Daily magnesium fluxes regulate cellular timekeeping and energy balance

Kevin A. Feeney, Louise L. Hansen, Marrit Putker, Consuelo Olivares-Yañez, Jason Day, Lorna J. Eades, Luis F. Larrondo, Nathaniel P. Hoyle, John S. O’Neill () and Gerben van Ooijen ()
Additional contact information
Kevin A. Feeney: MRC Laboratory for Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus
Louise L. Hansen: School of Biological Sciences, University of Edinburgh, Max Born Crescent
Marrit Putker: MRC Laboratory for Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus
Consuelo Olivares-Yañez: Millennium Nucleus for Fungal Integrative and Synthetic Biology, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile
Jason Day: University of Cambridge
Lorna J. Eades: School of Chemistry, University of Edinburgh
Luis F. Larrondo: Millennium Nucleus for Fungal Integrative and Synthetic Biology, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile
Nathaniel P. Hoyle: MRC Laboratory for Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus
John S. O’Neill: MRC Laboratory for Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus
Gerben van Ooijen: School of Biological Sciences, University of Edinburgh, Max Born Crescent

Nature, 2016, vol. 532, issue 7599, 375-379

Abstract: Circadian rhythms in the intracellular concentration of magnesium ions act as a cell-autonomous timekeeping component to determine key clock properties and tune cellular metabolism both in a human cell line and in a unicellular alga.

Date: 2016
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DOI: 10.1038/nature17407

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