Normalizing the environment recapitulates adult human immune traits in laboratory mice

Lalit K. Beura, Sara E. Hamilton, Kevin Bi, Jason M. Schenkel, Oludare A. Odumade, Kerry A. Casey, Emily A. Thompson, Kathryn A. Fraser, Pamela C. Rosato, Ali Filali-Mouhim, Rafick P. Sekaly, Marc K. Jenkins, Vaiva Vezys, W. Nicholas Haining, Stephen C. Jameson () and David Masopust ()
Additional contact information
Lalit K. Beura: Center for Immunology, University of Minnesota, Minneapolis
Sara E. Hamilton: Center for Immunology, University of Minnesota, Minneapolis
Kevin Bi: Dana-Farber Cancer Institute, and Pediatric Hematology and Oncology, Children's Hospital
Jason M. Schenkel: Center for Immunology, University of Minnesota, Minneapolis
Oludare A. Odumade: Center for Immunology, University of Minnesota, Minneapolis
Kerry A. Casey: Center for Immunology, University of Minnesota, Minneapolis
Emily A. Thompson: Center for Immunology, University of Minnesota, Minneapolis
Kathryn A. Fraser: Center for Immunology, University of Minnesota, Minneapolis
Pamela C. Rosato: Center for Immunology, University of Minnesota, Minneapolis
Ali Filali-Mouhim: Case Western Reserve University
Rafick P. Sekaly: Case Western Reserve University
Marc K. Jenkins: Center for Immunology, University of Minnesota, Minneapolis
Vaiva Vezys: Center for Immunology, University of Minnesota, Minneapolis
W. Nicholas Haining: Dana-Farber Cancer Institute, and Pediatric Hematology and Oncology, Children's Hospital
Stephen C. Jameson: Center for Immunology, University of Minnesota, Minneapolis
David Masopust: Center for Immunology, University of Minnesota, Minneapolis

Nature, 2016, vol. 532, issue 7600, 512-516

Abstract: The immune system of laboratory mice raised in an ultra-hygienic environment resembles that ofnewborn humans, but can be induced to resemble the immune system of adult humans or 'dirty' mice by co-housing with pet store-bought mice.

Date: 2016
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DOI: 10.1038/nature17655

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