab life: Daydream and discover pp. 255-257

Emily Sohn

Trade talk: Star selector pp. 257-257

Monya Baker

Try catch throw pp. 259-270

Andrew Neil Gray

2016, volume 537, articles 7618

Verifying quantum superpositions at metre scales pp. E1-E2

D. M. Stamper-Kurn, G. E. Marti and H. Müller

Science-led economies pp. S1-S1

Herb Brody

Big science spenders pp. S2-S3

Alla Katsnelson

Kovachy et al. reply pp. E2-E3

T. Kovachy, P. Asenbaum, C. Overstreet, C. A. Donnelly, S. M. Dickerson, A. Sugarbaker, J. M. Hogan and M. A. Kasevich

Questioning Holocene community shifts pp. E4-E5

Cleo Bertelsmeier and Sébastien Ollier

Rwanda: From killing fields to technopolis pp. S4-S5

Linda Nordling

Lyons et al. reply pp. E5-E6

S. Kathleen Lyons, Joshua H. Miller, Anikó Tóth, Kathryn L. Amatangelo, Anna K. Behrensmeyer, Antoine Bercovici, Jessica L. Blois, Matt Davis, William A. DiMichelle, Andrew Du, Jussi T. Eronen, J. Tyler Faith, Gary R. Graves, Nathan Jud, Conrad Labandeira, Cindy V. Looy, Brian McGill, David Patterson, Silvia Pineda-Munoz, Richard Potts, Brett Riddle, Rebecca Terry, Werner Ulrich, Amelia Villaseñor, Scott Wing, Heidi Anderson, John Anderson and Nicholas J. Gotelli

The Middle East: An end to oil dependency pp. S6-S7

Louise Sarant

China: High-tech transformation pp. S8-S9

Annabel McGilvray

Preserve personal freedom in networked societies pp. 9-9

Christoph Bock

Russia: A faltering recovery pp. S10-S11

Olga Dobrovidova

Germany: Equality or excellence pp. S12-S13

Anja Krieger

Australia: Balancing act pp. S14-S15

Bianca Nogrady

Italian scientists shocked by earthquake devastation pp. 15-16

Alison Abbott and Quirin Schiermeier

Nuclear power plants prepare for old age pp. 16-17

Jeff Tollefson

Singapore: The brain-gain game pp. S16-S17

Annabel McGilvray

Massachusetts: Mass effect pp. S18-S19

Neil Savage

Print your own 3D Lucy to work out how the famous hominin died pp. 19-20

Ewen Callaway

Perspective: Fix the incentives pp. S20-S20

Julia Lane

Majority of mathematicians hail from just 24 scientific ‘families’ pp. 20-21

Davide Castelvecchi

How DNA could store all the world’s data pp. 22-24

Andy Extance

Vipers, mambas and taipans: the escalating health crisis over snakebites pp. 26-28

Carrie Arnold

Stop ignoring misconduct pp. 29-30

Donald S. Kornfeld and Sandra L. Titus

In retrospect: A New System of Chemical Philosophy pp. 32-33

Philip Ball

Books in brief pp. 33-33

Barbara Kiser

Fallacy of perfection harms peer review pp. 34-34

James C. Zimring and Steven L. Spitalnik

Hallmark labs with a replicability record pp. 34-34

Mattia Andreoletti

Stuck between a rock and a hard place pp. 34-34

Yingchao Hu and Liangjun Hu

Rate oceans' capital to help achieve SDGs pp. 34-34

Yonglong Lu

Could Pokémon Go boost birding? pp. 34-34

Fabio de Oliveira Roque

Attack on amyloid-β protein pp. 36-37

Eric M. Reiman

Cometary dust under the microscope pp. 37-38

Ludmilla Kolokolova

Moulding the ribosome pp. 38-40

Marlene Oeffinger

Southern Ocean freshened by sea ice pp. 40-41

Ted Maksym

Suffocation of gene expression pp. 42-43

Dan Ye and Yue Xiong

More is less pp. 42-42

Ryan Wilkinson

Muddy messages about American migration pp. 43-44

Suzanne McGowan

Postglacial viability and colonization in North America’s ice-free corridor pp. 45-49

Mikkel W. Pedersen, Anthony Ruter, Charles Schweger, Harvey Friebe, Richard A. Staff, Kristian K. Kjeldsen, Marie L. Z. Mendoza, Alwynne B. Beaudoin, Cynthia Zutter, Nicolaj K. Larsen, Ben A. Potter, Rasmus Nielsen, Rebecca A. Rainville, Ludovic Orlando, David J. Meltzer, Kurt H. Kjær and Eske Willerslev

The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease pp. 50-56

Jeff Sevigny, Ping Chiao, Thierry Bussière, Paul H. Weinreb, Leslie Williams, Marcel Maier, Robert Dunstan, Stephen Salloway, Tianle Chen, Yan Ling, John O’Gorman, Fang Qian, Mahin Arastu, Mingwei Li, Sowmya Chollate, Melanie S. Brennan, Omar Quintero-Monzon, Robert H. Scannevin, H. Moore Arnold, Thomas Engber, Kenneth Rhodes, James Ferrero, Yaming Hang, Alvydas Mikulskis, Jan Grimm, Christoph Hock, Roger M. Nitsch and Alfred Sandrock

A developmental coordinate of pluripotency among mice, monkeys and humans pp. 57-62

Tomonori Nakamura, Ikuhiro Okamoto, Kotaro Sasaki, Yukihiro Yabuta, Chizuru Iwatani, Hideaki Tsuchiya, Yasunari Seita, Shinichiro Nakamura, Takuya Yamamoto and Mitinori Saitou

Tumour hypoxia causes DNA hypermethylation by reducing TET activity pp. 63-68

Bernard Thienpont, Jessica Steinbacher, Hui Zhao, Flora D’Anna, Anna Kuchnio, Athanasios Ploumakis, Bart Ghesquière, Laurien Van Dyck, Bram Boeckx, Luc Schoonjans, Els Hermans, Frederic Amant, Vessela N. Kristensen, Kian Peng Koh, Massimiliano Mazzone, Mathew L. Coleman, Thomas Carell, Peter Carmeliet and Diether Lambrechts

A combined transmission spectrum of the Earth-sized exoplanets TRAPPIST-1 b and c pp. 69-72

Julien de Wit, Hannah R. Wakeford, Michaël Gillon, Nikole K. Lewis, Jeff A. Valenti, Brice-Olivier Demory, Adam J. Burgasser, Artem Burdanov, Laetitia Delrez, Emmanuël Jehin, Susan M. Lederer, Didier Queloz, Amaury H. M. J. Triaud and Valérie Van Grootel

Aggregate dust particles at comet 67P/Churyumov–Gerasimenko pp. 73-75

Mark S. Bentley, Roland Schmied, Thurid Mannel, Klaus Torkar, Harald Jeszenszky, Jens Romstedt, Anny-Chantal Levasseur-Regourd, Iris Weber, Elmar K. Jessberger, Pascale Ehrenfreund, Christian Koeberl and Ove Havnes

Dynamically encircling an exceptional point for asymmetric mode switching pp. 76-79

Jörg Doppler, Alexei A. Mailybaev, Julian Böhm, Ulrich Kuhl, Adrian Girschik, Florian Libisch, Thomas J. Milburn, Peter Rabl, Nimrod Moiseyev and Stefan Rotter

Topological energy transfer in an optomechanical system with exceptional points pp. 80-83

H. Xu, D. Mason, Luyao Jiang and J. G. E. Harris

Ablation-cooled material removal with ultrafast bursts of pulses pp. 84-88

Can Kerse, Hamit Kalaycıoğlu, Parviz Elahi, Barbaros Çetin, Denizhan K. Kesim, Önder Akçaalan, Seydi Yavaş, Mehmet D. Aşık, Bülent Öktem, Heinar Hoogland, Ronald Holzwarth and Fatih Ömer Ilday

Sea-ice transport driving Southern Ocean salinity and its recent trends pp. 89-92

F. Alexander Haumann, Nicolas Gruber, Matthias Münnich, Ivy Frenger and Stefan Kern

Addition of multiple limiting resources reduces grassland diversity pp. 93-96

W. Stanley Harpole, Lauren L. Sullivan, Eric M. Lind, Jennifer Firn, Peter B. Adler, Elizabeth T. Borer, Jonathan Chase, Philip A. Fay, Yann Hautier, Helmut Hillebrand, Andrew S. MacDougall, Eric W. Seabloom, Ryan Williams, Jonathan D. Bakker, Marc W. Cadotte, Enrique J. Chaneton, Chengjin Chu, Elsa E. Cleland, Carla D’Antonio, Kendi F. Davies, Daniel S. Gruner, Nicole Hagenah, Kevin Kirkman, Johannes M. H. Knops, Kimberly J. La Pierre, Rebecca L. McCulley, Joslin L. Moore, John W. Morgan, Suzanne M. Prober, Anita C. Risch, Martin Schuetz, Carly J. Stevens and Peter D. Wragg

Serotonin engages an anxiety and fear-promoting circuit in the extended amygdala pp. 97-101

Catherine A. Marcinkiewcz, Christopher M. Mazzone, Giuseppe D’Agostino, Lindsay R. Halladay, J. Andrew Hardaway, Jeffrey F. DiBerto, Montserrat Navarro, Nathan Burnham, Claudia Cristiano, Cayce E. Dorrier, Gregory J. Tipton, Charu Ramakrishnan, Tamas Kozicz, Karl Deisseroth, Todd E. Thiele, Zoe A. McElligott, Andrew Holmes, Lora K. Heisler and Thomas L. Kash

HER2 expression identifies dynamic functional states within circulating breast cancer cells pp. 102-106

Nicole Vincent Jordan, Aditya Bardia, Ben S. Wittner, Cyril Benes, Matteo Ligorio, Yu Zheng, Min Yu, Tilak K. Sundaresan, Joseph A. Licausi, Rushil Desai, Ryan M. O’Keefe, Richard Y. Ebright, Myriam Boukhali, Srinjoy Sil, Maristela L. Onozato, Anthony J. Iafrate, Ravi Kapur, Dennis Sgroi, David T. Ting, Mehmet Toner, Sridhar Ramaswamy, Wilhelm Haas, Shyamala Maheswaran and Daniel A. Haber

An endosomal tether undergoes an entropic collapse to bring vesicles together pp. 107-111

David H. Murray, Marcus Jahnel, Janelle Lauer, Mario J. Avellaneda, Nicolas Brouilly, Alice Cezanne, Hernán Morales-Navarrete, Enrico D. Perini, Charles Ferguson, Andrei N. Lupas, Yannis Kalaidzidis, Robert G. Parton, Stephan W. Grill and Marino Zerial

Small molecule stabilization of the KSR inactive state antagonizes oncogenic Ras signalling pp. 112-116

Neil S. Dhawan, Alex P. Scopton and Arvin C. Dar

Structural basis for inhibition of a voltage-gated Ca2+ channel by Ca2+ antagonist drugs pp. 117-121

Lin Tang, Tamer M. Gamal El-Din, Teresa M. Swanson, David C. Pryde, Todd Scheuer, Ning Zheng and William A. Catterall

Correction: Corrigendum: A novel multiple-stage antimalarial agent that inhibits protein synthesis pp. 122-122

Beatriz Baragaña, Irene Hallyburton, Marcus C. S. Lee, Neil R. Norcross, Raffaella Grimaldi, Thomas D. Otto, William R. Proto, Andrew M. Blagborough, Stephan Meister, Grennady Wirjanata, Andrea Ruecker, Leanna M. Upton, Tara S. Abraham, Mariana J. Almeida, Anupam Pradhan, Achim Porzelle, María Santos Martínez, Judith M. Bolscher, Andrew Woodland, Torsten Luksch, Suzanne Norval, Fabio Zuccotto, John Thomas, Frederick Simeons, Laste Stojanovski, Maria Osuna-Cabello, Paddy M. Brock, Tom S. Churcher, Katarzyna A. Sala, Sara E. Zakutansky, María Belén Jiménez-Díaz, Laura Maria Sanz, Jennifer Riley, Rajshekhar Basak, Michael Campbell, Vicky M. Avery, Robert W. Sauerwein, Koen J. Dechering, Rintis Noviyanti, Brice Campo, Julie A. Frearson, Iñigo Angulo-Barturen, Santiago Ferrer-Bazaga, Francisco Javier Gamo, Paul G. Wyatt, Didier Leroy, Peter Siegl, Michael J. Delves, Dennis E. Kyle, Sergio Wittlin, Jutta Marfurt, Ric N. Price, Robert E. Sinden, Elizabeth A. Winzeler, Susan A. Charman, Lidiya Bebrevska, David W. Gray, Simon Campbell, Alan H. Fairlamb, Paul A. Willis, Julian C. Rayner, David A. Fidock, Kevin D. Read and Ian H. Gilbert

Correction: Corrigendum: Robust neuronal dynamics in premotor cortex during motor planning pp. 122-122

Nuo Li, Kayvon Daie, Karel Svoboda and Shaul Druckmann

Correction: Corrigendum: Convection in a volatile nitrogen-ice-rich layer drives Pluto’s geological vigour pp. 122-122

William B. McKinnon, Francis Nimmo, Teresa Wong, Paul M. Schenk, Oliver L. White, J. H. Roberts, J. M. Moore, J. R. Spencer, A. D. Howard, O. M. Umurhan, S. A. Stern, H. A. Weaver, C. B. Olkin, L. A. Young and K. E. Smith

Computers on the reef pp. 123-124

Jeff Tollefson

Art–science collaborations: Change of perspective pp. 125-126

Sheila Mulrooney Eldred

Skin hunger pp. 128-128

Bo Balder