Anatomy and function of an excitatory network in the visual cortex

Wei-Chung Allen Lee (), Vincent Bonin, Michael Reed, Brett J. Graham, Greg Hood, Katie Glattfelder and R. Clay Reid ()
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Wei-Chung Allen Lee: Harvard Medical School
Vincent Bonin: Harvard Medical School
Michael Reed: Harvard Medical School
Brett J. Graham: Harvard Medical School
Greg Hood: Biomedical Applications Group, Pittsburgh Supercomputing Center, Carnegie Mellon University
Katie Glattfelder: Allen Institute for Brain Science
R. Clay Reid: Harvard Medical School

Nature, 2016, vol. 532, issue 7599, 370-374

Abstract: Two-photon calcium imaging and electron microscopy were used to explore the relationship between structure and function in mouse primary visual cortex, showing that layer 2/3 neurons are connected in subnetworks, that pyramidal neurons with similar orientation selectivity preferentially form synapses with each other, and that neurons with similar orientation tuning form larger synapses; this study exemplifies functional connectomics as a powerful method for studying the organizational logic of cortical networks.

Date: 2016
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DOI: 10.1038/nature17192

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