Thalamic reticular impairment underlies attention deficit in Ptchd1Y/− mice

Michael F. Wells, Ralf D. Wimmer, L. Ian Schmitt, Guoping Feng () and Michael M. Halassa
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Michael F. Wells: Duke University Medical Center
Ralf D. Wimmer: Neuroscience Institute, New York University Langone Medical Center
L. Ian Schmitt: Neuroscience Institute, New York University Langone Medical Center
Guoping Feng: McGovern Institute for Brain Research, Massachusetts Institute of Technology
Michael M. Halassa: Neuroscience Institute, New York University Langone Medical Center

Nature, 2016, vol. 532, issue 7597, 58-63

Abstract: Increased activity of dopamine receptor type-2 (D2R)-expressing cells in the nucleus accumbens of rats during a ‘decision’ period reflects a ‘loss’ outcome of the previous decision, and predicts a subsequent safe choice; by artificially increasing the activity of D2R neurons during the decision period, risk-seeking rats could be converted to risk-avoiding rats.

Date: 2016
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DOI: 10.1038/nature17427

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