The necrosome promotes pancreatic oncogenesis via CXCL1 and Mincle-induced immune suppression

Lena Seifert, Gregor Werba, Shaun Tiwari, Nancy Ngoc Giao Ly, Sara Alothman, Dalia Alqunaibit, Antonina Avanzi, Rocky Barilla, Donnele Daley, Stephanie H. Greco, Alejandro Torres-Hernandez, Matthew Pergamo, Atsuo Ochi, Constantinos P. Zambirinis, Mridul Pansari, Mauricio Rendon, Daniel Tippens, Mautin Hundeyin, Vishnu R. Mani, Cristina Hajdu, Dannielle Engle and George Miller ()
Additional contact information
Lena Seifert: S. Arthur Localio Laboratory, New York University School of Medicine
Gregor Werba: S. Arthur Localio Laboratory, New York University School of Medicine
Shaun Tiwari: S. Arthur Localio Laboratory, New York University School of Medicine
Nancy Ngoc Giao Ly: S. Arthur Localio Laboratory, New York University School of Medicine
Sara Alothman: S. Arthur Localio Laboratory, New York University School of Medicine
Dalia Alqunaibit: S. Arthur Localio Laboratory, New York University School of Medicine
Antonina Avanzi: S. Arthur Localio Laboratory, New York University School of Medicine
Rocky Barilla: S. Arthur Localio Laboratory, New York University School of Medicine
Donnele Daley: S. Arthur Localio Laboratory, New York University School of Medicine
Stephanie H. Greco: S. Arthur Localio Laboratory, New York University School of Medicine
Alejandro Torres-Hernandez: S. Arthur Localio Laboratory, New York University School of Medicine
Matthew Pergamo: New York University School of Medicine
Atsuo Ochi: S. Arthur Localio Laboratory, New York University School of Medicine
Constantinos P. Zambirinis: S. Arthur Localio Laboratory, New York University School of Medicine
Mridul Pansari: S. Arthur Localio Laboratory, New York University School of Medicine
Mauricio Rendon: S. Arthur Localio Laboratory, New York University School of Medicine
Daniel Tippens: S. Arthur Localio Laboratory, New York University School of Medicine
Mautin Hundeyin: S. Arthur Localio Laboratory, New York University School of Medicine
Vishnu R. Mani: S. Arthur Localio Laboratory, New York University School of Medicine
Cristina Hajdu: New York University School of Medicine
Dannielle Engle: Cold Spring Harbor Laboratories
George Miller: S. Arthur Localio Laboratory, New York University School of Medicine

Nature, 2016, vol. 532, issue 7598, 245-249

Abstract: A study of pancreatic ductal adenocarcinoma shows that cancer cell proliferation is associated with increased expression of proteins that control programmed necrotic cell death and suppress the adaptive immune system.

Date: 2016
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/nature17403 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:532:y:2016:i:7598:d:10.1038_nature17403

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature17403

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().