A stromal cell population that inhibits adipogenesis in mammalian fat depots

Petra C. Schwalie, Hua Dong, Magda Zachara, Julie Russeil, Daniel Alpern, Nassila Akchiche, Christian Caprara, Wenfei Sun, Kai-Uwe Schlaudraff, Gianni Soldati, Christian Wolfrum () and Bart Deplancke ()
Additional contact information
Petra C. Schwalie: Ecole Polytechnique Fédérale de Lausanne (EPFL) and Swiss Institute of Bioinformatics
Hua Dong: Eidgenössische Technische Hochschule Zürich
Magda Zachara: Ecole Polytechnique Fédérale de Lausanne (EPFL) and Swiss Institute of Bioinformatics
Julie Russeil: Ecole Polytechnique Fédérale de Lausanne (EPFL) and Swiss Institute of Bioinformatics
Daniel Alpern: Ecole Polytechnique Fédérale de Lausanne (EPFL) and Swiss Institute of Bioinformatics
Nassila Akchiche: Eidgenössische Technische Hochschule Zürich
Christian Caprara: Swiss Stem Cell Foundation
Wenfei Sun: Eidgenössische Technische Hochschule Zürich
Kai-Uwe Schlaudraff: Concept-Clinic
Gianni Soldati: Swiss Stem Cell Foundation
Christian Wolfrum: Eidgenössische Technische Hochschule Zürich
Bart Deplancke: Ecole Polytechnique Fédérale de Lausanne (EPFL) and Swiss Institute of Bioinformatics

Nature, 2018, vol. 559, issue 7712, 103-108

Abstract: Abstract Adipocyte development and differentiation have an important role in the aetiology of obesity and its co-morbidities1,2. Although multiple studies have investigated the adipogenic stem and precursor cells that give rise to mature adipocytes3–14, our understanding of their in vivo origin and properties is incomplete2,15,16. This is partially due to the highly heterogeneous and unstructured nature of adipose tissue depots17, which has proven difficult to molecularly dissect using classical approaches such as fluorescence-activated cell sorting and Cre–lox lines based on candidate marker genes16,18. Here, using the resolving power of single-cell transcriptomics19 in a mouse model, we reveal distinct subpopulations of adipose stem and precursor cells in the stromal vascular fraction of subcutaneous adipose tissue. We identify one of these subpopulations as CD142+ adipogenesis-regulatory cells, which can suppress adipocyte formation in vivo and in vitro in a paracrine manner. We show that adipogenesis-regulatory cells are refractory to adipogenesis and that they are functionally conserved in humans. Our findings point to a potentially critical role for adipogenesis-regulatory cells in modulating adipose tissue plasticity, which is linked to metabolic control, differential insulin sensitivity and type 2 diabetes.

Date: 2018
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DOI: 10.1038/s41586-018-0226-8

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