Differential DNA repair underlies mutation hotspots at active promoters in cancer genomes

Dilmi Perera, Rebecca C. Poulos, Anushi Shah, Dominik Beck, John E. Pimanda and Jason W. H. Wong ()
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Dilmi Perera: Prince of Wales Clinical School and Lowy Cancer Research Centre
Rebecca C. Poulos: Prince of Wales Clinical School and Lowy Cancer Research Centre
Anushi Shah: Prince of Wales Clinical School and Lowy Cancer Research Centre
Dominik Beck: Prince of Wales Clinical School and Lowy Cancer Research Centre
John E. Pimanda: Prince of Wales Clinical School and Lowy Cancer Research Centre
Jason W. H. Wong: Prince of Wales Clinical School and Lowy Cancer Research Centre

Nature, 2016, vol. 532, issue 7598, 259-263

Abstract: Analysis of 1,161 cancer genomes across 14 cancer types shows that increased mutation density at gene promoters can be linked to transcription initiation activity and impairment of nucleotide excision repair.

Date: 2016
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DOI: 10.1038/nature17437

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