Age-dependent modulation of vascular niches for haematopoietic stem cells

Anjali P. Kusumbe (), Saravana K. Ramasamy, Tomer Itkin, Maarja Andaloussi Mäe, Urs H. Langen, Christer Betsholtz, Tsvee Lapidot and Ralf H. Adams ()
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Anjali P. Kusumbe: Max-Planck-Institute for Molecular Biomedicine, and University of Münster, Faculty of Medicine
Saravana K. Ramasamy: Max-Planck-Institute for Molecular Biomedicine, and University of Münster, Faculty of Medicine
Tomer Itkin: The Weizmann Institute of Science
Maarja Andaloussi Mäe: Vascular Biology Program, Genetics and Pathology, Uppsala University
Urs H. Langen: Max-Planck-Institute for Molecular Biomedicine, and University of Münster, Faculty of Medicine
Christer Betsholtz: Vascular Biology Program, Genetics and Pathology, Uppsala University
Tsvee Lapidot: The Weizmann Institute of Science
Ralf H. Adams: Max-Planck-Institute for Molecular Biomedicine, and University of Münster, Faculty of Medicine

Nature, 2016, vol. 532, issue 7599, 380-384

Abstract: Notch signalling in endothelial cells of the bone induces change in the capillaries and mesenchymal stem cells of the environment to support haematopoietic stem cell amplification.

Date: 2016
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DOI: 10.1038/nature17638

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