sFRP2 in the aged microenvironment drives melanoma metastasis and therapy resistance

Kaur, Amanpreet; Webster, Marie R.; Marchbank, Katie; Behera, Reeti; Ndoye, Abibatou; Kugel, Curtis H.; Dang, Vanessa M.; Appleton, Jessica; O’Connell, Michael P.; Cheng, Phil; Valiga, Alexander A.; Morissette, Rachel; McDonnell, Nazli B.; Ferrucci, Luigi; Kossenkov, Andrew V.; Meeth, Katrina; Tang, Hsin-Yao; Yin, Xiangfan; Wood, William H.; Lehrmann, Elin; Becker, Kevin G.; Flaherty, Keith T.; Frederick, Dennie T.; Wargo, Jennifer A.; Cooper, Zachary A.; Tetzlaff, Michael T.; Hudgens, Courtney; Aird, Katherine M.; Zhang, Rugang; Xu, Xiaowei; Liu, Qin; Bartlett, Edmund; Karakousis, Giorgos; Eroglu, Zeynep; Lo, Roger S.; Chan, Matthew; Menzies, Alexander M.; Long, Georgina V.; Johnson, Douglas B.; Sosman, Jeffrey; Schilling, Bastian; Schadendorf, Dirk; Speicher, David W.; Bosenberg, Marcus; Ribas, Antoni; Weeraratna, Ashani T.

sFRP2 in the aged microenvironment drives melanoma metastasis and therapy resistance

Amanpreet Kaur, Marie R. Webster, Katie Marchbank, Reeti Behera, Abibatou Ndoye, Curtis H. Kugel, Vanessa M. Dang, Jessica Appleton, Michael P. O’Connell, Phil Cheng, Alexander A. Valiga, Rachel Morissette, Nazli B. McDonnell, Luigi Ferrucci, Andrew V. Kossenkov, Katrina Meeth, Hsin-Yao Tang, Xiangfan Yin, William H. Wood, Elin Lehrmann, Kevin G. Becker, Keith T. Flaherty, Dennie T. Frederick, Jennifer A. Wargo, Zachary A. Cooper, Michael T. Tetzlaff, Courtney Hudgens, Katherine M. Aird, Rugang Zhang, Xiaowei Xu, Qin Liu, Edmund Bartlett, Giorgos Karakousis, Zeynep Eroglu, Roger S. Lo, Matthew Chan, Alexander M. Menzies, Georgina V. Long, Douglas B. Johnson, Jeffrey Sosman, Bastian Schilling, Dirk Schadendorf, David W. Speicher, Marcus Bosenberg, Antoni Ribas and Ashani T. Weeraratna ()
Additional contact information
Amanpreet Kaur: The Wistar Institute
Marie R. Webster: The Wistar Institute
Katie Marchbank: The Wistar Institute
Reeti Behera: The Wistar Institute
Abibatou Ndoye: The Wistar Institute
Curtis H. Kugel: The Wistar Institute
Vanessa M. Dang: The Wistar Institute
Jessica Appleton: The Wistar Institute
Michael P. O’Connell: The Wistar Institute
Phil Cheng: University of Zurich
Alexander A. Valiga: The Wistar Institute
Rachel Morissette: The National Institute on Aging, National Institutes of Health
Nazli B. McDonnell: The National Institute on Aging, National Institutes of Health
Luigi Ferrucci: The National Institute on Aging, National Institutes of Health
Andrew V. Kossenkov: The Wistar Institute
Katrina Meeth: Yale University
Hsin-Yao Tang: The Wistar Institute
Xiangfan Yin: The Wistar Institute
William H. Wood: The National Institute on Aging, National Institutes of Health
Elin Lehrmann: The National Institute on Aging, National Institutes of Health
Kevin G. Becker: The National Institute on Aging, National Institutes of Health
Keith T. Flaherty: Massachusetts General Hospital Cancer Center, Developmental Therapeutics, Boston 02114, Massachusetts, USA
Dennie T. Frederick: Massachusetts General Hospital Cancer Center, Developmental Therapeutics, Boston 02114, Massachusetts, USA
Jennifer A. Wargo: MD Anderson Cancer Center
Zachary A. Cooper: MD Anderson Cancer Center
Michael T. Tetzlaff: MD Anderson Cancer Center
Courtney Hudgens: MD Anderson Cancer Center
Katherine M. Aird: The Wistar Institute
Rugang Zhang: The Wistar Institute
Xiaowei Xu: Abramson Cancer Center, University of Pennsylvania
Qin Liu: The Wistar Institute
Edmund Bartlett: Abramson Cancer Center, University of Pennsylvania
Giorgos Karakousis: Abramson Cancer Center, University of Pennsylvania
Zeynep Eroglu: City of Hope Medical Center
Roger S. Lo: University of California Los Angeles
Matthew Chan: Crown Princess Mary Cancer Centre
Alexander M. Menzies: Melanoma Institute Australia and The University of Sydney
Georgina V. Long: Melanoma Institute Australia and The University of Sydney
Douglas B. Johnson: Vanderbilt University Medical Center
Jeffrey Sosman: Vanderbilt University Medical Center
Bastian Schilling: University Hospital, West German Cancer Center, University Duesburg-Essen
Dirk Schadendorf: University Hospital, West German Cancer Center, University Duesburg-Essen
David W. Speicher: The Wistar Institute
Marcus Bosenberg: Yale University
Antoni Ribas: University of California Los Angeles
Ashani T. Weeraratna: The Wistar Institute

Nature, 2016, vol. 532, issue 7598, 250-254

Abstract: Aged fibroblasts release a Wnt antagonist, sFRP2, which drives a signalling cascade in melanoma cells, leading to increased metastasis and reduced effectiveness of targeted therapy.

Date: 2016
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DOI: 10.1038/nature17392

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