Musashi-2 attenuates AHR signalling to expand human haematopoietic stem cells

Stefan Rentas, Nicholas T. Holzapfel, Muluken S. Belew, Gabriel A. Pratt, Veronique Voisin, Brian T. Wilhelm, Gary D. Bader, Gene W. Yeo () and Kristin J. Hope ()
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Stefan Rentas: Stem Cell and Cancer Research Institute, McMaster University
Nicholas T. Holzapfel: Stem Cell and Cancer Research Institute, McMaster University
Muluken S. Belew: Stem Cell and Cancer Research Institute, McMaster University
Gabriel A. Pratt: Institute for Genomic Medicine, University of California, San Diego
Veronique Voisin: The Donnelly Centre, University of Toronto
Brian T. Wilhelm: Institute for Research in Immunology and Cancer, University of Montreal
Gary D. Bader: The Donnelly Centre, University of Toronto
Gene W. Yeo: Institute for Genomic Medicine, University of California, San Diego
Kristin J. Hope: Stem Cell and Cancer Research Institute, McMaster University

Nature, 2016, vol. 532, issue 7600, 508-511

Abstract: The RNA-binding protein Musashi-2 increases the self-renewing abilities of human haematopoietic stem cells, which have the potential to be used for regenerative therapies.

Date: 2016
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DOI: 10.1038/nature17665

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