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2014, volume 510, articles 7506

Stroke pp. S1-S1

Brian Owens

A growing global burden pp. S2-S3

Zoë Corbyn

Perspective: Time to tackle blood pressure pp. S4-S4

Walter J. Koroshetz

First response: Race against time pp. S5-S5

Ed Yong

Drug delivery: Brain food pp. S6-S7

Hannah Hoag

Rehabilitation: Machine recovery pp. S8-S9

Moheb Costandi

Mental health: Ups and downs pp. S10-S11

Sujata Gupta

Perspective: Silent, but preventable, perils pp. S12-S12

Antoine M. Hakim

Rural students are being left behind in China pp. 445-445

Qiang Wang

Secret publishing deals exposed pp. 447-447

Chris Woolston

NASA carbon-monitoring orbiter readies for launch pp. 451-452

Lauren Morello

Africa science plan attacked pp. 452-453

Linda Nordling

Resurrected cancer drug faces regulators pp. 454-454

Heidi Ledford

‘Life on Earth’ project gets under way pp. 455-455

Natasha Gilbert

Brain wave hits California pp. 456-456

Helen Shen

Love in the lab: Close collaborators pp. 458-460

Kerri Smith

Nutrition: Vitamins on trial pp. 462-464

Melinda Wenner Moyer

Energy: Consider the global impacts of oil pipelines pp. 465-467

Wendy J. Palen, Thomas D. Sisk, Maureen E. Ryan, Joseph L. Árvai, Mark Jaccard, Anne K. Salomon, Thomas Homer-Dixon and Ken P. Lertzman

Physics: Bell’s theorem still reverberates pp. 467-469

Howard Wiseman

Bibliometrics: The citation game pp. 470-471

Jonathan Adams

Books in brief pp. 471-471

Barbara Kiser

Space science: Lunar star pp. 472-472

Roger D. Launius

Assess benefits and costs of shale energy pp. 473-473

Thomas G. Measham and David A. Fleming

Maize is not a clue to Puerto Rican origins pp. 473-473

Jaime R. Pagán-Jiménez, Reniel Rodríguez-Ramos and José R. Oliver

Greek science must reform to survive pp. 473-473

Nikolaos Vrachnis, Nikolaos Vlachadis and Dionisios Vrachnis

Update German view of genetic testing pp. 473-473

Peter Propping and Heinz Schott

Gerald Edelman (1929–2014) pp. 474-474

Urs Rutishauser

Identifying a hidden warhead pp. 476-477

John Finney and James M. Acton

To the rescue of old drugs pp. 477-478

Djalal Meziane-Cherif and Patrice Courvalin

A cool way to measure big G pp. 478-480

Stephan Schlamminger

Wobble puts RNA on target pp. 480-481

Oscar Vargas-Rodriguez and Karin Musier-Forsyth

Trawling for complements pp. 481-482

J. Marty Gregg and Amit Kumar

Enzyme assembly line pictured pp. 482-483

Peter F. Leadlay

An overview of N-heterocyclic carbenes pp. 485-496

Matthew N. Hopkinson, Christian Richter, Michael Schedler and Frank Glorius

A zero-knowledge protocol for nuclear warhead verification pp. 497-502

Alexander Glaser, Boaz Barak and Robert J. Goldston

Aspergillomarasmine A overcomes metallo-β-lactamase antibiotic resistance pp. 503-506

Andrew M. King, Sarah A. Reid-Yu, Wenliang Wang, Dustin T. King, Gianfranco De Pascale, Natalie C. Strynadka, Timothy R. Walsh, Brian K. Coombes and Gerard D. Wright

The selective tRNA aminoacylation mechanism based on a single G•U pair pp. 507-511

Masahiro Naganuma, Shun-ichi Sekine, Yeeting Esther Chong, Min Guo, Xiang-Lei Yang, Howard Gamper, Ya-Ming Hou, Paul Schimmel and Shigeyuki Yokoyama

Structure of a modular polyketide synthase pp. 512-517

Somnath Dutta, Jonathan R. Whicher, Douglas A. Hansen, Wendi A. Hale, Joseph A. Chemler, Grady R. Congdon, Alison R. H. Narayan, Kristina Håkansson, David H. Sherman, Janet L. Smith and Georgios Skiniotis

Precision measurement of the Newtonian gravitational constant using cold atoms pp. 518-521

G. Rosi, F. Sorrentino, L. Cacciapuoti, M. Prevedelli and G. M. Tino

Chirality-specific growth of single-walled carbon nanotubes on solid alloy catalysts pp. 522-524

Feng Yang, Xiao Wang, Daqi Zhang, Juan Yang, Da Luo, Ziwei Xu, Jiake Wei, Jian-Qiang Wang, Zhi Xu, Fei Peng, Xuemei Li, Ruoming Li, Yilun Li, Meihui Li, Xuedong Bai, Feng Ding and Yan Li

South Greenland ice-sheet collapse during Marine Isotope Stage 11 pp. 525-528

Alberto V. Reyes, Anders E. Carlson, Brian L. Beard, Robert G. Hatfield, Joseph S. Stoner, Kelsey Winsor, Bethany Welke and David J. Ullman

Purkinje-cell plasticity and cerebellar motor learning are graded by complex-spike duration pp. 529-532

Yan Yang and Stephen G. Lisberger

Human oocytes reprogram adult somatic nuclei of a type 1 diabetic to diploid pluripotent stem cells pp. 533-536

Mitsutoshi Yamada, Bjarki Johannesson, Ido Sagi, Lisa Cole Burnett, Daniel H. Kort, Robert W. Prosser, Daniel Paull, Michael W. Nestor, Matthew Freeby, Ellen Greenberg, Robin S. Goland, Rudolph L. Leibel, Susan L. Solomon, Nissim Benvenisty, Mark V. Sauer and Dieter Egli

Decoding the regulatory landscape of medulloblastoma using DNA methylation sequencing pp. 537-541

Volker Hovestadt, David T. W. Jones, Simone Picelli, Wei Wang, Marcel Kool, Paul A. Northcott, Marc Sultan, Katharina Stachurski, Marina Ryzhova, Hans-Jörg Warnatz, Meryem Ralser, Sonja Brun, Jens Bunt, Natalie Jäger, Kortine Kleinheinz, Serap Erkek, Ursula D. Weber, Cynthia C. Bartholomae, Christof von Kalle, Chris Lawerenz, Jürgen Eils, Jan Koster, Rogier Versteeg, Till Milde, Olaf Witt, Sabine Schmidt, Stephan Wolf, Torsten Pietsch, Stefan Rutkowski, Wolfram Scheurlen, Michael D. Taylor, Benedikt Brors, Jörg Felsberg, Guido Reifenberger, Arndt Borkhardt, Hans Lehrach, Robert J. Wechsler-Reya, Roland Eils, Marie-Laure Yaspo, Pablo Landgraf, Andrey Korshunov, Marc Zapatka, Bernhard Radlwimmer, Stefan M. Pfister and Peter Lichter

Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase pp. 542-546

Anila K. Madiraju, Derek M. Erion, Yasmeen Rahimi, Xian-Man Zhang, Demetrios T. Braddock, Ronald A. Albright, Brett J. Prigaro, John L. Wood, Sanjay Bhanot, Michael J. MacDonald, Michael J. Jurczak, Joao-Paulo Camporez, Hui-Young Lee, Gary W. Cline, Varman T. Samuel, Richard G. Kibbey and Gerald I. Shulman

Cyclin D1–Cdk4 controls glucose metabolism independently of cell cycle progression pp. 547-551

Yoonjin Lee, John E. Dominy, Yoon Jong Choi, Michael Jurczak, Nicola Tolliday, Joao Paulo Camporez, Helen Chim, Ji-Hong Lim, Hai-Bin Ruan, Xiaoyong Yang, Francisca Vazquez, Piotr Sicinski, Gerald I. Shulman and Pere Puigserver

Structure of a lipid-bound extended synaptotagmin indicates a role in lipid transfer pp. 552-555

Curtis M. Schauder, Xudong Wu, Yasunori Saheki, Pradeep Narayanaswamy, Federico Torta, Markus R. Wenk, Pietro De Camilli and Karin M. Reinisch

BRCA1 controls homologous recombination at Tus/Ter-stalled mammalian replication forks pp. 556-559

Nicholas A. Willis, Gurushankar Chandramouly, Bin Huang, Amy Kwok, Cindy Follonier, Chuxia Deng and Ralph Scully

Structural rearrangements of a polyketide synthase module during its catalytic cycle pp. 560-564

Jonathan R. Whicher, Somnath Dutta, Douglas A. Hansen, Wendi A. Hale, Joseph A. Chemler, Annie M. Dosey, Alison R. H. Narayan, Kristina Håkansson, David H. Sherman, Janet L. Smith and Georgios Skiniotis

Symposia: Behind the scenes pp. 565-566

Cameron Walker

Turning point: Katharine Hayhoe pp. 567-567

Virginia Gewin

A one-sided argument pp. 570-570

Alex Shvartsman

2014, volume 510, articles 7505

Uprooting researchers can drive them out of science pp. 313-313

Russell Garwood

Lab animals spark debate pp. 315-315

Chris Woolston

3D images remodel history pp. 319-320

Ewen Callaway

Tree hitched a ride to island pp. 320-321

Emma Marris

US child study hits buffers pp. 323-323

Heidi Ledford

HIV trial attacked pp. 324-324

Erika Check Hayden

Irish university labs face external audits pp. 325-325

Richard Van Noorden

The parched planet: Water on tap pp. 326-328

Quirin Schiermeier

Scientific publishing: The inside track pp. 330-332

Peter Aldhous

Stem cells: Taking a stand against pseudoscience pp. 333-335

Elena Cattaneo and Gilberto Corbellini

Regulation: Sell help not hope pp. 336-337

Paolo Bianco and Douglas Sipp

Evolution: The complexity chronicles pp. 338-339

Nancy A. Moran

Books in brief pp. 339-339

Barbara Kiser

NIH policy: Mandate goes too far pp. 340-340

R. Douglas Fields

NIH policy: Status quo is also costly pp. 340-340

Louise D. McCullough, Margaret M. McCarthy and Geert J. de Vries

Sharing your data is easier than you think pp. 340-340

Stephen Eglen

Justifying embryo research in Europe pp. 340-340

Joep Geraedts

Still too many red–green figures pp. 340-340

S. Colby Allred, William J. Schreiner and Oliver Smithies

Natural-born killers unleashed pp. 342-343

Emilio Hirsch and Francesco Novelli

How chaos forgets and remembers pp. 343-344

P.-M. Binder and R. M. Pipes

Immaturity in the gut microbial community pp. 344-345

Elizabeth K. Costello and David A. Relman

Powered by magic pp. 345-347

Stephen D. Bartlett

Balancing act pp. 347-348

Alban Ordureau and J. Wade Harper

Feel the force pp. 349-349

Ferdinand Schmidt-Kaler

Contextuality supplies the ‘magic’ for quantum computation pp. 351-355

Mark Howard, Joel Wallman, Victor Veitch and Joseph Emerson

The genome of Eucalyptus grandis pp. 356-362

Alexander A. Myburg, Dario Grattapaglia, Gerald A. Tuskan, Uffe Hellsten, Richard D. Hayes, Jane Grimwood, Jerry Jenkins, Erika Lindquist, Hope Tice, Diane Bauer, David M. Goodstein, Inna Dubchak, Alexandre Poliakov, Eshchar Mizrachi, Anand R. K. Kullan, Steven G. Hussey, Desre Pinard, Karen van der Merwe, Pooja Singh, Ida van Jaarsveld, Orzenil B. Silva-Junior, Roberto C. Togawa, Marilia R. Pappas, Danielle A. Faria, Carolina P. Sansaloni, Cesar D. Petroli, Xiaohan Yang, Priya Ranjan, Timothy J. Tschaplinski, Chu-Yu Ye, Ting Li, Lieven Sterck, Kevin Vanneste, Florent Murat, Marçal Soler, Hélène San Clemente, Naijib Saidi, Hua Cassan-Wang, Christophe Dunand, Charles A. Hefer, Erich Bornberg-Bauer, Anna R. Kersting, Kelly Vining, Vindhya Amarasinghe, Martin Ranik, Sushma Naithani, Justin Elser, Alexander E. Boyd, Aaron Liston, Joseph W. Spatafora, Palitha Dharmwardhana, Rajani Raja, Christopher Sullivan, Elisson Romanel, Marcio Alves-Ferreira, Carsten Külheim, William Foley, Victor Carocha, Jorge Paiva, David Kudrna, Sergio H. Brommonschenkel, Giancarlo Pasquali, Margaret Byrne, Philippe Rigault, Josquin Tibbits, Antanas Spokevicius, Rebecca C. Jones, Dorothy A. Steane, René E. Vaillancourt, Brad M. Potts, Fourie Joubert, Kerrie Barry, Georgios J. Pappas, Steven H. Strauss, Pankaj Jaiswal, Jacqueline Grima-Pettenati, Jérôme Salse, Yves Van de Peer, Daniel S. Rokhsar and Jeremy Schmutz

Single-cell RNA-seq reveals dynamic paracrine control of cellular variation pp. 363-369

Alex K. Shalek, Rahul Satija, Joe Shuga, John J. Trombetta, Dave Gennert, Diana Lu, Peilin Chen, Rona S. Gertner, Jellert T. Gaublomme, Nir Yosef, Schraga Schwartz, Brian Fowler, Suzanne Weaver, Jing Wang, Xiaohui Wang, Ruihua Ding, Raktima Raychowdhury, Nir Friedman, Nir Hacohen, Hongkun Park, Andrew P. May and Aviv Regev

The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy pp. 370-375

Baris Bingol, Joy S. Tea, Lilian Phu, Mike Reichelt, Corey E. Bakalarski, Qinghua Song, Oded Foreman, Donald S. Kirkpatrick and Morgan Sheng

Measurement of the magnetic interaction between two bound electrons of two separate ions pp. 376-380

Shlomi Kotler, Nitzan Akerman, Nir Navon, Yinnon Glickman and Roee Ozeri

Ultrafast X-ray probing of water structure below the homogeneous ice nucleation temperature pp. 381-384

J. A. Sellberg, C. Huang, T. A. McQueen, N. D. Loh, H. Laksmono, D. Schlesinger, R. G. Sierra, D. Nordlund, C. Y. Hampton, D. Starodub, D. P. DePonte, M. Beye, C. Chen, A. V. Martin, A. Barty, K. T. Wikfeldt, T. M. Weiss, C. Caronna, J. Feldkamp, L. B. Skinner, M. M. Seibert, M. Messerschmidt, G. J. Williams, S. Boutet, L. G. M. Pettersson, M. J. Bogan and A. Nilsson

Metastable liquid–liquid transition in a molecular model of water pp. 385-388

Jeremy C. Palmer, Fausto Martelli, Yang Liu, Roberto Car, Athanassios Z. Panagiotopoulos and Pablo G. Debenedetti

Possible control of subduction zone slow-earthquake periodicity by silica enrichment pp. 389-392

Pascal Audet and Roland Bürgmann

mTORC1 controls the adaptive transition of quiescent stem cells from G0 to GAlert pp. 393-396

Joseph T. Rodgers, Katherine Y. King, Jamie O. Brett, Melinda J. Cromie, Gregory W. Charville, Katie K. Maguire, Christopher Brunson, Namrata Mastey, Ling Liu, Chang-Ru Tsai, Margaret A. Goodell and Thomas A. Rando

The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR pp. 397-401

Randall M. Chin, Xudong Fu, Melody Y. Pai, Laurent Vergnes, Heejun Hwang, Gang Deng, Simon Diep, Brett Lomenick, Vijaykumar S. Meli, Gabriela C. Monsalve, Eileen Hu, Stephen A. Whelan, Jennifer X. Wang, Gwanghyun Jung, Gregory M. Solis, Farbod Fazlollahi, Chitrada Kaweeteerawat, Austin Quach, Mahta Nili, Abby S. Krall, Hilary A. Godwin, Helena R. Chang, Kym F. Faull, Feng Guo, Meisheng Jiang, Sunia A. Trauger, Alan Saghatelian, Daniel Braas, Heather R. Christofk, Catherine F. Clarke, Michael A. Teitell, Michael Petrascheck, Karen Reue, Michael E. Jung, Alison R. Frand and Jing Huang

PTEN action in leukaemia dictated by the tissue microenvironment pp. 402-406

Cornelius Miething, Claudio Scuoppo, Benedikt Bosbach, Iris Appelmann, Joy Nakitandwe, Jing Ma, Gang Wu, Laura Lintault, Martina Auer, Prem K. Premsrirut, Julie Teruya-Feldstein, James Hicks, Helene Benveniste, Michael R. Speicher, James R. Downing and Scott W. Lowe

Inactivation of PI(3)K p110δ breaks regulatory T-cell-mediated immune tolerance to cancer pp. 407-411

Khaled Ali, Dalya R. Soond, Roberto Piñeiro, Thorsten Hagemann, Wayne Pearce, Ee Lyn Lim, Hicham Bouabe, Cheryl L. Scudamore, Timothy Hancox, Heather Maecker, Lori Friedman, Martin Turner, Klaus Okkenhaug and Bart Vanhaesebroeck

CFIm25 links alternative polyadenylation to glioblastoma tumour suppression pp. 412-416

Chioniso P. Masamha, Zheng Xia, Jingxuan Yang, Todd R. Albrecht, Min Li, Ann-Bin Shyu, Wei Li and Eric J. Wagner

Persistent gut microbiota immaturity in malnourished Bangladeshi children pp. 417-421

Sathish Subramanian, Sayeeda Huq, Tanya Yatsunenko, Rashidul Haque, Mustafa Mahfuz, Mohammed A. Alam, Amber Benezra, Joseph DeStefano, Martin F. Meier, Brian D. Muegge, Michael J. Barratt, Laura G. VanArendonk, Qunyuan Zhang, Michael A. Province, William A. Petri, Tahmeed Ahmed and Jeffrey I. Gordon

Ribosomal oxygenases are structurally conserved from prokaryotes to humans pp. 422-426

Rasheduzzaman Chowdhury, Rok Sekirnik, Nigel C. Brissett, Tobias Krojer, Chia-hua Ho, Stanley S. Ng, Ian J. Clifton, Wei Ge, Nadia J. Kershaw, Gavin C. Fox, Joao R. C. Muniz, Melanie Vollmar, Claire Phillips, Ewa S. Pilka, Kathryn L. Kavanagh, Frank von Delft, Udo Oppermann, Michael A. McDonough, Aidan J. Doherty and Christopher J. Schofield

Co-opting sulphur-carrier proteins from primary metabolic pathways for 2-thiosugar biosynthesis pp. 427-431

Eita Sasaki, Xuan Zhang, He G. Sun, Mei-Yeh Jade Lu, Tsung-lin Liu, Albert Ou, Jeng-yi Li, Yu-hsiang Chen, Steven E. Ealick and Hung-wen Liu

Correction: Corrigendum: Sea-level and deep-sea-temperature variability over the past 5.3 million years pp. 432-432

E. J. Rohling, G. L. Foster, K. M. Grant, G. Marino, A. P. Roberts, M. E. Tamisiea and F. Williams

Correction: Corrigendum: Fuel gain exceeding unity in an inertially confined fusion implosion pp. 432-432

O. A. Hurricane, D. A. Callahan, D. T. Casey, P. M. Celliers, C. Cerjan, E. L. Dewald, T. R. Dittrich, T. Döppner, D. E. Hinkel, L. F. Berzak Hopkins, J. L. Kline, S. LePape, T. Ma, A. G. MacPhee, J. L. Milovich, A. Pak, H.-S. Park, P. K. Patel, B. A. Remington, J. D. Salmonson, P. T. Springer and R. Tommasini

Laboratory careers: Catalysts for efficient science pp. 433-434

Helen Shen

Emancipation pp. 436-436

João Ramalho-Santos

2014, volume 510, articles 7504

Jordan’s stem-cell law can guide the Middle East pp. 189-189

Rana Dajani

Papers predict future lab heads pp. 191-191

Chris Woolston

Fetal-cell revival for Parkinson’s pp. 195-196

Alison Abbott

Space-station science ramps up pp. 196-197

Alexandra Witze

Cancer-gene data sharing boosted pp. 198-198

Erika Check Hayden

Sound clue in hunt for MH370 pp. 199-200

Declan Butler

The impact gap: South America by the numbers pp. 202-203

Richard Van Noorden

South American science: Big players pp. 204-206

Michele Catanzaro, Giuliana Miranda, Lisa Palmer and Aleszu Bajak

Research training: Homeward bound pp. 207-207

Barbara Fraser

Fellowships: Turning brain drain into brain circulation pp. 213-214

Torsten Wiesel

Arts: The third culture pp. 216-216

Michael John Gorman

Q&A: The nutrient hunter pp. 217-217

Jascha Hoffman

An early champion of women's rights pp. 218-218

U. Kutschera

Synthetic biology: Missing the point pp. 218-218

Sam Weiss Evans

Synthetic biology: A global approach pp. 218-218

Jay D. Keasling

Successes for UK cancer partnership pp. 218-218

Paul Workman

Forgotten founder of bibliometrics pp. 218-218

Ronald Rousseau

Diamond gets harder pp. 220-221

James Boland

Pass the ammunition pp. 221-222

Mark C. Mescher and Consuelo M. De Moraes

When lymphocytes run out of steam pp. 222-223

André Veillette and Dominique Davidson

The hunt for Majorana neutrinos hots up pp. 224-225

David Wark

Enzyme meets a surprise target pp. 225-226

Marian M. Deuker and Martin McMahon

Repair and replace pp. 226-227

Alain Fischer

Targeted genome editing in human repopulating haematopoietic stem cells pp. 235-240

Pietro Genovese, Giulia Schiroli, Giulia Escobar, Tiziano Di Tomaso, Claudia Firrito, Andrea Calabria, Davide Moi, Roberta Mazzieri, Chiara Bonini, Michael C. Holmes, Philip D. Gregory, Mirjam van der Burg, Bernhard Gentner, Eugenio Montini, Angelo Lombardo and Luigi Naldini

Homologue engagement controls meiotic DNA break number and distribution pp. 241-246

Drew Thacker, Neeman Mohibullah, Xuan Zhu and Scott Keeney

Two γ-ray bursts from dusty regions with little molecular gas pp. 247-249

B. Hatsukade, K. Ohta, A. Endo, K. Nakanishi, Y. Tamura, T. Hashimoto and K. Kohno

Nanotwinned diamond with unprecedented hardness and stability pp. 250-253

Quan Huang, Dongli Yu, Bo Xu, Wentao Hu, Yanming Ma, Yanbin Wang, Zhisheng Zhao, Bin Wen, Julong He, Zhongyuan Liu and Yongjun Tian

Increased frequency of extreme Indian Ocean Dipole events due to greenhouse warming pp. 254-258

Wenju Cai, Agus Santoso, Guojian Wang, Evan Weller, Lixin Wu, Karumuri Ashok, Yukio Masumoto and Toshio Yamagata

Elevated CO2 further lengthens growing season under warming conditions pp. 259-262

Melissa Reyes-Fox, Heidi Steltzer, M. J. Trlica, Gregory S. McMaster, Allan A. Andales, Dan R. LeCain and Jack A. Morgan

Emergence of reproducible spatiotemporal activity during motor learning pp. 263-267

Andrew J. Peters, Simon X. Chen and Takaki Komiyama

The unfolded protein response governs integrity of the haematopoietic stem-cell pool during stress pp. 268-272

Peter van Galen, Antonija Kreso, Nathan Mbong, David G. Kent, Timothy Fitzmaurice, Joseph E. Chambers, Stephanie Xie, Elisa Laurenti, Karin Hermans, Kolja Eppert, Stefan J. Marciniak, Jane C. Goodall, Anthony R. Green, Bradly G. Wouters, Erno Wienholds and John E. Dick

Human embryonic-stem-cell-derived cardiomyocytes regenerate non-human primate hearts pp. 273-277

James J. H. Chong, Xiulan Yang, Creighton W. Don, Elina Minami, Yen-Wen Liu, Jill J. Weyers, William M. Mahoney, Benjamin Van Biber, Savannah M. Cook, Nathan J. Palpant, Jay A. Gantz, James A. Fugate, Veronica Muskheli, G. Michael Gough, Keith W. Vogel, Cliff A. Astley, Charlotte E. Hotchkiss, Audrey Baldessari, Lil Pabon, Hans Reinecke, Edward A. Gill, Veronica Nelson, Hans-Peter Kiem, Michael A. Laflamme and Charles E. Murry

Therapeutic targeting of BET bromodomain proteins in castration-resistant prostate cancer pp. 278-282

Irfan A. Asangani, Vijaya L. Dommeti, Xiaoju Wang, Rohit Malik, Marcin Cieslik, Rendong Yang, June Escara-Wilke, Kari Wilder-Romans, Sudheer Dhanireddy, Carl Engelke, Mathew K. Iyer, Xiaojun Jing, Yi-Mi Wu, Xuhong Cao, Zhaohui S. Qin, Shaomeng Wang, Felix Y. Feng and Arul M. Chinnaiyan

SMYD3 links lysine methylation of MAP3K2 to Ras-driven cancer pp. 283-287

Pawel K. Mazur, Nicolas Reynoird, Purvesh Khatri, Pascal W. T. C. Jansen, Alex W. Wilkinson, Shichong Liu, Olena Barbash, Glenn S. Van Aller, Michael Huddleston, Dashyant Dhanak, Peter J. Tummino, Ryan G. Kruger, Benjamin A. Garcia, Atul J. Butte, Michiel Vermeulen, Julien Sage and Or Gozani

CTP synthase 1 deficiency in humans reveals its central role in lymphocyte proliferation pp. 288-292

Emmanuel Martin, Noé Palmic, Sylvia Sanquer, Christelle Lenoir, Fabian Hauck, Cédric Mongellaz, Sylvie Fabrega, Patrick Nitschké, Mauro Degli Esposti, Jeremy Schwartzentruber, Naomi Taylor, Jacek Majewski, Nada Jabado, Robert F. Wynn, Capucine Picard, Alain Fischer, Peter D. Arkwright and Sylvain Latour

A Ctf4 trimer couples the CMG helicase to DNA polymerase α in the eukaryotic replisome pp. 293-297

Aline C. Simon, Jin C. Zhou, Rajika L. Perera, Frederick van Deursen, Cecile Evrin, Marina E. Ivanova, Mairi L. Kilkenny, Ludovic Renault, Svend Kjaer, Dijana Matak-Vinković, Karim Labib, Alessandro Costa and Luca Pellegrini

Quantitative flux analysis reveals folate-dependent NADPH production pp. 298-302

Jing Fan, Jiangbin Ye, Jurre J. Kamphorst, Tomer Shlomi, Craig B. Thompson and Joshua D. Rabinowitz

A test that fails pp. 303-304

Casey Miller and Keivan Stassun

Face in the dark pp. 306-306

Deborah Walker

2014, volume 510, articles 7503

Big Bang blunder bursts the multiverse bubble pp. 9-9

Paul Steinhardt

Winner takes all in science pp. 11-11

Chris Woolston

Phage therapy gets revitalized pp. 15-16

Sara Reardon

Land models put to climate test pp. 16-17

Jane Qiu

Funding windfall rescues abandoned stem-cell trial pp. 18-18

Erika Check Hayden

Federal boost for German science pp. 19-19

Quirin Schiermeier

Big Bang finding challenged pp. 20-20

Ron Cowan

Solar energy: Springtime for the artificial leaf pp. 22-24

Jessica Marshall

Alzheimer's disease: The forgetting gene pp. 26-28

Laura Spinney

Environment: Accelerate research on land creation pp. 29-31

Peiyue Li, Hui Qian and Jianhua Wu

Molecular biology: Of DNA and broken dreams pp. 32-33

Georgina Ferry

Books in brief pp. 33-33

Barbara Kiser

Health: The medicalization of fat pp. 34-34

David Katz

Design animal studies better pp. 35-35

Malcolm R. Macleod

Investment suggests RNAi is on the up pp. 35-35

John Maraganore

Mine centuries-old citizen science pp. 35-35

Miguel Clavero and Eloy Revilla

Moon mapped by an artist's impression pp. 35-35

José Rafael Martínez Enríquez

Experimentation needs theory, too pp. 35-35

Min-Liang Wong

Gerald Guralnik (1936–2014) pp. 36-36

Tom Kibble

Excitation over jelly nerves pp. 38-39

Andreas Hejnol

How Antarctic ice retreats pp. 39-40

Trevor Williams

Short RNAs and shortness of breath pp. 40-42

Irma Sánchez and Brian D. Dynlacht

The MAD world of black holes pp. 42-43

Denise Gabuzda

Treatment triumphs pp. 43-44

Charles M. Rice and Mohsan Saeed

Quality-control pathway unlocked pp. 44-45

Asa Abeliovich

Lipids in health and disease pp. 47-47

Joshua Finkelstein, Marie-Thérèse Heemels, Sadaf Shadan and Ursula Weiss

Lipid landscapes and pipelines in membrane homeostasis pp. 48-57

Joost C.M. Holthuis and Anant K. Menon

Sphingolipid metabolites in inflammatory disease pp. 58-67

Michael Maceyka and Sarah Spiegel

Sphingolipid lysosomal storage disorders pp. 68-75

Frances M. Platt

The different shades of fat pp. 76-83

Vivian Peirce, Stefania Carobbio and Antonio Vidal-Puig

The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes pp. 84-91

Rachel J. Perry, Varman T. Samuel, Kitt F. Petersen and Gerald I. Shulman

Pro-resolving lipid mediators are leads for resolution physiology pp. 92-101

Charles N. Serhan

Accurate design of co-assembling multi-component protein nanomaterials pp. 103-108

Neil P. King, Jacob B. Bale, William Sheffler, Dan E. McNamara, Shane Gonen, Tamir Gonen, Todd O. Yeates and David Baker

The ctenophore genome and the evolutionary origins of neural systems pp. 109-114

Leonid L. Moroz, Kevin M. Kocot, Mathew R. Citarella, Sohn Dosung, Tigran P. Norekian, Inna S. Povolotskaya, Anastasia P. Grigorenko, Christopher Dailey, Eugene Berezikov, Katherine M. Buckley, Andrey Ptitsyn, Denis Reshetov, Krishanu Mukherjee, Tatiana P. Moroz, Yelena Bobkova, Fahong Yu, Vladimir V. Kapitonov, Jerzy Jurka, Yuri V. Bobkov, Joshua J. Swore, David O. Girardo, Alexander Fodor, Fedor Gusev, Rachel Sanford, Rebecca Bruders, Ellen Kittler, Claudia E. Mills, Jonathan P. Rast, Romain Derelle, Victor V. Solovyev, Fyodor A. Kondrashov, Billie J. Swalla, Jonathan V. Sweedler, Evgeny I. Rogaev, Kenneth M. Halanych and Andrea B. Kohn

miR-34/449 miRNAs are required for motile ciliogenesis by repressing cp110 pp. 115-120

Rui Song, Peter Walentek, Nicole Sponer, Alexander Klimke, Joon Sub Lee, Gary Dixon, Richard Harland, Ying Wan, Polina Lishko, Muriel Lize, Michael Kessel and Lin He

Crystal structure of the human glucose transporter GLUT1 pp. 121-125

Dong Deng, Chao Xu, Pengcheng Sun, Jianping Wu, Chuangye Yan, Mingxu Hu and Nieng Yan

Dynamically important magnetic fields near accreting supermassive black holes pp. 126-128

M. Zamaninasab, E. Clausen-Brown, T. Savolainen and A. Tchekhovskoy

Palladium-catalysed C–H activation of aliphatic amines to give strained nitrogen heterocycles pp. 129-133

Andrew McNally, Benjamin Haffemayer, Beatrice S. L. Collins and Matthew J. Gaunt

Millennial-scale variability in Antarctic ice-sheet discharge during the last deglaciation pp. 134-138

M. E. Weber, P. U. Clark, G. Kuhn, A. Timmermann, D. Sprenk, R. Gladstone, X. Zhang, G. Lohmann, L. Menviel, M. O. Chikamoto, T. Friedrich and C. Ohlwein

Increasing CO2 threatens human nutrition pp. 139-142

Samuel S. Myers, Antonella Zanobetti, Itai Kloog, Peter Huybers, Andrew D. B. Leakey, Arnold J. Bloom, Eli Carlisle, Lee H. Dietterich, Glenn Fitzgerald, Toshihiro Hasegawa, N. Michele Holbrook, Randall L. Nelson, Michael J. Ottman, Victor Raboy, Hidemitsu Sakai, Karla A. Sartor, Joel Schwartz, Saman Seneweera, Michael Tausz and Yasuhiro Usui

Coordination of entorhinal–hippocampal ensemble activity during associative learning pp. 143-147

Kei M. Igarashi, Li Lu, Laura L. Colgin, May-Britt Moser and Edvard I. Moser

Trace-gas metabolic versatility of the facultative methanotroph Methylocella silvestris pp. 148-151

Andrew T. Crombie and J. Colin Murrell

Focused specificity of intestinal TH17 cells towards commensal bacterial antigens pp. 152-156

Yi Yang, Miriam B. Torchinsky, Michael Gobert, Huizhong Xiong, Mo Xu, Jonathan L. Linehan, Francis Alonzo, Charles Ng, Alessandra Chen, Xiyao Lin, Andrew Sczesnak, Jia-Jun Liao, Victor J. Torres, Marc K. Jenkins, Juan J. Lafaille and Dan R. Littman

Nociceptive sensory neurons drive interleukin-23-mediated psoriasiform skin inflammation pp. 157-161

Lorena Riol-Blanco, Jose Ordovas-Montanes, Mario Perro, Elena Naval, Aude Thiriot, David Alvarez, Silke Paust, John N. Wood and Ulrich H. von Andrian

Ubiquitin is phosphorylated by PINK1 to activate parkin pp. 162-166

Fumika Koyano, Kei Okatsu, Hidetaka Kosako, Yasushi Tamura, Etsu Go, Mayumi Kimura, Yoko Kimura, Hikaru Tsuchiya, Hidehito Yoshihara, Takatsugu Hirokawa, Toshiya Endo, Edward A. Fon, Jean-François Trempe, Yasushi Saeki, Keiji Tanaka and Noriyuki Matsuda

Oncogene-like induction of cellular invasion from centrosome amplification pp. 167-171

Susana A. Godinho, Remigio Picone, Mithila Burute, Regina Dagher, Ying Su, Cheuk T. Leung, Kornelia Polyak, Joan S. Brugge, Manuel Théry and David Pellman

Membrane proteins bind lipids selectively to modulate their structure and function pp. 172-175

Arthur Laganowsky, Eamonn Reading, Timothy M. Allison, Martin B. Ulmschneider, Matteo T. Degiacomi, Andrew J. Baldwin and Carol V. Robinson

Correction: Corrigendum: Realizing the promise of cancer predisposition genes pp. 176-176

Nazneen Rahman

Erratum: Recent advances in homogeneous nickel catalysis pp. 176-176

Sarah Z. Tasker, Eric A. Standley and Timothy F. Jamison

Science and the arts: Rock and research pp. 177-179

Karen Kaplan

Turning point: Winnie Tang pp. 179-179

Virginia Gewin

Maxwell's Demon went down to Georgia pp. 182-182

Marissa Lingen